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5. Guidelines on perioperative optimization protocol for the adult patient 2023

Author

Bloc, Sébastien, Alfonsi, Pascal, Belbachir, Anissa, Beaussier, Marc, Bouvet, Lionel, Campard, Sébastien, Campion, Sébastien, Cazenave, Laure, Diemunsch, Pierre, Di Maria, Sophie, Dufour, Guillaume, Fabri, Stéphanie, Fletcher, Dominique, Garnier, Marc, Godier, Anne, Grillo, Philippe, Huet, Olivier, Joosten, Alexandre, Lasocki, Sigismond, Le Guen, Morgan, Le Saché, Frédéric, Macquer, Isabelle, Marquis, Constance, de Montblanc, Jacques, Maurice-Szamburski, Axel, Nguyen, Yên-Lan, Ruscio, Laura, Zieleskiewicz, Laurent, Caillard, Anaîs, and Weiss, Emmanuel

Published
2023
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6. Association of preoperative COVID-19 and postoperative respiratory morbidity during the Omicron epidemic wave: the DROMIS-22 multicentre prospective observational cohort study

Author

Garnier, Marc, Constantin, Jean-Michel, Cinotti, Raphaël, Daoui, Chafia, Leone, Marc, Lapidus, Nathanaël, Hafiani, El Mahdi, Quesnel, Christophe, Imauven, Olivier, Lasocki, Sigismond, Rineau, Emmanuel, Léger, Maxime, Danguy des Deserts, Marc, Schmitt, Johan, Aries, Philippe, Gouel, Aurélie, Voulgaropoulos, Julia, Soldan, Laura, Deransy, Romain, Laurent, Quentin, Gayat, Etienne, Verdonk, Franck, Chaouche, Sabrina, Cambriel, Amélie, Degos, Vincent, Dupont, Julie, Daoud, Laura, Margetis, Dimitri, Salettes, Romain, Favreau, Malory, Noll, Eric, Pottecher, Julien, Diemunsch, Sophie, Abrard, Stanislas, Bidon, Cyril, Roy, Clémence, Destruhaut, Grégory, Ottolenghi, Laëtitia, Edouard, Damien, Lecinq, Agnès, Mercier, Frédéric, Cirenei, Cédric, Garrigue, Delphine, Jozefowicz, Elsa, Pariès, Marie, Espitalier, Fabien, Piat, Charlène, Descamps, Richard, Duchesne, Maëlle, Sigaut, Stéphanie, Thion, Laurie-Anne, Renard, Julie, Brocas, Elsa, Zbidi, Besma, Fki, Mohamed, Quemeneur, Cyril, Dufour, Guillaume, Bucciero, Mario, Rochon, Charles-Edouard, Delerue, Céline, Trehel-Tursis, Virginie, Raft, Julien, Rangeard, Olivier, Thiriet, Claire, Lagarde, Kevin, Pollet, Angélina, Pelen, Félix, Caillard, Anaïs, Penven, Philippe, Huet, Olivier, Puel, Floriane, Pichon, Xavier, Ligneres, Laetitia, Bleuze, Pauline, Deryckere, Stéphanie, Velly, Lionel, Simeone, Pierre, Andrianjatovo, Hery, Chipouline, Youri, Boolad, Mouna, Frasca, Denis, Plouviez, Quentin, Plaud, Benoit, Roland, Eric, Cheron-Leroy, Delphine, Figueiredo, Samy, Blanié, Antonia, Joannes-Boyau, Olivier, Monziols, Simon, Robin, Jean-Jacques, Biais, Matthieu, De Courson, Hugues, Degryse, Cécile, Do-Khac, Marie, Bonnet, Marie-Pierre, Mazeraud, Aurélien, Bardon, Jean, Bouchereau, Eléonore, Pastene, Bruno, Bezulier, Karine, Charbonneau, Hélène, Mrozek, Ségolène, Mayeur, Nicolas, Lopez, Sandrine, and Lecinq, Agnes

Published
2023
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20. From early risk to 1-year mortality: a comprehensive assessment of postoperative venous thromboembolism in upper gastrointestinal cancer patients -- a nationwide cohort study.

Author

Thereaux, Jérémie, Badic, Bogdan, Fuchs, Basile, Leven, Cyril, Caillard, Anais, Lacut, Karin, Metges, Jean-Philippe, and Couturaud, Francis

Abstract

Background: Venous thromboembolism (VTE) is a well-recognized complication following gastrointestinal cancer surgery, particularly early postoperatively. The incidence and risk factors of VTE within 1-year after esophageal (including esophago-gastric junction) (ECS) and gastric (GCS) cancer surgeries, and especially its impact on 1-year global mortality, are yet under-explored. Methods: This nationwide observational population-based cohort study used data extracted from all patients undergoing ECS and GCS in France between 1 January 2015 and 31 December 2017. Multivariate logistic regression was used to identify risk factors for 90 postoperative days (POD) VTE (OR 95% CI). Cox proportional hazards models investigated the impact of 1-year postoperative VTE on 1-year global mortality [HR (95% CI)]. Results: During the study period, 8005 patients underwent ECS (N=3429) or GCS (N=4576) (31.8% female; 66.7 ±12.1 years old). Majority (N=4951) of patients had preoperative treatment (chemotherapy or radiochemotherapy). Ninety POD incidence of VTE were 4.7% (ECS=6.2%) (GCS=3.6%) (44.7% during first hospitalization, 19.0% needing readmission, and 36.3% ambulatory management). Main risk factors were three and two field esophagectomy [3.6 (2.20-5.83) and 2.2 (1.68-3.0)], obesity [1.9 (1.40-2.58)] and history of VTE [5.1 (2.72-9.45)]. Late-onset VTE rates (occurring between the 6th and 12th month) represented 1.80 and 1.46% of the overall ECS and GCS groups. Patients with VTE within 1-year had higher risks of 1-year global mortality: (2.04 1.52; 2.73) and 2.71 (2.09; 3.51), respectively. Conclusion: Our extensive analysis of a nationwide database highlights the significant risk of postoperative VTE after ECS and GCS, persisting within 90 POD and up to 1-year. Crucially, a higher risk of global mortality within 1-year for patients experiencing early or late VTE was found. These findings could advocate for further research into extended prophylactic regimens, particularly for those most at risk. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Health-related quality of life in older patients surviving ICU treatment for COVID-19: results from an international observational study of patients older than 70 years

Author

Soliman, Ivo, Leaver, Susannah, Flaatten, Hans, Fjølner, Jesper, Wernly, Bernhard, Bruno, Raphael, Artigas, Antonio, Bollen Pinto, Bernardo, Schefold, Joerg, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Zafeiridis, Tilemachos, Wollborn, Jakob, Banzo, Maria Jose Arche, Fuest, Kristina, Marsh, Brian, Andersen, Finn, Moreno, Rui, Boumendil, Ariane, Guidet, Bertrand, Jung, Christian, de Lange, Dylan, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Brix, Helene, Brushoej, Jens, Villefrance, Maja, Nedergaard, Helene Korvenius, Bjerregaard, Anders Thais, Balleby, Ida Riise, Andersen, Kasper, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Mohamed, Aliae Ar Hussein, Salah, Rehab, Ali, Yasmin Khairy Nasreldin Mohamed, Wassim, Kyrillos, Elgazzar, Yumna, Tharwat, Samar, Azzam, Ahmed, Habib, Ayman Abdelmawgoad, Abosheaishaa, Hazem Maarouf, Azab, Mohammed, Galbois, Arnaud, Charron, Cyril, Guerot, Emmanuel, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Bruno, Caillard, Anais, Valent, Arnaud, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Raphaelen, Jean-Herlé, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Piton, Gaël, Bruno, Raphael Romano, Kelm, Malte, Wolff, Georg, Barth, Eberhard, Goebel, Ulrich, Kunstein, Anselm, Schuster, Michael, Welte, Martin, Lutz, Matthias, Meybohm, Patrick, Steiner, Stephan, Poerner, Tudor, Haake, Hendrik, Schaller, Stefan, Kindgen-Milles, Detlef, Meyer, Christian, Kurt, Muhammed, Kuhn, Karl Friedrich, Randerath, Winfried, Dindane, Zouhir, Kabitz, Hans-Joachim, Voigt, Ingo, Shala, Gonxhe, Faltlhauser, Andreas, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Papadogoulas, Antonios, Gurjar, Mohan, Mahmoodpoor, Ata, Ahmed, Abdullah Khudhur, Elsaka, Ahmed, Comellini, Vittoria, Rabha, Ahmed, Ahmed, Hazem, Namendys-Silva, Silvio, Ghannam, Abdelilah, Groenendijk, Martijn, Zegers, Marieke, Cornet, Alex, Evers, Mirjam, Haas, Lenneke, Dormans, Tom, Dieperink, Willem, Romundstad, Luis, Sjøbø, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Hahn, Michael, Czuczwar, Miroslaw, Gawda, Ryszard, Klimkiewicz, Jakub, de Lurdessantos, Maria Campos, Gordinho, André, Santos, Henrique, Assis, Rui, Oliveira, Ana Isabel Pinho, Badawy, Mohamed Raafat, Perez-Torres, David, Gomà, Gemma, Villamayor, Mercedes Ibarz, Mira, Angela Prado, Cubero, Patricia Jimeno, Rivera, Susana Arias, Tomasa, Teresa, Iglesias, David, Vázquez, Eric Mayor, Aldecoa, Cesar, Ferreira, Aida Fernández, Zalba-Etayo, Begoña, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, Sancho, Susana, Priego, Jesús, Abualqumboz, Enas, Hilles, Momin Majed Yousuf, Saleh, Mahmoud, Ben-Hamouda, Nawfel, Roberti, Andrea, Dullenkopf, Alexander, Fleury, Yvan, Pinto, Bernardo Bollen, Al-Sadawi, Mohammed, Serck, Nicolas, Dewaele, Elisabeth, Kumar, Pritpal, Bundesen, Camilla, Innes, Richard, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Humphreys, Sally, Berlemont, Caroline Hauw, Chousterman, Benjamin Glenn, Dépret, François, Ferre, Alexis, Vettoretti, Lucie, Thevenin, Didier, Milovanovic, Milena, Simon, Philipp, Lorenz, Marco, Stoll, Sandra Emily, Dubler, Simon, Mulita, Francesk, Kondili, Eumorifa, Andrianopoulos, Ioannis, Meynaar, Iwan, Cornet, Alexander Daniel, Sjøbøe, Britt, Kluzik, Anna, Zatorski, Paweł, Drygalski, Tomasz, Solek-Pastuszka, Joanna, Onichimowski, Dariusz, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Cardoso, Filipe Sousa, Banzo, Maria José Arche, Tomasa-Irriguible, Teresa Maria, Mira, Ángela Prado, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, de Gopegui, Pablo Ruiz, Abidi, Nour, Chau, Ivan, Pugh, Richard, Smuts, Sara, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Bouchard, Mélanie, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), COVIP-study group, Eller, P., Joannidis, M., Mesotten, D., Reper, P., Oeyen, S., Swinnen, W., Brix, H., Brushoej, J., Villefrance, M., Nedergaard, H.K., Bjerregaard, A.T., Balleby, I.R., Andersen, K., Hansen, M.A., Uhrenholt, S., Bundgaard, H., Fjølner, J., Mohamed, AAH, Salah, R., Ali, YKNM, Wassim, K., Elgazzar, Y.A., Tharwat, S., Azzam, A.Y., Habib, A.A., Abosheaishaa, H.M., Azab, M.A., Leaver, S., Galbois, A., Guidet, B., Charron, C., Guerot, E., Besch, G., Rigaud, J.P., Maizel, J., Djibré, M., Burtin, P., Garcon, P., Nseir, S., Valette, X., Alexandru, N., Marin, N., Vaissiere, M., Plantefeve, G., Vanderlinden, T., Jurcisin, I., Megarbane, B., Caillard, A., Valent, A., Garnier, M., Besset, S., Oziel, J., Raphaelen, J.H., Dauger, S., Dumas, G., Goncalves, B., Piton, G., Jung, C., Bruno, R.R., Kelm, M., Wolff, G., Barth, E., Goebel, U., Kunstein, A., Schuster, M., Welte, M., Lutz, M., Meybohm, P., Steiner, S., Poerner, T., Haake, H., Schaller, S., Kindgen-Milles, D., Meyer, C., Kurt, M., Kuhn, K.F., Randerath, W., Wollborn, J., Dindane, Z., Kabitz, H.J., Voigt, I., Shala, G., Faltlhauser, A., Rovina, N., Aidoni, Z., Chrisanthopoulou, E., Papadogoulas, A., Gurjar, M., Mahmoodpoor, A., Ahmed, A.K., Marsh, B., Elsaka, A., Sviri, S., Comellini, V., Rabha, A., Ahmed, H., Namendys-Silva, S.A., Ghannam, A., Groenendijk, M., Zegers, M., de Lange, D., Cornet, A., Evers, M., Haas, L., Dormans, T., Dieperink, W., Romundstad, L., Sjøbø, B., Andersen, F.H., Strietzel, H.F., Olasveengen, T., Hahn, M., Czuczwar, M., Gawda, R., Klimkiewicz, J., de LurdesSantos, M.C., Gordinho, A., Santos, H., Assis, R., Oliveira, AIP, Badawy, M.R., Perez-Torres, D., Gomà, G., Villamayor, M.I., Mira, A.P., Cubero, P.J., Rivera, S.A., Tomasa, T., Iglesias, D., Vázquez, E.M., Aldecoa, C., Ferreira, A.F., Zalba-Etayo, B., Canas-Perez, I., Tamayo-Lomas, L., Diaz-Rodriguez, C., Sancho, S., Priego, J., Abualqumboz, EMY, Hilles, MMY, Saleh, M., Ben-HAmouda, N., Roberti, A., Dullenkopf, A., Fleury, Y., Pinto, B.B., Schefold, J.C., Al-Sadawi, M., Serck, N., Dewaele, E., Kumar, P., Bundesen, C., Innes, R., Gooch, J., Cagova, L., Potter, E., Reay, M., Davey, M., Humphreys, S., Berlemont, C.H., Chousterman, B.G., Dépret, F., Ferre, A., Vettoretti, L., Thevenin, D., Milovanovic, M., Simon, P., Lorenz, M., Stoll, S.E., Dubler, S., Fuest, K., Mulita, F., Kondili, E., Andrianopoulos, I., Meynaar, I., Cornet, A.D., Sjøbøe, B., Kluzik, A., Zatorski, P., Drygalski, T., Szczeklik, W., Solek-Pastuszka, J., Onichimowski, D., Stefaniak, J., Stefanska-Wronka, K., Zabul, E., Cardoso, F.S., Banzo, MJA, Tomasa-Irriguible, T.M., Mira, Á.P., Arias-Rivera, S., Frutos-Vivar, F., Lopez-Cuenca, S., de Gopegui, P.R., Abidi, N., Chau, I., Pugh, R., and Smuts, S.

Subjects
Aging, Activities of Daily Living, Aged, COVID-19, Humans, Intensive Care Units, Prospective Studies, Quality of Life, SARS-CoV-2, Intensive Care Unit (ICU), Older people, Survival, frailty, [SDV]Life Sciences [q-bio], SOCIETY, 610 Medicine & health, General Medicine, INTENSIVE-CARE, humanities, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], [SDV] Life Sciences [q-bio], Medicine and Health Sciences, Geriatrics and Gerontology
Abstract

Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to quantify HRQoL in order to identify areas of interventions. Design prospective observation study. Setting admissions to European ICUs between March 2020 and February 2021. Subjects patients aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of ≥4 on any of Euro-QoL-5D-5L domains was considered unfavourable. Results in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71–1.87) for CFS 2 to OR 4.33 (95% CI: 1.57–11.9) for CFS ≧ 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. Conclusions in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.

Published
2022
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23. Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study

Author

Polok, Kamil, Fronczek, Jakub, Artigas, Antonio, Flaatten, Hans, Guidet, Bertrand, De Lange, Dylan W., Fjølner, Jesper, Leaver, Susannah, Beil, Michael, Sviri, Sigal, Bruno, Raphael Romano, Wernly, Bernhard, Bollen Pinto, Bernardo, Schefold, Joerg C., Studzińska, Dorota, Joannidis, Michael, Oeyen, Sandra, Marsh, Brian, Andersen, Finn H., Moreno, Rui, Cecconi, Maurizio, Jung, Christian, Szczeklik, Wojciech, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Brix, Helene, Brushoej, Jens, Villefrance, Maja, Nedergaard, Helene Korvenius, Bjerregaard, Anders Thais, Balleby, Ida Riise, Andersen, Kasper, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Hussein, Aliae A. R. Mohamed, Salah, Rehab, Ali, Yasmin Khairy NasrEldin Mohamed, Wassim, Kyrillos, Elgazzar, Yumna A., Tharwat, Samar, Azzam, Ahmed Y., habib, Ayman abdelmawgoad, Abosheaishaa, Hazem Maarouf, Azab, Mohammed A., Galbois, Arnaud, Charron, Cyril, Guerot, Emmanuel, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Caillard, Anais, Valent, Arnaud, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, RAPHALEN, Jean-herlé, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Piton, Gaël, Barth, Eberhard, Goebel, Ulrich, Kunstein, Anselm, Schuster, Michael, Welte, Martin, Lutz, Matthias, Meybohm, Patrick, Steiner, Stephan, Poerner, Tudor, Haake, Hendrik, Schaller, Stefan, Kindgen-Milles, Detlef, Meyer, Christian, Kurt, Muhammed, Kuhn, Karl Friedrich, Randerath, Winfried, Wollborn, Jakob, Dindane, Zouhir, Kabitz, Hans-Joachim, Voigt, Ingo, Shala, Gonxhe, Faltlhauser, Andreas, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Papadogoulas, Antonios, Gurjar, Mohan, Mahmoodpoor, Ata, Ahmed, Abdullah khudhur, Elsaka, Ahmed, Comellini, Vittoria, Rabha, Ahmed, Ahmed, Hazem, Namendys-Silva, Silvio A., Ghannam, Abdelilah, Groenendijk, Martijn, Zegers, Marieke, de Lange, Dylan, Cornet, Alex, Evers, Mirjam, Haas, Lenneke, Dormans, Tom, Dieperink, Willem, Romundstad, Luis, Sjøbø, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Hahn, Michael, Czuczwar, Miroslaw, Gawda, Ryszard, Klimkiewicz, Jakub, de Lurdes Campos Santos, Maria, Gordinho, André, Santos, Henrique, Assis, Rui, Oliveira, Ana Isabel Pinho, Badawy, Mohamed Raafat, Perez-Torres, David, Gomà, Gemma, Villamayor, Mercedes Ibarz, Mira, Angela Prado, Cubero, Patricia Jimeno, Rivera, Susana Arias, Tomasa, Teresa, Iglesias, David, Vázquez, Eric Mayor, Aldecoa, Cesar, Ferreira, Aida Fernández, Zalba-Etayo, Begoña, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, Sancho, Susana, Priego, Jesús, Abualqumboz, Enas M. Y., Hilles, Momin Majed Yousuf, Saleh, Mahmoud, Ben-HAmouda, Nawfel, Roberti, Andrea, Dullenkopf, Alexander, Fleury, Yvan, Al-Sadawi, Mohammed, COVIP Study Group, [missing], and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Male, Noninvasive Ventilation, Frailty, COVID-19, 610 Medicine & health, Critical Care and Intensive Care Medicine, Noninvasive Ventilation/adverse effects, Respiration, Artificial, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Cohort Studies, Intensive Care Units, Respiratory Insufficiency/therapy, Elderly, Medicine and Health Sciences, Humans, Intensive care unit, Female, Prospective Studies, 610 Medizin und Gesundheit, Respiratory Insufficiency, Noninvasive ventilation, Pandemics, COVID-19/therapy, Aged
Abstract

Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. We aimed to evaluate the use of NIV in Europe and factors associated with outcomes of patients treated with NIV. Methods This is a substudy of COVIP study—an international prospective observational study enrolling patients aged ≥ 70 years with confirmed COVID-19 treated in ICU. We enrolled patients in 156 ICUs across 15 European countries between March 2020 and April 2021.The primary endpoint was 30-day mortality. Results Cohort included 3074 patients, most of whom were male (2197/3074, 71.4%) at the mean age of 75.7 years (SD 4.6). NIV frequency was 25.7% and varied from 1.1 to 62.0% between participating countries. Primary NIV failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred in 470/629 (74.7%) of patients. Factors associated with increased NIV failure risk were higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) and Clinical Frailty Scale (CFS) on admission (OR 1.46, 95% CI 1.06–2.00). Patients initially treated with NIV (n = 630) lived for 1.36 fewer days (95% CI − 2.27 to − 0.46 days) compared to primary IMV group (n = 1876). Conclusions Frequency of NIV use varies across European countries. Higher severity of illness and more severe frailty were associated with a risk of NIV failure among critically ill older adults with COVID-19. Primary IMV was associated with better outcomes than primary NIV. Clinical Trial RegistrationNCT04321265, registered 19 March 2020, https://clinicaltrials.gov.

Published
2022
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24. Les auteurs

Author

Degos, Vincent, Lasocki, Sigismond, Albaladejo, Pierre, Alfonsi, Pascal, Amal, Alicia, Amzallag, Juliette, Assad, Alizée, Baraut, Paul, Barouk, David, Beloeil, Hélène, Besch, Guillaume, Besnard, Aurélie, Blanc, Alexiane, Bloc, Sébastien, Boddaert, Jacques, Boisson, Matthieu, Bonhomme, Fanny, Bonnet, Marie-Pierre, Bordenave, Lauriane, Borgel, Delphine, Bouglé, Adrien, Bounes, Fanny, Bouteau, Astrid, Bucciero, Mario, Caillard, Anaïs, Cambriel, Amélie, Campfort, Maëva, Carval, Aurélien, Cheisson, Gaëlle, Cohen-Bittan, Judith, Collange, Vincent, Constant, Isabelle, Coutrot, Maxime, Cuny, Ambre, De Jong, Audrey, Deme, Mamadou Gaël, Deniau, Benjamin, Depret, François, Desmard, Mathieu, Devys, Jean-Michel, Ditchi, David, Doirado, Mélanie, Duceau, Baptiste, Duclos, Antoine, Dudoignon, Emmanuel, Dufour, Guillaume, Duthoit, Guillaume, Fitoussi, Laura, Frasca, Denis, Garnier, Marc, Gerbaud, Alexandre, Geslain, Marie, Godier, Anne, Godon, Alexandre, Goldstein, Valérie, Guillemin, Jérémie, Huet-Garrigue, Delphine, Jaber, Samir, Jacquens, Alice, Kapandji, Natacha, Kerhuel, Lionel, Laatar, Chahir, Labbariere, Ambroise, Lamamri, Myriam, Lamothe, Sophie, Latreille, Samuel, Lebrun, Romain, Le Gal, Grégoire, Léger, Maxime, Le Guen, Morgan, Legrand, Matthieu, Le Saché, Fréderic, Lieppe, Chloé, Manzano, Virginie, Martinez, Valéria, Mathon, Bertrand, Maurice-Szamburski, Axel, Molliex, Serge, Nesseler, Nicolas, Pardo, Emmanuel, Pastene, Bruno, Plaud, Benoît, Po, Marie Hélène, Pouzeratte, Yvan, Quemeneur, Cyril, Rieg, Bertrand, Rineau, Emmanuel, Roullet, Stéphanie, Royer, Luca, Rozec, Bertrand, Saint-Genis, Quentin, Seguin, Philippe, Sfara, Thomas, Shaffii, Anoushée, Sigaut, Stéphanie, Soulier, Anne, Tacquard, Charles, Tamames, Corinne, Verdonk, Franck, Virolle, Sara, Vourc'h, Mickael, Weiss, Emmanuel, Wodey, Maxime, and Zieleskiewicz, Laurent

Published
2024
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29. Peace, not war in Ukraine or anywhere else, please

Author

Lefrant, Jean-Yves, Pirracchio, Romain, Benhamou, Dan, Fischer, Marc-Olivier, Njeim, Rosanna, Allaouchiche, Bernard, Bastide, Sophie, Biais, Matthieu, Bouvet, Lionel, Brissaud, Olivier, Brull, Sorin J., Capdevila, Xavier, Clausen, Nicola, Cuvillon, Philippe, Dadure, Christophe, David, Jean-Stéphane, Du, Bin, Einav, Sharon, Eley, Victoria, Forget, Patrice, Fujii, Tomoko, Godier, Anne, Gopalan, Dean P., Hamada, Sophie, Hasanin, Ahmed, Joannes-boyau, Olivier, Kerever, Sébastien, Kipnis, Éric, Kolodzie, Kerstin, Landau, Ruth, Le Gall, Arthur, Le Guen, Morgan, Legrand, Matthieu, Lorne, Emmanuel, Mercier, Frédéric J., Mongardon, Nicolas, Myatra, Sheila, Nicolas-Robin, Armelle, John Peters, Mark, Quintard, Hervé, Rello, Jordi, Richebé, Philippe, Roberts, Jason Alexander, Rocquilly, Antoine, Sanfilippo, Filippo, Schneider, Antoine, Sofonea, Mircea T., Veyckemans, Francis, Zetlaoui, Paul, Zeidan, Ahed, Zieleskiewicz, Laurent, Zielinska, Marzena, Von Ungern-Sternberg, Britta, Abou Arab, Osama, Blet, Alice, Bounes, Fanny, Boisson, Matthieu, Caillard, Anaïs, Carillion, Aude, Clavier, Thomas, Frasca, Denis, James, Arthur, Sigaut, Stéphanie, Rozencwajg, Sacha, Albaladejo, Pierre, and Bouaziz, Hervé

Published
2022
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30. La revue Anesthésie & Réanimation (ANREA) : des nouveautés et une nouvelle impulsion

Author

Lefrant, Jean-Yves, Fischer, Marc-Olivier, Pirracchio, Romain, Benhamou, Dan, Njeim, Rosanna, Ausset, Sylvain, Bastide, Sophie, Biais, Matthieu, Bouvet, Lionel, Brissaud, Olivier, Capdevila, Xavier, Cuvillon, Philippe, Dadure, Christophe, David, Jean-Stéphane, Forget, Patrice, Godier, Anne, Hamada, Sophie, Joannes-Boyau, Olivier, Kerever, Sébastien, Kipnis, Éric, Landau, Ruth, Le Gall, Arthur, Le Guen, Morgan, Legrand, Matthieu, Lorne, Emmanuel, Mercier, Frédéric, Mongardon, Nicolas, Nicolas-Robin, Armelle, Quintard, Hervé, Richebé, Philippe, Rocquilly, Antoine, Schneider, Antoine, Veyckemans, Francis, Zetlaoui, Paul, Zieleskiewicz, Laurent, Abou Arab, Osama, Blet, Alice, Bounes, Fanny, Boisson, Matthieu, Caillard, Anaïs, Carillon, Aude, Clavier, Thomas, Frasca, Denis, James, Arthur, Sigaut, Stéphanie, Rozencwajg, Sacha, and Bouaziz, Hervé

Published
2022
Full Text
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