Search

Your search keyword '"Bhalla, Diksha"' showing total 6 results
Start Over Author "Bhalla, Diksha" Publication Year Range Last 3 years
6 results on '"Bhalla, Diksha"'

2. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, and Wildwater, Marjolein

Abstract

SUMMARY: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths.AVAILABILITY AND IMPLEMENTATION: All code is available on GitHub https://github.com/Xpaths/dartpaths-app under Apache license 2.0, detailed overview with demo is available at https://www.vivaltes.com/dartpaths/.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Published
2023

3. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

IRAS OH Toxicology, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein, IRAS OH Toxicology, Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, and Wildwater, Marjolein

Published
2023

4. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Author

Bhalla, Diksha, primary, Steijaert, Marvin N, additional, Poppelaars, Eefje S, additional, Teunis, Marc, additional, van der Voet, Monique, additional, Corradi, Marie, additional, Dévière, Elisabeth, additional, Noothout, Luke, additional, Tomassen, Wilco, additional, Rooseboom, Martijn, additional, Currie, Richard A, additional, Krul, Cyrille, additional, Pieters, Raymond, additional, van Noort, Vera, additional, and Wildwater, Marjolein, additional

Published
2022
Full Text
View/download PDF

6. DARTpaths, an in silico platform to investigate molecular mechanisms of compounds.

Author

Bhalla D, Steijaert MN, Poppelaars ES, Teunis M, van der Voet M, Corradi M, Dévière E, Noothout L, Tomassen W, Rooseboom M, Currie RA, Krul C, Pieters R, van Noort V, and Wildwater M

Subjects
Software, Algorithms
Abstract

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths., Availability and Implementation: All code is available on GitHub https://github.com/Xpaths/dartpaths-app under Apache license 2.0, detailed overview with demo is available at https://www.vivaltes.com/dartpaths/., Supplementary Information: Supplementary data are available at Bioinformatics online., (© The Author(s) 2022. Published by Oxford University Press.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results