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Your search keyword '"Casini, Ilenia"' showing total 8 results
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8 results on '"Casini, Ilenia"'

3. Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist.

Author

Pessina, Federica, Casini, Ilenia, Gamberucci, Alessandra, Carullo, Gabriele, Signorini, Cinzia, Brizzi, Antonella, Aiello, Francesca, Aloisi, Anna Maria, and Pieretti, Stefano

Subjects
*INTRACELLULAR calcium, *CYTOTOXINS, *CELL survival, *OXIDATIVE stress, *ZYMOSAN, *FREE fatty acids
Abstract

Free fatty acid receptor 1 (FFAR1) has emerged as the most targeted isoform of the free fatty acid receptors because of its involvement in the modulation of energy balance and its potential role in the control of inflammatory and pain conditions. Quercetin-3-oleate (AV2), recognized as a new FFAR1 partial agonist, was investigated for its ability to modulate inflammation and nociception. Human immortal neuroblastoma SH and the murine macrophagic RAW 264.7 cells were used to evaluate cell viability, the potential cytoprotective activity, and the anti-inflammatory properties of AV2 in vitro. Paw edema, caused by zymosan-A, and the formalin test were used to assess the in vivo anti-inflammatory and antinociceptive effects in CD-1 mice. In vitro, AV2 was devoid of cytotoxicity, significantly reduced ROS in both cell types, and protected RAW 264.7 cells from lipopolysaccharide damage by reducing tumor necrosis factor-α production. Interestingly, AV2 induced a transient elevation of intracellular calcium that was reduced in cells, pre-incubated with the FFAR1 antagonist DC260126. In vivo, AV2 reduced formalin-induced nociception and zymosan A-induced paw edema, and both effects were reversed by the FFAR1 antagonist GW1100. In conclusion, these data strongly support the AV2-mediated antioxidant, anti-inflammatory, and antinociceptive activity. AV2 represents a promising molecule for the clinical management of inflammatory-related pain conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Estrogens and phytoestrogens in body functions

Author

Ceccarelli, Ilaria, primary, Bioletti, Lucia, additional, Peparini, Sofia, additional, Solomita, Erminia, additional, Ricci, Comasia, additional, Casini, Ilenia, additional, Miceli, Elisangela, additional, and Aloisi, Anna Maria, additional

Published
2022
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8. Age and training intensity differently affect male runners' endocrine and sexual parameters

Author

Passavanti, Giandomenico, Paoli, Antonio, Rizzato, Alex, Ceccarelli, Ilaria, Fiorenzani, Paolo, Casini, Ilenia, and Aloisi, Anna Maria

Subjects
sexual functions, Adult, Male, Estradiol, Physiology, Sexual Behavior, Middle Aged, Hormones, Surveys and Questionnaires, Physiology (medical), runner, testosterone, Humans, Testosterone
Abstract

Physical activity is widely recognized to improve health and its inclusion in daily life at all ages is highly recommended. Gonadal hormones are known to be affected by physical activity. The exercise-induced effects on male runners of different ages were investigated by dividing 31 runners by age (Young, Y, 30-55 years; Old, O, 56-70 years) and amount of training (Light, L,50 km/week; Heavy, H, 50 or more km/week). To test the somatic, sexual, and psychological health aspects, the Aging Male's Symptoms Scale (AMS) and the International Index of Erectile Function-6 (IIEF-6) questionnaires were administered and blood samples were drawn for adrenocorticotropic hormone, testosterone (Total-TT), free testosterone (Free-T), cortisol (C), dihydrotestosterone (DHT), estradiol, and sex hormone-binding globulin determinations. Clinical evaluations and questionnaire results showed the presence in all groups of some subclinical symptoms and "Light" dysfunctions. TT in the old-heavy (OH) group was significantly lower than in the OL group (2.38 ± 0.18 ng/mL vs. 3.36 ± 0.44 ng/ml, P = 0.05). The TT/DHT ratio was significantly higher in YH than in OH (3.64 ± 0.16 vs. 2.92 ± 0.23, P0.05). TT was positively correlated with AMS sexual subscale and negatively correlated with IIEF-6. Physical activity can significantly affect andrological health and testosterone levels in runners at all ages. Thus, due to the important testosterone-mediated vital functions in men, the evaluation of these parameters would be indicated in old as well as in young subjects.

Published
2022
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