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2. Islet Isolation Outcomes in Patients Undergoing Total Pancreatectomy With Islet Autotransplantation in the POST Consortium

Author

Mattke, Jordan, Eaton, Anne, Wijkstrom, Martin, Witkowski, Piotr, Trikudanathan, Guru, Singh, Vikesh K., Schwarzenberg, Sarah J., Ramanathan, Karthik, Pruett, Timothy L., Posselt, Andrew, Nathan, Jaimie D., Morgan, Katherine, Mokshagundam, Sri Prakash, Lara, Luis, Gardner, Timothy B., Freeman, Martin, Downs, Elissa, Chinnakotla, Srinath, Beilman, Gregory J., Ahmad, Syed, Adams, David, Abu-El-Haija, Maisam, Naziruddin, Bashoo, and Bellin, Melena D.

Published
2025
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3. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.

Author

Mastracci, Teresa L, Apte, Minoti, Amundadottir, Laufey T, Alvarsson, Alexandra, Artandi, Steven, Bellin, Melena D, Bernal-Mizrachi, Ernesto, Caicedo, Alejandro, Campbell-Thompson, Martha, Cruz-Monserrate, Zobeida, El Ouaamari, Abdelfattah, Gaulton, Kyle J, Geisz, Andrea, Goodarzi, Mark O, Hara, Manami, Hull-Meichle, Rebecca L, Kleger, Alexander, Klein, Alison P, Kopp, Janel L, Kulkarni, Rohit N, Muzumdar, Mandar D, Naren, Anjaparavanda P, Oakes, Scott A, Olesen, Søren S, Phelps, Edward A, Powers, Alvin C, Stabler, Cherie L, Tirkes, Temel, Whitcomb, David C, Yadav, Dhiraj, Yong, Jing, Zaghloul, Norann A, Pandol, Stephen J, and Sander, Maike

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Diabetes, Cancer, Rare Diseases, Pancreatic Cancer, Metabolic and endocrine, Good Health and Well Being, Humans, Diabetes Mellitus, Islets of Langerhans, Pancreas, Pancreas, Exocrine, Pancreatic Diseases, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences
Abstract

The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine-endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.

Published
2023

5. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases

Author

Mastracci, Teresa L, Apte, Minoti, Amundadottir, Laufey T, Alvarsson, Alexandra, Artandi, Steven, Bellin, Melena D, Bernal-Mizrachi, Ernesto, Caicedo, Alejandro, Campbell-Thompson, Martha, Cruz-Monserrate, Zobeida, Ouaamari, Abdelfattah El, Gaulton, Kyle J, Geisz, Andrea, Goodarzi, Mark O, Hara, Manami, Hull-Meichle, Rebecca L, Kleger, Alexander, Klein, Alison P, Kopp, Janel L, Kulkarni, Rohit N, Muzumdar, Mandar D, Naren, Anjaparavanda P, Oakes, Scott A, Olesen, Søren S, Phelps, Edward A, Powers, Alvin C, Stabler, Cherie L, Tirkes, Temel, Whitcomb, David C, Yadav, Dhiraj, Yong, Jing, Zaghloul, Norann A, Sander, Maike, and Pandol, Stephen J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Pancreatic Cancer, Cancer, Rare Diseases, Diabetes, Metabolic and endocrine, Good Health and Well Being, Humans, Diabetes Mellitus, Islets of Langerhans, Pancreas, Pancreas, Exocrine, Pancreatic Diseases, exocrine pancreas, endocrine pancreas, exocrine-endocrine crosstalk, integrated physiology, interpancreatic communication, AP, acute pancreatitis, AP-D, acute pancreatitis-related diabetes, CCK, cholecystokinin, cCRE, cis-regulatory element, CF, cystic fibrosis, CFRD, cystic fibrosis-related diabetes, CFTR, cystic fibrosis transmembrane conductance regulator, CP, chronic pancreatitis, CP-D, chronic pancreatitis-related diabetes, ECM, extracellular matrix, eIF5A, eukaryotic initiation factor 5A, EPI, exocrine pancreatic insufficiency, GWAS, genome-wide association study, MRI, magnetic resonance imaging, MRCP, magnetic resonance cholangiopancreatography, NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, National Institutes of Health, PSC, pancreatic stellate cells, PDAC, pancreatic ductal adenocarcinoma, PDLO, pancreatic-duct-like organoid, PRSS1, trypsinogen, T1D, type 1 diabetes, T2D, type 2 diabetes, Gastroenterology & Hepatology, Clinical sciences
Abstract

AbstractThe "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases" Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report summarizes the workshop proceedings. The goal of the workshop was to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into 6 major themes, including (a) Pancreas Anatomy and Physiology; (b) Diabetes in the Setting of Exocrine Disease; (c) Metabolic Influences on the Exocrine Pancreas; (d) Genetic Drivers of Pancreatic Diseases; (e) Tools for Integrated Pancreatic Analysis; and (f) Implications of Exocrine-Endocrine Crosstalk. For each theme, there were multiple presentations followed by panel discussions on specific topics relevant to each area of research; these are summarized herein. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of the normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.

Published
2022

6. Single-cell sequencing unveils distinct immune microenvironments with CCR6-CCL20 crosstalk in human chronic pancreatitis

Author

Lee, Bomi, Namkoong, Hong, Yang, Yan, Huang, Huang, Heller, David, Szot, Gregory L, Davis, Mark M, Husain, Sohail Z, Pandol, Stephen J, Bellin, Melena D, and Habtezion, Aida

Subjects
Biomedical and Clinical Sciences, Immunology, Cancer, Rare Diseases, Clinical Research, Digestive Diseases, Pancreatic Cancer, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Oral and gastrointestinal, Adaptive Immunity, CD8-Positive T-Lymphocytes, Chemokine CCL20, Flow Cytometry, Humans, Pancreatitis, Chronic, Receptors, CCR6, pancreatitis, immunology, T-cell receptor, chronic pancreatitis, RNA expression, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

ObjectiveChronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little is known about local immune responses or pathogenesis in human CP. We sought to characterise pancreatic immune responses using tissues derived from patients with different aetiologies of CP and non-CP organ donors in order to identify key signalling molecules associated with human CP.DesignWe performed single-cell level cellular indexing of transcriptomes and epitopes by sequencing and T-cell receptor (TCR) sequencing of pancreatic immune cells isolated from organ donors, hereditary and idiopathic patients with CP who underwent total pancreatectomy. We validated gene expression data by performing flow cytometry and functional assays in a second patient with CP cohort.ResultsDeep single-cell sequencing revealed distinct immune characteristics and significantly enriched CCR6+ CD4+ T cells in hereditary compared with idiopathic CP. In hereditary CP, a reduction in T-cell clonality was observed due to the increased CD4+ T (Th) cells that replaced tissue-resident CD8+ T cells. Shared TCR clonotype analysis among T-cell lineages also unveiled unique interactions between CCR6+ Th and Th1 subsets, and TCR clustering analysis showed unique common antigen binding motifs in hereditary CP. In addition, we observed a significant upregulation of the CCR6 ligand (CCL20) expression among monocytes in hereditary CP as compared with those in idiopathic CP. The functional significance of CCR6 expression in CD4+ T cells was confirmed by flow cytometry and chemotaxis assay.ConclusionSingle-cell sequencing with pancreatic immune cells in human CP highlights pancreas-specific immune crosstalk through the CCR6-CCL20 axis, a signalling pathway that might be leveraged as a potential future target in human hereditary CP.

Published
2022

9. Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study

Author

Hart, Phil A, Papachristou, Georgios I, Park, Walter G, Dyer, Anne-Marie, Chinchilli, Vernon M, Afghani, Elham, Akshintala, Venkata S, Andersen, Dana K, Buxbaum, James L, Conwell, Darwin L, Dungan, Kathleen M, Easler, Jeffrey J, Fogel, Evan L, Greenbaum, Carla J, Kalyani, Rita R, Korc, Murray, Kozarek, Richard, Laughlin, Maren R, Lee, Peter J, Maranki, Jennifer L, Pandol, Stephen J, Phillips, Anna Evans, Serrano, Jose, Singh, Vikesh K, Speake, Cate, Tirkes, Temel, Toledo, Frederico GS, Trikudanathan, Vege, Santhi Swaroop, Wang, Ming, Yazici, Cemal, Zaheer, Atif, Forsmark, Christopher E, Bellin, Melena D, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Diabetes, Acute Disease, Diabetes Mellitus, Type 1, Humans, Incidence, Pancreatitis, Prospective Studies, pancreatogenic diabetes, type 3c diabetes, beta cell, insulin, autoantibody, epidemiology, AP, acute pancreatitis, CP, chronic pancreatitis, DCC, data coordinating center, DM, diabetes mellitus, DREAM, Diabetes RElated to Acute pancreatitis and its Mechanisms, FSIGTT, frequently sampled intravenous glucose tolerance testing, OGTT, oral glucose tolerance testing, MMTT, mixed meal tolerance testing, T1DAPC, Type 1 Diabetes in Acute Pancreatitis Consortium, Gastroenterology & Hepatology, Clinical sciences
Abstract

AbstractAcute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study.

Published
2022

10. Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium

Author

Downs, Elissa M., Eaton, Anne, Witkowski, Piotr, Wijkstrom, Martin, Walsh, Matthew, Trikudanathan, Guru, Singh, Vikesh K., Schwarzenberg, Sarah J., Pruett, Timothy L., Posselt, Andrew, Naziruddin, Bashoo, Nathan, Jaimie D., Mokshagundam, Sri Prakash, Morgan, Katherine, Lara, Luis F., Gardner, Timothy B., Freeman, Martin L., Ellery, Kate, Chinnakotla, Srinath, Beilman, Gregory J., Adams, David, Ahmad, Syed, Abu-El-Haija, Maisam, and Bellin, Melena D.

Published
2023
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11. Health-Related Quality of Life in Pediatric Acute Recurrent or Chronic Pancreatitis: Association With Biopsychosocial Risk Factors

Author

Tham, See Wan, Wang, Fuchenchu, Gariepy, Cheryl E, Cress, Gretchen A, Abu-El-Haija, Maisam A, Bellin, Melena D, Ellery, Kate M, Fishman, Douglas S, Gonska, Tanja, Heyman, Melvin B, Lin, Tom K, Maqbool, Asim, McFerron, Brian A, Morinville, Veronique D, Nathan, Jaimie D, Ooi, Chee Y, Perito, Emily R, Schwarzenberg, Sarah Jane, Sellers, Zachary M, Shah, Uzma, Troendle, David M, Wilschanski, Michael, Zheng, Yuhua, Yuan, Ying, Lowe, Mark E, Uc, Aliye, and Palermo, Tonya M

Subjects
Prevention, Chronic Pain, Mind and Body, Behavioral and Social Science, Pain Research, Pediatric, Digestive Diseases, Clinical Research, Oral and gastrointestinal, Abdominal Pain, Child, Female, Humans, Male, Pancreatitis, Chronic, Quality of Life, Recurrence, Risk Factors, children, emotional functioning, pain, pancreatitis, quality of life, INternational Study Group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE) and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer, Medical and Health Sciences, Gastroenterology & Hepatology
Abstract

ObjectivesAbdominal pain, emergency department visits, and hospitalizations impact lives of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Data on health-related quality of life (HRQOL) in this population, however, remains limited. We aimed to evaluate HRQOL in children with ARP or CP; and test biopsychosocial risk factors associated with low HRQOL.MethodsData were acquired from the INternational Study Group of Pediatric Pancreatitis: In search for a cuRE registry. Baseline demographic and clinical questionnaires, the Child Health Questionnaire (measures HRQOL) and Child Behavior Checklist (measures emotional and behavioral functioning) were completed at enrollment.ResultsThe sample included 368 children (54.3% girls, mean age = 12.7years, standard deviation [SD] = 3.3); 65.2% had ARP and 34.8% with CP. Low physical HRQOL (M = 38.5, SD = 16.0) was demonstrated while psychosocial HRQOL (M = 49.5, SD = 10.2) was in the normative range. Multivariate regression analysis revealed that clinical levels of emotional and behavioral problems (B = -10.28, P

Published
2022

13. Circulating immune signatures in chronic pancreatitis with and without preceding acute pancreatitis: A pilot study

Author

Hagn-Meincke, Rasmus, Yadav, Dhiraj, Andersen, Dana K., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Bellin, Melena D., Topazian, Mark D., Conwell, Darwin L., Li, Liang, Van Den Eeden, Stephen K., Drewes, Asbjørn M., Pandol, Stephen J., Forsmark, Chris E., Fisher, William E., Hart, Phil A., Olesen, Søren S., and Park, Walter G.

Published
2024
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19. Distinct Serum Immune Profiles Define the Spectrum of Acute and Chronic Pancreatitis From the Multicenter Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) Study

Author

Li, Liang, Yadav, Dhiraj, Conwell, Darwin L., Hart, Phil A., Vege, Santhi Swaroop, Fogel, Evan L., Serrano, Jose, Andersen, Dana, Bellin, Melena D., Topazian, Mark, Van Den Eeden, Stephen K., Pandol, Stephen J., Forsmark, Chris, Fisher, William E., Park, Walter G., Lee, Bomi, Jones, Elaina K., Manohar, Murli, Topazian, Mark D., Forsmark, Chris E., Husain, Sohail Z., and Habtezion, Aida

Published
2023
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21. The University of Minnesota's Clinical Research Support Center Feasibility Review: An Objective Protocol Assessment Carving a Pathway to Study Success

Author

Tosun, Nicole, Lee, Ryan, Crevel, Francoise, McKenzie, Carrie, Odlaug, Brian, Bellin, Melena D., Prich, Brenda, and Weisdorf, Daniel

Subjects
Medical research -- Usage, Medicine, Experimental -- Usage, Clinical trials -- Usage, Business, general, Business
Abstract

To initiate clinical research studies successfully and efficiently, it is critical to develop a strong, feasible, and well-written study protocol early in the start-up phase. The University of Minnesota's Clinical Research Support Center designed and implemented a structured Feasibility Review process in 2018 that addresses common start-up challenges such as poor study design, inappropriate outcomes, and limited resources. This process has been shown to turn an unfeasible study into a well-designed protocol that is IRB-approved with few protocol-related stipulations and well prepared for execution. It has also educated study teams on how to write better-quality and more robust protocols for subsequent studies. Once a draft protocol is available, the entire process takes just six working days and is free of charge to investigators, study teams, and departments. From 2018-2021, one hundred sixteen Feasibility Reviews (n=116) have been completed across eight schools or colleges. Mean satisfaction scores for study team members who responded werehigh (N=126,M=4.71 + 0.5) on a 5-point Likert-type scale. Most respondents (96%) indicated that they planned to modify theirprotocol based on reviewerfeedback. Open ended/qualitative feedback was highly positive with most responses centered around the helpfulness offeasibility review, the high level of expertise, and fast turnaround time. The Feasibility Review is a valuable and multifunctional program providing timely expert guidance to study teams to efficiently and successfully launch and execute clinical research studies. It can be easily replicated, adapted, and implemented at other institutions to increase the quality and efficacy of academic research. Keywords: feasibility review, protocol development, study start-up, clinical and translational science, Introduction Anyone who has conducted a clinical research study at an academic institution knows how complex and challenging the process can be. Barriers to successful execution often begin during start-up [...]

Published
2022

22. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Author

Bellin, Melena D., Beilman, Greg, Brand, Randall E., Shelton Ohlsen, Celeste, Saloman, Jami L., Whitcomb, David C., Park, H.J., Lee, Kenneth K., Paniccia, Alessandro, Zureikat, Amer, Alkaade, Samer, Amann, Stephen, Anderson, Michelle A., Banks, Peter, Conwell, Darwin L., Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini M., Lewis, Michele D., Muniraj, Thiruvengadam, Papachristou, Georgios I., Romagnuolo, Joseph, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Melbern Wilcox, Charles, Yadav, Dhiraj, Fu, Dongni, Blobner, Brandon M., Greer, Phil J., and Lafyatis, Robert

Published
2023
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26. α- or β-Adrenergic blockade does not affect transplanted islet cell responses to hypoglycemia in type 1 diabetes.

Author

Rickels, Michael R., Bellin, Melena D., Stefanovski, Darko, Peleckis, Amy J., Dalton-Bakes, Cornelia, Markmann, Eileen, Nguyen, Huong-Lan, Townsend, Raymond R., Hering, Bernhard J., and Naji, Ali

Subjects
*TYPE 1 diabetes, *FREE fatty acids, *ADRENERGIC receptors, *HYPOGLYCEMIA, *ISLANDS of Langerhans, *INSULIN, *TACROLIMUS
Abstract

Type 1 diabetes recipients of intrahepatic islet transplantation exhibit glucose-dependent suppression of insulin and activation of glucagon secretion in response to insulin-induced hypoglycemia associated with clinical protection from hypoglycemia. Whether sympathetic activation of adrenergic receptors on transplanted islets is required for these responses in defense against hypoglycemia is not known. To evaluate the adrenergic contribution to posttransplant glucose counterregulation, we performed a randomized, double-blind crossover study of responses during a hyperinsulinemic euglycemic-hypoglycemic clamp under phentolamine (α-adrenergic blockage), propranolol (β-adrenergic blockage), or placebo infusion. Characteristics of participants (5 females/4 males) were as follows: median (range) age 53 (34–63) yr, diabetes duration 29 (18–56) yr, posttransplant 7.0 (1.9–8.4) yr, HbA1c 5.8 (4.5–6.8)%, insulin in-/dependent 5/4, all on tacrolimus-based immunosuppression. During the clamp, blood pressure was lower with phentolamine and heart rate was lower with propranolol versus placebo (P < 0.05). There was no difference in the suppression of endogenous insulin secretion (derived from C-peptide measurements) during the euglycemic or hypoglycemic phases, and although levels of glucagon were similar with phentolamine or propranolol vs. placebo, the increase in glucagon from eu- to hypoglycemia was greater with propranolol vs. placebo (P < 0.05). Pancreatic polypeptide was greater with phentolamine versus placebo during the euglycemic phase (P < 0.05), and free fatty acids were lower and the glucose infusion rate was higher with propranolol versus placebo during the hypoglycemic phase (P < 0.05 for both). These results indicate that neither physiological α- nor β-adrenergic blockade attenuates transplanted islet responses to hypoglycemia, suggesting sympathetic reinnervation of the islet graft is not necessary for posttransplant glucose counterregulation. NEW & NOTEWORTHY: Whether adrenergic input to islets is necessary for glucose homeostasis in humans is debated. Here, the adrenergic contribution to intrahepatically transplanted islet cell responses to hypoglycemia in individuals with type 1 diabetes was investigated through α- or β-adrenergic receptor blockade during hyperinsulinemic euglycemic-hypoglycemic clamps. Neither α- nor β-adrenergic blockage affected the suppression of endogenous insulin or activation of glucagon secretion, suggesting that sympathetic reinnervation of islet grafts is not required for posttransplant defense against hypoglycemia. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality

Author

Serrano, Jose, Laughlin, Maren R., Bellin, Melena D., Yadav, Dhiraj, Chinchilli, Vernon M., Andersen, Dana K., Greenbaum, Carla, Kozarek, Richard, Speake, Cate, Lord, Sandra, Irani, Shayan, Linsley, Peter, Kwok, William, Lacy-Hulbert, Adam, Hamerman, Jessica, Bahnson, Henry, Grubb, Brooke, Williams, Cassandra, Ackermann, Sarah, Varner, Kimberly, Goodarzi, Mark O., Pandol, Stephen J., Buxbaum, James, Diniz, Marcio, Goodman, Marc, Hines, O. Joe, Jeon, Christie, Korc, Murray, Li, Debiao, Petrov, Maxim, Pisegna, Joseph, Van Eyk, Jennifer, Vege, Santhi Swaroop, Fogel, Evan, Evans-Molina, Carmella, Tirkes, Temel, Sherman, Stuart, Easler, Jeffrey, Saeed, Zed, Sims, Emily, Oram, Richard, Weedon, Michael, Singh, Vikesh, Sun, Zhaoli, Afghani, Elham, Kalyani, Rita, Jacobs, Michael, Zaheer, Atif, Zhu, Heng, Akshintala, Venkata S., Papachristou, Georgios I., Hart, Phil A., Conwell, Darwin L., Bradley, David, Dungan, Kathleen, Shah, Zarine, Krebs, Zoe, Hazelett, Samantha, Forsmark, Christopher E., Casu, Anna, Hughes, Steven, Pratley, Richard E., Thompson, Martha Campbell, Wasserfall, Clive, Grajo, Joseph, Yazici, Cemal, Layden, Brian, Danielson, Kirstie, Boulay, Brian, Villa, Edward, Mutlu, Ece, Xia, Yinglin, Green, Stefan, Tussing-Humphreys, Lisa, Prabhakar, Bellur, Gaba, Ron, Ratia, Kiira, Daviglus, Martha, Spaggiari, Mario, Grippo, Paul J., Setiawan, Veronica, Keswani, Rajesh, Komanduri, Srinadh, Aadam, Aziz, Bellin, Melena, Trikudanathan, Guru, Fife, Brian, Freeman, Martin, Harindhanavudhi, Tasma, Moran, Antoinette, Spilseth, Benjamin, Hodges, James, Yadav, Dhiraj, Toledo, Frederico G. S., Dasyam, Anil, Phillips, Anna E., Kang, Chae-Ryon, Yechoor, Vijay, Saloman, Jami, Becker, Dorothy, Reynolds, Shari, Hall, Kristin, Stello, Kim, Mays, Melanie, Saul, Melissa, Park, Walter G., Basina, Marina, Habtezion, Aida, Poullos, Peter, Meyer, Everett, Chinchilli, Vernon M., Kong, Lan, Liu, Dajiang, Maranki, Jennifer, McCormick, Jennifer, Pichardo-Lowden, Ariana, Siddiqui, Ayesha, Raja-Khan, Nazia, Wang, Ming, Zhan, Xiang, Bottino, Rita, Faulkner, Georgia, Baab, Kendall Thomas, Dyer, Anne-Marie, Guzman, Jennifer, Holmes, Beth, Baron, Rose, Merchlinski, Aimee, Valencia-Moulton, Paula, Broach, James, and Bradley, David

Published
2022
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32. Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Dungan, Kathleen M., Hart, Phil A., Andersen, Dana K., Basina, Marina, Chinchilli, Vernon M., Danielson, Kirstie K., Evans-Molina, Carmella, Goodarzi, Mark O., Greenbaum, Carla J., Kalyani, Rita R., Laughlin, Maren R., Pichardo-Lowden, Ariana, Pratley, Richard E., Serrano, Jose, Sims, Emily K., Speake, Cate, Yadav, Dhiraj, Bellin, Melena D., and Toledo, Frederico G. S.

Published
2022
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33. Recruitment and Retention Strategies for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Yazici, Cemal, Dyer, Anne-Marie, Conwell, Darwin L., Afghani, Elham, Andersen, Dana K., Basina, Marina, Bellin, Melena D., Boone, Leslie R., Casu, Anna, Easler, Jeffrey J., Greenbaum, Carla J., Hart, Phil A., Jeon, Christie Y., Lee, Peter J., Meier, Shelby, Papachristou, Georgios I., Raja-Khan, Nazia T., Saeed, Zeb I., Serrano, Jose, Yadav, Dhiraj, and Fogel, Evan L.

Published
2022
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34. Design and Rationale for the Use of Magnetic Resonance Imaging Biomarkers to Predict Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Tirkes, Temel, Chinchilli, Vernon M., Bagci, Ulas, Parker, Jason G., Zhao, Xuandong, Dasyam, Anil K., Feranec, Nicholas, Grajo, Joseph R., Shah, Zarine K., Poullos, Peter D., Spilseth, Benjamin, Zaheer, Atif, Xie, Karen L., Wachsman, Ashley M., Campbell-Thompson, Martha, Conwell, Darwin L., Fogel, Evan L., Forsmark, Christopher E., Hart, Phil A., Pandol, Stephen J., Park, Walter G., Pratley, Richard E., Yazici, Cemal, Laughlin, Maren R., Andersen, Dana K., Serrano, Jose, Bellin, Melena D., and Yadav, Dhiraj

Published
2022
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35. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Wasserfall, Clive, Dyer, Anne-Marie, Speake, Cate, Andersen, Dana K., Baab, Kendall Thomas, Bellin, Melena D., Broach, James R., Campbell-Thompson, Martha, Chinchilli, Vernon M., Lee, Peter J., Park, Walter G., Pratley, Richard E., Saloman, Jami L., Sims, Emily K., Tang, Gong, Yadav, Dhiraj, Yazici, Cemal, and Conwell, Darwin L.

Published
2022
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36. Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium

Author

Casu, Anna, Grippo, Paul J., Wasserfall, Clive, Sun, Zhaoli, Linsley, Peter S., Hamerman, Jessica A., Fife, Brian T., Lacy-Hulbert, Adam, Toledo, Frederico G.S., Hart, Phil A., Papachristou, Georgios I., Bellin, Melena D., Yadav, Dhiraj, Laughlin, Maren R., Goodarzi, Mark O., and Speake, Cate

Published
2022
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38. Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients

Author

Abdel-Karim, Tasneem R., primary, Hodges, James S., additional, Herold, Kevan C., additional, Pruett, Timothy L., additional, Ramanathan, Karthik V., additional, Hering, Bernhard J., additional, Dunn, Ty B., additional, Kirchner, Varvara A., additional, Beilman, Gregory J., additional, and Bellin, Melena D., additional

Published
2024
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40. Early Metabolic Measures Predict Long-term Insulin Independence in Recipients of Total Pancreatectomy and Islet Autotransplantation

Author

Nanno, Yoshihide, primary, Hodges, James S., additional, Freeman, Martin L., additional, Trikudanathan, Guru, additional, Schwarzenberg, Sarah J., additional, Downs, Elissa M., additional, Ramanathan, Karthik, additional, Pruett, Timothy L., additional, Beilman, Gregory J., additional, Chinnakotla, Srinath, additional, Hering, Bernhard J., additional, and Bellin, Melena D., additional

Published
2023
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42. TPIAT improves pain burden and quality of life at 1 year: Results from the Prospective Observational Study of TPIAT (POST) cohort

Author

Trikudanathan, Guru, primary, Eaton, Anne, additional, Abu-El-Haija, Maisam, additional, Adams, David, additional, Ahmad, Syed, additional, Beilman, Gregory J., additional, Chinnakotla, Srinath, additional, Downs, Elissa M., additional, Freeman, Martin L., additional, B. Gardner, Timothy, additional, Lara, Luis F., additional, Morgan, Katherine, additional, Mokshagundam, Sri Prakash, additional, Nathan, Jaimie D., additional, Naziruddin, Bashoo, additional, Posselt, Andrew, additional, Pruett, Timothy L., additional, Schwarzenberg, Sarah J., additional, Singh, Vikesh K., additional, Wijkstrom, Martin, additional, Witkowski, Piotr, additional, and Bellin, Melena D., additional

Published
2023
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43. Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes

Author

Keymeulen, Bart, primary, De Groot, Kaat, additional, Jacobs-Tulleneers-Thevissen, Daniel, additional, Thompson, David M., additional, Bellin, Melena D., additional, Kroon, Evert J., additional, Daniels, Mark, additional, Wang, Richard, additional, Jaiman, Manasi, additional, Kieffer, Timothy J., additional, Foyt, Howard L., additional, and Pipeleers, Daniel, additional

Published
2023
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45. Case Report: Insulin hypersensitivity in youth with type 1 diabetes

Author

Alkhatib, Einas H., primary, Grundman, Jody B., additional, Adamusiak, Anna M., additional, Bellin, Melena D., additional, Brooks, Joel P., additional, Buckley, Kevin S., additional, Janssen, Erin M., additional, Kitcharoensakkul, Maleewan, additional, McNerney, Kyle P., additional, Pfeifer, Thea L., additional, Polk, Brooke I., additional, and Marks, Brynn E., additional

Published
2023
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50. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448

Author

Mastracci, Teresa L., primary, Apte, Minoti, additional, Amundadottir, Laufey T., additional, Alvarsson, Alexandra, additional, Artandi, Steven, additional, Bellin, Melena D., additional, Bernal-Mizrachi, Ernesto, additional, Caicedo, Alejandro, additional, Campbell-Thompson, Martha, additional, Cruz-Monserrate, Zobeida, additional, Ouaamari, Abdelfattah El, additional, Gaulton, Kyle J., additional, Geisz, Andrea, additional, Goodarzi, Mark O., additional, Hara, Manami, additional, Hull-Meichle, Rebecca L., additional, Kleger, Alexander, additional, Klein, Alison P., additional, Kopp, Janel L., additional, Kulkarni, Rohit N., additional, Muzumdar, Mandar D., additional, Naren, Anjaparavanda P., additional, Oakes, Scott A., additional, Olesen, Søren S., additional, Phelps, Edward A., additional, Powers, Alvin C., additional, Stabler, Cherie L., additional, Tirkes, Temel, additional, Whitcomb, David C., additional, Yadav, Dhiraj, additional, Yong, Jing, additional, Zaghloul, Norann A., additional, Pandol, Stephen J., additional, and Sander, Maike, additional

Published
2023
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