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We investigate the efficacy of photodynamic antimicrobial chemotherapy (PACT) and its combination with an antibiotic in the treatment of diabetic foot ulcers (DFUs) in rats using a novel cationic amino acid porphyrin-based photosensitizer. The research findings demonstrate that the combination of novel cationic photosensitizer-mediated PACT and an antibiotic exhibits significant therapeutic efficacy in treating deep ulcers in a rat model of DFUs. Moreover, the PACT + Antibiotic group displays enhanced angiogenesis, improved tissue maturation, and superior wound healing effect. Micro-computed tomography examination showed that the periosteal reaction was most obvious in the PACT + Antibiotic group. The cortical bone volume ratio (BV/TV), the bone mineral density, and trabecular thickness were significantly higher in the PACT + Antibiotic group than in the model group (p < 0.05). The combination of PACT and antibiotic plays a sensitizing therapeutic role, which provides a new idea for the clinical treatment of DFUs., (© 2024 Wiley‐VCH GmbH.)

Background: Bone marrow lesions (BMLs) are a common finding after acute bone trauma. BMLs are assessed with conventional MRI sequences. Unlike conventional MR imaging sequences, diffusionweighted imaging depends on the random movement of water molecules. Intact bone marrow shows directional diffusion, whereas BML shows facilitated diffusion. ADC maps might add value to conventional MRI sequences in trauma imaging protocols. Objective: To compare ADC map with conventional fat saturation imaging sequences in the detection of bone marrow lesions (BMLs) after knee trauma. Methods: This study was carried out at Radio diagnosis Department in University Hospitals; the present study was carried on 20 patients after suffering from knee trauma. Patients underwent Conventional and diffusion MRI, the lesions were calculated in ADC maps, STIR and FS PD weighted imaging. Results: The BMLs have been calculated in terms of the number and volume in ADC map, PD FS weighted TSE imaging and STIR. The median volumes were calculated to test the level of significance. The total median value of all knee bones collectively in ADC map was (53.4 cm3) approximately twice the median lesion volume in STIR (20.7 cm3) and FS PD weighted images (24.7 cm3). The median values of the BML in ADC map of knee were statistically higher than the median value of BML in SITR and FS PD weighted TSE imaging sequences. All p-values were statistically significant. Conclusion: Our results indicated that ADC maps are more sensitive than conventional MRI sequences as it improves the detection of small bone marrow lesions. [ABSTRACT FROM AUTHOR]

Purpose: Corrective long spinal fusion is a widely accepted surgical method for patients with adult spinal deformities. However, instrumented long fusion is associated with a significant risk of complications. Therefore, we aimed to assess the success of short-segment spinal fusion, particularly for bone marrow edema (BME) adjacent to the vertebral endplate, in patients with low back pain (LBP) and spinal deformity., Methods: A prospective study was performed at multiple hospitals wherein we monitored patients with spinal deformities and accompanying LBP. Patients aged ≥ 50 years with a minimum LBP severity score of 40 mm on the visual analog scale (VAS) were included in the study. We also included patients with lumbar BME on magnetic resonance imaging. Short spinal fusion was performed on segments with BME. Clinical evaluations of LBP on VAS and Oswestry Disability Index (ODI), and radiological parameters for sagittal vertical axis (SVA), pelvic incidence (PI), lumbar lordosis (LL) and pelvic tilt (PT) were carried out., Results: Overall, 35 patients (22 men and 13 women), with a mean age of 66.7 years and a mean follow-up period of 32 months, were included in the study. The mean VAS and ODI scores were 72.4 mm and 49.0% before surgery and 25.5 mm and 29.9% at the final follow-up, respectively; these parameters significantly improved after surgery. The SVA, PI-LL, and PT scores were 70.1 mm, 20.9°, and 22.8° before surgery and 85.4 mm, 13.8°, and 22.7° at the final follow-up, respectively. The spinal alignment parameters did not change significantly after surgery., Conclusions: Short-segment spinal fusion is effective for treating LBP and spinal deformity with BME adjacent to the vertebral endplate without spinal correction., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Despite its prevalence in the environment, the chemistry of the Ti4+ ion has long been relegated to organic solutions or hydrolyzed TiO2 polymorphs. A knowledge gap in stabilizing molecular Ti4+ species in aqueous environments has prevented the use of this ion for various applications such as radioimaging, design of water‐compatible metal–organic frameworks (MOFs), and aqueous‐phase catalysis applications. Herein, we show a thorough thermodynamic screening of bidentate chelators with Ti4+ in aqueous solution, as well as computational and structural analyses of key compounds. In addition, the hexadentate analogues of catechol (benzene‐1,2‐diol) and deferiprone (3‐hydroxy‐1,2‐dimethyl‐4(1H)‐pyridone), TREN‐CAM and THPMe respectively, were assessed for chelation of the 45Ti isotope (t1/2=3.08 h, β+=85 %, Eβ+=439 keV) towards positron emission tomography (PET) imaging applications. Both were found to have excellent capacity for kit‐formulation, and [45Ti]Ti‐TREN‐CAM was found to have remarkable stability in vivo. [ABSTRACT FROM AUTHOR]