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Your search keyword '"Cammarata, Francesco P."' showing total 13 results
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13 results on '"Cammarata, Francesco P."'

2. Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

Author

Cammarata, Francesco Paolo, Torrisi, Filippo, Vicario, Nunzio, Bravatà, Valentina, Stefano, Alessandro, Salvatorelli, Lucia, D’Aprile, Simona, Giustetto, Pierangela, Forte, Giusi Irma, Minafra, Luigi, Calvaruso, Marco, Richiusa, Selene, Cirrone, Giuseppe Antonio Pablo, Petringa, Giada, Broggi, Giuseppe, Cosentino, Sebastiano, Scopelliti, Fabrizio, Magro, Gaetano, Porro, Danilo, Libra, Massimo, Ippolito, Massimo, Russo, Giorgio, Parenti, Rosalba, and Cuttone, Giacomo

Published
2023
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3. Radioprotectors, Radiomitigators, and Radiosensitizers

Author

Montoro, Alegría, Obrador, Elena, Mistry, Dhruti, Forte, Giusi I., Bravatà, Valentina, Minafra, Luigi, Calvaruso, Marco, Cammarata, Francesco P., Falk, Martin, Schettino, Giuseppe, Ahire, Vidhula, Daems, Noami, Boterberg, Tom, Dainiak, Nicholas, Chaudhary, Pankaj, Baatout, Sarah, Mishra, Kaushala Prasad, and Baatout, Sarah, editor

Published
2023
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5. Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications

Author

Chaudhary, Pankaj, Gwynne, Deborah C., Odlozilik, Boris, McMurray, Aaron, Milluzzo, Giuliana, Maiorino, Carla, Doria, Domenico, Ahmed, Hamad, Romagnani, Lorenzo, Alejo, Aaron, Padda, Hersimerjit, Green, James, Carroll, David, Booth, Nicola, McKenna, Paul, Kar, Satyabrata, Petringa, Giada, Catalano, Roberto, Cammarata, Francesco P., Cirrone, Giuseppe A. P., McMahon, Stephen J., Prise, Kevin M., and Borghesi, Marco

Published
2022
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8. Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off‐target effect of radiotherapy.

Author

Alberghina, Cristiana, Torrisi, Filippo, D'Aprile, Simona, Longhitano, Lucia, Giallongo, Sebastiano, Scandura, Grazia, Mannino, Giuliana, Mele, Stefania, Sabini, Maria Gabriella, Cammarata, Francesco P., Russo, Giorgio, Abdelhameed, Ali S., Zappalà, Agata, Lo Furno, Debora, Giuffrida, Rosario, Li Volti, Giovanni, Tibullo, Daniele, Vicario, Nunzio, and Parenti, Rosalba

Subjects
MICROGLIA, BRAIN tumors, GLIOBLASTOMA multiforme, TUMOR microenvironment, OXIDATIVE phosphorylation
Abstract

Glioblastoma (GBM), a WHO grade IV glioma, is a malignant primary brain tumour for which combination of surgery, chemotherapy and radiotherapy is the first‐line approach despite adverse effects. Tumour microenvironment (TME) is characterized by an interplay of cells and soluble factors holding a critical role in neoplastic development. Significant pathophysiological changes have been found in GBM TME, such as glia activation and oxidative stress. Microglia play a crucial role in favouring GBM growth, representing target cells of immune escape mechanisms. Our study aims at analysing radiation‐induced effects in modulating intercellular communication and identifying the basis of protective mechanisms in radiation‐naïve GBM cells. Tumour cells were treated with conditioned media (CM) derived from 0, 2 or 15 Gy irradiated GBM cells or 0, 2 or 15 Gy irradiated human microglia. We demonstrated that irradiated microglia promote an increase of GBM cell lines proliferation through paracrine signalling. On the contrary, irradiated GBM‐derived CM affect viability, triggering cell death mechanisms. In addition, we investigated whether these processes involve mitochondrial mass, fitness and oxidative phosphorylation and how GBM cells respond at these induced alterations. Our study suggests that off‐target radiotherapy modulates microglia to support GBM proliferation and induce metabolic modifications. [ABSTRACT FROM AUTHOR]

Published
2024
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10. The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression

Author

Torrisi, Filippo, primary, Alberghina, Cristiana, additional, D’Aprile, Simona, additional, Pavone, Anna M., additional, Longhitano, Lucia, additional, Giallongo, Sebastiano, additional, Tibullo, Daniele, additional, Di Rosa, Michelino, additional, Zappalà, Agata, additional, Cammarata, Francesco P., additional, Russo, Giorgio, additional, Ippolito, Massimo, additional, Cuttone, Giacomo, additional, Li Volti, Giovanni, additional, Vicario, Nunzio, additional, and Parenti, Rosalba, additional

Published
2022
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11. Additional file 1 of Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications

Author

Chaudhary, Pankaj, Gwynne, Deborah C., Odlozilik, Boris, McMurray, Aaron, Milluzzo, Giuliana, Maiorino, Carla, Doria, Domenico, Ahmed, Hamad, Romagnani, Lorenzo, Alejo, Aaron, Padda, Hersimerjit, Green, James, Carroll, David, Booth, Nicola, McKenna, Paul, Kar, Satyabrata, Petringa, Giada, Catalano, Roberto, Cammarata, Francesco P., Cirrone, Giuseppe A. P., McMahon, Stephen J., Prise, Kevin M., and Borghesi, Marco

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1. Supplementary tables and figures.

Published
2022
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