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5 results on '"Breton, Jean-Jacques"'

1. Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions

Author

Aardema, Frederic, Bentaleb, Lahcen Ait, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Doney, Ellen, Dion-Albert, Laurence, Coulombe-Rozon, Francois, Osborne, Natasha, Bernatchez, Renaud, Paton, Sam E.J., Kaufmann, Fernanda Neutzling, Agomma, Roseline Olory, Solano, José L., Gaumond, Raphael, Dudek, Katarzyna A., Szyszkowicz, Joanna Kasia, Lebel, Manon, Doyen, Alain, Durand, Audrey, Lavoie-Cardinal, Flavie, Audet, Marie-Claude, and Menard, Caroline

Published
2024
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2. A Delphi consensus among experts on assessment and treatment of disruptive mood dysregulation disorder.

Author

Boudjerida, Assia, Guilé, Jean-Marc, Breton, Jean-Jacques, Benarous, Xavier, Cohen, David, and Labelle, Réal

Subjects
DELPHI method, DIALECTICAL behavior therapy, AFFECTIVE disorders, PARENT-child relationships, RESEARCH personnel
Abstract

Objective: The aim of this study was to explore consensus among clinicians and researchers on how to assess and treat Disruptive Mood Dysregulation Disorder (DMDD). Methods: The Delphi method was used to organize data collected from an initial sample of 23 child psychiatrists and psychologists. Three rounds of closed/open questions were needed to achieve the objective. Results: Fifteen experts in the field completed the whole study. Finally, 122 proposals were validated and 5 were rejected. Globally, consensus was more easily reached on items regarding assessment than on those regarding treatment. Specifically, experts agreed that intensity, frequency, and impact of DMDD symptoms needed to be measured across settings, including with parents, siblings, peers, and teachers. While a low level of consensus emerged regarding optimal pharmacological treatment, the use of psychoeducation, behavior-focused therapies (e.g., dialectical behavior therapy, chain analysis, exposure, relaxation), and systemic approaches (parent management training, family therapy, parent-child interaction therapy) met with a high degree of consensus. Conclusion: This study presents recommendations that reached a certain degree of consensus among researchers and clinicians regarding the assessment and treatment of youths with DMDD. These findings may be useful to clinicians working with this population and to researchers since they also highlight non-consensual areas that need to be further investigated. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions

Author

Doney, Ellen, Dion-Albert, Laurence, Coulombe-Rozon, Francois, Osborne, Natasha, Bernatchez, Renaud, Paton, Sam E.J., Kaufmann, Fernanda Neutzling, Agomma, Roseline Olory, Solano, José L., Gaumond, Raphael, Dudek, Katarzyna A., Szyszkowicz, Joanna Kasia, Aardema, Frederic, Bentaleb, Lahcen Ait, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Lebel, Manon, Doyen, Alain, Durand, Audrey, Lavoie-Cardinal, Flavie, Audet, Marie-Claude, and Menard, Caroline

Abstract

Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place.

Published
2024
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4. Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Author

Dion-Albert, Laurence, Cadoret, Alice, Doney, Ellen, Kaufmann, Fernanda Neutzling, Dudek, Katarzyna A., Daigle, Beatrice, Parise, Lyonna F., Cathomas, Flurin, Samba, Nalia, Hudson, Natalie, Lebel, Manon, Aardema, Frederic, Ait Bentaleb, Lahcen, Beauchamp, Janique, Bendahmane, Hicham, Benoit, Elise, Bergeron, Lise, Bertone, Armando, Bertrand, Natalie, Berube, Felix-Antoine, Blanchet, Pierre, Boissonneault, Janick, Bolduc, Christine J., Bonin, Jean-Pierre, Borgeat, Francois, Boyer, Richard, Breault, Chantale, Breton, Jean-Jacques, Briand, Catherine, Brodeur, Jacques, Brule, Krystele, Brunet, Lyne, Carriere, Sylvie, Chartrand, Carine, Chenard-Soucy, Rosemarie, Chevrette, Tommy, Cloutier, Emmanuelle, Cloutier, Richard, Cormier, Hugues, Cote, Gilles, Cyr, Joanne, David, Pierre, De Benedictis, Luigi, Delisle, Marie-Claude, Deschenes, Patricia, Desjardins, Cindy D., Desmarais, Gilbert, Dubreucq, Jean-Luc, Dumont, Mimi, Dumais, Alexandre, Ethier, Guylaine, Feltrin, Carole, Felx, Amelie, Findlay, Helen, Fortier, Linda, Fortin, Denise, Fortin, Leo, Francois, Nathe, Gagne, Valerie, Gagnon, Marie-Pierre, Gignac-Hens, Marie-Claude, Giguere, Charles-Edouard, Godbout, Roger, Grou, Christine, Guay, Stephane, Guillem, Francois, Hachimi-Idrissi, Najia, Herry, Christophe, Hodgins, Sheilah, Homayoun, Saffron, Jemel, Boutheina, Joyal, Christian, Kouassi, Edouard, Labelle, Real, Lafortune, Denis, Lahaie, Michel, Lahlafi, Souad, Lalonde, Pierre, Landry, Pierre, Lapaige, Veronique, Larocque, Guylaine, Larue, Caroline, Lavoie, Marc, Leclerc, Jean-Jacques, Lecomte, Tania, Lecours, Cecile, Leduc, Louise, Lelan, Marie-France, Lemieux, Andre, Lesage, Alain, Letarte, Andree, Lepage, Jean, Levesque, Alain, Lipp, Olivier, Luck, David, Lupien, Sonia, Lusignan, Felix-Antoine, Lusignan, Richard, Luyet, Andre J., Lynhiavu, Alykhanhthi, Melun, Jean-Pierre, Morin, Celine, Nicole, Luc, Noel, Francois, Normandeau, Louise, O’Connor, Kieron, Ouellette, Christine, Parent, Veronique, Parizeau, Marie-Helene, Pelletier, Jean-Francois, Pelletier, Julie, Pelletier, Marc, Plusquellec, Pierrich, Poirier, Diane, Potvin, Stephane, Prevost, Guylaine, Prevost, Marie-Josee, Racicot, Pierre, Racine-Gagne, Marie-France, Renaud, Patrice, Ricard, Nicole, Rivet, Sylvie, Rolland, Michel, Sasseville, Marc, Safadi, Gabriel, Smith, Sandra, Smolla, Nicole, Stip, Emmanuel, Teitelbaum, Jakob, Thibault, Alfred, Thibault, Lucie, Thibault, Stephanye, Thomas, Frederic, Todorov, Christo, Tourjman, Valerie, Tranulis, Constantin, Trudeau, Sonia, Trudel, Gilles, Vacri, Nathalie, Valiquette, Luc, Vanier, Claude, Villeneuve, Kathe, Villeneuve, Marie, Vincent, Philippe, Wolfe, Marcel, Xiong, Lan, Zizzi, Angela, Campbell, Matthew, Turecki, Gustavo, Mechawar, Naguib, and Menard, Caroline

Subjects
Male, Science, Prefrontal Cortex, General Physics and Astronomy, Nerve Tissue Proteins, Anxiety, Article, Nucleus Accumbens, General Biochemistry, Genetics and Molecular Biology, Mice, Animals, Humans, skin and connective tissue diseases, Depressive Disorder, Major, Sex Characteristics, Multidisciplinary, Depression, Gene Expression Profiling, Endothelial Cells, Diagnostic markers, Biological Transport, General Chemistry, nervous system, Blood-Brain Barrier, Female, sense organs, E-Selectin, Transcriptome, Stress and resilience, Biomarkers, Stress, Psychological
Abstract

Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice; however, this association is unclear in females. Here, we report that chronic social and subchronic variable stress promotes blood-brain barrier (BBB) alterations in mood-related brain regions of female mice. Targeted disruption of the BBB in the female prefrontal cortex (PFC) induces anxiety- and depression-like behaviours. By comparing the endothelium cell-specific transcriptomic profiling of the mouse male and female PFC, we identify several pathways and genes involved in maladaptive stress responses and resilience to stress. Furthermore, we confirm that the BBB in the PFC of stressed female mice is leaky. Then, we identify circulating vascular biomarkers of chronic stress, such as soluble E-selectin. Similar changes in circulating soluble E-selectin, BBB gene expression and morphology can be found in blood serum and postmortem brain samples from women diagnosed with MDD. Altogether, we propose that BBB dysfunction plays an important role in modulating stress responses in female mice and possibly MDD., The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Published
2022
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