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3. Artificial intelligence to predict individualized outcome of acute ischemic stroke patients: The SIBILLA project

Author

Caliandro, Pietro, primary, Lenkowicz, Jacopo, additional, Reale, Giuseppe, additional, Scaringi, Simone, additional, Zauli, Aurelia, additional, Uccheddu, Christian, additional, Fabiole-Nicoletto, Simone, additional, Patarnello, Stefano, additional, Damiani, Andrea, additional, Tagliaferri, Luca, additional, Valente, Iacopo, additional, Moci, Marco, additional, Monforte, Mauro, additional, Valentini, Vincenzo, additional, and Calabresi, Paolo, additional

Published
2024
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4. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional

Published
2024
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6. Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity

Author

Rigon, Leonardo, primary, Genovese, Danilo, additional, Piano, Carla, additional, Brunetti, Valerio, additional, Guglielmi, Valeria, additional, Cimmino, Angelo Tiziano, additional, Scala, Irene, additional, Citro, Salvatore, additional, Bentivoglio, Anna Rita, additional, Rollo, Eleonora, additional, Di Iorio, Riccardo, additional, Broccolini, Aldobrando, additional, Morosetti, Roberta, additional, Monforte, Mauro, additional, Frisullo, Giovanni, additional, Caliandro, Pietro, additional, Pedicelli, Alessandro, additional, Caricato, Anselmo, additional, Masone, Giovanna, additional, Calabresi, Paolo, additional, and Marca, Giacomo Della, additional

Published
2024
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7. The Immediate Effects of Immersive Virtual Reality on Autonomic Nervous System Function in Patients with Disorders of Consciousness after Severe Acquired Brain Injury: A Pilot Study

Author

Reale, Giuseppe, primary, Fusco, Augusto, additional, Calciano, Rossella, additional, Vallario, Noemi, additional, Vagnarelli, Gabriele, additional, Caliandro, Pietro, additional, Castelli, Letizia, additional, Moci, Marco, additional, Tieri, Gaetano, additional, Iasevoli, Luigi, additional, and Padua, Luca, additional

Published
2023
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9. Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Romoli, Michele, additional, Becattini, Cecilia, additional, Salerno, Alexander, additional, Rapillo, Costanza, additional, Simonnet, Fanny, additional, Strambo, Davide, additional, Canavero, Isabella, additional, Zedde, Marialuisa, additional, Pascarella, Rosario, additional, Sohn, Sung-Il, additional, Sacco, Simona, additional, Ornello, Raffaele, additional, Barlinn, Kristian, additional, Schoene, Daniela, additional, Rahmig, Jan, additional, Mosconi, Maria Giulia, additional, Leone De Magistris, Ilaria, additional, Alberti, Andrea, additional, Venti, Michele, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Padroni, Marina, additional, Laudisi, Michele, additional, Zini, Andrea, additional, Gentile, Luana, additional, Kargiotis, Odysseas, additional, Tsivgoulis, Georgios, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Karapanayiotides, Theodore, additional, Engelter, Stefan T, additional, Polymeris, Alexandros A, additional, Zietz, Annaelle, additional, Bandini, Fabio, additional, Caliandro, Pietro, additional, Reale, Giuseppe, additional, Moci, Marco, additional, Zauli, Aurelia, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Giorli, Elisa, additional, Toni, Danilo, additional, Andrighetti, Marco, additional, Falcou, Anne, additional, Palaiodimou, Lina, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Karagkiozi, Efstathia, additional, Adamou, Anastasia, additional, Halvatsiotis, Panagiotis, additional, Flomin, Yuriy, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Popovic, Nemanja, additional, Pantoni, Leonardo, additional, Mele, Francesco, additional, Molitierno, Nicola, additional, Lochner, Piergiorgio, additional, Pezzini, Alessandro, additional, Del Sette, Massimo, additional, Sassos, Davide, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Lotti, Enrico Maria, additional, Mastrangelo, Vincenzo, additional, Chiti, Alberto, additional, Naldi, Andrea, additional, Vanacker, Peter, additional, Ferrante, Mario, additional, Volodina, Vera, additional, Mancuso, Michelangelo, additional, Giannini, Nicola, additional, Baldini, Marco, additional, Vadikolias, Kostantinos, additional, Kitmeridou, Sofia, additional, Saggese, Carlo Emanuele, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, and Michel, Patrik, additional

Published
2023
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10. Timing of Antithrombotic Secondary Prevention in Patients with Intracranial Hemorrhage after Stroke Thrombolysis and Thrombectomy

Author

Reale, Giuseppe, primary, Caliandro, Pietro, additional, Moreira, Tiago T. P., additional, Almqvist, Håkan, additional, Giovannini, Silvia, additional, Grannas, David, additional, Kotopouli, Maria Ioanna, additional, Laurienzo, Andrea, additional, Löfberg, Harald, additional, Moci, Marco, additional, Sköldblom, Sebastian, additional, Valente, Iacopo, additional, Zauli, Aurelia, additional, Holmin, Staffan, additional, and Mazya, Michael V., additional

Published
2023
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12. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy.

Author

Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, and Putaala, Jukka

Published
2023
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13. Actigraphic Sensors Describe Stroke Severity in the Acute Phase: Implementing Multi-Parametric Monitoring in Stroke Unit

Author

Reale, Giuseppe, primary, Iacovelli, Chiara, additional, Rabuffetti, Marco, additional, Manganotti, Paolo, additional, Marinelli, Lucio, additional, Sacco, Simona, additional, Furlanis, Giovanni, additional, Ajčević, Miloš, additional, Zauli, Aurelia, additional, Moci, Marco, additional, Giovannini, Silvia, additional, Crosetti, Simona, additional, Grazzini, Matteo, additional, Castiglia, Stefano Filippo, additional, Podestà, Matteo, additional, Calabresi, Paolo, additional, Ferrarin, Maurizio, additional, and Caliandro, Pietro, additional

Published
2023
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16. Anticoagulation in acute ischemic stroke patients with mechanical heart valves: To bridge or not with heparin. The ESTREM study

Author

Paciaroni, Maurizio, Caso, Valeria, Romoli, Michele, Becattini, Cecilia, Salerno, Alexander, Rapillo, Costanza, Simonnet, Fanny, Strambo, Davide, Canavero, Isabella, Zedde, Marialuisa, Pascarella, Rosario, Sohn, Sung-Il, Sacco, Simona, Ornello, Raffaele, Barlinn, Kristian, Schoene, Daniela, Rahmig, Jan, Mosconi, Maria Giulia, Leone De Magistris, Ilaria, Alberti, Andrea, Venti, Michele, Silvestrelli, Giorgio, Ciccone, Alfonso, Padroni, Marina, Laudisi, Michele, Zini, Andrea, Gentile, Luana, Kargiotis, Odysseas, Tsivgoulis, Georgios, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Masotti, Luca, Grifoni, Elisa, Rocco, Alessandro, Diomedi, Marina, Karapanayiotides, Theodore, Engelter, Stefan T, Polymeris, Alexandros A, Zietz, Annaelle, Bandini, Fabio, Caliandro, Pietro, Reale, Giuseppe, Moci, Marco, Zauli, Aurelia, Cappellari, Manuel, Emiliani, Andrea, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Giorli, Elisa, Toni, Danilo, Andrighetti, Marco, Falcou, Anne, Palaiodimou, Lina, Ntaios, George, Sagris, Dimitrios, Karagkiozi, Efstathia, Adamou, Anastasia, Halvatsiotis, Panagiotis, Flomin, Yuriy, Scoditti, Umberto, Genovese, Antonio, Popovic, Nemanja, Pantoni, Leonardo, Mele, Francesco, Molitierno, Nicola, Lochner, Piergiorgio, Pezzini, Alessandro, Del Sette, Massimo, Sassos, Davide, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Lotti, Enrico Maria, Mastrangelo, Vincenzo, Chiti, Alberto, Naldi, Andrea, Vanacker, Peter, Ferrante, Mario, Volodina, Vera, Mancuso, Michelangelo, Giannini, Nicola, Baldini, Marco, Vadikolias, Kostantinos, Kitmeridou, Sofia, Saggese, Carlo Emanuele, Tassinari, Tiziana, Saia, Valentina, and Michel, Patrik

Subjects
Mechanical heart valve, acute stroke, oral anticoagulants, prevention
Published
2023

17. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco

Abstract

Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability.

Published
2023
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18. Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Agnelli, Giancarlo, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Seiffge, David Julian, additional, Engelter, Stefan T., additional, Lyrer, Philippe, additional, Polymeris, Alexandros A., additional, Kriemler, Lilian, additional, Zietz, Annaelle, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Remillard, Suzette, additional, Buehrer, Manuela, additional, Bavaud, Odessa, additional, Vanacker, Peter, additional, Zuurbier, Susanna, additional, Yperzeele, Laetitia, additional, Loos, Caroline M.J., additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra, additional, Reznik, Michael, additional, Schomer, Ashley, additional, Grory, Brian Mac, additional, Jayaraman, Mahesh, additional, McTaggart, Ryan, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Padroni, Marina, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Traballi, Laura, additional, Urbini, Chiara, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Caliandro, Pietro, additional, Zauli, Aurelia, additional, Reale, Giuseppe, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D’Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Tsivgoulis, Georgios, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Denti, Licia, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Ferrari, Elena, additional, Caselli, Maria Chiara, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, and De Marchis, Gian Marco, additional

Published
2022
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19. Extensive corpus callosum ischemia after coronary artery bypass grafting on extracorporeal circulation.

Author

Colò, Francesca, Cammertoni, Federico, Nesta, Marialisa, Caliandro, Pietro, Bruno, Piergiorgio, Massetti, Massimo, and Broccolini, Aldobrando

Subjects
ARTIFICIAL blood circulation, ISCHEMIA, CORONARY artery bypass, SURGICAL complications, MAGNETIC resonance imaging, RARE diseases, DISEASE risk factors
Abstract

Introduction: Heart surgery can be associated with adverse ischemic brain events. Case report: Here, we describe two patients who presented extensive infarction of the corpus callosum and of other brain watershed areas following coronary artery bypass grafting (CABG) on extracorporeal circulation (ECC). Discussion: Infarction of the corpus callosum is an extremely rare condition due to its abundant blood supply. Our findings are noteworthy since they diverge from classical brain watershed infarcts and from other cases of corpus callosum involvement. This suggests that in some cases, CABG surgery on ECC may be associated to a profound impairment of intracerebral circulation. However, it is also possible that the corpus callosum is particularly vulnerable to yet unknown metabolic modifications connected to ECC. Conclusions: Further studies are needed in order to investigate the complex response of brain circulation and metabolism during heart surgery with ECC. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Identification of Gait Unbalance and Fallers Among Subjects with Cerebellar Ataxia by a Set of Trunk Acceleration-Derived Indices of Gait

Author

Castiglia, Stefano Filippo, primary, Trabassi, Dante, additional, Tatarelli, Antonella, additional, Ranavolo, Alberto, additional, Varrecchia, Tiwana, additional, Fiori, Lorenzo, additional, Di Lenola, Davide, additional, Cioffi, Ettore, additional, Raju, Manikandan, additional, Coppola, Gianluca, additional, Caliandro, Pietro, additional, Casali, Carlo, additional, and Serrao, Mariano, additional

Published
2022
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25. Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study

Author

Maurizio Paciaroni, Valeria Caso, Giancarlo Agnelli, Maria Giulia Mosconi, Michela Giustozzi, David Julian Seiffge, Stefan T. Engelter, Philippe Lyrer, Alexandros A. Polymeris, Lilian Kriemler, Annaelle Zietz, Jukka Putaala, Daniel Strbian, Liisa Tomppo, Patrik Michel, Davide Strambo, Alexander Salerno, Suzette Remillard, Manuela Buehrer, Odessa Bavaud, Peter Vanacker, Susanna Zuurbier, Laetitia Yperzeele, Caroline M.J. Loos, Manuel Cappellari, Andrea Emiliani, Marialuisa Zedde, Azmil Abdul-Rahim, Jesse Dawson, Robert Cronshaw, Erika Schirinzi, Massimo Del Sette, Christoph Stretz, Narendra Kala, Michael Reznik, Ashley Schomer, Brian Mac Grory, Mahesh Jayaraman, Ryan McTaggart, Shadi Yaghi, Karen L. Furie, Luca Masotti, Elisa Grifoni, Danilo Toni, Angela Risitano, Anne Falcou, Luca Petraglia, Enrico Maria Lotti, Marina Padroni, Lucia Pavolucci, Piergiorgio Lochner, Giorgio Silvestrelli, Alfonso Ciccone, Andrea Alberti, Michele Venti, Laura Traballi, Chiara Urbini, Odysseas Kargiotis, Alessandro Rocco, Marina Diomedi, Simona Marcheselli, Pietro Caliandro, Aurelia Zauli, Giuseppe Reale, Kateryna Antonenko, Eugenia Rota, Tiziana Tassinari, Valentina Saia, Francesco Palmerini, Paolo Aridon, Valentina Arnao, Serena Monaco, Salvatore Cottone, Antonio Baldi, Cataldo D’Amore, Walter Ageno, Samuela Pegoraro, George Ntaios, Dimitrios Sagris, Sotirios Giannopoulos, Maria Kosmidou, Evangelos Ntais, Michele Romoli, Leonardo Pantoni, Silvia Rosa, Pierluigi Bertora, Alberto Chiti, Isabella Canavero, Carlo Emanuele Saggese, Maurizio Plocco, Elisa Giorli, Lina Palaiodimou, Eleni Bakola, Georgios Tsivgoulis, Fabio Bandini, Antonio Gasparro, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Raffaele Ornello, Simona Sacco, Nemanja Popovic, Umberto Scoditti, Antonio Genovese, Licia Denti, Yuriy Flomin, Michelangelo Mancuso, Elena Ferrari, Maria Chiara Caselli, Leonardo Ulivi, Nicola Giannini, Gian Marco De Marchis, Paciaroni, Maurizio, Caso, Valeria, Agnelli, Giancarlo, Mosconi, Maria Giulia, Giustozzi, Michela, Seiffge, David Julian, Engelter, Stefan T, Lyrer, Philippe, Polymeris, Alexandros A, Kriemler, Lilian, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M J, Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Grory, Brian Mac, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L, Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Traballi, Laura, Urbini, Chiara, Kargiotis, Odyssea, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D'Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrio, Giannopoulos, Sotirio, Kosmidou, Maria, Ntais, Evangelo, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Tsivgoulis, Georgio, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, De Marchis, Gian Marco, and Neurology

Subjects
Oral, Advanced and Specialized Nursing, hypertension, recurrence, anticoagulant, Administration, Oral, Anticoagulants, Hemorrhage, Settore MED/26, Brain Ischemia, Stroke, Risk Factors, Administration, Atrial Fibrillation, Humans, Settore MED/26 - Neurologia, Human medicine, Neurology (clinical), Prospective Studies, Cardiology and Cardiovascular Medicine, atrial fibrillation, ischemic stroke, Ischemic Stroke
Abstract

Background: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings remain uncertain. Methods: This prospective multicenter observational study aimed to estimate the rates of ischemic and bleeding events and their determinants in the follow-up of consecutive patients with atrial fibrillation who suffered an acute cerebrovascular ischemic event while on nonvitamin K antagonist oral anticoagulant treatment. Afterwards, we compared the estimated risks of ischemic and bleeding events between the patients in whom anticoagulant therapy was changed to those who continued the original treatment. Results: After a mean follow-up time of 15.0±10.9 months, 192 out of 1240 patients (15.5%) had 207 ischemic or bleeding events corresponding to an annual rate of 13.4%. Among the events, 111 were ischemic strokes, 15 systemic embolisms, 24 intracranial bleedings, and 57 major extracranial bleedings. Predictive factors of recurrent ischemic events (strokes and systemic embolisms) included CHA 2 DS 2 -VASc score after the index event (odds ratio [OR], 1.2 [95% CI, 1.0–1.3] for each point increase; P =0.05) and hypertension (OR, 2.3 [95% CI, 1.0–5.1]; P =0.04). Predictive factors of bleeding events (intracranial and major extracranial bleedings) included age (OR, 1.1 [95% CI, 1.0–1.2] for each year increase; P =0.002), history of major bleeding (OR, 6.9 [95% CI, 3.4–14.2]; P =0.0001) and the concomitant administration of an antiplatelet agent (OR, 2.8 [95% CI, 1.4–5.5]; P =0.003). Rates of ischemic and bleeding events were no different in patients who changed or not changed the original nonvitamin K antagonist oral anticoagulants treatment (OR, 1.2 [95% CI, 0.8–1.7]). Conclusions: Patients suffering a stroke despite being on nonvitamin K antagonist oral anticoagulant therapy are at high risk of recurrent ischemic stroke and bleeding. In these patients, further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischemic stroke and bleeding.

Published
2022

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