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Your search keyword '"Cao, Su-Mei"' showing total 27 results
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27 results on '"Cao, Su-Mei"'

1. Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation

Author

Xu, Miao, Feng, Ruimei, Liu, Zhonghua, Zhou, Xiang, Chen, Yanhong, Cao, Yulu, Valeri, Linda, Li, Zilin, Liu, Zhiwei, Cao, Su-Mei, Liu, Qing, Xie, Shang-Hang, Chang, Ellen T., Jia, Wei-Hua, Shen, Jincheng, Yao, Youyuan, Cai, Yong-Lin, Zheng, Yuming, Zhang, Zhe, Huang, Guangwu, Ernberg, Ingemar, Tang, Minzhong, Ye, Weimin, Adami, Hans-Olov, Zeng, Yi-Xin, and Lin, Xihong

Published
2024
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3. Highly sensitive detection platform-based diagnosis of oesophageal squamous cell carcinoma in China: a multicentre, case–control, diagnostic study

Author

Wang, Yu, Xing, Shan, Xu, Yi-Wei, Xu, Qing-Xia, Ji, Ming-Fang, Peng, Yu-Hui, Wu, Ya-Xian, Wu, Meng, Xue, Ning, Zhang, Biao, Xie, Shang-Hang, Zhu, Rui-Dan, Ou, Xin-Yuan, Huang, Qi, Tian, Bo-Yu, Li, Hui-Lan, Jiang, Yu, Yao, Xiao-Bin, Li, Jian-Pei, Ling, Li, Cao, Su-Mei, Zhong, Qian, Liu, Wan-Li, and Zeng, Mu-Sheng

Abstract

Early detection and screening of oesophageal squamous cell carcinoma rely on upper gastrointestinal endoscopy, which is not feasible for population-wide implementation. Tumour marker-based blood tests offer a potential alternative. However, the sensitivity of current clinical protein detection technologies is inadequate for identifying low-abundance circulating tumour biomarkers, leading to poor discrimination between individuals with and without cancer. We aimed to develop a highly sensitive blood test tool to improve detection of oesophageal squamous cell carcinoma.

Published
2024
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4. The interaction and mediation effects between the host genetic factors and Epstein–Barr virus VCA‐IgA in the risk of nasopharyngeal carcinoma

Author

Diao, Hua, primary, Xue, Wen‐Qiong, additional, Wang, Tong‐Min, additional, Yang, Da‐Wei, additional, Deng, Chang‐Mi, additional, Li, Dan‐Hua, additional, Zhang, Wen‐Li, additional, Liao, Ying, additional, Wu, Yan‐Xia, additional, Chen, Xue‐Yin, additional, Zhou, Ting, additional, Li, Xi‐Zhao, additional, Zhang, Pei‐Fen, additional, Zheng, Xiao‐Hui, additional, Zhang, Shao‐Dan, additional, Hu, Ye‐Zhu, additional, Cao, Su‐Mei, additional, Liu, Qing, additional, Ye, Wei‐Min, additional, He, Yong‐Qiao, additional, and Jia, Wei‐Hua, additional

Published
2023
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9. Development and analytical validation of a novel nasopharynx swab-based Epstein-Barr virus C promoter methylation quantitative assay for nasopharyngeal carcinoma detection

Author

Wu, Zhi-Cong, primary, Lin, Ke-Na, additional, Li, Xue-Qi, additional, Ye, Xin, additional, Chen, Hua, additional, Tao, Jun, additional, Zhou, Hang-Ning, additional, Chen, Wen-Jie, additional, Lin, Dong-Feng, additional, Xie, Shang-Hang, additional, and Cao, Su-Mei, additional

Published
2023
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11. An increase in early cancer detection rates at a single cancer center: Experiences from Sun Yat-sen University Cancer Center

Author

Xie Shang-Hang, Huang Ri-Qing, Liu Yi-Long, Cao Su-Mei, and Qian Chao-Nan

Subjects
cancer incidence rate, early detection, lung cancer, thyroid cancer, nasopharyngeal cancer, colorectal cancer, gastric cancer, cervical cancer, renal cancer, Medicine
Abstract

Cancer has become a major fatal disease in China. The relatively lower early detection rates for multiple cancer types have been one of the main reasons for a relatively lower cancer curative rate in China compared with the developed countries. To investigate trends in the early cancer detection rate over the past 5 years in a major city of China, 45,260 patients with newly diagnosed cancers of the nasopharynx, lung, thyroid, colorectum, liver, breast, uteral cervix, stomach, esophagus, blood, and kidney from 2016 to 2020 at Sun Yat-sen University Cancer Center were evaluated. The early detection rate (stage I disease) for all cancer types in combination significantly increased from 14.4 to 23.07%. Among the studied cancer types, a significant increase in stage I cancers was proportionally seen in cancers of the lung, thyroid, colorectum, and uterine cervix. While for cancers of the liver and stomach, a significant proportional increment was only observed when combining stage I and stage II diseases. No significant alteration in early cancer detection of the nasopharynx, breast, esophagus, blood, or kidney was observed. Three limitations of this present study include relatively small cohorts of cancer patients, relatively short observation periods, and limited sample representativeness. Further efforts are anticipated to validate our findings with larger patient cohorts from different parts of China and enhance early cancer detection rates by promoting public awareness, applying better health care policies, and improving insurance coverage and medical resources.

Published
2022
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13. Development and analytical validation of a novel nasopharynx swab-based Epstein-Barr virus C promoter methylation quantitative assay for nasopharyngeal carcinoma detection.

Author

Wu, Zhi-Cong, Lin, Ke-Na, Li, Xue-Qi, Ye, Xin, Chen, Hua, Tao, Jun, Zhou, Hang-Ning, Chen, Wen-Jie, Lin, Dong-Feng, Xie, Shang-Hang, and Cao, Su-Mei

Subjects
EPSTEIN-Barr virus, NASOPHARYNX cancer, METHYLATION, NASOPHARYNX, LATENT infection, EPITHELIAL cells
Abstract

Epstein-Barr virus (EBV) C promoter (Cp) hypermethylation, a crucial factor for EBV latent infection of nasopharyngeal epithelial cells, has been recognized as a promising biomarker for nasopharyngeal carcinoma (NPC) detection. In this study, we develop a novel EBV Cp methylation quantification (E-CpMQ) assay and evaluate its diagnostic performance for NPC detection. A novel qPCR assay for simultaneous quantification of methylated- and unmethylated EBV Cp was developed by the combinational modification of MethyLight and QASM, with an innovative calibrator to improve the detection accuracy and consistency. The NP swab samples and synthetic standards were used for the analytical validation of the E-CpMQ. The diagnostic efficacy of the developed E-CpMQ assay was validated in 137 NPC patients and 137 non-NPC controls. The E-CpMQ assay can detect the EBV Cp methylation ratio in one reaction system under 10 copies with 100 % recognition specificity, which is highly correlated to pyrosequencing with a correlation coefficient over 0.99. The calibrated E-CpMQ assay reduces the coefficient of variation by an average of 55.5 % with a total variance of less than 0.06 units standard deviation (SD). Linear methylation ratio detection range from 4.76 to 99.01 %. The sensitivity and specificity of the E-CpMQ respectively are 96.4 % (95 % CI: 91.7–98.8 %), 89.8 % (95 % CI: 83.5–94.3 %). The developed E-CpMQ assay with a calibrator enables accurate and reproducible EBV Cp methylation ratio quantification and offers a sensitive, specific, cost-effective method for NPC early detection. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Supplementary Materials from Induction Chemotherapy plus Concurrent Chemoradiotherapy in Endemic Nasopharyngeal Carcinoma: Individual Patient Data Pooled Analysis of Four Randomized Trials

Author

Chen, Yu-Pei, primary, Tang, Ling-Long, primary, Yang, Qi, primary, Poh, Sharon-Shuxian, primary, Hui, Edwin P., primary, Chan, Anthony T.C., primary, Ong, Whee-Sze, primary, Tan, Terence, primary, Wee, Joseph, primary, Li, Wen-Fei, primary, Chen, Lei, primary, Ma, Brigette B.Y., primary, Tong, Macy, primary, Tan, Sze-Huey, primary, Cheah, Shie-Lee, primary, Fong, Kam-Weng, primary, Sommat, Kiattisa, primary, Soong, Yoke Lim, primary, Guo, Ying, primary, Lin, Ai-Hua, primary, Sun, Ying, primary, Hong, Ming-Huang, primary, Cao, Su-Mei, primary, Chen, Ming-Yuan, primary, and Ma, Jun, primary

Published
2023
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15. Supplementary Table S1. CVs and ICCs of the pooled quality control sample for HBV assays from Hepatitis B Virus Infection and Risk of Nasopharyngeal Carcinoma in Southern China

Author

Ye, Yan-Fang, primary, Xiang, Yan-Qun, primary, Fang, Fang, primary, Gao, Rui, primary, Zhang, Li-Fang, primary, Xie, Shang-Hang, primary, Liu, Zhiwei, primary, Du, Jin-Lin, primary, Chen, Sui-Hong, primary, Hong, Ming-Huang, primary, Qian, Chao-Nan, primary, Ye, Weimin, primary, Zeng, Yi-Xin, primary, Liu, Qing, primary, and Cao, Su-Mei, primary

Published
2023
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16. Supplementary Tables 1 - 4 from Oral Hygiene and Risk of Nasopharyngeal Carcinoma—A Population-Based Case–Control Study in China

Author

Liu, Zhiwei, primary, Chang, Ellen T., primary, Liu, Qing, primary, Cai, Yonglin, primary, Zhang, Zhe, primary, Chen, Guomin, primary, Xie, Shang-Hang, primary, Cao, Su-Mei, primary, Shao, Jian-Yong, primary, Jia, Wei-Hua, primary, Zheng, Yuming, primary, Liao, Jian, primary, Chen, Yufeng, primary, Ernberg, Ingemar, primary, Vaughan, Thomas L., primary, Adami, Hans-Olov, primary, Huang, Guangwu, primary, Zeng, Yi, primary, Zeng, Yi-Xin, primary, and Ye, Weimin, primary

Published
2023
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19. Effect of EBV Serology-based Screening Program on NPC Mortality: A Cluster Randomized Controlled Trial

Author

Chen, Wen-Jie, primary, Yu, Xia, additional, Lu, Yu-Qiang, additional, Pfeiffer, Ruth M., additional, Ling, Wei, additional, Xie, Shang-Hang, additional, Wu, Zhi-Cong, additional, Li, Xue-Qi, additional, Fan, Yu-Ying, additional, Wu, Biao-Hua, additional, Wei, Kuang-Rong, additional, Rao, Hui-Lan, additional, Huang, Qi-Hong, additional, Guo, Xiang, additional, Sun, Ying, additional, Ma, Jun, additional, Liu, Qing, additional, Hildesheim, Allan, additional, Hong, Ming-Huang, additional, Zeng, Yi-Xin, additional, Ji, Ming-Fang, additional, Liu, Zhi-wei, additional, and Cao, Su-Mei, additional

Published
2022
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21. Transcriptome‐wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma

Author

He, Yong‐Qiao, primary, Xue, Wen‐Qiong, additional, Li, Dan‐Hua, additional, Wang, Tong‐Min, additional, Mai, Zhi‐Ming, additional, Yang, Da‐Wei, additional, Deng, Chang‐Mi, additional, Liao, Ying, additional, Zhang, Wen‐Li, additional, Xiao, Ruo‐Wen, additional, Luo, Luting, additional, Diao, Hua, additional, Tong, Xiating, additional, Wu, Yanxia, additional, Zhang, Jiang‐Bo, additional, Zhou, Ting, additional, Li, Xi‐Zhao, additional, Zhang, Pei‐Fen, additional, Zheng, Xiao‐Hui, additional, Zhang, Shao‐Dan, additional, Hu, Ye‐Zhu, additional, Tang, Minzhong, additional, Zheng, Yuming, additional, Cai, Yonglin, additional, Chang, Ellen T., additional, Zhang, Zhe, additional, Huang, Guangwu, additional, Cao, Su‐Mei, additional, Liu, Qing, additional, Feng, Lin, additional, Sun, Ying, additional, Lung, Maria Li, additional, Adami, Hans‐Olov, additional, Ye, Weimin, additional, Lam, Tai‐Hing, additional, and Jia, Wei‐Hua, additional

Published
2022
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22. Utility of Epstein–Barr Virus DNA in Nasopharynx Swabs as a Reflex Test to Triage Seropositive Individuals in Nasopharyngeal Carcinoma Screening Programs

Author

Chen, Geng Hang, primary, Liu, Zhiwei, additional, Yu, Kelly J, additional, Coghill, Anna E, additional, Chen, Xiao Xia, additional, Xie, Shang Hang, additional, Lin, Dong Feng, additional, Huang, Qi Hong, additional, Lu, Yu Qiang, additional, Ling, Wei, additional, Lin, Chu Yang, additional, Lu, Zi Jian, additional, Fan, Yu Ying, additional, Tang, Lin Quan, additional, Sampson, Joshua N, additional, Li, Hui, additional, King, Ann D, additional, Middeldorp, Jaap M, additional, Hildesheim, Allan, additional, and Cao, Su Mei, additional

Published
2022
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23. Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study

Author

Chen, Yufeng, primary, Chang, Ellen T, additional, Liu, Qing, additional, Cai, Yonglin, additional, Zhang, Zhe, additional, Chen, Guomin, additional, Huang, Qi-Hong, additional, Xie, Shang-Hang, additional, Cao, Su-Mei, additional, Jia, Wei-Hua, additional, Zheng, Yuming, additional, Li, Yancheng, additional, Lin, Longde, additional, Ernberg, Ingemar, additional, Huang, Guangwu, additional, Zeng, Yi-Xin, additional, Adami, Hans-Olov, additional, and Ye, Weimin, additional

Published
2022
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27. Optimization and Local Cost-Effectiveness of Nasopharyngeal Carcinoma Screening Strategies in Southern China: Secondary Analysis of the Guangdong Randomized Trial.

Author

Miller JA, Liu Z, Pinsky BA, Le QT, Li T, Yu KJ, Hildesheim A, and Cao SM

Subjects
Humans, Female, Middle Aged, China epidemiology, Male, Adult, Aged, Epstein-Barr Virus Infections diagnosis, Epstein-Barr Virus Infections complications, Mass Screening economics, Mass Screening methods, Cost-Benefit Analysis, Nasopharyngeal Carcinoma diagnosis, Nasopharyngeal Carcinoma virology, Nasopharyngeal Carcinoma economics, Nasopharyngeal Neoplasms diagnosis, Nasopharyngeal Neoplasms economics, Nasopharyngeal Neoplasms virology, Early Detection of Cancer economics, Early Detection of Cancer methods
Abstract

Background: Screening with anti-Epstein-Barr virus (EBV) serology and endoscopy decreased nasopharyngeal carcinoma (NPC) mortality in Guangdong in a randomized trial. We conducted a secondary analysis of this trial using local incidence and cost data to optimize screening programs, hypothesizing that screening could be cost-effective in southern China., Methods: Screening costs and life-years after NPC diagnosis were obtained from the Guangdong trial's intent-to-screen population (men and women aged 30-69). Seropositive subjects were rescreened annually for 5 years. Thereafter, we evaluated 12 screening strategies in Guangdong and Guangxi using a validated model. Strategies used combinations of serology, nasopharyngeal swab PCR (NP PCR), endoscopy, and MRI from trial subcohorts. Incidence data and costs were obtained from local cancer registries and the provincial healthcare system., Results: In the intent-to-screen population, screening with serology and endoscopy was cost-effective (¥42,366/life-year, 0.52 GDP per capita). Screening for 5 to 15 years between ages 35 and 59 years met a willingness-to-pay threshold of 1.5 GDP/quality-adjusted life-years in all modeled populations. Despite doubling costs, adding MRI could be cost-effective via improved sensitivity. NP PCR triage reduced endoscopy/MRI referrals by 37%. One-lifetime screen could reduce NPC mortality by approximately 20%., Conclusions: EBV-based serologic screening for NPC is likely to be cost-effective in southern China. Among seropositive subjects, the preferred strategies use endoscopy alone or selective endoscopy triaged by MRI with or without NP PCR. These data may aid the design of screening programs in this region., Impact: These findings support population-based screening in southern China by defining the target population, cost-effectiveness, and optimized screening approach., (©2024 American Association for Cancer Research.)

Published
2024
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