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Your search keyword '"Bourdel‐marchasson, Isabelle"' showing total 12 results
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12 results on '"Bourdel‐marchasson, Isabelle"'

1. Essential steps in primary care management of older people with Type 2 diabetes: an executive summary on behalf of the European geriatric medicine society (EuGMS) and the European diabetes working party for older people (EDWPOP) collaboration

Author

Bourdel-Marchasson, Isabelle, Maggi, Stefania, Abdelhafiz, Ahmed, Bellary, Sri, Demurtas, Jacopo, Forbes, Angus, Ivory, Philip, Rodríguez-Mañas, Leocadio, Sieber, Cornel, Strandberg, Timo, Tessier, Daniel, Vergara, Itziar, Veronese, Nicola, Zeyfang, Andrej, Christiaens, Antoine, and Sinclair, Alan

Published
2023
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4. Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort

Author

Planche, Vincent, Bouteloup, Vincent, Pellegrin, Isabelle, Mangin, Jean-Francois, Dubois, Bruno, Ousset, Pierre-Jean, Pasquier, Florence, Blanc, Frederic, Paquet, Claire, Hanon, Olivier, Bennys, Karim, Ceccaldi, Mathieu, Annweiler, Cédric, Krolak-Salmon, Pierre, Godefroy, Olivier, Wallon, David, Sauvee, Mathilde, Boutoleau-Bretonnière, Claire, Bourdel-Marchasson, Isabelle, Jalenques, Isabelle, Chene, Genevieve, and Dufouil, Carole

Published
2022
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6. Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies

Author

Calvani, Riccardo, primary, Picca, Anna, additional, Rodriguez-Mañas, Leocadio, additional, Tosato, Matteo, additional, Coelho-Júnior, Hélio José, additional, Biancolillo, Alessandra, additional, Laosa, Olga, additional, Gervasoni, Jacopo, additional, Primiano, Aniello, additional, Santucci, Lavinia, additional, Giampaoli, Ottavia, additional, Bourdel-Marchasson, Isabelle, additional, Regueme, Sophie C., additional, Sinclair, Alan J., additional, Urbani, Andrea, additional, Landi, Francesco, additional, Gambassi, Giovanni, additional, Marini, Federico, additional, and Marzetti, Emanuele, additional

Published
2023
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7. Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies

Author

Calvani, Riccardo, Picca, Anna, Rodríguez-Mañas, Leocadio, Tosato, Matteo, José Coelho-Júnior, Hélio, Biancolillo, Alessandra, Laosa, Olga, Gervasoni, Jacopo, Primiano, Aniello, Santucci, Lavinia, Giampaoli, Ottavia, Bourdel-Marchasson, Isabelle, Regueme, Sophie C., Sinclair, Alan J., Urbani, Andrea, Landi, Francesco, Gambassi, Giovanni, Marini, Federico, Marzetti, Emanuele, Riccardo Calvani (ORCID:0000-0001-5472-2365), Matteo Tosato, Jacopo Gervasoni, Aniello Primiano, Lavinia Santucci, Andrea Urbani (ORCID:0000-0001-9168-3174), Francesco Landi (ORCID:0000-0002-3472-1389), Giovanni Gambassi (ORCID:0000-0002-7030-9359), Emanuele Marzetti (ORCID:0000-0001-9567-6983), Calvani, Riccardo, Picca, Anna, Rodríguez-Mañas, Leocadio, Tosato, Matteo, José Coelho-Júnior, Hélio, Biancolillo, Alessandra, Laosa, Olga, Gervasoni, Jacopo, Primiano, Aniello, Santucci, Lavinia, Giampaoli, Ottavia, Bourdel-Marchasson, Isabelle, Regueme, Sophie C., Sinclair, Alan J., Urbani, Andrea, Landi, Francesco, Gambassi, Giovanni, Marini, Federico, Marzetti, Emanuele, Riccardo Calvani (ORCID:0000-0001-5472-2365), Matteo Tosato, Jacopo Gervasoni, Aniello Primiano, Lavinia Santucci, Andrea Urbani (ORCID:0000-0001-9168-3174), Francesco Landi (ORCID:0000-0002-3472-1389), Giovanni Gambassi (ORCID:0000-0002-7030-9359), and Emanuele Marzetti (ORCID:0000-0001-9567-6983)

Abstract

An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S, n = 94), frail/pre-frail older adults with type 2 diabetes mellitus (F-T2DM, n = 66), and robust non-diabetic controls (n = 40). Partial least squares discriminant analysis (PLS-DA) models were built to define the amino acid signatures associated with the different frailty phenotypes. PLS-DA allowed correct classification of participants with 78.2 ± 1.9% accuracy. Older adults with F-T2DM showed an amino acid profile characterized by higher levels of 3-methylhistidine, alanine, arginine, ethanolamine, and glutamic acid. PF&S and control participants were discriminated based on serum concentrations of aminoadipic acid, aspartate, citrulline, cystine, taurine, and tryptophan. These findings suggest that different types of frailty may be characterized by distinct metabolic perturbations. Amino acid profiling may therefore serve as a valuable tool for frailty biomarker discovery.

Published
2023

10. Weight loss

Author

Bourdel‐Marchasson, Isabelle, primary and Thomas, David R., additional

Published
2022
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11. Validity and Performance of Blood Biomarkers for Alzheimer Disease to Predict Dementia Risk in a Large Clinic-Based Cohort.

Author

Planche, Vincent, Bouteloup, Vincent, Pellegrin, Isabelle, Mangin, Jean-Francois, Dubois, Bruno, Ousset, Pierre-Jean, Pasquier, Florence, Blanc, Frederic, Paquet, Claire, Hanon, Olivier, Bennys, Karim, Ceccaldi, Mathieu, Annweiler, Cédric, Krolak-Salmon, Pierre, Godefroy, Olivier, Wallon, David, Sauvee, Mathilde, Boutoleau-Bretonnière, Claire, Bourdel-Marchasson, Isabelle, and Jalenques, Isabelle

Published
2023
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12. New setup for multi‐parametric MRI in young and old rat gastrocnemius at 4.7 and 7 T during muscle stimulation.

Author

Loubrie, Stéphane, Trotier, Aurelien, Ribot, Emeline, Massot, Philippe, Lefrançois, William, Thiaudière, Eric, Dallaudière, Benjamin, Miraux, Sylvain, and Bourdel‐Marchasson, Isabelle

Subjects
MAGNETIC resonance imaging, RATS, SPECTROMETRY, AGING, LEG muscles
Abstract

T1 and T2 relaxation times combined with 31P spectroscopy have been proven efficient for muscular disease characterization as well as for pre‐ and post‐muscle stimulation measurements. Even though 31P spectroscopy can already be performed during muscle exercise, no method for T1 and T2 measurement enables this possibility. In this project, a complete setup and protocol for multi‐parametrical MRI of the rat gastrocnemius before, during and after muscle stimulation at 4.7 and 7 T is presented. The setup is fully MRI compatible and is composed of a cradle, an electro‐stimulator and an electronic card in order to synchronize MRI sequences with muscle stimulation. A 2D triggered radial‐encoded Look‐Locker sequence was developed, and enabled T1 measurements in less than 2 min on stimulated muscle. Also, a multi‐slice multi‐echo sequence was adapted and synchronized for T2 measurements as well as 31P spectroscopy acquisitions in less than 4 min in both cases on stimulated muscle. Methods were validated on young rats using different stimulation paradigms. Then they were applied on older rats to compare quantification results, using the different stimulation paradigms, and allowed observation of metabolic changes related to aging with good reproducibility. The robustness of the whole setup shows wide application opportunities. [ABSTRACT FROM AUTHOR]

Published
2022
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