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The dynamics and kinetics of spin-forbidden transitions between N(2D) and N(4S) via collisions with N2 molecules are investigated using a quantum wave packet (WP) method and the semi-classical coherent switches...

Hereditary angioedema (HAE) poses a high burden of disease, being its epidemiological and clinical data heterogeneous among countries, with no recent published studies concerning Portuguese patients. Therefore, we aimed to raise awareness of HAE and to contribute to clinical knowledge. An observational, descriptive, retrospective, and cross-sectional study was performed, that included a cohort of 126 patients followed in a single Portuguese Center. We observed a high prevalence of HAE-C1-INH type II (45.2% of patients). Most HAE patients (67.4%) presented the initial manifestations of the disease before adulthood, at a mean age of 12.6 ± 8.4 years. However, we found a long delay in HAE diagnosis, especially in those without family history (mean 20.7 ± 17.3 years). Stress was the most common trigger, followed by trauma and infection. Symptoms involving different systems were increasingly reported with increased disease duration. Cutaneous symptoms (95.0%) were more frequent, followed by gastrointestinal (80.7%), and respiratory symptoms (50.4%). HAE symptoms led to abdominal surgery in 22 (17.5%) patients and induced laryngeal edema requiring intubation/tracheostomy in 8 (6.3%) patients. Most patients were under long-term prophylaxis, mainly with attenuated androgens (62.7% of patients).The correct distinction between HAE and other common causes of angioedema is critical, allowing reduction of diagnostic delay, improvement of adequate management, and ultimately improving outcomes and quality of life of HAE patients.

SiC

We have carried out quantum dynamics calculations for the O + OH → H + O

Despite its paradigmatic role in early molecular beam experiments and theoretical molecular reaction dynamics, an attempt is made in the present work to elucidate basic aspects of the title reaction. Both thermal rate constants and its rotation specificity are studied using two recently reported ab initio potential energy surfaces by running quasiclassical trajectories. Some inconsistencies in previous studies are pinpointed, but the results show that they do not alter significantly the agreement between experiment and theory, thus suggesting that further work at both levels is necessary for a more complete understanding.