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3. Evolving Practice and Outcomes in Grade 2 Glioma: Real-World Data from a Multi-Institutional Registry.

Author

Gately, Lucy, Drummond, Katharine, Dowling, Anthony, Bennett, Iwan, Freilich, Ronnie, Phillips, Claire, Ahern, Elizabeth, Campbell, David, Dumas, Megan, Campbell, Robert, Harrup, Rosemary, Kim, Grace Y., Reeves, Simone, Collins, Ian M., and Gibbs, Peter

Subjects
RISK assessment, BIOPSY, GLIOMAS, RADIOTHERAPY, RESEARCH funding, TUMOR grading, REPORTING of diseases, CANCER patients, DESCRIPTIVE statistics, RETROSPECTIVE studies, CANCER chemotherapy, KAPLAN-Meier estimator, MEDICAL records, ACQUISITION of data, PROGRESSION-free survival, TIME, OVERALL survival
Abstract

Simple Summary: This study explored the current practices in the real world for grade 2 glioma, an uncommon primary brain cancer. Leveraging the prospective BRAIN registry, this study demonstrates that whilst sequential radiotherapy and chemotherapy improve progression-free survival in high-risk grade 2 glioma, the majority of patients are observed following surgery. In high-risk patients who are observed, 61% remain progression-free at 12 months, with 10% being progression-free at 5 years. This clinically meaningful progression-free survival suggests that validated biomarkers beyond the usual definition of high-risk are required to better inform patient management. Factors contributing to decision-making are underway. Background: Grade-2 gliomas (G2-glioma) are uncommon. In 2016, RTOG9802 established the addition of chemotherapy after radiation (CRT) as a new standard of care for patients with high-risk G2-glioma, defined as subtotal resection or age ≥40 yrs. Here, we report current practices using real-world data. Methods: Patients diagnosed with G2-glioma from 1 January 2016 to 31 December 2022 were identified in BRAIN, a prospective clinical registry collecting data on patients with brain tumours. High- and low-risk were defined as per RTOG9802. Two time periods, January 2016–December 2019 (TP1) and January 2020–December 2022 (TP2), were defined. Survival was estimated using the Kaplan–Meier method. Results: 224 patients were identified. Overall, 38 (17%) were low-risk, with 35 (91%) observed without further treatment. A total of 186 (83%) were high-risk, with 96 (52%) observed, 63 (34%) receiving CRT, and 19 (10%) receiving radiation. Over time, CRT use increased (TP1 vs. TP2: 22% vs. 36%, p = 0.004), and the rate of biopsy (TP1 vs. TP2: 35% vs. 20%, p = 0.02) and radiotherapy alone (TP1 vs. TP2: 14% vs. 4%, p = 0.01) decreased. Median progression-free survival (PFS) was significantly longer in high-risk patients who received CRT (NR) over observation (39 months) (HR 0.49, p = 0.007). In high-risk patients who were observed, 59 (61%) were progression-free at 12 months and 10 (10%) at 5 years. OS data remains immature. Conclusion: Congruent with RTOG9802, real-world BRAIN data shows CRT is associated with improved PFS compared to observation in high-risk G2-glioma. Whilst CRT use has increased over time, observation after surgery remains the most common strategy, with some high-risk patients achieving clinically meaningful PFS. Validated biomarkers are urgently required to better inform patient management. [ABSTRACT FROM AUTHOR]

Published
2024
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4. QLTI-04. LINKING DATA FROM A BRAIN CANCER CLINICAL REGISTRY (BRAIN) WITH THE STATE-BASED REGISTRY OF BIRTHS DEATHS MARRIAGES: IMPROVING THE QUALITY OF CLINICAL REGISTRY SURVIVAL DATA

Author

Smith, Samuel, primary, Drummond, Kate, additional, Dowling, Anthony, additional, Bennett, Iwan, additional, Freilich, Ronnie, additional, Phillips, Claire, additional, Ahern, Elizabeth, additional, Reeves, Simone, additional, Campbell, Robert, additional, Collins, Ian, additional, Johns, Julie, additional, Dumas, Megan, additional, Gibbs, Peter, additional, and Gately, Lucy, additional

Published
2023
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5. Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study

Author

Woodfield, Julie, primary, Hoeritzauer, Ingrid, additional, Jamjoom, Aimun A.B., additional, Jung, Josephine, additional, Lammy, Simon, additional, Pronin, Savva, additional, Hannan, Cathal J., additional, Watts, Anna, additional, Hughes, Laura, additional, Moon, Richard D.C., additional, Darwish, Stacey, additional, Roy, Holly, additional, Copley, Phillip C., additional, Poon, Michael T.C., additional, Thorpe, Paul, additional, Srikandarajah, Nisaharan, additional, Grahovac, Gordan, additional, Demetriades, Andreas K., additional, Eames, Niall, additional, Sell, Philip J., additional, Statham, Patrick F.X., additional, Abdelsadg, Mohamed, additional, Abulaila, Motaz MS, additional, Ahmed, Usman, additional, Ajmi, Qasim, additional, Al-Mahfoudh, Rafid, additional, Ali, Chadi, additional, Amarouche, Meriem, additional, Andalib, Amin, additional, Arora, Mohit, additional, Arora, Mukul, additional, Awan, Mariam, additional, Baig Mirza, Asfand, additional, Bateman, Antony, additional, Bennett, Iwan, additional, Bhatti, Imran, additional, Bodkin, Peter, additional, Bommireddy, Lalasa, additional, Bonanos, George, additional, Borg, Anouk, additional, Boukas, Alexandros, additional, Bourne, James, additional, Brennan, Rachael, additional, Brown, Jennifer, additional, Brown, Katie, additional, Burton, Oliver, additional, Busby, Christopher, additional, Chiverton, Neil, additional, Clark, Simon, additional, Copley, Phillip C, additional, Cudlip, Simon, additional, Cunningham, Yan, additional, Dardis, Ronan, additional, Davies, Benjamin, additional, Demetriades, Andreas K, additional, Deore, Saurabh, additional, Derham, Chris, additional, Dherijha, Muhammad, additional, Dobson, Gareth, additional, Duncan, James, additional, Durnford, Andrew, additional, Durst, Alexander ZE, additional, Dyson, Edward W, additional, Edlmann, Ellie, additional, Edwards-Bailey, Andrew, additional, Elserius, Anne, additional, Elson, Becca, additional, Fadelalla, Mohammed, additional, Fountain, Daniel M, additional, Gardner, Adrian, additional, Ghosh, Arnab, additional, Gill, James R, additional, Glasmacher, Stella A, additional, Gordon, Robin, additional, Grenfell, Rebecca, additional, Habeebullah, Awais, additional, Haliasos, Nikolaos, additional, Hammett, Tim, additional, Hannan, Cathal John, additional, Hill, Ciaran Scott, additional, Holmes, David, additional, Hossain-Ibrahim, Kismet, additional, Hussain, Muhammad, additional, Hussain, Shakir, additional, Ibrahim, Ramez, additional, Jamjoom, Aimun AB, additional, John, Bethan, additional, Joshi, Shabin, additional, Kennion, Oliver, additional, Khan, Muhammad, additional, Klejnotowska, Adriana, additional, Kumaria, Ashwin, additional, LaCava, Roberta, additional, Lawrence, Alistair, additional, Lea, Matthew, additional, Leung, Andraay HC, additional, Liew, Ignatius, additional, Luo, Weisang, additional, MacCormac, Oscar, additional, Manfield, James, additional, Mannion, Richard, additional, Merola, Joseph, additional, Mishra, Pranav, additional, Mohmoud, Khalid Abubaker, additional, Moon, Richard, additional, Morrison, Rory, additional, Murray, Odhran, additional, Nader-Sepahi, Ali, additional, Nnandi, Colin, additional, Pandit, Anand, additional, Patel, Nitin, additional, Philip, Anita, additional, Poon, Michael TC, additional, Prasad, Kuskoor Seethram Manjunath, additional, Pujara, Shyam, additional, Purushothaman, Balaji, additional, Rajwani, Kapil, additional, Rasul, Fahid Tariq, additional, Sadek, Ahmed-Ramadan, additional, Schramm, Moritz, additional, Scicluna, Gabrielle, additional, Sell, Philip J, additional, Shafafy, Roozbeh, additional, Sharma, Himanshu, additional, Sheikh, Asim, additional, Sivasubramaniam, Vinothan, additional, Sofela, Agbolahan, additional, Spink, George, additional, Statham, Patrick FX, additional, Stokes, Stuart, additional, Strachan, Euan, additional, Thakar, Chrishan, additional, Thanabalasundaram, Gopiga, additional, Ulbricht, Christian, additional, Whitcher, Alison, additional, White, David, additional, Whitehouse, Kathrin, additional, Wilby, Martin, additional, Woodfield, Julie, additional, and Zolnourian, Ardalan, additional

Published
2023
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6. 2305 Glioblastoma – inhibition of P2X7R as a potential therapeutic target for treatment of this aggressive cancer

Author

Monif, Mastura, primary, Kan, Liyen Katrina, additional, Drill, Matthew, additional, Galea, Emily, additional, Todaro, Marian, additional, Ali, Rashida, additional, Bennett, Iwan, additional, Powell, Kim, additional, Williams, David, additional, Hamilton, John, additional, Zhu, Hongjian, additional, McLean, Catriona, additional, Jones, Nigel C, additional, Hunn, Martin, additional, Drummond, Kate J, additional, and O’Brien, Terence J, additional

Published
2022
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7. Additional file 1 of Beyond standard data collection – the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry)

Author

Gately, Lucy, Drummond, Katharine, Rosenthal, Mark, Harrup, Rosemary, Dowling, Anthony, Gogos, Andrew, Lwin, Zarnie, Collins, Ian, Campbell, David, Ahern, Elizabeth, Phillips, Claire, Gan, Hui K., Bennett, Iwan, Sieber, Oliver M., and Gibbs, Peter

Abstract

Additional file 1: Supplementary Table 1. Data points collected in BRAIN. Supplementary Figure 1. Schematic overview of BRAIN with surrounding tumour types representing predetermined modules.

Published
2022
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