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This article explores the politics of policy change by focusing on agenda setting through the lens of the Multiple Streams Approach (MSA), which has been travelling to ever-larger geographies. We aim to produce signposts for future case studies of policy change by bringing together insights from MSA and New Institutionalism. We ask: Which institutions should we focus on when studying agenda-setting politics in different geographies? How do these institutions shape MSA's structural elements - problem stream, policy stream, political stream, policy windows, and policy entrepreneur? In answering these questions, we hope to weave not only formal but also informal institutions into MSA's backbone more tightly. We bring together diverse case studies that are sufficiently abstract and whose findings travel easily across other institutional contexts. We revisit the structural elements of MSA and illustrate how key formal and informal rules structure the politics in these structural elements. © 2022 The Author(s). Published by Cambridge University Press.