26 results on '"Bentes, Carla"'
Search Results
2. Characterization and quantification of epilepsy patients with hospital episodes in Portugal: A multicenter retrospective study from Liga Portuguesa Contra a Epilepsia
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Bentes, Carla, Canas, Nuno, Pedrosa, Hugo, Completo, João, Pereira, Fábio, Carrilho, Magda, Lopes Lima, José, Pereira, Cristina, Rego, Ricardo, Rocha, Helena, Sá, Francisca, Sales, Francisco, Santos, Manuela, and Teotónio, Rute
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- 2024
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3. Proceedings of the “International Congress on Structural Epilepsy & Symptomatic Seizures” (STESS, Gothenburg, Sweden, 29–31 March 2023)
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Brigo, Francesco, Zelano, Johan, Abraira, Laura, Bentes, Carla, Ekdahl, Christine T, Lattanzi, Simona, Ingvar Lossius, Morten, Redfors, Petra, Rouhl, Rob P.W., Russo, Emilio, Sander, Josemir W., Vogrig, Alberto, and Wickström, Ronny
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- 2024
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4. Implications for driving based on the risk of seizures after ischaemic stroke
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Schubert, Kai Michael, primary, Bicciato, Giulio, additional, Sinka, Lucia, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Terziev, Robert, additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J, additional, Wagner, Judith N, additional, Gigli, Gian Luigi, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Mayor-Romero, Luis Carlos, additional, Conrad, Julian, additional, Evers, S, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R, additional, Duncan, John Sidney, additional, Sander, Josemir W, additional, Tettenborn, Barbara, additional, Koepp, Matthias, additional, and Galovic, Marian, additional
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- 2024
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5. Factors associated with failed epidural blood patch after accidental dural puncture in obstetrics: a prospective, multicentre, international cohort study
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Casier, Isabelle, Bryon, Bart, Soetens, Filiep, Dewandre, Pierre-Yves, Lambert, Geraldine, Christiaen, Jan, Schepers, Roel, Van Houwe, Patrick, Kalmar, Alain, Vanoverschelde, Henk, Bauters, Monique, Roofthooft, Eva, Devroe, Sarah, Van de Velde, Marc, Jadrijevic, Ana, Jokic, Aleksandra, Marin, Damjan, Sklebar, Ivan, Mihaljević, Slobodan, Kosinova, Martina, Stourac, Petr, Adamus, Milan, Kufa, Christian, Volfová, Ivana, Zaoralová, Blažena, Froeslev-Friis, Christina, Mygil, Bjoern, Krebs Albrechtsen, Charlotte, Kavasmaa, Tomi, Alahuhta, Seppo, Mäyrä, Anne, Mennander, Susanna, Rautaneva, Kati, Hiekkanen, Tuula, Kontinen, Vesa, Linden, Kirsti, Toivakka, Sara, Boselli, Emmanuel, Greil, Pierre-Édouard, Mascle, Olivier, Courbon, Aurelie, Lutz, Jean., Simonet, Thérèse, Barbier, Marie, Hlioua, Tarik, Meniolle d’Hauthville, Fleur, Quintin, Christine, Bouattour, Karim, Lecinq, Agnès, Mercier, Frederic, Bonnet, Marie-Pierre, Carbonniere, Mathieu, Fischer, Catherine, Picard, Paola-Carla, Bonnin, Martine, Storme, Brigitte, Bouthors, Anne-Sophie, Detente, Thomas, Nguyen, Truong Minh, Keita, Hawa, Nebout, Sophie, Osse, Lauranne, Delmas, Anne, Vial, Florence, Kaufner, Lutz, Hoefing, Christoph, Mueller, Stefan, Becke, Karin, Blobner, Manfred, Lewald, Heidrun, Schaller, Stefan Josef, Muggleton, Ellis, Bette, Birgit, Neumann, Claudia, Weber, Stefan, Grünewald, Matthias, Ohnesorge, Henning, Helf, Antonia, Jelting, Yvonne, Kranke, Peter, von Heymann, Christian, Welfle, Sabine, Staikou, Chryssoula, Stavrianopoulou, Antonia, Stamelos, Mattheios, Kalopita, Konstantina, Loukeri, Anastasia, Valsamidis, Dimitrios, Matsota, Paraskevi, Thorsteinsson, Adalbjörn, Tome, Riad, Eidelman, Leonid A., Davis, Atara, Orbach-Zinger, Sharon, Ioscovich, Alexander, Ramona, Iacob, De Simone, Luigi, Pesetti, Barbara, Brazzi, Luca, Zito, Alessandro, Camorcia, Michela, Della Rocca, Giorgio, Aversano, Marco, Frigo, Maria Grazia, Todde, Cristina, Macas, Andrius, Keraitiene, Grazina, Rimaitis, Kestutis, Borg, Francis, Tua, Carl, Kuijpers-Visser, Agnes Geertje, Schyns-van den Berg, Alexandra, Hollmann, Markus W., van den Berg, Tijs, Koolen, Eric, Dons, Ilse, van der Knijff, Anouk, van der Marel, Caroline, Ruysschaert, Nele, Pelka, Michal, Pluymakers, Christine, Koopman, Seppe, Teunissen, Aart-Jan, Cornelisse, Dick, van Dasselaar, Nick, Verdouw, Bastiaan, Beenakkers, Ingrid, Dahl, Vegard, Hagen, Robert, Vivaldi, Francesco, Eriksen, John Reidar, Wiszt, Radovan, Aslam Tayyba, Naz, Ringvold, Else-Marie, Chutkowski, Radosław, Skirecki, Tomasz, Wódarski, Bartłomiej, Faria, Maria Aida, Ferreira, Amélia, Sampaio, Ana Catarina, Ferreira, Irene, Matias, Bernardo, Teixeira, Joana, Araujo, Rita, Cabido, Herminia, Fortuna, Rosario, Lemos, Paulo, Cardoso, Carolina, Moura, Fernando, Pereira, Cristiana, Pereira, Sandra, Abecasis, Manuel, Lança, Filipa, Muchacho, Paulo, Ormonde, Lucindo, Guedes-Araujo, Isabel, Pinho-Oliveira, Vitor, Paredes, Paulo, Bentes, Carla, Gouveia, Francisco, Milheiro, Ana, Castanheira, Cláudia, Neves, Miriam, Pacheco, Vânia, Cortez, Mara, Tranquada, Raquel, Tareco, Glória, Furtado, Inês, Pereira, Estela, Marinho, Luísa, Seabra, Manuel, Bulasevic, Aleksandra, Kendrisic, Mirjana, Jovanovic, Lidija, Pujić, Borislava, Kutlesic, Marija, Grochova, Monika, Simonova, Jana, Pavlovic, Gordana, Rozman, Ales, Blajic, Iva, Graovac, Dragan, Stopar Pintaric, Tatjana, Chiquito, Teresa, Monedero, Pablo, De Carlos-Errea, Joaquin, Guillén-Casbas, Roque, Veiga-Gil, Leonor, Basso, Morena, Garcia Bartolo, Carolina, Hernandez, Cristian, Ricol, Laura, De Santos, Maroto Pinar, Gràcia Solsona, Josep A., López-Baamonde, Manuel, Magaldi Mendaña, Marta, Plaza Moral, Ana María, Vendrell, Marina, Trillo, Lourdes, Perez Garcia, Anibal Ricardo, Alamillo Salas, Clara, Moret, Enric, Ramió, Laura, Aguilar Sanchez, Jose Luis, Soler Pedrola, Maria, Valldeperas Hernandez, Maria Inmaculada, Aldalur, Gorka, Bárcena, Estíbaliz, Herrera, Julia, Iturri, Fernando, Martínez, Alberto, Martínez, Leire, Serna, Rosa, Gilsanz, Fernando, Guasch Arevalo, Emilia, Iannuccelli, Fabrizio, Latorre, Julieta, Rodriguez Roca, Cristina, Pérez Pardo, Osvaldo Ceferino, Sierra Biddle, Natalia, Suárez Castaño, Ceferina, Hernández González, Lourdes, Remacha González, Caridad, Sánchez Nuez, Raquel, Anta, Diego, Beleña, Jose M., García-Cuadrado, Carmen, Garcia, Irene, Manrique, Susana, Suarez, Elena, Hein, Anette, Arbman, Elisabet, Hansson, Helena, Tillenius, Monika, Al-Taie, Ruaa, Ledin-Eriksson, Susanne, Lindén-Söndersö, Anja, Rosén, Ola, Austruma, Evija, Gillberg, Lars, Darvish, Bijan, Gupta, Anil, Jörnvall, Henrik, Nordström, Johan, Persson, Jan, Rosenberg, Jan, Brühne, Lars, Forshammar, Johan, Ugarph Edfeldt, Malin, Rolfsson, Håkan, Hellblom, Anna, Levin, Katarina, Rabow, Sofus, Thorlacius, Karin, Bansch, Peter, Robertson (Baeriswyl), Moira, Stamer, Ulrike, Mathivon, Stanislas, Savoldelli, Georges, Auf der Maur, Pia, Filipovic, Miodrag, Dullenkopf, Alexander, Brunner, Maya, Girard, Thierry, Vonlanthen, Claudia, Ozbilgin, Sule, Gunaydin D, Berrin, Corman Dincer, Pelin, Tas Tuna, Ayca, Daamen, Sylvia, Farsi, Slama, Feijten, Prisca, Harlet, Pierre, Leva, Brigitte, Plichon, Benoît, Magnuson, Anders, Guasch, Emilia, Mercier, Frédéric J., and Schyns-van den Berg, Alexandra M.J.V.
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- 2022
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6. Frequency of epileptic seizures in patients undergoing decompressive craniectomy after ischemic stroke
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Franco, Ana Catarina, Fernandes, Tiago, Peralta, Ana Rita, Basílio, Gonçalo, Carneiro, Inês, Pinho e Melo, Teresa, and Bentes, Carla
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- 2022
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7. Long‐term evaluation of anterior thalamic deep brain stimulation for epilepsy in the European MORE registry.
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Kaufmann, Elisabeth, Peltola, Jukka, Colon, Albert J., Lehtimäki, Kai, Majtanik, Milan, Mai, Jürgen K., Bóné, Beata, Bentes, Carla, Coenen, Volker, Gil‐Nagel, Antonio, Goncalves‐Ferreira, Antonio J., Ryvlin, Philippe, Taylor, Rod, Brionne, Thomas C., Gielen, Frans, Song, Shannon, and Boon, Paul
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DEEP brain stimulation ,PARTIAL epilepsy ,EPILEPSY surgery ,NEURAL stimulation ,EPILEPSY ,BRAIN stimulation ,TEMPORAL lobectomy - Abstract
Objective: Short‐term outcomes of deep brain stimulation of the anterior nucleus of the thalamus (ANT‐DBS) were reported for people with drug‐resistant focal epilepsy (PwE). Because long‐term data are still scarce, the Medtronic Registry for Epilepsy (MORE) evaluated clinical routine application of ANT‐DBS. Methods: In this multicenter registry, PwE with ANT‐DBS were followed up for safety, efficacy, and battery longevity. Follow‐up ended after 5 years or upon study closure. Clinical characteristics and stimulation settings were compared between PwE with no benefit, improvers, and responders, that is, PwE with average monthly seizure frequency reduction rates of ≥50%. Results: Of 170 eligible PwE, 104, 62, and 49 completed the 3‐, 4‐, and 5‐year follow‐up, respectively. Most discontinuations (68%) were due to planned study closure as follow‐up beyond 2 years was optional. The 5‐year follow‐up cohort had a median seizure frequency reduction from 16 per month at baseline to 7.9 per month at 5‐year follow‐up (p <.001), with most‐pronounced effects on focal‐to‐bilateral tonic–clonic seizures (n = 15, 77% reduction, p =.008). At last follow‐up (median 3.5 years), 41% (69/170) of PwE were responders. Unifocal epilepsy (p =.035) and a negative history of epilepsy surgery (p =.002) were associated with larger average monthly seizure frequency reductions. Stimulation settings did not differ between response groups. In 179 implanted PwE, DBS‐related adverse events (AEs, n = 225) and serious AEs (n = 75) included deterioration in epilepsy or seizure frequency/severity/type (33; 14 serious), memory/cognitive impairment (29; 3 serious), and depression (13; 4 serious). Five deaths occurred (none were ANT‐DBS related). Most AEs (76.3%) manifested within the first 2 years after implantation. Activa PC depletion (n = 37) occurred on average after 45 months. Significance: MORE provides further evidence for the long‐term application of ANT‐DBS in clinical routine practice. Although clinical benefits increased over time, side effects occurred mainly during the first 2 years. Identified outcome modifiers can help inform PwE selection and management. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Molecular characterization of the circadian clock in patients with Parkinson's disease–CLOCK4PD Study protocol.
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Yalçin, Müge, Peralta, Ana Rita, Bentes, Carla, Silva, Cristiana, Guerreiro, Tiago, Ferreira, Joaquim J., and Relógio, Angela
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CIRCADIAN rhythms ,PARKINSON'S disease ,RESEARCH protocols ,SLEEP ,SLEEP interruptions ,SEX (Biology) ,GENE expression profiling ,DEEP brain stimulation - Abstract
Introduction: Circadian rhythms (CRs) orchestrate intrinsic 24-hour oscillations which synchronize an organism's physiology and behaviour with respect to daily cycles. CR disruptions have been linked to Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, and are associated to several PD-symptoms such as sleep disturbances. Studying molecular changes of CR offers a potential avenue for unravelling novel insights into the PD progression, symptoms, and can be further used for optimization of treatment strategies. Yet, a comprehensive characterization of the alterations at the molecular expression level for core-clock and clock-controlled genes in PD is still missing. Methods and analysis: The proposed study protocol will be used to characterize expression profiles of circadian genes obtained from saliva samples in PD patients and controls. For this purpose, 20 healthy controls and 70 PD patients will be recruited. Data from clinical assessment, questionnaires, actigraphy tracking and polysomnography will be collected and clinical evaluations will be repeated as a follow-up in one-year time. We plan to carry out sub-group analyses considering several clinical factors (e.g., biological sex, treatment dosages, or fluctuation of symptoms), and to correlate reflected changes in CR of measured genes with distinct PD phenotypes (diffuse malignant and mild/motor-predominant). Additionally, using NanoString
Ⓡ multiplex technology on a subset of samples, we aim to further explore potential CR alterations in hundreds of genes involved in neuropathology pathways. Discussion: CLOCK4PD is a mono-centric, non-interventional observational study aiming at the molecular characterization of CR alterations in PD. We further plan to determine physiological modifications in sleep and activity patterns, and clinical factors correlating with the observed CR changes. Our study may provide valuable insights into the intricate interplay between CR and PD with a potential to be used as a predictor of circadian alterations reflecting distinct disease phenotypes, symptoms, and progression outcomes. [ABSTRACT FROM AUTHOR]- Published
- 2024
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9. PreEpiSeizures: description and outcomes of physiological data acquisition using wearable devices during video-EEG monitoring in people with epilepsy
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Abreu, Mariana, primary, Carmo, Ana Sofia, additional, Peralta, Ana Rita, additional, Sá, Francisca, additional, Plácido da Silva, Hugo, additional, Bentes, Carla, additional, and Fred, Ana Luísa, additional
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- 2023
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10. Opioid-Free Anaesthesia Reduces Complications in Head and Neck Microvascular Free-Flap Reconstruction
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Ferreira, Paulo-Roberto, primary, De Oliveira, Rita, additional, Vaz, Marta, additional, Bentes, Carla, additional, and Costa, Horácio, additional
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- 2023
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11. Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: A case–control study
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Coelho, Pedro, primary, Madureira, João, additional, Franco, Ana, additional, Peralta, Ana Rita, additional, Bentes, Carla, additional, Campos, Alexandre Rainha, additional, Anink, Jasper, additional, Aronica, Eleonora, additional, Roque, Rafael, additional, and Pimentel, José, additional
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- 2023
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12. A novel approach to automatic seizure detection using computer vision and independent component analysis
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Garção, Vicente M., primary, Abreu, Mariana, additional, Peralta, Ana R., additional, Bentes, Carla, additional, Fred, Ana, additional, and P. da Silva, Hugo, additional
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- 2023
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13. Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate
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Koepp, Matthias J., primary, Trinka, Eugen, additional, Mah, Yee‐Haur, additional, Bentes, Carla, additional, Knake, Susanne, additional, Gigli, Gian Luigi, additional, Serratosa, José M., additional, Zelano, Johan, additional, Magalhães, Luís M., additional, Pereira, Ana, additional, Moreira, Joana, additional, and Soares‐da‐Silva, Patrício, additional
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- 2023
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14. Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model
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Sinka, Lucia, primary, Abraira, Laura, additional, Imbach, Lukas L., additional, Zieglgänsberger, Dominik, additional, Santamarina, Estevo, additional, Álvarez-Sabín, José, additional, Ferreira-Atuesta, Carolina, additional, Katan, Mira, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Terziev, Robert, additional, Simmen, Cyril, additional, Schubert, Kai Michael, additional, Elshahabi, Adham, additional, Baumann, Christian R., additional, Döhler, Nico, additional, Erdélyi-Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Nilo, Annacarmen, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Zafra-Sierra, María Paula, additional, Bayona-Ortiz, Hernan, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Pinho e Melo, Teresa, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional
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- 2023
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15. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry
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Peltola, Jukka, Colon, Albert J., Pimentel, José, Coenen, Volker A., Gil-Nagel, Antonio, Gonçalves Ferreira, António, Lehtimäki, Kai, Ryvlin, Philippe, Taylor, Rod S., Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla, Bosak, Magdalena, Burneo, Jorge G., Chamadoira, Clara, Elger, Christian E., Erőss, Loránd, Fabo, Dániel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Järvenpää, Soila, Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew, Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana, Rácz, Attila, Rainha Campos, Alexandre, Rego, Ricardo, Ricciuti, Riccardo A., Rona, Sabine, Rouhl, Rob P.W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack, Abouihia, Abdallah, Brionne, Thomas C., Gielen, Frans, Boon, Paul A.J.M., Tampere University, Clinical Medicine, Department of Neurosciences and Rehabilitation, and Repositório da Universidade de Lisboa
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Medicine and Health Sciences ,Neurology (clinical) ,3124 Neurology and psychiatry - Abstract
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Background and objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation. Classification of evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., The MORE registry was sponsored and funded by Medtronic, plc.
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- 2023
16. Editorial: Acute symptomatic seizures and epileptiform abnormalities: Management and outcomes
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Punia, Vineet, primary, Galovic, Marian, additional, Chen, Zhibin, additional, and Bentes, Carla, additional
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- 2023
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17. Acute Symptomatic Seizures and Epileptiform Abnormalities: Management and Outcomes
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Punia, Vineet, primary, Chen, Zhibin, additional, and Bentes, Carla, additional
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- 2023
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18. PO 75 - EPIDURAL CATHETER: SMALL SIZE, BIG TROUBLE
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de Oliveira, Rita, Roberto C. Ferreira, Paulo, and Bentes, Carla
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x
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- 2023
19. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults
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Ferreira-Atuesta, Carolina, primary, de Tisi, Jane, additional, McEvoy, Andrew W, additional, Miserocchi, Anna, additional, Khoury, Jean, additional, Yardi, Ruta, additional, Vegh, Deborah T, additional, Butler, James, additional, Lee, Hamin J, additional, Deli-Peri, Victoria, additional, Yao, Yi, additional, Wang, Feng-Peng, additional, Zhang, Xiao-Bin, additional, Shakhatreh, Lubna, additional, Siriratnam, Pakeeran, additional, Neal, Andrew, additional, Sen, Arjune, additional, Tristram, Maggie, additional, Varghese, Elizabeth, additional, Biney, Wendy, additional, Gray, William P, additional, Peralta, Ana Rita, additional, Rainha-Campos, Alexandre, additional, Gonçalves-Ferreira, António J C, additional, Pimentel, José, additional, Arias, Juan Fernando, additional, Terman, Samuel, additional, Terziev, Robert, additional, Lamberink, Herm J, additional, Braun, Kees P J, additional, Otte, Willem M, additional, Rugg-Gunn, Fergus J, additional, Gonzalez, Walter, additional, Bentes, Carla, additional, Hamandi, Khalid, additional, O'Brien, Terence J, additional, Perucca, Piero, additional, Yao, Chen, additional, Burman, Richard J, additional, Jehi, Lara, additional, Duncan, John S, additional, Sander, Josemir W, additional, Koepp, Matthias, additional, and Galovic, Marian, additional
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- 2022
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20. Mobile Applications for Epilepsy: Where Are We? Where Should We Go? A Systematic Review
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Abreu, Mariana, primary, Carmo, Ana Sofia, additional, Franco, Ana, additional, Parreira, Sara, additional, Vidal, Beatriz, additional, Costa, Mariana, additional, Peralta, Ana Rita, additional, da Silva, Hugo Plácido, additional, Bentes, Carla, additional, and Fred, Ana, additional
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- 2022
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21. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
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Mishra, Nishant K., primary, Engel, Jerome, additional, Liebeskind, David S., additional, Sharma, Vijay K., additional, Hirsch, Lawrence J., additional, Kasner, Scott E, additional, French, Jacqueline A., additional, Devinsky, Orrin, additional, Friedman, Alon, additional, Dawson, Jesse, additional, Quinn, Terence J., additional, Selim, Magdy, additional, de Havenon, Adam, additional, Yasuda, Clarissa L., additional, Cendes, Fernando, additional, Benninger, Felix, additional, Zaveri, Hitten P., additional, Burneo, Jorge G., additional, Srivastava, Padma, additional, Bhushan Singh, Mamta, additional, Bhatia, Rohit, additional, Vishnu, V.Y., additional, Bentes, Carla, additional, Ferro, Jose, additional, Weiss, Shennan, additional, Sivaraju, Adithya, additional, Kim, Jennifer A., additional, Galovic, Marian, additional, Gilmore, Emily J., additional, Pitkänen, Asla, additional, Davis, Kathryn, additional, Sansing, Lauren H., additional, Sheth, Kevin N., additional, Paz, Jeanne T., additional, Singh, Anuradha, additional, Sheth, Sunil, additional, Worrall, Bradford B., additional, Grotta, James C., additional, Casillas-Espinos, Pablo M., additional, Chen, Zhibin, additional, Nicolo, John-Paul, additional, Yan, Bernard, additional, and Kwan, Patrick, additional
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- 2022
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22. Anterior Nucleus of Thalamus Deep Brain Stimulation: A Clinical-Based Analysis of the Ideal Target in Drug-Resistant Epilepsy
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Costa-Gertrudes, Ricardo, primary, Simão, Diogo, additional, Franco, Ana, additional, Morgado, Carlos, additional, Peralta, Ana Rita, additional, Pimentel, José, additional, Gonçalves-Ferreira, António, additional, Bentes, Carla, additional, and Campos, Alexandre Rainha, additional
- Published
- 2021
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23. Seizures after Ischemic Stroke: A Matched Multicenter Study
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Ferreira‐Atuesta, Carolina, primary, Döhler, Nico, additional, Erdélyi‐Canavese, Barbara, additional, Felbecker, Ansgar, additional, Siebel, Philip, additional, Scherrer, Natalie, additional, Bicciato, Giulio, additional, Schweizer, Juliane, additional, Sinka, Lucia, additional, Imbach, Lukas L., additional, Katan, Mira, additional, Abraira, Laura, additional, Santamarina, Estevo, additional, Álvarez‐Sabín, José, additional, Winklehner, Michael, additional, von Oertzen, Tim J., additional, Wagner, Judith N., additional, Gigli, Gian Luigi, additional, Serafini, Anna, additional, Janes, Francesco, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Gregoraci, Giorgia, additional, Conrad, Julian, additional, Evers, Stefan, additional, Lochner, Piergiorgio, additional, Roell, Frauke, additional, Brigo, Francesco, additional, Bentes, Carla, additional, Peralta, Ana Rita, additional, Melo, Teresa Pinho e, additional, Keezer, Mark R., additional, Duncan, John S., additional, Sander, Josemir W., additional, Tettenborn, Barbara, additional, Koepp, Matthias J., additional, and Galovic, Marian, additional
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- 2021
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24. Anterior Nucleus of Thalamus Deep Brain Stimulation: A Clinical-Based Analysis of the Ideal Target in Drug-Resistant Epilepsy.
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Costa-Gertrudes, Ricardo, Simão, Diogo, Franco, Ana, Morgado, Carlos, Peralta, Ana Rita, Pimentel, José, Gonçalves-Ferreira, António, Bentes, Carla, and Campos, Alexandre Rainha
- Abstract
Introduction: Deep brain stimulation of the anterior nucleus of thalamus (ANT-DBS) is an approved procedure for drug-resistant epilepsy. However, the preferred location inside ANT is not well known. In this study, we investigated the relationship between stereotactical coordinates of stimulated contacts and clinical improvement, in order to define the ideal target for ANT-DBS. Methods: Individual contact's coordinates were obtained in the Montreal Neurological Institute (MNI) 152 space, with the utilization of advanced normalization tools and co-registration of pre- and postoperative MRI and CT images in open-source toolbox lead-DBS with the "Atlas of the Human Thalamus." Each contact's pair was either classified as a responder (≥50% seizure reduction and absence of intolerable adverse effects) or nonresponder, with a minimum follow-up of 11 continuous months of stimulation. Results: A total of 19 contacts' pairs were tested in 14 patients. The responder rate was 9 out of 14 patients (64.3%). In 4 patients, a change in contacts' pairs was needed to achieve this result. A highly encouraging location inside ANT (HELIA) was delimited in MNI space, corresponding to an area in the anterior and inferior portion of the anteroventral (AV) nucleus, medially to the endpoint of the mammillothalamic tract (ANT-mtt junction) (x [3.8; 5.85], y [−2.1; −6.35] and z [6.2; 10.1] in MNI space). Statistically significant difference was observed between responders and nonresponders, in terms of the number of coordinates inside this volume. Seven responders and two nonresponders had at least 5 of 6 coordinates (2 electrodes) inside HELIA (77.8% sensitivity and 80% specificity). In 3 patients, changing to contacts that were better placed inside HELIA changed the status from nonresponder to responder. Conclusions: A relationship between stimulated contacts' coordinates and responder status was observed in drug-resistant epilepsy. The possibility to target different locations inside HELIA may help surpass anatomical variations and eventually obtain increased clinical benefit. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
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Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, and Galovic M
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- Humans, Adult, Anticonvulsants adverse effects, Neoplasm Recurrence, Local drug therapy, Seizures drug therapy, Epilepsy drug therapy, Epilepsy surgery, Epilepsy, Generalized drug therapy, Epilepsies, Partial
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More than half of adults with epilepsy undergoing resective epilepsy surgery achieve long-term seizure freedom and might consider withdrawing antiseizure medications. We aimed to identify predictors of seizure recurrence after starting postoperative antiseizure medication withdrawal and develop and validate predictive models. We performed an international multicentre observational cohort study in nine tertiary epilepsy referral centres. We included 850 adults who started antiseizure medication withdrawal following resective epilepsy surgery and were free of seizures other than focal non-motor aware seizures before starting antiseizure medication withdrawal. We developed a model predicting recurrent seizures, other than focal non-motor aware seizures, using Cox proportional hazards regression in a derivation cohort (n = 231). Independent predictors of seizure recurrence, other than focal non-motor aware seizures, following the start of antiseizure medication withdrawal were focal non-motor aware seizures after surgery and before withdrawal [adjusted hazard ratio (aHR) 5.5, 95% confidence interval (CI) 2.7-11.1], history of focal to bilateral tonic-clonic seizures before surgery (aHR 1.6, 95% CI 0.9-2.8), time from surgery to the start of antiseizure medication withdrawal (aHR 0.9, 95% CI 0.8-0.9) and number of antiseizure medications at time of surgery (aHR 1.2, 95% CI 0.9-1.6). Model discrimination showed a concordance statistic of 0.67 (95% CI 0.63-0.71) in the external validation cohorts (n = 500). A secondary model predicting recurrence of any seizures (including focal non-motor aware seizures) was developed and validated in a subgroup that did not have focal non-motor aware seizures before withdrawal (n = 639), showing a concordance statistic of 0.68 (95% CI 0.64-0.72). Calibration plots indicated high agreement of predicted and observed outcomes for both models. We show that simple algorithms, available as graphical nomograms and online tools (predictepilepsy.github.io), can provide probabilities of seizure outcomes after starting postoperative antiseizure medication withdrawal. These multicentre-validated models may assist clinicians when discussing antiseizure medication withdrawal after surgery with their patients., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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26. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry.
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Peltola J, Colon AJ, Pimentel J, Coenen VA, Gil-Nagel A, Gonçalves Ferreira A, Lehtimäki K, Ryvlin P, Taylor RS, Ackermans L, Ardesch J, Bentes C, Bosak M, Burneo JG, Chamadoira C, Elger CE, Erőss L, Fabo D, Faulkner H, Gawlowicz J, Gharabaghi A, Iacoangeli M, Janszky J, Järvenpää S, Kaufmann E, Kho KH, Kumlien E, Laufs H, Lettieri C, Linhares P, Noachtar S, Parrent A, Pataraia E, Patel NK, Peralta AR, Rácz A, Campos AR, Rego R, Ricciuti RA, Rona S, Rouhl RPW, Schulze-Bonhage A, Schuurman R, Sprengers M, Sufianov A, Temel Y, Theys T, Van Paesschen W, Van Roost D, Vaz R, Vonck K, Wagner L, Zwemmer J, Abouihia A, Brionne TC, Gielen F, and Boon PAJM
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- Humans, Female, Child, Adolescent, Male, Quality of Life, Retrospective Studies, Prospective Studies, Thalamus, Seizures etiology, Registries, Deep Brain Stimulation adverse effects, Epilepsy etiology, Drug Resistant Epilepsy therapy, Anterior Thalamic Nuclei
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Background and Objectives: The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice., Methods: MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes., Results: Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years ( p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years ( p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported., Discussion: The MORE registry supports the effectiveness and safety of ANT DBS therapy in a real-world setting in the 2 years following implantation., Classification of Evidence: This study provides Class IV evidence that ANT DBS reduces the frequency of seizures in patients with drug-resistant focal epilepsy., Trial Registration Information: MORE ClinicalTrials.gov Identifier: NCT01521754, first posted on January 31, 2012., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
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- 2023
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