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3. Data from Exploiting the Mutanome for Tumor Vaccination

Author

Castle, John C., primary, Kreiter, Sebastian, primary, Diekmann, Jan, primary, Löwer, Martin, primary, van de Roemer, Niels, primary, de Graaf, Jos, primary, Selmi, Abderraouf, primary, Diken, Mustafa, primary, Boegel, Sebastian, primary, Paret, Claudia, primary, Koslowski, Michael, primary, Kuhn, Andreas N., primary, Britten, Cedrik M., primary, Huber, Christoph, primary, Türeci, Özlem, primary, and Sahin, Ugur, primary

Published
2023
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4. Supplementary Table 2 from Exploiting the Mutanome for Tumor Vaccination

Author

Castle, John C., primary, Kreiter, Sebastian, primary, Diekmann, Jan, primary, Löwer, Martin, primary, van de Roemer, Niels, primary, de Graaf, Jos, primary, Selmi, Abderraouf, primary, Diken, Mustafa, primary, Boegel, Sebastian, primary, Paret, Claudia, primary, Koslowski, Michael, primary, Kuhn, Andreas N., primary, Britten, Cedrik M., primary, Huber, Christoph, primary, Türeci, Özlem, primary, and Sahin, Ugur, primary

Published
2023
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5. Supplementary Methods from Exploiting the Mutanome for Tumor Vaccination

Author

Castle, John C., primary, Kreiter, Sebastian, primary, Diekmann, Jan, primary, Löwer, Martin, primary, van de Roemer, Niels, primary, de Graaf, Jos, primary, Selmi, Abderraouf, primary, Diken, Mustafa, primary, Boegel, Sebastian, primary, Paret, Claudia, primary, Koslowski, Michael, primary, Kuhn, Andreas N., primary, Britten, Cedrik M., primary, Huber, Christoph, primary, Türeci, Özlem, primary, and Sahin, Ugur, primary

Published
2023
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6. Supplementary Table 1 from Exploiting the Mutanome for Tumor Vaccination

Author

Castle, John C., primary, Kreiter, Sebastian, primary, Diekmann, Jan, primary, Löwer, Martin, primary, van de Roemer, Niels, primary, de Graaf, Jos, primary, Selmi, Abderraouf, primary, Diken, Mustafa, primary, Boegel, Sebastian, primary, Paret, Claudia, primary, Koslowski, Michael, primary, Kuhn, Andreas N., primary, Britten, Cedrik M., primary, Huber, Christoph, primary, Türeci, Özlem, primary, and Sahin, Ugur, primary

Published
2023
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7. The effects of coagulation factors and their inhibitors on proliferation and migration in colorectal cancer.

Author

Rees, Peter Adam, Castle, John, Clouston, Hamish William, Lamb, Rebecca, Singh, Urvashi, Duff, Sarah Elizabeth, and Kirwan, Cliona Clare

Subjects
*BLOOD coagulation factors, *CARCINOGENS, *THROMBIN, *COLORECTAL cancer, *ANTINEOPLASTIC agents, *ANTITHROMBINS
Abstract

Background/Aim: Clotting factors promote cancer development. We investigated if coagulation proteins promote proliferation and migration in colorectal cancer (CRC) cell lines and whether their direct inhibitors can attenuate these effects. Materials and Methods: DLD‐1 and SW620 cells were treated with tissue factor (0, 50, 100 and 500 pg/mL ± 10 μg/mL 10H10 [anti‐tissue factor antibody]), thrombin (0.0, 0.1, 1.0 and 10.0 U/mL ± 0.5 μM dabigatran [thrombin inhibitor]) and Factor Xa, FXa (0.0, 0.1, 1.0 and 10.0 U/mL ± 100 ng/mL rivaroxaban [FXa inhibitor]) and their effects on proliferation and migration were quantified using the PrestoBlue® and transwell migration assays, respectively. Results: Thrombin increased proliferation from 48 h treatment compared to its control (48 h 6.57 ± 1.36 u vs. 2.42 ± 0.13 u, p = 0.001, 72 h 9.50 ± 1.54 u vs. 4.50 ± 0.47 u, p = 0.004 and 96 h 10.77 ± 1.72 u vs. 5.57 ± 0.25 u, p = 0.008). This increase in proliferation was attenuated by dabigatran at 72 h (2.23 ± 0.16 u vs. 3.26 ± 0.43 u, p = 0.04). Tissue factor (0 pg/mL 20.7 ± 1.6 cells/view vs. 50 pg/mL 32.4 ± 1.9 cells/view, p = 0.0002), FXa (0.0 U/mL 8.9 ± 1.1 cells/view vs. 10.0 U/mL 17.7 ± 1.7 cells/view, p < 0.0001) and thrombin (0.0 U/mL 8.9 ± 1.3 cells/view vs. 10.0 U/mL 20.2 ± 2.0 cells/view, p < 0.0001) all increased migration compared to their controls. However, their direct inhibitors did not attenuate these increases. Conclusion: Thrombin, FXa and TF all increase migration in CRC in vitro. Thrombin induced increase in proliferation is abrogated by dabigatran. Dabigatran may have potential as an anti‐cancer therapy in CRC. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction

Author

Gavory, Gerald, primary, Ghandi, Mahmoud, additional, d’Alessandro, Anne-Cecile, additional, Bonenfant, Debora, additional, Chicas, Agustin, additional, Delobel, Frederic, additional, Demarco, Brad, additional, Flohr, Alexander, additional, King, Christopher, additional, Laine, Anne-Laure, additional, Massafra, Vittoria, additional, Narayan, Rajiv, additional, Osmont, Arnaud, additional, Ottaviani, Giorgio, additional, Peck, Dave, additional, Pessa, Sarah, additional, Rubin, Nooreen, additional, Ryckmans, Thomas, additional, Schillo, Martin, additional, Singh, Ambika, additional, Tortoioli, Simone, additional, Vigil, Dominico, additional, Zarayskiy, Vladislav, additional, Castle, John, additional, Janku, Filip, additional, Wallace, Owen, additional, Buonamici, Silvia, additional, and Fasching, Bernhard, additional

Published
2022
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12. Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer

Author

Gavory, Gerald, primary, Fasching, Bernhard, additional, Bonenfant, Debora, additional, Sadok, Amine, additional, Singh, Ambika, additional, Schillo, Martin, additional, Massafra, Vittoria, additional, d’Alessandro, Anne-Cecile, additional, Castle, John, additional, Ghandi, Mahmoud, additional, Chicas, Agustin, additional, Delobel, Frederic, additional, Flohr, Alexander, additional, Ottaviani, Giorgio, additional, Ryckmans, Thomas, additional, Laine, Anne-Laure, additional, Eidam, Oliv, additional, Wang, Hannah, additional, Bernett, Ilona, additional, Chan, Laura, additional, Gorrini, Chiara, additional, Roumiliotis, Theo, additional, Choudhary, Jyoti, additional, LeBihan, Yann-Vai, additional, Cabry, Marc, additional, Stubbs, Mark, additional, Burke, Rosemary, additional, Van Montfort, Rob, additional, Caldwell, John, additional, Chopra, Rajesh, additional, Collins, Ian, additional, and Buonamici, Silvia, additional

Published
2021
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