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\(\bf Introduction:\) For over 30 years, ascites has been postulated to facilitate fibrinolysis in patients with liver cirrhosis. In contrast to previous research employing conventional coagulation tests, this study aimed to characterize hemostatic interactions between blood and ascites using the rotational thromboelastometry (ROTEM). \(\bf Methods:\) Blood samples – pure or mixed with ascites in a ratio of 1:1 – from cirrhotic patients (\(\it n\) = 10) were subjected to ROTEM analysis. In addition, a negative control group was built with cirrhotic patients (\(\it n\) = 10) whose blood was mixed with physiologic sodium chloride (0.9% NaCl) solution in a ratio of 1:1. Subsequently, ROTEM measurements were subjected to statistical analysis. \(\bf Results:\) During ascites challenge, clotting time (CT, measured in seconds) was significantly prolonged in EXTEM (blood: 70.40 \(\pm\) 20.40 vs. ascites/blood: 109.8 \(\pm\) 47.7) and APTEM (blood: 66.50 \(\pm\) 14.55 vs. ascites/blood: 138.7 \(\pm\) 105.8), likely reflecting a dilution effect. However, CT in INTEM remained unchanged, suggesting a sustained intrinsic pathway function. Maximal clot firmness (measured in millimeters) in FIBTEM decreased significantly (blood: 14.70 \(\pm\) 9.55 vs. ascites/blood: 6.00 \(\pm\) 5.66), thus indicating depletion of fibrinogen in ascites. Strikingly, maximum lysis (measured in %) significantly decreased in EXTEM (blood: 9.30 \(\pm\) 2.79 vs. ascites/blood: 5.50 \(\pm\) 2.84), APTEM (blood: 8.50 \(\pm\) 3.10 vs. ascites/blood: 5.60 \(\pm\) 2.88), and INTEM (blood: 7.50 \(\pm\) 2.27 vs. ascites/blood: 5.10 \(\pm\) 3.48). \(\bf Conclusions:\) ROTEM provided new evidence that ascites may not primarily induce fibrinolysis in cirrhotic patients. This finding seems to be of significant importance for the clinical management of cirrhotic patients experiencing complications, for example, abdominal hemorrhage after liver biopsy or paracentesis; here, replacement of prothrombin complex concentrates and/or fibrinogen concentrates may prove more beneficial than the use of fresh frozen plasma or antifibrinolytic drugs.