1. The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population.
- Author
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Blake JJ, Munyombwe T, Fischer F, Quinn TJ, Van der Feltz-Cornelis CM, De Man-van Ginkel JM, Santos IS, Jeon HJ, Köhler S, Schram MT, Wang JL, Levin-Aspenson HF, Whooley MA, Hobfoll SE, Patten SB, Simning A, Gracey F, and Broomfield NM
- Subjects
- Humans, Female, Male, Middle Aged, Aged, Factor Analysis, Statistical, Psychometrics, Adult, Self Report, Surveys and Questionnaires, Stroke psychology, Stroke complications, Patient Health Questionnaire, Depression psychology, Depression diagnosis
- Abstract
Background: It is unclear if certain post-stroke somatic symptoms load onto items of the Patient Health Questionnaire-9 (PHQ-9), a self-report depression questionnaire. We investigated these concerns in a stroke sample using factor analysis, benchmarked against a non-stroke comparison group., Methods: The secondary dataset constituted 787 stroke and 12,016 non-stroke participants. A subsample of 1574 comparison participants was selected via propensity score matching. Dimensionality was assessed by comparing fit statistics of one-factor, two-factor, and bi-factor models. Between-group differences in factor structure were explored using measurement invariance., Results: A two-factor model, consisting of somatic and cognitive-affective factors, showed better fit than the unidimensional model (CFI = 0.984 versus CFI = 0.974, p < .001), but the high correlation between the factors indicated unidimensionality (r = 0.866). Configural invariance between stroke and non-stroke was supported (CFI = 0.983, RMSEA = 0.080), as were invariant thresholds (p = .092) and loadings (p = .103). Strong invariance was violated (p < .001, ΔCFI = -0.003), stemming from differences in the tiredness and appetite intercepts. These differences resulted in a moderate overestimation of depression in stroke when using a summed score approach, relative to the comparison sample (Cohen's d = 0.434)., Conclusions: The findings suggest that the PHQ-9 measures a single factor in stroke. Because stroke patients may report higher tiredness on item 4, caution is advisable when classifying patients as depressed if they are near the cut-off and have significant post-stroke fatigue. Caution is also advised when comparing total scores between stroke and other populations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2025
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