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7. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Pohl, Wolfgang, Doberer, Daniel, Martinot, Jean Benoit, Deschampheleire, Maud, Himpe, Ulrike, Chapman, Kenneth, Cheema, Amarjit, Dorscheid, Delbert, Ramsey, Clare, Rolf, Jeffrey, Walker, Brandie, Olivenstein, Ronald, Poirier, Claude, Larivee, Pierre, Bjerrum, Anne Sofie, Titlestad, Ingrid, Hilberg, Ole, Kilpeläinen, Maritta, Bonniaud, Philippe, Taillé, Camille, Tiotiu, Iuliana-Angelica, Girodet, Pierre-Olivier, Blanc, François-Xavier, Pradelli, Johana, Didier, Alain, Nocent Ejnaini, Cecilia, Deslee, Gaetan, Pison, Christophe, Douadi, Youcef, Mahay, Guillaume, Devouassoux, Gilles, Melloni, Boris, Roux, Pauline-Marie, Bourdin, Arnaud, Fry, Stephanie, Schaum, Thomas, Schulz, Christian, Skowasch, Dirk, Taube, Christian, Welte, Tobias, Gleiber, Wolfgang, Brehler, Randolf, Schreiber, Jens, Schuette, Wolfgang, Kronsbein, Juliane, Bonnet, Reiner, Beck, Ekkehard, Lacedonia, Donato, Senna, Gianenrico, Caruso, Cristiano, Crimi, Nunzio, Blasi, Francesco, Santus, Pierachille, Canonica, Giorgio Walter, Guarnieri, Gabriella, Pelaia, Girolamo, Milanese, Manlio, Micheletto, Claudio, Corsico, Angelo Guido, Scichilone, Nicola, Spadaro, Giuseppe, Langeveld, Bas, Holters, Jurgen, Willem van den Berg, Jan, Smit, Arthur, Conemans, Lennart, van Veen, Helena, Staaks, Gerald, Lehmann, Sverre, Echave-Sustaeta, Jose Maria, Ribas, Christian Domingo, de Luiz Martinez, Gustavo, Gonzalez Perez, Ruperto, Garcia Rivero, Juan Luis, Gall, Xavier Muñoz, Soto Campos, Jose Gregorio, Mozo, Paloma Campo, Pan, Carmen Vidal, Fernandez, Ana Gomez-Bastero, Tellez, Sergio Campos, Rivera, Carlos Martinez, Bobolea, Irina Diana, Guerrero, Raquel Morillo, Garcia, Ismael Ali, Rodriguez Hermosa, Juan Luis, Stenfors, Nikolai, Tunsäter, Alf, Curiac, Dan, von Garnier, Christophe, Leuppi, Joerg, Schmid-Grendelmeier, Peter, Nasser, Shuaib, Chaudhuri, Rekha, Nordstrom, Monica, Saralaya, Dinesh, Pfeffer, Paul, Mansur, Adel, Short, Philip, Wenzel, Sally, Cherry, William Brett, Zafra, Heidi, Gonzalez, Erika, Soong, Weily, Davis, Benjamin, Kao, Neil, Hussain, Iftikhar, Maselli Caceres, Diego Jose, Harris, James, Calhoun, William, Rodicio, Ileana, Kaufman, David, Moss, Mark, Sztejman, Eric, DeLeon, Samuel, Sumino, Kaharu, Kashyap, Ravindra, Leflein, Jeffrey, Hajal, Rizan, Fakih, Faisal, Hill, David, Lin, Robert, Jarratt, Mikell, Subramaniam, Vijay, Sussman, Robert, Mumneh, Nayla, Reibman, Joan, Darveaux, Jared, Tan, Ricardo, Tanus, Tonny, Sikand, Vinay, Marshall, Gailen, Mehta, Hemalini, Cole, Jeremy, Goodman, Brad, Goss, Deborah, Bardelas, Jose, Milstone, Aaron, Mehta, Vinay, Clore, Lee, Millard, Mark, Palumbo, Michael, Puppala, Dileep, Leong, Mila, Prenner, Bruce, Robinette, Emory, Heidarian Raissy, Hengameh, Fost, David, Pleskow, Warren, Marcus, Michael, Ilowite, Jonathan, Moore, Wendy, Steven, Gary, De la Cruz, Luis, Chupp, Geoffrey, Berger, William, Randolph, Christopher, Holguin, Fernando, Kureishy, Shahrukh, Campbell, Edward, Peche, Rudi, Pini, Laura, Papi, Alberto, Beghé, Bianca, Peveri, Silvia, Henriquez Santa, Aythamy, Ramos Gonzalez, Jacinto, Vinge, Ines, St. John, Roy, Louis, Renaud, Harrison, Tim W., Chanez, Pascal, Menzella, Francesco, Philteos, George, Cosio, Borja G., Lugogo, Njira L., de Luiz, Gustavo, Burden, Annie, Adlington, Timothy, Keeling, Nanna, Kwiatek, Justin, and Garcia Gil, Esther

Published
2023
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10. IgE-vermittelte Nahrungsmittelallergien - eine Umfrage des Ärzteverbands Deutscher Allergologen (AeDA)

Author

Brehler, Randolf, primary, Nungesser, Jutta, additional, Merk, Hans F., additional, Jung, Kirsten, additional, Schlenter, Wolfgang W., additional, Wehrmann, Wolfgang, additional, Becker, Sven, additional, K. Mülleneisen, Norbert, additional, Wrede, Holger, additional, Cuevas, Mandy, additional, Fuchs, Thomas, additional, Dickel, Heinrich, additional, and Klimek, Ludger, additional

Published
2024
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11. White paper on peanut allergy – part 1: Epidemiology, burden of disease, health economic aspects

Author

Lange, Lars, Klimek, Ludger, Beyer, Kirsten, Blümchen, Katharina, Novak, Natalija, Hamelmann, Eckard, Bauer, Andrea, Merk, Hans, Rabe, Uta, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Jakob, Thilo, Ankermann, Tobias, Schmidt, Sebastian M., Gerstlauer, Michael, Zuberbier, Torsten, Spindler, Thomas, and Vogelberg, Christian

Published
2021
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13. Karenzmaßnahmen bei Milbenallergie - ein Update

Author

Klimek, Ludger, primary, Brehler, Randolf, additional, Bergmann, Karl-Christian, additional, Casper, Ingrid, additional, Klimek, Felix, additional, Hagemann, Jan, additional, Polk, Marie-Luise, additional, and Cuevas, Mandy, additional

Published
2024
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14. Efficacy and safety of on‐demand versus daily rupatadine in chronic spontaneous urticaria: A randomized trial.

Author

Weller, Karsten, Gimenez‐Arnau, Ana Maria, Baron, Jens, Brehler, Randolf, Ferrer, Marta, Groffik, Adriane, Grundmann, Sonja, Jakob, Thilo, Labrador‐Horrillo, Moisés, Müller, Sabine, Staubach, Petra, Wurpts, Gerda, Metz, Martin, and Maurer, Marcus

Subjects
URTICARIA, PREVENTIVE medicine
Abstract

Background: Non‐sedating H1‐antihistamines (nsAH) are the most commonly used treatment for chronic spontaneous urticaria (CSU). Many patients use them as on‐demand (OD) therapy rather than a maintenance treatment. Here, we compared OD versus daily maintenance treatment with the nsAH rupatadine, assessed the efficacy of rupatadine updosing, and investigated potential long‐term disease‐modifying effects. Methods: This multicenter, randomized study consisted of 2 weeks of screening, 8 weeks of double‐blind treatment, and 6 weeks of treatment‐free follow‐up (OD allowed). Adult patients were randomized to 10 mg rupatadine OD or 10 mg rupatadine daily. At Week 4, if patients did not have a complete response, they switched from 10 to 20 mg rupatadine daily or underwent sham updosing (patients on 10 mg rupatadine OD). The primary aim was to compare CSU disease activity at the end of follow‐up between daily versus OD. Additionally, we assessed the efficacy of rupatadine updosing. Major outcomes were disease activity, CSU‐related quality of life (QoL), and disease control. Results: At Week 4, disease activity and QoL significantly improved in daily versus OD‐treated patients. Updosing of rupatadine did not improve the mean disease activity, but the number of complete responders increased during updosing from 5% to 22%. At the end of follow‐up, the disease activity of patients treated OD versus daily was not significantly different. Conclusions: Daily rupatadine treatment significantly improved CSU disease activity and QoL during treatment versus OD treatment but not after discontinuation of rupatadine, indicating the benefits of a daily maintenance nsAH schedule. [ABSTRACT FROM AUTHOR]

Published
2024
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15. S2k guideline diagnosis, prevention, and therapy of hand eczema

Author

Bauer, Andrea, primary, Brans, Richard, additional, Brehler, Randolf, additional, Büttner, Marion, additional, Dickel, Heinrich, additional, Elsner, Peter, additional, Fartasch, Manigé, additional, Herzog, Claudia, additional, John, Swen‐Malte, additional, Köllner, Arno, additional, Maul, Julia‐Tatjana, additional, Merk, Hans, additional, Molin, Sonja, additional, Nast, Alexander, additional, Nikolakis, Georgios D., additional, Schliemann, Sybille, additional, Skudlik, Christoph, additional, Weisshaar, Elke, additional, Werfel, Thomas, additional, Zidane, Miriam, additional, and Worm, Margitta, additional

Published
2023
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17. S2k‐Leitlinie Diagnostik, Prävention und Therapie des Handekzems

Author

Bauer, Andrea, primary, Brans, Richard, additional, Brehler, Randolf, additional, Büttner, Marion, additional, Dickel, Heinrich, additional, Elsner, Peter, additional, Fartasch, Manigé, additional, Herzog, Claudia, additional, John, Swen‐Malte, additional, Köllner, Arno, additional, Maul, Julia‐Tatjana, additional, Merk, Hans, additional, Molin, Sonja, additional, Nast, Alexander, additional, Nikolakis, Georgios D., additional, Schliemann, Sybille, additional, Skudlik, Christoph, additional, Weisshaar, Elke, additional, Werfel, Thomas, additional, Zidane, Miriam, additional, and Worm, Margitta, additional

Published
2023
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18. Efficacy and safety of on‐demand versus daily rupatadine in chronic spontaneous urticaria: A randomized trial

Author

Weller, Karsten, primary, Gimenez‐Arnau, Ana Maria, additional, Baron, Jens, additional, Brehler, Randolf, additional, Ferrer, Marta, additional, Groffik, Adriane, additional, Grundmann, Sonja, additional, Jakob, Thilo, additional, Labrador‐Horrillo, Moisés, additional, Müller, Sabine, additional, Staubach, Petra, additional, Wurpts, Gerda, additional, Metz, Martin, additional, and Maurer, Marcus, additional

Published
2023
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19. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Louis, Renaud, primary, Harrison, Tim W., additional, Chanez, Pascal, additional, Menzella, Francesco, additional, Philteos, George, additional, Cosio, Borja G., additional, Lugogo, Njira L., additional, de Luiz, Gustavo, additional, Burden, Annie, additional, Adlington, Timothy, additional, Keeling, Nanna, additional, Kwiatek, Justin, additional, Garcia Gil, Esther, additional, Pohl, Wolfgang, additional, Doberer, Daniel, additional, Martinot, Jean Benoit, additional, Deschampheleire, Maud, additional, Himpe, Ulrike, additional, Chapman, Kenneth, additional, Cheema, Amarjit, additional, Dorscheid, Delbert, additional, Ramsey, Clare, additional, Rolf, Jeffrey, additional, Walker, Brandie, additional, Olivenstein, Ronald, additional, Poirier, Claude, additional, Larivee, Pierre, additional, Bjerrum, Anne Sofie, additional, Titlestad, Ingrid, additional, Hilberg, Ole, additional, Kilpeläinen, Maritta, additional, Bonniaud, Philippe, additional, Taillé, Camille, additional, Tiotiu, Iuliana-Angelica, additional, Girodet, Pierre-Olivier, additional, Blanc, François-Xavier, additional, Pradelli, Johana, additional, Didier, Alain, additional, Nocent Ejnaini, Cecilia, additional, Deslee, Gaetan, additional, Pison, Christophe, additional, Douadi, Youcef, additional, Mahay, Guillaume, additional, Devouassoux, Gilles, additional, Melloni, Boris, additional, Roux, Pauline-Marie, additional, Bourdin, Arnaud, additional, Fry, Stephanie, additional, Schaum, Thomas, additional, Schulz, Christian, additional, Skowasch, Dirk, additional, Taube, Christian, additional, Welte, Tobias, additional, Gleiber, Wolfgang, additional, Brehler, Randolf, additional, Schreiber, Jens, additional, Schuette, Wolfgang, additional, Kronsbein, Juliane, additional, Bonnet, Reiner, additional, Beck, Ekkehard, additional, Lacedonia, Donato, additional, Senna, Gianenrico, additional, Caruso, Cristiano, additional, Crimi, Nunzio, additional, Blasi, Francesco, additional, Santus, Pierachille, additional, Canonica, Giorgio Walter, additional, Guarnieri, Gabriella, additional, Pelaia, Girolamo, additional, Milanese, Manlio, additional, Micheletto, Claudio, additional, Corsico, Angelo Guido, additional, Scichilone, Nicola, additional, Spadaro, Giuseppe, additional, Langeveld, Bas, additional, Holters, Jurgen, additional, Willem van den Berg, Jan, additional, Smit, Arthur, additional, Conemans, Lennart, additional, van Veen, Helena, additional, Staaks, Gerald, additional, Lehmann, Sverre, additional, Echave-Sustaeta, Jose Maria, additional, Ribas, Christian Domingo, additional, de Luiz Martinez, Gustavo, additional, Gonzalez Perez, Ruperto, additional, Garcia Rivero, Juan Luis, additional, Gall, Xavier Muñoz, additional, Soto Campos, Jose Gregorio, additional, Mozo, Paloma Campo, additional, Pan, Carmen Vidal, additional, Fernandez, Ana Gomez-Bastero, additional, Tellez, Sergio Campos, additional, Rivera, Carlos Martinez, additional, Bobolea, Irina Diana, additional, Guerrero, Raquel Morillo, additional, Garcia, Ismael Ali, additional, Rodriguez Hermosa, Juan Luis, additional, Stenfors, Nikolai, additional, Tunsäter, Alf, additional, Curiac, Dan, additional, von Garnier, Christophe, additional, Leuppi, Joerg, additional, Schmid-Grendelmeier, Peter, additional, Nasser, Shuaib, additional, Chaudhuri, Rekha, additional, Nordstrom, Monica, additional, Saralaya, Dinesh, additional, Pfeffer, Paul, additional, Mansur, Adel, additional, Short, Philip, additional, Wenzel, Sally, additional, Cherry, William Brett, additional, Zafra, Heidi, additional, Gonzalez, Erika, additional, Soong, Weily, additional, Davis, Benjamin, additional, Kao, Neil, additional, Hussain, Iftikhar, additional, Maselli Caceres, Diego Jose, additional, Harris, James, additional, Calhoun, William, additional, Rodicio, Ileana, additional, Kaufman, David, additional, Moss, Mark, additional, Sztejman, Eric, additional, DeLeon, Samuel, additional, Sumino, Kaharu, additional, Kashyap, Ravindra, additional, Leflein, Jeffrey, additional, Hajal, Rizan, additional, Fakih, Faisal, additional, Hill, David, additional, Lin, Robert, additional, Jarratt, Mikell, additional, Subramaniam, Vijay, additional, Sussman, Robert, additional, Mumneh, Nayla, additional, Reibman, Joan, additional, Darveaux, Jared, additional, Tan, Ricardo, additional, Tanus, Tonny, additional, Sikand, Vinay, additional, Marshall, Gailen, additional, Mehta, Hemalini, additional, Cole, Jeremy, additional, Goodman, Brad, additional, Goss, Deborah, additional, Bardelas, Jose, additional, Milstone, Aaron, additional, Mehta, Vinay, additional, Clore, Lee, additional, Millard, Mark, additional, Palumbo, Michael, additional, Puppala, Dileep, additional, Leong, Mila, additional, Prenner, Bruce, additional, Robinette, Emory, additional, Heidarian Raissy, Hengameh, additional, Fost, David, additional, Pleskow, Warren, additional, Marcus, Michael, additional, Ilowite, Jonathan, additional, Moore, Wendy, additional, Steven, Gary, additional, De la Cruz, Luis, additional, Chupp, Geoffrey, additional, Berger, William, additional, Randolph, Christopher, additional, Holguin, Fernando, additional, Kureishy, Shahrukh, additional, and Campbell, Edward, additional

Published
2023
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21. Karenzmaßnahmen bei Milbenallergie - ein Update

Author

Klimek, Ludger, primary, Brehler, Randolf, additional, Bergmann, Karl-Christian, additional, Casper, Ingrid, additional, Klimek, Felix, additional, Hagemann, Jan, additional, Polk, Marie-Luise, additional, and Cuevas, Mandy, additional

Published
2023
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23. S3‐Leitlinie Urtikaria. Teil 2: Therapie der Urtikaria – deutschsprachige Adaption der internationalen S3‐Leitlinie

Author

Zuberbier, Torsten, primary, Altrichter, Sabine, additional, Bauer, Sabine, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Dressler, Corinna, additional, Fluhr, Joachim, additional, Gaskins, Matthew, additional, Hamelmann, Eckard, additional, Kühne, Kathrin, additional, Merk, Hans, additional, Mülleneisen, Norbert K., additional, Nast, Alexander, additional, Olze, Heidi, additional, Ott, Hagen, additional, Pleimes, Marc, additional, Ruëff, Franziska, additional, Staubach‐Renz, Petra, additional, Wedi, Bettina, additional, and Maurer, Marcus, additional

Published
2023
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27. S3 Guideline Urticaria. Part 2: Treatment of urticaria – German‐language adaptation of the international S3 guideline

Author

Zuberbier, Torsten, primary, Altrichter, Sabine, additional, Bauer, Sabine, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Dressler, Corinna, additional, Fluhr, Joachim, additional, Gaskins, Matthew, additional, Hamelmann, Eckard, additional, Kühne, Kathrin, additional, Merk, Hans, additional, Mülleneisen, Norbert K., additional, Nast, Alexander, additional, Olze, Heidi, additional, Ott, Hagen, additional, Pleimes, Marc, additional, Ruëff, Franziska, additional, Staubach‐Renz, Petra, additional, Wedi, Bettina, additional, and Maurer, Marcus, additional

Published
2023
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28. Diagnosis and treatment of Hymenoptera venom allergy

Author

Ruëff, Franziska, primary, Bauer, Andrea, additional, Becker, Sven, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Chaker, Adam M., additional, Darsow, Ulf, additional, Fischer, Jörg, additional, Fuchs, Thomas, additional, Gerstlauer, Michael, additional, Gernert, Sunhild, additional, Hamelmann, Eckard, additional, Hötzenecker, Wolfram, additional, Klimek, Ludger, additional, Lange, Lars, additional, Merk, Hans, additional, Mülleneisen, Norbert K., additional, Neustädter, Irena, additional, Pfützner, Wolfgang, additional, Sieber, Wolfgang, additional, Sitter, Helmut, additional, Skudlik, Christoph, additional, Treudler, Regina, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Worm, Margitta, additional, and Jakob, Thilo, additional

Published
2023
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29. S3 Guideline Urticaria. Part 1: Classification and diagnosis of urticaria – German‐language adaptation of the international S3 Guideline

Author

Zuberbier, Torsten, primary, Altrichter, Sabine, additional, Bauer, Sabine, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Dressler, Corinna, additional, Fluhr, Joachim, additional, Gaskins, Matthew, additional, Hamelmann, Eckard, additional, Kühne, Kathrin, additional, Merk, Hans, additional, Mülleneisen, Norbert K., additional, Nast, Alexander, additional, Olze, Heidi, additional, Ott, Hagen, additional, Pleimes, Marc, additional, Ruëff, Franziska, additional, Staubach‐Renz, Petra, additional, Wedi, Bettina, additional, and Maurer, Marcus, additional

Published
2023
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31. S3‐Leitlinie Urtikaria. Teil 1: Klassifikation und Diagnostik der Urtikaria – deutschsprachige Adaptation der internationalen S3‐Leitlinie

Author

Zuberbier, Torsten, primary, Altrichter, Sabine, additional, Bauer, Sabine, additional, Brehler, Randolf, additional, Brockow, Knut, additional, Dressler, Corinna, additional, Fluhr, Joachim, additional, Gaskins, Matthew, additional, Hamelmann, Eckard, additional, Kühne, Kathrin, additional, Merk, Hans, additional, Mülleneisen, Norbert K., additional, Nast, Alexander, additional, Olze, Heidi, additional, Ott, Hagen, additional, Pleimes, Marc, additional, Ruëff, Franziska, additional, Staubach‐Renz, Petra, additional, Wedi, Bettina, additional, and Maurer, Marcus, additional

Published
2023
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32. Guideline for allergological diagnosis of drug hypersensitivity reactions

Author

Brockow, Knut, primary, Wurpts, Gerda, additional, Trautmann, Axel, additional, Pfützner, Wolfgang, additional, Treudler, Regina, additional, Bircher, Andreas J., additional, Brehler, Randolf, additional, Buhl, Timo, additional, Dickel, Heinrich, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Kurz, Julia, additional, Kreft, Burkhard, additional, Lange, Lars, additional, Merk, Hans F., additional, Mockenhaupt, Maja, additional, Mülleneisen, Norbert, additional, Ott, Hagen, additional, Ring, Johannes, additional, Ruëff, Franziska, additional, Sachs, Bernhardt, additional, Sitter, Helmut, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Worm, Margitta, additional, and Zuberbier, Torsten, additional

Published
2023
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36. Management of suspected and confirmedCOVID‐19 (SARS‐CoV‐2) vaccine hypersensitivity

Author

Worm, Margitta, primary, Alexiou, Aikaterina, additional, Bauer, Andrea, additional, Treudler, Regina, additional, Wurpts, Gerda, additional, Dickel, Heinrich, additional, Buhl, Timo, additional, Müller, Sabine, additional, Jung, Andreas, additional, Brehler, Randolf, additional, Fluhr, Joachim, additional, Klimek, Ludger, additional, Mülleneisen, Norbert, additional, Pfützner, Wolfgang, additional, Raap, Ulrike, additional, Roeseler, Stefani, additional, Schuh, Sandra, additional, Timmermann, Hartmut, additional, Heine, Guido, additional, Wedi, Bettina, additional, and Brockow, Knut, additional

Published
2022
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37. German S1 guideline: Contact dermatitis

Author

Dickel, Heinrich, primary, Bauer, Andrea, additional, Brehler, Randolf, additional, Mahler, Vera, additional, Merk, Hans F., additional, Neustädter, Irena, additional, Strömer, Klaus, additional, Werfel, Thomas, additional, Worm, Margitta, additional, and Geier, Johannes, additional

Published
2022
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38. S1‐Leitlinie Kontaktekzem

Author

Dickel, Heinrich, primary, Bauer, Andrea, additional, Brehler, Randolf, additional, Mahler, Vera, additional, Merk, Hans F., additional, Neustädter, Irena, additional, Strömer, Klaus, additional, Werfel, Thomas, additional, Worm, Margitta, additional, and Geier, Johannes, additional

Published
2022
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39. Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (ÖGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD)

Author

Pfaar, Oliver, Ankermann, Tobias, Augustin, Matthias, Bubel, Petra, Boing, Sebastian, Brehler, Randolf, Eng, Peter A, Fischer, Peter J, Gerstlauer, Michael, Hamelmann, Eckard, Jakob, Thilo, Kleine-Tebbe, Jorg, Kopp, Matthias Volkmar, Lau, Susanne, Mulleneisen, Norbert, Muller, Christoph, Nemat, Katja, Pfutzner, Wolfgang, Saloga, Joachim, Stromer, Klaus, Schmid-Grendelmeier, Peter, Schuster, Antje, Sturm, Gunter Johannes, Taube, Christian, Szepfalusi, Zsolt, Vogelberg, Christian, Wagenmann, Martin, Wehrmann, Wolfgang, Werfel, Thomas, Wohrl, Stefan, Worm, Margitta, Wedi, Bettina, Kaul, Susanne, Mahler, Vera, and Schwalfenberg, Anja

Abstract

Not available. © Dustri-Verlag Dr. K. Feistle.

Published
2022

40. Contact sensitization to essential oils: IVDK data of the years 2010–2019

Author

Geier, Johannes, Schubert, Steffen, Reich, Kristian, Skudlik, Christoph, Ballmer-Weber, Barbara, Brehler, Randolf, Weisshaar, Elke, Uter, Wolfgang, University of Zurich, and Geier, Johannes

Subjects
10177 Dermatology Clinic, 610 Medicine & health, Dermatology, Allergens, Patch Tests, Perfume, 2708 Dermatology, Dermatitis, Allergic Contact, Oils, Volatile, 2723 Immunology and Allergy, Humans, Immunology and Allergy, Female, ddc:610, Retrospective Studies
Abstract

Background Essential oils (EOs) are widely used in cosmetics, perfumes, massage fluids, aroma therapy and natural medicine. Some EOs contain contact sensitizers. Objectives To describe the frequency of sensitization to EOs in dermatitis patients presenting in skin clinics including concomitant reactions, to evaluate the EO patch test preparations and to identify patient groups with an increased risk of EO sensitization. Patients and methods Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK), 2010–2019. Results Twelve EOs were patch tested in an aimed manner in 10 930 patients, of whom 908 (8.3%) reacted to at least 1 EO. Only 6 EOs elicited more than 1% positive patch test reactions: ylang ylang (I + II) oil (3.9%), lemongrass oil (2.6%), jasmine absolute (1.8%), sandalwood oil (1.8%), clove oil (1.6%) and neroli oil (1.1%). Concomitant reactions among EOs or to EOs and fragrances were frequent. Among EO‐positive patients, women, leg dermatitis patients, patients aged 40 years or more, masseurs and cosmeticians were over‐represented. Conclusions Sensitization to EOs occurs, albeit infrequently in most cases. Masseurs and cosmeticians have an increased risk of sensitization to EOs.

Published
2022
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41. Epidemiologie, Krankheitslast und gesundheitsökonomische Aspekte

Author

Lange, Lars, primary, Klimek, Ludger, additional, Vogelberg, Christian, additional, Beyer, Kirsten, additional, Blümchen, Katharina, additional, Novak, Natalija, additional, Hamelmann, Eckard, additional, Bauer, Andrea, additional, Merk, Hans F., additional, Rabe, Uta, additional, Jung, Kirsten, additional, W. Schlenter, Wolfgang, additional, Ring, Johannes, additional, Chaker, Adam M., additional, Wehrmann, Wolfgang, additional, Becker, Sven, additional, Mülleneisen, Norbert K., additional, Nemat, Katja, additional, Czech, Wolfgang, additional, Wrede, Holger, additional, Brehler, Randolf, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Ankermann, Tobias, additional, M. Schmidt, Sebastian, additional, Gerstlauer, Michael, additional, Zuberbier, Torsten, additional, and Spindler, Thomas, additional

Published
2022
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43. German S1 guideline: Contact dermatitis

Author

Dickel, Heinrich, Bauer, Andrea, Brehler, Randolf, Mahler, Vera, Merk, Hans F., Neustädter, Irena, Strömer, Klaus, Werfel, Thomas, Worm, Margitta, and Geier, Johannes

Subjects
Dermatitis, Allergic Contact, Eczema, Quality of Life, Humans, Dermatology, Allergens, Patch Tests
Abstract

Journal der Deutschen Dermatologischen Gesellschaft : JDDG = Journal of the German Society of Dermatology 20(5), 712-734 (2022). doi:10.1111/ddg.14734, Published by Wiley-Blackwell, Berlin

Published
2021

44. White Paper Erdnussallergie - Teil 1: Epidemiologie, Burden of Disease, gesundheitsökonomische Aspekte

Author

Lange, Lars, primary, Klimek, Ludger, additional, Beyer, Kirsten, additional, Blümchen, Katharina, additional, Novak, Natalija, additional, Hamelmann, Eckard, additional, Bauer, Andrea, additional, Merk, Hans F., additional, Rabe, Uta, additional, Jung, Kirsten, additional, Schlenter, Wolfgang W., additional, Ring, Johannes, additional, Chaker, Adam M., additional, Wehrmann, Wolfgang, additional, Becker, Sven, additional, Mülleneisen, Norbert K., additional, Nemat, Katja, additional, Czech, Wolfgang, additional, Wrede, Holger, additional, Brehler, Randolf, additional, Fuchs, Thomas, additional, Jakob, Thilo, additional, Ankermann, Tobias, additional, Schmidt, Sebastian M., additional, Gerstlauer, Michael, additional, Zuberbier, Torsten, additional, Spindler, Thomas, additional, and Vogelberg, Christian, additional

Published
2021
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45. Management of suspected and confirmed COVID‐19 (SARS‐CoV‐2) vaccine hypersensitivity.

Author

Worm, Margitta, Alexiou, Aikaterina, Bauer, Andrea, Treudler, Regina, Wurpts, Gerda, Dickel, Heinrich, Buhl, Timo, Müller, Sabine, Jung, Andreas, Brehler, Randolf, Fluhr, Joachim, Klimek, Ludger, Mülleneisen, Norbert, Pfützner, Wolfgang, Raap, Ulrike, Roeseler, Stefani, Schuh, Sandra, Timmermann, Hartmut, Heine, Guido, and Wedi, Bettina

Subjects
URTICARIA, COVID-19 vaccines, ALLERGIES, SARS-CoV-2, COVID-19, VACCINES
Abstract

Background: Systemic allergic reactions to vaccines are very rare. In this study we assessed the management and outcome of suspected SARS‐CoV‐2 vaccine hypersensitivity. Methods: Totally, 334 individuals underwent an allergy work up regarding SARS‐CoV‐2 vaccination (group A: 115 individuals suspected to be at increased risk for vaccine‐related reactions before vaccination and group B: 219 patients with reactions after COVID vaccination). The large majority of the SPT/IDT with the vaccines were negative; however, we identified in 14.1% (n = 47) a possible sensitization to the SARS‐CoV‐2 vaccine and/or its ingredients defined as one positive skin test. Of the 219 individuals (group B) who experienced symptoms suspicious for a hypersensitivity reaction after vaccination, 214 were reported after the first vaccination with a mRNA vaccine (157 mRNA (Comirnaty®, 38 Spikevax®) and 18 with a vector vaccine (Vaxzevria®), 5 cases were after the second vaccination. Results: The symptom profile in group B was as follows: skin symptoms occurred in 115 cases (n = 59 angioedema, n = 50 generalized urticaria and n = 23 erythema/flush. Seventy individuals had cardiovascular, 53 respiratory and 17 gastrointestinal symptoms. Of the overall 334 individuals, 78 patients tolerated (re)‐vaccination (out of skin test positive/negative 7/19 from group A and 17/35 from group B). Conclusion: Proven IgE‐mediated hypersensitivity to SARS‐CoV‐2 vaccines is extremely rare and not increased in comparison with reported hypersensitivity to other vaccines. The value of skin tests is unclear and nonspecific reactions, in particular when intradermal testing is applied, should be considered. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Impact of climate change on allergic diseases in Germany.

Author

Bergmann KC, Brehler R, Endler C, Höflich C, Kespohl S, Plaza M, Raulf M, Standl M, Thamm R, Traidl-Hoffmann C, and Werchan B

Abstract

Background: Allergic diseases, especially inhalation allergies, have reached epidemic levels and environmental factors play an important role in their development. Climate change influences the occurrence, frequency, and severity of allergic diseases., Methods: The contents of this article were selected by the authors and developed section by section according to their expertise and the current state of knowledge. The sections were then discussed and agreed upon amongst all authors., Results: The article highlights direct and indirect effects of climate change on allergies. It goes into detail about the connections between climate change and (new) pollen allergens as well as (new) occupational inhalation allergens, explains the effects of climate change on the clinical picture of atopic dermatitis, discusses the connections between air pollutants and allergies, and provides information about the phenomenon of thunderstorm asthma., Conclusions: There is a need for action in the field of pollen and fungal spore monitoring, allergy and sensitisation monitoring, urban planning from an allergological perspective, and changes in the working environment, among others., Competing Interests: Conflicts of interest Randolf Brehler declared lecturing activities (ALK, Allergopharma, Almirall, Astra Zeneca, Behring, Bencard, GlaxoSmithKline, HAL Allergie, Leti, MedUpdate, Merck, Novartis, Omnicuris, Oto-Rhino-Laryngologischer Verein, Sanofi, Stallergenes, Thermo-Fischer) and consulting activities (Allergopharma, Astra Zeneca, GlaxoSmithKline, HAL Allergie, Leti, Lofarma, Novartis). The other authors declared no conflicts of interest., (© Robert Koch Institute. All rights reserved unless explicitly granted.)

Published
2023
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47. S2k guideline diagnosis, prevention, and therapy of hand eczema.

Author

Bauer A, Brans R, Brehler R, Büttner M, Dickel H, Elsner P, Fartasch M, Herzog C, John SM, Köllner A, Maul JT, Merk H, Molin S, Nast A, Nikolakis GD, Schliemann S, Skudlik C, Weisshaar E, Werfel T, Zidane M, and Worm M

Subjects
Humans, Consensus, Eczema diagnosis, Eczema prevention & control, Dermatitis, Contact
Abstract

The consensus-based guideline "Diagnosis, prevention, and treatment of hand eczema (HE)" provides concrete instructions and recommendations for diagnosis, prevention, and therapy of HE based on an evidence- and consensus-based approach. The guideline was created based on the German guideline "Management von Handekzemen" from 2009 and the current guideline of the European Society of Contact Dermatitis (ESCD) "Guidelines for diagnosis, prevention, and treatment of hand eczema" from 2022. The general goal of the guideline is to provide dermatologists and allergologists in practice and clinics with an accepted, evidence-based decision-making tool for selecting and conducting suitable and sufficient therapy for patients with hand eczema. The guideline is based on two Cochrane reviews of therapeutic and preventive interventions for HE. The remaining chapters were mainly developed and consented based on non-systematic literature research by the expert group. The expert group consisted of members of allergological and occupational dermatological professional associations and working groups, a patient representative, and methodologists. The proposals for recommendations and key statements were consented by using a nominal group process during a consensus conference on September 15, 2022. The structured consensus-building process was professionally moderated. This guideline is valid until February 22, 2028., (© 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.)

Published
2023
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