9 results on '"Cargill, Tamsin"'
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2. Effect of Prior ChAdOx1 COVID-19 Immunisation on T-Cell Responses to ChAdOx1-HBV †.
- Author
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Davis, Charlotte, Singh, Dave, Anderson, Katie, Vardeu, Antonella, Kopycinski, Jakub, Bridges-Webb, Alice, Trickett, Alice, O'Brien, Susanne, Downs, Matthew, Kaur, Randip, Kolenovska, Radka, Bussey, Louise, Rutkowski, Kathryn, Sebastian, Sarah, Cargill, Tamsin, Barnes, Eleanor, Evans, Thomas G., and Cicconi, Paola
- Subjects
T cells ,IMMUNIZATION ,GENETIC vectors ,INTRAMUSCULAR injections ,ANTIBODY titer - Abstract
There are varying data concerning the effect of prior anti-vector immunity on the T-cell response induced by immunisation with an identical vectored vaccine containing a heterologous antigen insert. To determine whether prior exposure to ChAdOx1-SARS-CoV2 immunisation (Vaxzevria
® ) impacts magnitudes of antigen-specific T-cell responses elicited by subsequent administration of the same viral vector (encoding HBV antigens, ChAdOx1-HBV), healthy volunteers that had received Vaxzevria® (n = 15) or the Pfizer or Moderna mRNA COVID-19 vaccine (n = 11) between 10 and 18 weeks prior were recruited to receive a single intramuscular injection of ChAdOx1-HBV. Anti-ChAdOx1-neutralising antibody titers were determined, and vector or insert-specific T-cell responses were measured by a gamma-interferon ELISpot and intracellular cytokine staining (ICS) assay using multiparameter flow cytometry. Participants were followed for three months after the ChAdOx1-HBV injection, which was well-tolerated, and no dropouts occurred. The baseline ChAdOx1 neutralisation titers were higher in the Vaxzevria® cohort (median of 848) than in the mRNA cohort (median of 25). T-cell responses to HBV antigens, measured by ELISpot, were higher on day 28 in the mRNA group (p = 0.013) but were similar between groups on day 84 (p = 0.441). By ICS, these differences persisted at the last time point. There was no clear correlation between the baseline responses to the adenoviral hexon and the subsequent ELISpot responses. As vaccination within 3 months using the same viral vector backbone affected the insert-specific T-cell responses, a greater interval after prior adenoviral immunisation using heterologous antigens may be warranted in settings in which these cells play critical roles. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
3. Regional variation in characteristics of patients with decompensated cirrhosis admitted to hospitals in the UK
- Author
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Tavabie, Oliver D, primary, Abeysekera, Kushala WM, additional, Brennan, Paul N, additional, Marjot, Thomas, additional, Kronsten, Victoria T, additional, Li, Wenhao, additional, Nayagam, Jeremy S, additional, Dhaliwal, Amritpal, additional, Hardy, Tim, additional, Maurice, James B, additional, Zakeri, Nekisa, additional, Abbas, Nadir, additional, Abbasi, Abdullah, additional, Abbott, Jane, additional, Abdul, Rahman, additional, Abdulaziz, Mohamed, additional, Abduljabbar, Duaa, additional, Adamson, Robbie, additional, Adebayo, Danielle, additional, Adhikarla, Aditya Kumar, additional, Adler, Maciej, additional, Afifi, Mostafa, additional, Ahmad, Salman, additional, Ahmed, Shayan, additional, Aithal, Guruprasad, additional, Akram, Ali, additional, Al Radhi, Balqees, additional, Al-Talib, Ismaeel, additional, Alele, Jolomi, additional, Ali, Alaa Mohammed, additional, Almusai, Safa, additional, Appleby, Victoria, additional, Asmat, Huma, additional, Astbury, Sarah, additional, Atkinson, Ali, additional, Badrulhisham, Fakhirah, additional, Balachandrakumar, Vinay K, additional, Ball, Alexandra, additional, Banfa, Moses, additional, Barn, Jeevan, additional, Begum, Shahnaz, additional, Belfield, Katherine, additional, Bendall, Oliver, additional, Bennett, Kris, additional, Bernal, William, additional, Bhandari, Rajan, additional, Bhatti, Prashan, additional, Bradley, Meg, additional, Brown, Edward, additional, Bryce, Kathleen, additional, Buchanan, Ryan, additional, Burke, Laura, additional, Campbell, Roisin, additional, Cargill, Tamsin, additional, Carroll, Geraldine, additional, Cartledge, James, additional, Chatterjee, Devnandan, additional, Chaundry, Rayan, additional, Choudhry, Zeshan, additional, Clare, Kathleen, additional, Cobbold, Jeremy, additional, Coburn, Robert, additional, Cook, Charlotte, additional, Corvan, Fintan, additional, Cox, Rebecca, additional, Craig, Darren, additional, Creamer, John, additional, Curran, Christopher, additional, De Silva, Shanika, additional, Dean, Laurence, additional, Dillon, Jayne, additional, Dillon, John, additional, Dunn, Rebecca, additional, Eckersley, Robert, additional, Eike, Gidveig, additional, Elagib, Amul, additional, Elkholi, Ayman, additional, Elshaarawy, Omar, additional, Faloon, Sarah, additional, Fan, Francis, additional, Fazili, Mohammad, additional, Fernandes, Denzil, additional, Fox, James, additional, Foxton, Matthew, additional, Gaba, Waqas, additional, Gaikwad, Girish, additional, Gairola, Abishek, additional, Galanakis, Vasileios, additional, Gallaher, Charles, additional, Gautam, Nisham, additional, Germain, Lewis, additional, Giles, Ben, additional, Gill, Ceri, additional, Glover, Ben, additional, Glover, John, additional, Gomez, David, additional, Gomez, Michael, additional, Gordon, Victoria, additional, Gormley, Sarah, additional, Goulder, John, additional, Goyal, Simran, additional, Greenham, Olivia, additional, Guthrie, Sarah, additional, Hackett, Richard, additional, Haddadin, Yazan, additional, Hadjinicolaou, Andreas, additional, Hall, Jonathan, additional, Hamza, Mohammed, additional, Haque, Tasnuma, additional, Harris, Rebecca, additional, Hart, Catherine, additional, Hasan, Sundas, additional, Hasnain Nadir, Syed Mujtaba, additional, Hassall, James, additional, Hawker-Bond, George, additional, Hawkyard, Jake, additional, Healey, Scott, additional, Hogan, Brian, additional, Hornby, Catherine, additional, Humayun, MD, additional, Hutchison, John, additional, Iftikhar, Zahra, additional, Ismail, Asem, additional, James, Joel, additional, Jones, Rebecca, additional, Jopson, Laura, additional, Juthani, Dipal, additional, Kaina, Philippa, additional, Karim, Aadil, additional, Karim, Syed Misbah, additional, Kashyap, Vaishnavi, additional, Kassab, Mohamed, additional, Katarey, Dev, additional, Kenny, Lee, additional, Kerry, Georgina, additional, Khan, Adnan, additional, Khan, Ayesha, additional, Khan, Azab, additional, Khan, Muhammad Taha, additional, Khan, Tahir, additional, Khatib, Aseil, additional, Khattak, Mohammad Fawad, additional, King, Ji Jade, additional, Kooner, Emily, additional, Korani, Mohammed, additional, Kotha, Sreelakshmi, additional, Lam, Wai Liam, additional, Lateef, Mohammed, additional, Leighton, Jess, additional, Leith, Damien, additional, Liaros, Angela, additional, Liu Yin, James, additional, Lourenco, Floyd, additional, Lyles, Annabel, additional, Macken, Lucia, additional, Magee, Ciaran, additional, Maggs, Daniel, additional, Mahalingam, Aarani, additional, Mahenthiran, Midusa, additional, Mahmood, Rizwan, additional, Mandour, Mandour Omer, additional, Manocha, Namita, additional, Mansour, Dina, additional, Marks, Daniella, additional, Martin, Ciara, additional, Martin, Harry, additional, Martin, Iana, additional, Martin, Katherine, additional, Maruthan, Sachan, additional, Masin, Rhys, additional, Mason, Denise, additional, Matthews, Charmaine, additional, Mavrou, Athina, additional, Maxan, Ema, additional, Maxfield, Dominic, additional, McAvoy, Emma, additional, McCaughan, Hannah, additional, McColl, Kirsty, additional, McCorry, Roger, additional, McDonald, Stewart, additional, McDowell, Hannah, additional, McGoran, John, additional, McIlwane, Stewart, additional, McPherson, Stuart, additional, Meakin, Olivia, additional, Mebarek, Leila, additional, Merrill, Hannah, additional, Michail, Stephanie, additional, Modarres, Pedram, additional, Mohamedali, Alaa, additional, Mohammed, Yaser, additional, Mohammed, Zakiuddin, additional, Mohan, Jaiganesh, additional, Monnier, Chloe, additional, Moran, Eilis, additional, Moroni, Francesca, additional, Morrison, Gary, additional, Msaddi, Anas, additional, Mutar, Sarah, additional, Nahed, Ismail, additional, Navaratnam, Janardhan, additional, Neto-Pereira, Luis, additional, Ng, Jennifer, additional, Nwoguh, Chinonso, additional, O'Kane, Rebecca, additional, Omar, Sohail, additional, Ososanya, Abosede, additional, Parambil, Jessiya Veliyankodan, additional, Patel, Jay, additional, Pericleous, Marinos, additional, Pervais, Zeshan, additional, Phoolchund, Anju, additional, Pietrzycki, Julian, additional, Pillay, Lushen, additional, Pohl, Keith, additional, Prabhu, Kiran, additional, Putri, Yesita Rizky F., additional, Qazi, Umang, additional, Rafique, Khizar Khalid, additional, Raghuraman, Arun, additional, Raman, Krithivasan, additional, Ranade, Vaishali, additional, Rastelli, Francesca, additional, Ratcliffe, Elizabeth, additional, Rattehalli, Deepa, additional, Raza, Tufail, additional, Razak, Amir, additional, Read, George, additional, Robins, Anne, additional, Rowe, Ian, additional, Rushbrook, Simon, additional, Salama, Mohamed, additional, Saravan, Ramasamy, additional, Sarkar, Srishti, additional, Saunsbury, Emma, additional, Scott, Jennifer, additional, Serna, Solange, additional, Shahzad, Hassnain, additional, Shamsaldeen, Mohammed, additional, Sharip, Mohammed, additional, Shearer, Jessica, additional, Sheikh, Adam, additional, Sheiybani, Giovanna, additional, Sherwin, Michelle, additional, Sheth, Abhishek, additional, Shintre, Nidhi, additional, Singhal, Saket, additional, Sinha, Rohit, additional, Sinharay, Ricky, additional, Smith, Gloria, additional, Smith, Ria, additional, Snowdon, Victoria, additional, Spicer, Joanne, additional, Spoor, Johannes, additional, Sreenivasan, Shiva, additional, Srinivasa, Amar, additional, Srivastava, Ankur, additional, St. Aimee, Louise, additional, Stagg, Georgia, additional, Stanley, Jatinder, additional, Stevenson, Jason, additional, Stokes, Daniel, additional, Stroud, Robert, additional, Subhani, Mohsan, additional, Suliman, Hiba, additional, Sultana, Marium, additional, Summers, Nikki, additional, Sutherland, Chloe, additional, Swann, Rachael, additional, Sykes, Lynne, additional, Taha, Mostafa, additional, Tan, Kwei Eng, additional, Tariq, Zohaib, additional, Tay, Joshua Jun Ming, additional, Taylor, Alison, additional, Thakor, Amit, additional, Tsang, James, additional, Turner, Lucy, additional, Tyler, Zaccharie, additional, Unitt, Esther, additional, Volcek, Edward, additional, Watson, Iona, additional, Watters, Chris, additional, Wells, Gemma, additional, White, Helen, additional, Widlak, Monika, additional, Williams, Matthew, additional, Wischhusen, Jack, additional, Woodland, Hazel, additional, Wren, Louise, additional, Xyda, Souzana, additional, Yeh, Julian, additional, Young, Alison, additional, and Yuan, Jack Shie Jie, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Defining characteristics and outcomes for patients with non-alcoholic fatty liver disease admitted to hospital with decompensated cirrhosis
- Author
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Tavabie, Oliver D., Abbott, Jane, Abeysekera, Kushala WM., Balachandrakumar, Vinay K., Bennett, Kris, Brennan, Paul, Buchanan, Ryan, Dhaliwal, Amritpal, Galanakis, Vasileios, Hardy, Tim, Harris, Rebecca, Kronsten, Victoria T., Leighton, Jess, Li, Wenhao, Yin, James Liu, Macken, Lucia, Marjot, Thomas, Maurice, James B., McDowell, Hannah, Navaratnam, Janardhan, Pohl, Keith, Nayagam, Jeremy S., Saunsbury, Emma, Scott, Jennifer, Sheth, Abhishek, Sinharay, Ricky, Sheiybani, Giovanna, Subhani, Mohsan, Turner, Lucy, White, Helen, Zakeri, Nekisa, Cook, Charlotte, Abbas, Nadir, Abbasi, Abdullah, Abdul, Rahman, Abdulaziz, Mohamed, Abduljabbar, Duaa, Adamson, Robbie, Adebayo, Danielle, Adhikarla, Aditya Kumar, Adler, Maciej, Ahmad, Salman, Ahmed, Shayan, Afifi, Mostafa, Akram, Ali, Al Radhi, Balqees, Al-Talib, Ismaeel, Alele, Jolomi, Ali, Alaa Mohammed, Almusai, Safa, Appleby, Victoria, Asmat, Huma, Astbury, Sarah, Atkinson, Ali, Badrulhisham, Fakhirah, Ball, Alexandra, Banfa, Moses, Barn, Jeevan, Begum, Shahnaz, Belfield, Katherine, Bendall, Oliver, Bhandari, Rajan, Bhatti, Prashan, Bradley, Meg, Brown, Edward, Bryce, Kathleen, Burke, Laura, Campbell, Roisin, Cargill, Tamsin, Carroll, Geraldine, Cartledge, James, Chatterjee, Devnandan, Chaundry, Rayan, Choudhry, Zeshan, Clare, Kathleen, Cobbold, Jeremy, Coburn, Robert, Corvan, Fintan, Cox, Rebecca, Craig, Darren, Creamer, John, Curran, Christopher, De Silva, Shanika, Dean, Laurence, Dillon, Jayne, Dunn, Rebecca, Eckersley, Robert, Eike, Gidveig, Elagib, Amul, Elkholi, Ayman, Elshaarawy, Omar, Faloon, Sarah, Fan, Francis, Fazili, Mohammad, Fernandes, Denzil, Fox, James, Foxton, Matthew, Gaba, Waqas, Gaikwad, Girish, Gairola, Abishek, Gallaher, Charles, Gautam, Nisham, Germain, Lewis, Giles, Ben, Gill, Ceri, Glover, Ben, Glover, John, Gomez, David, Gomez, Michael, Gordon, Victoria, Gormley, Sarah, Goulder, John, Goyal, Simran, Greenham, Olivia, Guthrie, Sarah, Hackett, Richard, Haddadin, Yazan, Hadjinicolaou, Andreas, Hall, Jonathan, Haque, Tasnuma, Hart, Catherine, Hasnain Nadir, Syed Mujtaba, Hassall, James, Hasan, Sundas, Hawker-Bond, George, Hawkyard, Jake, Healey, Scott, Hornby, Catherine, Hamza, Mohammed, Humayun, M.D., Hutchison, John, Iftikhar, Zahra, Ismail, Asem, James, Joel, Jopson, Laura, Juthani, Dipal, Kaina, Philippa, Karim, Aadil, Karim, Syed Misbah, Kashyap, Vaishnavi, Kassab, Mohamed, Katarey, Dev, Kenny, Lee, Kerry, Georgina, Khan, Adnan, Khan, Ayesha, Khan, Azab, Khan, Muhammad Taha, Khan, Tahir, Khatib, Aseil, Khattak, Mohammad Fawad, King, Ji Jade, Korani, Mohammed, Kotha, Sreelakshmi, Kooner, Emily, Lam, Wai Liam, Lateef, Mohammed, Leith, Damien, Liaros, Angela, Lourenco, Floyd, Lyles, Annabel, Mahenthiran, Midusa, Magee, Ciaran, Maggs, Daniel, Mahalingam, Aarani, Mahmood, Rizwan, Mandour, Mandour Omer, Manocha, Namita, Mansour, Dina, Marks, Daniella, Martin, Ciara, Martin, Harry, Martin, Iana, Martin, Katherine, Maruthan, Sachan, Masin, Rhys, Mason, Denise, Matthews, Charmaine, Mavrou, Athina, Maxan, Ema, Maxfield, Dominic, McAvoy, Emma, McColl, Kirsty, McCaughan, Hannah, McCorry, Roger, McGoran, John, McDonald, Stewart, McIlwane, Stewart, Meakin, Olivia, Mebarek, Leila, Merrill, Hannah, Michail, Stephanie, Modarres, Pedram, Mohamedali, Alaa, Mohammed, Yaser, Mohammed, Zakiuddin, Mohan, Jaiganesh, Monnier, Chloe, Moran, Eilis, Morrison, Gary, Moroni, Francesca, Msaddi, Anas, Mutar, Sarah, Neto-Pereira, Luis, Nahed, Ismail, Ng, Jennifer, Nwoguh, Chinonso, O’Kane, Rebecca, Omar, Sohail, Ososanya, Abosede, Parambil, Jessiya Veliyankodan, Patel, Jay, Pericleous, Marinos, Pervais, Zeshan, Phoolchund, Anju, Pietrzycki, Julian, Pillay, Lushen, Prabhu, Kiran, Putri, Yesita Rizky F., Qazi, Umang, Rafique, Khizar Khalid, Raman, Krithivasan, Ranade, Vaishali, Rastelli, Francesca, Ratcliffe, Elizabeth, Rattehalli, Deepa, Raza, Tufail, Razak, Amir, Raghuraman, Arun, Read, George, Robins, Anne, Rushbrook, Simon, Salama, Mohamed, St. Aimee, Louise, Saravan, Ramasamy, Sarkar, Srishti, Serna, Solange, Shahzad, Hassnain, Shamsaldeen, Mohammed, Sharip, Mohammed, Shearer, Jessica, Sheikh, Adam, Sherwin, Michelle, Shintre, Nidhi, Singhal, Saket, Sinha, Rohit, Smith, Gloria, Smith, Ria, Spicer, Joanne, Spoor, Johannes, Sreenivasan, Shiva, Srinivasa, Amar, Srivastava, Ankur, Stagg, Georgia, Stanley, Jatinder, Stevenson, Jason, Stokes, Daniel, Stroud, Robert, Suliman, Hiba, Sultana, Marium, Summers, Nikki, Sutherland, Chloe, Swann, Rachael, Sykes, Lynne, Taha, Mostafa, Tan, Kwei Eng, Tariq, Zohaib, Ming Tay, Joshua Jun, Taylor, Alison, Thakor, Amit, Tsang, James, Tyler, Zaccharie, Unitt, Esther, Volcek, Edward, Wischhusen, Jack, Watson, Iona, Watters, Chris, Wells, Gemma, Widlak, Monika, Williams, Matthew, Woodland, Hazel, Wren, Louise, Xyda, Souzana, Yeh, Julian, Young, Alison, Jie Yuan, Jack Shie, Aithal, Guruprasad, Bernal, William, Dillon, John, Hogan, Brian, McPherson, Stuart, Jones, Rebecca, Rowe, Ian, and Snowdon, Victoria
- Published
- 2023
- Full Text
- View/download PDF
5. NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner
- Author
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Diniz, Mariana O., primary, Schurich, Anna, additional, Chinnakannan, Senthil K., additional, Duriez, Marion, additional, Stegmann, Kerstin A., additional, Davies, Jessica, additional, Kucykowicz, Stephanie, additional, Suveizdyte, Kornelija, additional, Amin, Oliver E., additional, Alcock, Frances, additional, Cargill, Tamsin, additional, Barnes, Eleanor, additional, and Maini, Mala K., additional
- Published
- 2022
- Full Text
- View/download PDF
6. NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner.
- Author
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Diniz, Mariana O., Schurich, Anna, Chinnakannan, Senthil K., Duriez, Marion, Stegmann, Kerstin A., Davies, Jessica, Kucykowicz, Stephanie, Suveizdyte, Kornelija, Amin, Oliver E., Alcock, Frances, Cargill, Tamsin, Barnes, Eleanor, and Maini, Mala K.
- Subjects
KILLER cells ,CHRONIC hepatitis B ,VACCINE effectiveness ,T cells ,HEPATITIS B virus ,IMMUNITY ,NUDGE theory - Abstract
A better understanding of mechanisms that regulate CD8
+ T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antigen-specific T cell responses to chimp adenoviral vector (ChAdOx) vaccination in a mouse model of chronic HBV infection (CHB). Probing the mechanism underlying this negative regulation, we observed that CHB drove parallel up-regulation of programmed cell death ligand 1 (PD-L1) on liver-resident NK cells and programmed cell death 1 (PD-1) on intrahepatic T cells. PD-L1–expressing liver-resident NK cells suppressed PD-1hi CD8+ T cells enriched within the HBV-specific response to therapeutic vaccination. Cytokine activation of NK cells also induced PD-L1, and combining cytokine activation with PD-L1 blockade resulted in conversion of NK cells into efficient helpers that boosted HBV-specific CD8+ T cell responses to therapeutic vaccination in mice and to chronic infection in humans. Our findings delineate an immunotherapeutic combination that can boost the response to therapeutic vaccination in CHB and highlight the broader importance of PD-L1–dependent regulation of T cells by cytokine-activated NK cells. NK cells nudge vaccine response: Therapeutic vaccines for chronic infections have reduced efficacy because of the presence of exhausted T cells and a tolerogenic environment that limits vaccine responses. Diniz et al. observed that NK cell depletion enhanced T cell responses to a chimp adenoviral vectored hepatitis B virus (HBV) vaccine in a mouse model of chronic hepatitis B virus (CHB) infection. CHB was associated with up-regulation of PD-1 on intrahepatic CD8+ T cells and PD-L1 on liver-resident NK cells. These NK cells suppressed HBV-specific responses of PD-1hi CD8+ T cells upon vaccination. Stimulation of NK cells with activating cytokines also induced PD-L1 expression, but cytokine activation combined with PD-L1 blockade altered NK cells to function as enhancers of HBV-specific CD8+ T cell responses. These findings highlight a strategy by which therapeutic vaccine responses can be restored even in tolerogenic settings. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
7. Editor's quiz: GI snapshot: Uphill or downhill bleeding?
- Author
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Cargill, Zillah, Cargill, Tamsin, Lei, Brian, Bekkali, Noor, East, James, and Marshall, Jonathan
- Subjects
HEMORRHAGE ,GASTROINTESTINAL hemorrhage ,MEDICAL personnel ,ESOPHAGEAL varices ,MEDICAL research ,VENA cava superior - Published
- 2021
- Full Text
- View/download PDF
8. NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner
- Author
-
Diniz, Mariana O., Schurich, Anna, Chinnakannan, Senthil K., Duriez, Marion, Stegmann, Kerstin A., Davies, Jessica, Kucykowicz, Stephanie, Suveizdyte, Kornelija, Amin, Oliver E., Alcock, Frances, Cargill, Tamsin, Barnes, Eleanor, and Maini, Mala K.
- Abstract
A better understanding of mechanisms that regulate CD8+T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antigen-specific T cell responses to chimp adenoviral vector (ChAdOx) vaccination in a mouse model of chronic HBV infection (CHB). Probing the mechanism underlying this negative regulation, we observed that CHB drove parallel up-regulation of programmed cell death ligand 1 (PD-L1) on liver-resident NK cells and programmed cell death 1 (PD-1) on intrahepatic T cells. PD-L1–expressing liver-resident NK cells suppressed PD-1hiCD8+T cells enriched within the HBV-specific response to therapeutic vaccination. Cytokine activation of NK cells also induced PD-L1, and combining cytokine activation with PD-L1 blockade resulted in conversion of NK cells into efficient helpers that boosted HBV-specific CD8+T cell responses to therapeutic vaccination in mice and to chronic infection in humans. Our findings delineate an immunotherapeutic combination that can boost the response to therapeutic vaccination in CHB and highlight the broader importance of PD-L1–dependent regulation of T cells by cytokine-activated NK cells.
- Published
- 2022
- Full Text
- View/download PDF
9. Uphill or downhill bleeding?
- Author
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Cargill Z, Cargill T, Lei B, Bekkali N, East J, and Marshall J
- Subjects
- Aged, 80 and over, Diagnosis, Differential, Female, Humans, Tomography, X-Ray Computed, Esophageal and Gastric Varices diagnostic imaging, Esophageal and Gastric Varices etiology, Goiter complications, Goiter diagnostic imaging
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2021
- Full Text
- View/download PDF
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