88 results on '"Baudin, F"'
Search Results
2. Marine records reveal multiple phases of Toba’s last volcanic activity
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Caron, B., Del Manzo, G., Villemant, B., Bartolini, A., Moreno, E., Le Friant, A., Bassinot, F., Baudin, F., and Alves, A.
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- 2023
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3. Impact of carbonization on oak wood δ18O: A preliminary study
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du Boisgueheneuc, D., Delarue, F., Daux, V., Nguyen Tu, T.T., Baudin, F., and Dufraisse, A.
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- 2023
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4. Diagenetic and detrital influences on clay mineralogy and carbon isotope geochemistry of Campanian–Maastrichtian sediments in the Tremp-Graus Basin (southern Pyrenees, Spain)
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Chenot, E., Deconinck, J. F., Baudin, F., Cocquerez, T., Pucéat, E., Razmjooei, M. J., and Thibault, N.
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- 2022
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5. Incidence of refeeding syndrome in critically ill children with nutritional support
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Blanc, S., primary, Vasileva, T., additional, Tume, L.N., additional, Baudin, F., additional, Chessel, C. Ford, additional, Chaparro, C. Jotterand, additional, and Valla, F.V., additional
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- 2023
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6. Crossbar Arrays based on “Wall” Phase-Change Memory (PCM) and Ovonic- Threshold Switching (OTS) Selector: a Device Integration Challenge Towards New Computing Paradigms in Embedded Applications
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Bourgeois, G., primary, Meli, V., additional, Antonelli, R., additional, Socquet-Clerc, C., additional, Magis, T., additional, Laulagnet, F., additional, Hemard, B., additional, Bernard, M., additional, Fellouh, L., additional, Dezest, P., additional, Krawczyk, J., additional, Dominguez, S., additional, Baudin, F., additional, Garrione, J., additional, Pellissier, C., additional, Dallery, J.-A., additional, Castellani, N., additional, Cyrille, M.-C., additional, Charpin, C., additional, Andrieu, F., additional, and Navarro, G., additional
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- 2023
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7. Molecular Characterization of Gloecapsomorpha Prisca Microfossils by Mass Spectrometry Down to the Cellular Scale
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Bon, M., primary, Lepot, K., additional, Carpentier, Y., additional, Bray, F., additional, Riboulleau, A., additional, Baudin, F., additional, Nuns, N., additional, Rolando, C., additional, Steemans, P., additional, and Vandenbroucke, T. R.A., additional
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- 2023
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8. Combined Nitrogen‐Isotope and Cyclostratigraphy Evidence for Temporal and Spatial Variability in Frasnian–Famennian Environmental Change
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Percival, L. M. E., primary, Marynowski, L., additional, Baudin, F., additional, Goderis, S., additional, De Vleeschouwer, D., additional, Rakociński, M., additional, Narkiewicz, K., additional, Corradini, C., additional, Da Silva, A.‐C., additional, and Claeys, P., additional
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- 2022
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9. Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA
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Baudin, F., primary, Murciano, B., additional, Fung, H.K.H., additional, Fromm, S.A., additional, and Mueller, C.W., additional
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- 2022
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10. Planned Peri-Extubation Fasting in Critically Ill Children: An International Survey of Practice
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Nabialek, T, Tume, LN, Cercueil, E, Morice, C, Bouvet, L, Baudin, F, and Valla, FV
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Pediatrics, Perinatology and Child Health - Abstract
IntroductionCumulative energy/protein deficit is associated with impaired outcomes in pediatric intensive care Units (PICU). Enteral nutrition is the preferred mode, but its delivery may be compromised by periods of feeding interruptions around procedures, with peri-extubation fasting the most common procedure. Currently, there is no evidence to guide the duration of the peri-extubation fasting in PICU. Therefore, we aimed to explore current PICU fasting practices around the time of extubation and the rationales supporting them.Materials and MethodsA cross sectional electronic survey was disseminated via the European Pediatric Intensive Care Society (ESPNIC) membership. Experienced senior nurses, dieticians or doctors were invited to complete the survey on behalf of their unit, and to describe their practice on PICU fasting prior to and after extubation.ResultsWe received responses from 122 PICUs internationally, mostly from Europe. The survey confirmed that fasting practices are often extrapolated from guidelines for fasting prior to elective anesthesia. However, there were striking differences in the duration of fasting times, with some units not fasting at all (in patients considered to be low risk), while others withheld feeding for all patients. Fasting following extubation also showed large variations in practice: 46 (38%) and 26 (21%) of PICUs withheld oral and gastric/jejunal nutrition more than 5 h, respectively, and 45 (37%) started oral feeding based on child demand. The risk of vomiting/aspiration and reducing nutritional deficit were the main reasons for fasting children [78 (64%)] or reducing fasting times [57 (47%)] respectively.DiscussionThis variability in practices suggests that shorter fasting times might be safe. Shortening the duration of unnecessary fasting, as well as accelerating the extubation process could potentially be achieved by using other methods of assessing gastric emptiness, such as gastric point of care ultrasonography (POCUS). Yet only half of the units were aware of this technique, and very few used it.
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- 2022
11. La Crosse virus polymerase at replication initiation stage
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Arragain, B., primary, Durieux Trouilleton, Q., additional, Baudin, F., additional, Cusack, S., additional, Schoehn, G., additional, and Malet, H., additional
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- 2022
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12. Syndrome de fluide dans l’interface secondaire à un traumatisme contusif chez un patient aux antécédents de chirurgie réfractive par femtoLASIK
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Ducray, V., primary, Baudin, F., additional, de Bosredon, Q., additional, Theillac, V., additional, Creuzot-Garcher, C., additional, and Arnould, L., additional
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- 2022
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13. Precipitation of greigite and pyrite induced by Thermococcales: an advantage to live in Fe‐ and S‐rich environments?
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Gorlas, A., primary, Mariotte, T., additional, Morey, L., additional, Truong, C., additional, Bernard, S., additional, Guigner, J.‐M., additional, Oberto, J., additional, Baudin, F., additional, Landrot, G., additional, Baya, C., additional, Le Pape, P., additional, Morin, G., additional, Forterre, P., additional, and Guyot, F., additional
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- 2022
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14. Diagenetic and detrital influences on clay mineralogy and carbon isotope geochemistry of Campanian–Maastrichtian sediments in the Tremp-Graus Basin (southern Pyrenees, Spain)
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Chenot, E., primary, Deconinck, J. F., additional, Baudin, F., additional, Cocquerez, T., additional, Pucéat, E., additional, Razmjooei, M. J., additional, and Thibault, N., additional
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- 2021
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15. A tribute to Jean Dercourt (1935–2019)—Editorial
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Baudin, François
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Geophysics. Cosmic physics ,QC801-809 ,Chemistry ,QD1-999 ,Geology ,QE1-996.5 - Published
- 2023
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16. Molecular fossils of Aptian–Albian blue marls of the Vocontian Basin (France), depositional conditions and connections to the Tethys Ocean
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Riboulleau, Armelle, Quijada, Melesio, Caillaud, Alexis, Baudin, François, Ferry, Jean-Noël, and Tribovillard, Nicolas
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Vocontian basin ,Organic matter ,Lower Cretaceous ,OAE1a ,OAE1b ,Biomarkers ,Geophysics. Cosmic physics ,QC801-809 ,Chemistry ,QD1-999 ,Geology ,QE1-996.5 - Abstract
The Mesozoic witnessed some episodes of marked accumulation and burial of organic matter (OM) in the Tethys Ocean and satellite basins, such as the Vocontian Basin (SE-France). These famous episodes, termed Oceanic Anoxic Events (OAEs), resulted from various factors, acting in complex synergies; the consensus about the key factors has not been reached yet. The Aptian–Albian Blue Marls Formation (Fm.) of the Vocontian Basin recorded the various substages of OAE1, plus additional organic-rich levels of regional extension. The semi-pelagic marlstones of the Blue Marls Fm. allow to carry out a detailed examination of the molecular fossils, to assess the respective weights of the factors involved in the OM storage process. In this work, we examined the lipid biomarkers of six organic-rich levels ranging from the Goguel Level to the Paquier Level in stratigraphic order. Biomarkers reputed to be characteristic of some OAEs are observed here: 2-methylhopanoids in the Goguel Level (OAE1a) and archaeal lipids in the Jacob, Kilian and Paquier Levels (OAE1b). This study shows that, in the Vocontian Basin, OM deposition resulted mostly from local factors and that each level has its own peculiarities; however, overarching connections with the Tethys Ocean were critical for the recording of global anoxic events.
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- 2023
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17. A sedimentological oxymoron: highly evolved glauconite of earliest diagenetic origin
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Tribovillard, Nicolas, Bout-Roumazeilles, Viviane, Guillot, François, Baudin, François, Deconinck, Jean-François, Abraham, Romain, and Ventalon, Sandra
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Glauconite ,Late Jurassic ,Tithonian ,Boulonnais ,Authigenic minerals ,Diagenesis ,Geophysics. Cosmic physics ,QC801-809 ,Chemistry ,QD1-999 ,Geology ,QE1-996.5 - Abstract
This work examines the possibility of a rapid formation of glauconite in a relatively shallow platform environment (below fair-weather wave baseline). The materials studied here are uppermost Jurassic alternations of carbonate beds and marly interbeds, namely, the Assises de Croï Formation of the Boulonnais area (northernmost France). The carbonate beds yield field evidences of an early diagenetic origin and both beds and interbeds contain glauconite, questioning the duration of formation of the glauconite, relative to that of the diagenetic carbonate beds. Carbon and oxygen stable isotope composition of the carbonate beds confirm an early diagenetic growth. Contrasted grain-size distribution patterns of glauconite and quartz grain populations (isolated after acid digestion and magnetic separation) evidenced that glauconite formed after sediment deposition. Glauconite formation allegedly requires protracted episodes of ion capture from the water column, which is no longer possible when glauconite gets trapped within authigenic carbonates. Therefore, in-situ glauconite formation preceded carbonate authigenesis. Yet, the chemical composition of grains (Fe and K) typifies glauconite as highly evolved, meaning that its formation must have lasted over times, according to conventional views. Consequently, our results challenge these conventional views and confirm that glauconite can form in relatively shallow environments (which has been already brought to light previously) and it is concluded that early diagenetic glauconite can be markedly enriched in both K and Fe, which is an unprecedented result.
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- 2023
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18. The Oxfordian–Kimmeridgian transition in the Boulonnais (France) and the onset of organic-rich marine deposits in NW Europe: a climatic control?
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Schnyder, Johann, Baudin, François, and Jan Du Chêne, Roger
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Organic rich band ,Jurassic ,Organic geochemistry ,Palynofacies ,Palaeogeography ,Palaeoclimate ,Palaeoproductivity ,Geophysics. Cosmic physics ,QC801-809 ,Chemistry ,QD1-999 ,Geology ,QE1-996.5 - Abstract
We characterised the organic matter content of marine deposits at the Oxfordian–Kimmeridgian transition in the Boulonnais (France). Organic rich deposits in platform environments are evidenced in the uppermost Cymodoce and lowermost Mutabilis Zone (early late Kimmeridgian), associated with enhanced planktonic palaeoproductivity and/or developing dysoxia/anoxia. Similar organic rich intervals in early late Kimmeridgian are also evidenced in platform deposits in Normandy and Charentes in France, and in basinal deposits from Yorkshire and Dorset in UK. This refined onset of the organic rich bands (ORB), as described in NW Europe during the late Jurassic, is coeval with seawater warming. We propose that this seawater warming was an important trigger of the onset of the late Jurassic ORB deposition system in NW Europe, which began at the Cymodoce–Mutabilis boundary during the early late Kimmeridgian and lasted until the middle part of the Tithonian, over a time span of 6.8 Myr.
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- 2023
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19. The contrasting origins of glauconite in the shallow marine environment highlight this mineral as a marker of paleoenvironmental conditions
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Tribovillard, Nicolas, Bout-Roumazeilles, Viviane, Abraham, Romain, Ventalon, Sandra, Delattre, Marion, and Baudin, François
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Jurassic ,Cretaceous ,Boulonnais ,Oyster reefs ,Redox-proxies ,Geophysics. Cosmic physics ,QC801-809 ,Chemistry ,QD1-999 ,Geology ,QE1-996.5 - Abstract
Glauconite is an authigenic mineral reputed to form during long-lasting contact between a nucleus (a pre-existing phyllosilicate) and seawater. This protracted contact makes it possible to subtract the ions necessary for the construction of the neoformed phyllosilicate, here, glauconite (a mineral very close to an illite, rich in K and Fe). As a result, glauconite is often associated with sediments deposited in a transgressive context with a strong slowdown in the rate of sedimentation and a relatively large water layer thickness. This is the case of the Cenomanian chalk of Boulonnais (north of France). Being chemically and physically resistant, glauconite is a mineral that is often reworked, like quartz grains. This is frequently the case of the Jurassic deposits of the Boulonnais, where glauconite, almost ubiquitous, either in traces or in significant proportions of the sediments, presents a grain size sorting attesting to its transport and reworking. However, these Jurassic deposits are shallow (shoreface, upper offshore), which supports the idea that the “glauconite factory” was itself in the shallow areas of the Boulonnais. The only identified Jurassic facies of the Boulonnais where glauconite is both relatively abundant, large in size and unsorted (non reworked) are oyster reefs that formed at the outlet of cold seeps linked to a late-Jurassic synsedimentary tectonic (Kimmeridgian, Tithonian). Our work makes it possible to hypothesize that isolated oyster reefs were environments combining the redox conditions and in contact with seawater favoring the authigenic formation of glauconite. The weakly reducing conditions necessary for the formation of glauconite here are attested by the contents of metallic trace elements sensitive to redox conditions (vanadium, germanium, arsenic, in this case). Our work thus adds a new element to the understanding of the mechanisms of formation of glauconite in shallow environments.
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- 2022
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20. Prise en charge de la bronchiolite aiguë grave chez le nourrisson de moins de 12 mois hospitalisé en soins critiques pédiatriques
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Mortamet, G., Baudin, F., Pouyau, R., Durand, P., Essouri, S., Emeriaud, G., Ferraro, G., and Milési, C.
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Le Groupe francophone de réanimation et d’urgences pédiatriques (GFRUP) publie des recommandations concernant la prise en charge des enfants de moins de 12 mois présentant une bronchiolite aiguë grave, sous-groupe de patients mal individualisé dans les recommandations nationales et internationales. Vingt-cinq experts francophones réanimateurs pédiatres issus du GFRUP ont collaboré de 2021 à 2022 au travers de réunions en téléconférence et présentielles. Ces recommandations recouvrent cinq champs : premièrement, critères d’admission en unité de soins critiques ; deuxièmement, conditionnement, examens paracliniques et modalités de surveillance ; troisièmement, modalités d’alimentation et d’hydratation ; quatrièmement, choix et mise en place du support ventilatoire, et cinquièmement, place des thérapeutiques adjuvantes. Les questions ont été élaborées sous le format PICO (patient intervention comparison outcome). Une recherche bibliographique extensive de la littérature anglophone et francophone indexée dans les bases de données MEDLINE via PubMed, Web of Science, Cochrane et Embase a été réalisée à partir de mots clés préétablis. Les articles ont été analysés et classés selon la méthodologie GRADE. Lorsque cette méthode ne s’appliquait pas, un avis d’expert était donné. Chacune de ces recommandations a fait l’objet d’un vote par l’ensemble des experts selon la méthodologie Delphi. Le groupe a formulé 40 recommandations. La méthodologie GRADE a pu s’appliquer à 17 d’entre elles (3 forts, 14 faibles) et un avis d’expert a été donné pour les 23 autres. Toutes ont reçues un accord fort lors du premier tour de vote.
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- 2023
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21. Combined Nitrogen‐Isotope and Cyclostratigraphy Evidence for Temporal and Spatial Variability in Frasnian–Famennian Environmental Change
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Katarzyna Narkiewicz, Francois Baudin, Michał Rakociński, Lawrence Percival, Philippe Claeys, CARLO CORRADINI, Anne-Christine Da Silva, Leszek Marynowski, Steven Goderis, David De Vleeschouwer, Percival, L. M. E., Marynowski, L., Baudin, F., Goderis, S., Vleeschouwer, D., Rakociński, M., Narkiewicz, K., Corradini, C., Silva, A. ‐C., Claeys, P., Analytical, Environmental & Geo-Chemistry, Chemistry, and Earth System Sciences
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Geochemistry ,Frasnian/Famennian boundary ,Cyclostratigraphy ,Nitrogen isotopes ,Geophysics ,Geochemistry and Petrology ,biomarkers ,Frasnian-Famennian extinction ,Phosphorus ,Upper Kellwasser Event ,Marine anoxia - Abstract
Widespread marine anoxia triggered by the runoff and recycling of nutrients was a key phenomenon associated with the Frasnian–Famennian (FF) mass extinction. However, the relative importance of global-scale processes versus local influences on site-specific environmental change remains poorly understood. Here, nitrogen-isotope (δ15N) trends are combined with organic-biomarker, phosphorus, and Rock-Eval data in FF sites from the USA (H-32 core, Iowa), Poland (Kowala Quarry), and Belgium (Sinsin). Up-to-date cyclostratigraphic age models for all three sites allow the nature and timing of changes to be precisely compared across the globe. Negative δ15N excursions across the FF interval from the H-32 core and Kowala correlate with geochemical evidence for euxinic, phosphorus-rich, water columns, and possible cyanobacterial activity, suggestive of increased diazotrophic N fixation, potentially coupled with ammonium assimilation at the latter site. By contrast, previously studied sites from Western Canada and South China document enhanced water-column denitrification around the onset of the Upper Kellwasser (UKW) Event, re-emphasizing the geographical heterogeneity in environmental perturbations at that time. Moreover, environmental degradation began >100 kyr earlier in Poland, coeval with a major increase in bioavailable phosphorus supply, than in Iowa, where no such influx is recorded. These regional differences in both the timing and nature of marine perturbations during the FF interval likely resulted from the variable influx of terrigenous nutrients to different marine basins at that time, highlighting the importance of local processes such as terrestrial runoff in driving environmental degradation during times of climate cooling such as the UKW Event.
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- 2022
22. Comment on: Comparison of volume-controlled ventilation, pressure-controlled ventilation and pressure-controlled ventilation-volume guaranteed in infants and young children in the prone position: A prospective randomized study.
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Baudin F, Salaün JP, and Kern D
- Abstract
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Florent BAUDIN reports a relationship with Dräger Medical GmbH that includes: non-financial support and travel reimbursement. Florent BAUDIN reports a relationship with Fisher & Paykel Healthcare Limited that includes: funding grants. Florent BAUDIN reports a relationship with Sedana Medical AB (publ) that includes: travel reimbursement. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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23. DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration.
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Mathis T, Baudin F, Mariet AS, Augustin S, Bricout M, Przegralek L, Roubeix C, Benzenine É, Blot G, Nous C, Kodjikian L, Mauget-Faÿsse M, Sahel JA, Plevin R, Zeitz C, Delarasse C, Guillonneau X, Creuzot-Garcher C, Quantin C, Hunot S, and Sennlaub F
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- Humans, Animals, Mice, Male, Female, Aged, Retrospective Studies, Vascular Endothelial Growth Factor A metabolism, Mice, Inbred C57BL, Dopamine Agonists therapeutic use, Receptors, Dopamine D2 metabolism, Choroidal Neovascularization drug therapy, Choroidal Neovascularization pathology, Choroidal Neovascularization metabolism, Parkinson Disease drug therapy, Levodopa adverse effects, Macular Degeneration drug therapy, Macular Degeneration pathology
- Abstract
Neovascular age-related macular degeneration (nAMD) remains a major cause of visual impairment and puts considerable burden on patients and health care systems. l-DOPA-treated Parkinson's disease (PD) patients have been shown to be partially protected from nAMD, but the mechanism remains unknown. Using murine models that combine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced (MPTP-induced) PD and laser-induced nAMD with standard PD treatment of l-DOPA/DOPA-decarboxylase inhibitor or specific dopamine receptor inhibitors, we here demonstrate that l-DOPA treatment-induced increase of dopamine-mediated dopamine receptor D2 (DRD2) signaling inhibits choroidal neovascularization independently of MPTP-associated nigrostriatal pathway lesion. Analyzing a retrospective cohort of more than 200,000 patients with nAMD receiving anti-VEGF treatment from the French nationwide insurance database, we show that DRD2 agonist-treated PD patients have a significantly delayed age of onset of nAMD and reduced need for anti-VEGF therapies, similar to the effects of the l-DOPA treatment. While providing a mechanistic explanation for an intriguing epidemiological observation, our findings suggest that systemic DRD2 agonists might constitute an adjuvant therapy to delay and reduce the need for anti-VEGF therapy in patients with nAMD.
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- 2024
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24. Management of diabetic macular oedema in France from 2012 to 2018: The nationwide LANDSCAPE study.
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Creuzot Garcher CP, Massin P, Srour M, Baudin F, Dot C, Nghiem-Buffet S, Girmens JF, Collin C, Ponthieux A, and Delcourt C
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- Humans, France epidemiology, Retrospective Studies, Male, Female, Middle Aged, Aged, Follow-Up Studies, Visual Acuity, Receptors, Vascular Endothelial Growth Factor therapeutic use, Receptors, Vascular Endothelial Growth Factor administration & dosage, Vascular Endothelial Growth Factor A antagonists & inhibitors, Disease Management, Recombinant Fusion Proteins therapeutic use, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Ranibizumab administration & dosage, Macular Edema diagnosis, Macular Edema epidemiology, Macular Edema drug therapy, Diabetic Retinopathy diagnosis, Diabetic Retinopathy epidemiology, Diabetic Retinopathy drug therapy, Diabetic Retinopathy therapy, Tomography, Optical Coherence methods, Intravitreal Injections, Angiogenesis Inhibitors therapeutic use, Angiogenesis Inhibitors administration & dosage, Glucocorticoids therapeutic use, Glucocorticoids administration & dosage
- Abstract
Objective: To describe the management of diabetic macular oedema (DME) patients from the entire French population between 2012 and 2018., Methods: In this retrospective longitudinal study, we identified adults treated for DME from the French population using the exhaustive French National Health Information database (SNDS), and an algorithm based on diagnosis and procedure codes, and reimbursed treatments., Results: Between 2012 and 2018, we identified 53 584 treated DME patients, who were followed for up to 7 years from DME treatment initiation. Optical coherence tomography (OCT) became the predominant imaging tool to diagnose DME. Only 14% of patients consulted a diabetologist or endocrinologist in the 3 months prior to initiating DME treatment, whereas 84% consulted a general practitioner. The percentage of patients consulting an ophthalmologist declined over time, from 97% of patients in Year 1 (median of 9 consultations), to 46% in Year 7 (median of 7 consultations). The median DME treatment duration with an anti-VEGF and/or dexamethasone implant treatment was 9 months; 54% of patients had a treatment duration less than 1 year. First-line treatment was more common with ranibizumab (55% of patients) than with aflibercept (30%), or dexamethasone implant (15%). About 25% of patients who initiated anti-VEGF treatment switched treatment at least once, while 30% of patients who initiated dexamethasone implant switched to anti-VEGF treatment at least once., Conclusions: French DME patients seem well-monitored by their ophthalmologist, but median DME treatment duration was just 9 months. These results emphasise the challenge to manage and treat patients with DME over the long term., (© 2023 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
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- 2024
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25. Weaning from noninvasive respiratory support in children in acute settings: Expert consensus statement using modified Delphi methodology.
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Mortamet G, Milési C, Baudin F, Yalindag N, Kneyber M, and Pons-Odena M
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- Child, Humans, Delphi Technique, Surveys and Questionnaires, Consensus, Ventilator Weaning, Noninvasive Ventilation
- Abstract
Objective: To reach a consensus on the definition and modalities of weaning from noninvasive ventilation in acute settings., Design: A modified Delphi survey using closed and open-ended questions., Setting: Three rounds of consensus determination were sent via electronic mail survey to 33 experts. The survey questionnaire had four sections: definition of weaning, definition of weaning failure, criteria to initiate weaning, and modalities of weaning. Questions where agreement had been reached on round 1 were no longer part of the survey in rounds 2 and 3., Subjects: Twenty-five international experts from 10 countries., Measurement and Main Results: Overall, this survey generated positive consensus from experts for 19/35 statements (9 with strong agreement and 10 with weak agreement) about weaning from noninvasive respiratory support. No negative consensus could be identified., Conclusion: The clinical practice statements issued address important aspects of definition of weaning, definition of weaning failure, criteria to initiate weaning, and modalities of weaning in acute settings., (© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
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- 2024
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26. Stress cardiomyopathy in the paediatric population: a case series.
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Annino N, Cantais A, Javouhey E, and Baudin F
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Background: Stress cardiomyopathy (Takotsubo syndrome) defined as Takotsubo syndrome is defined as a reversible acute myocardial syndrome with myocardial injury with regional wall motion abnormality and no coronary explanations in the context of stress. The pathophysiology remains partially unknown, and these cases are probably underestimated in paediatrics. We report six cases of Takotsubo probably secondary to neurological damage., Case Summary: Six patients (10, 13, 16, 10, and 9 years and 5 months) presented with haemodynamic lability with echocardiography data leading to suspicion of Takotsubo syndrome. These cases were secondary to neurological involvement (cerebral haemorrhage, intraventricular haemorrhage, brain damage due to bifrontal oedema, posterior fossa tumour, pneumococcal meningitis, high-grade glioma). All patients were rapidly started on amine. Reversibility of the acute myocardial syndrome was complete in all but one child, who rapidly progressed to encephalic death., Discussion: Neurological distress has been suggested as a potential cause of Takotsubo syndrome. The pathophysiology is possibly related to excessive stimulation of the sympathetic system. This syndrome should probably be considered in the setting of left heart failure with neurological distress so as not to delay the use of amines especially since in the paediatric population the probability of a coronary origin is low., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2024
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27. Polycyclic aromatic hydrocarbon dynamics in soils along proglacial chronosequences in the Alps.
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Marchal L, Gateuille D, Naffrechoux E, Deline P, Baudin F, Clément JC, and Poulenard J
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Polycyclic aromatic hydrocarbons (PAHs) were studied in the soils of three proglacial areas in France (Noir and Chardon Glaciers) and Italy (Miage Glacier). PAH contents, PAH stocks and PAH contents normalized to the total organic carbon contents (PAHs/TOC ratio) were investigated along proglacial soil chronosequences to infer their evolutions with soil age (from 3 to 4200 years), where the PAH contamination was only related to long-range atmospheric transport. Evolutions of PAH and TOC contents, PAHs/TOC ratio and PAH stock were fitted with exponential and logarithmic relations. For the three proglacial areas, PAH contents increased rapidly during the first 150 years of soil development, ranged from 4 to 152 ng·g
-1 , and showed a strong relationship with total organic carbon (TOC) contents (r = 0.83, p < 0.05). The joint increase of PAH and TOC contents suggested that PAH accumulation in soils were not only driven by PAH inputs but also by the capacity of soils to store these contaminants. PAH contents in the oldest soils (from 1200 BCE and 2200 BCE) were similar than for soils from 1850 CE. The period 1850-2019 CE corresponded to a decrease in the PAHs/TOC ratio suggesting both a faster accumulation of TOC than PAHs and a dilution effect of PAHs already present in soils. For the oldest soils, the PAHs/TOC ratio appeared similar to those for soils from 1850 CE, with values ranging from 0.48 to 2.06 ng·mg-1 , suggesting an equilibrium between both parameters for soils older than 170 years. Finally, PAH stocks ranged from 0.41 mg·m-2 to 6.80 mg·m-2 in the youngest and oldest soils, respectively. These results do not allow us to identify the same period of greatest emission as other studies (estimated ~1960), but they revealed changes in the capacity of soils to store these pollutants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2023
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28. The AMG model coupled with Rock-Eval® analysis accurately predicts cropland soil organic carbon dynamics in the Tuojiang River Basin, Southwest China.
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Wang Q, Barré P, Baudin F, Clivot H, Ferchaud F, Li Y, Gao X, and Le Noë J
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- Rivers, Reproducibility of Results, Crops, Agricultural, Carbon Sequestration, China, Agriculture methods, Soil, Carbon analysis
- Abstract
Accurate soil organic carbon models are key to understand the mechanisms governing carbon sequestration in soil and to help develop targeted management strategies to carbon budget. The accuracy and reliability of soil organic carbon (SOC) models remains strongly limited by incorrect initialization of the conceptual kinetic pools and lack of stringent model evaluation using time-series datasets. Notably, due to legacy effects of management and land use change, the traditional spin-up approach for initial allocation of SOC among kinetic pools can bring substantial uncertainties in predicting the evolution of SOC stocks. The AMG model can fulfill these conditions as it is a parsimonious yet accurate SOC model using widely-available input data. In this study, we first evaluated the performance of AMGv2 before and after optimizing the potential mineralization rate (k
0 ) of SOC stock following a leave-one-site-out cross-validation based on 24 long-term field experiments (LTEs) in the Southwest of China. Then, we used Rock-Eval® thermal analysis results as input variables in the PARTYSOC machine learning model to estimate the initial stable SOC fraction (CS /C0 ) for the 14 LTEs where soil samples were available. The results showed that initializing the CS /C0 ratio using PARTYSOC combined with the optimized k0 further improved the accuracy of model simulations (R2 = 0.87, RMSE = 0.25, d = 0.90). Combining average measured CS /C0 and k0 optimization across all 24 LTEs also improved the model predictive capability by 25% compared to using default parameterization, thus suggesting promising avenue for upscaling model applications at the regional level where only a few measurement data on SOC stability can be available. In conclusion, the new version of the AMG model developed in the Tuojiang River Basin context exhibits excellent performance. This result paves the way for further calibration and validation of the AMG model in a wider set of contexts, with the potential to significantly improve confidence in SOC predictions in croplands over regional scales., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2023
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29. Management of Neovascular Age-Related Macular Degeneration Treatment in France from 2008-2018: The Nationwide LANDSCAPE Study.
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Creuzot Garcher CP, Srour M, Baudin F, Dot C, Nghiem-Buffet S, Girmens JF, Collin C, Ponthieux A, and Delcourt C
- Abstract
Introduction: The aim of this study was to describe the management of neovascular age-related macular degeneration (nAMD) in French patients between 2008 and 2018., Methods: This was a retrospective longitudinal cohort study using exhaustive nationwide health records from the French National Health Information database. Enrollment criteria were adults aged ≥ 50 years, nAMD diagnosis, or reimbursement for nAMD treatments (anti-vascular epithelial growth factor [VEGF] injection or dynamic phototherapy with verteporfin). Exclusion criteria were high myopia, diagnosis of other retinal diseases, and treatments for other macular diseases (dexamethasone implant, laser). Main outcome measures were consumption of medical care and nAMD treatments per calendar year and number of years of follow-up., Results: Between 2008 and 2018, we identified 342,961 patients who have been treated for nAMD. Median duration of ophthalmological follow-up exceeded 7 years (90 months). The median annual number of ophthalmology consultations decreased from nine visits in year 1 after treatment initiation to four visits from year 7 onwards. The median duration of nAMD treatment was 10.1 months for all patients, with 48.5% of patients undergoing treatment for < 1 year. Only 24.4% of patients had maintained treatment at year 11. Patients remaining under treatment had a median of four anti-VEGF treatments per year throughout the 10-year study period. Ranibizumab was the more common first-line treatment (67.5% of patients) compared to aflibercept (32.4%). About 20% of patients who initiated treatment switched treatment at least once., Conclusions: LANDSCAPE provides exhaustive nationwide data on the real-world management of nAMD in France over a 10-year period. Further investigation into short treatment duration is required, especially in terms of understanding its relation to visual outcomes., (© 2023. The Author(s).)
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- 2023
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30. Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study.
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Emeriaud G, Pons-Òdena M, Bhalla AK, Shein SL, Killien EY, Modesto I Alapont V, Rowan C, Baudin F, Lin JC, Grégoire G, Napolitano N, Mayordomo-Colunga J, Diaz F, Cruces P, Medina A, Smith L, and Khemani RG
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- Humans, Child, Male, Respiration, Artificial, Prospective Studies, Incidence, Noninvasive Ventilation, Respiratory Distress Syndrome epidemiology, Respiratory Distress Syndrome therapy, Respiratory Distress Syndrome diagnosis
- Abstract
Objectives: The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS., Design: Planned ancillary study to the 2016/2017 prospective Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study., Setting: One hundred five international PICUs., Patients: Patients with newly diagnosed PARDS admitted during 10 study weeks., Interventions: None., Measurements and Main Results: Children were categorized by their respiratory support at PARDS diagnosis into NIV or invasive mechanical ventilation (IMV) groups. Of 708 subjects with PARDS, 160 patients (23%) received NIV at PARDS diagnosis (NIV group). NIV failure rate (defined as tracheal intubation or death) was 84 of 160 patients (53%). Higher nonrespiratory pediatric logistic organ dysfunction (PELOD-2) score, Pa o2 /F io2 was less than 100 at PARDS diagnosis, immunosuppression, and male sex were independently associated with NIV failure. NIV failure was 100% among patients with nonrespiratory PELOD-2 score greater than 2, Pa o2 /F io2 less than 100, and immunosuppression all present. Among patients with Pa o2 /F io2 greater than 100, children in the NIV group had shorter total duration of NIV and IMV, than the IMV at initial diagnosis group. We failed to identify associations between NIV use and PICU survival in a multivariable Cox regression analysis (hazard ratio 1.04 [95% CI, 0.61-1.80]) or mortality in a propensity score matched analysis ( p = 0.369)., Conclusions: Use of NIV at PARDS diagnosis was associated with shorter exposure to IMV in children with mild to moderate hypoxemia. Even though risk of NIV failure was high in some children, we failed to identify greater hazard of mortality in these patients., Competing Interests: Dr. Emeriaud’s institution received funding from Fonds de recherche du Quebec Santé (research public agency award) and Maquet. Dr. Pons-Òdena’s institution received funding from Medtronic; he received funding from Philips Respironics. Drs. Bhalla and Killien received support for article research from the National Institutes of Health. Dr. Shein received funding from Hill Ward Henderson. Dr. Killien’s institution received funding from the National Institutes of Child Health and Human Development. Dr. Rowan’s institution received funding from the National Heart, Lung, and Blood Institute (K23). Dr. Lin received funding from ROMTech. Dr. Napolitano’s institution received funding from Drager, Actuated Medical, Philips/Respinronics, and VeroBiotech. Dr. Khemani received funding from Orange Med and Bayer. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
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- 2023
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31. Hypophosphatemia in infants with severe bronchiolitis and association with length of mechanical ventilation.
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Lusteau A, Valla F, Javouhey E, and Baudin F
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- Infant, Humans, Child, Infant, Newborn, Respiration, Artificial, Retrospective Studies, Length of Stay, Intensive Care Units, Pediatric, Bronchiolitis complications, Bronchiolitis epidemiology, Bronchiolitis therapy, Hypophosphatemia complications, Hypophosphatemia epidemiology
- Abstract
Objectives: Electrolyte disorders occurs frequently in children with bronchiolitis. The aim of the present study was to describe the frequency of hypophosphatemia and to evaluate its association with length of mechanical ventilation in infants admitted to a pediatric intensive care unit (PICU) with bronchiolitis., Methods: This retrospective cohort study included infants aged between 7 days and 3 months admitted to a PICU between September 2018 and March 2020 and diagnosed with severe acute bronchiolitis requiring respiratory support. Infants with a chronic condition that could potentially be a confounding factor were excluded. The primary outcome was the frequency of hypophosphatemia (<1.55 mmol/L); the secondary outcomes were the frequency of hypophosphatemia during the PICU stay, and the association with length of mechanical ventilation (LOMV)., Results: Among the 319 infants admitted 178 had at least one phosphatemia value and were included in the study. The frequency of hypophosphatemia was 41% at PICU admission (61/148) and 46% during the PICU stay (80/172). The median [IQR] LOMV was significantly longer in children with hypophosphatemia at admission (109 [65-195] h vs. 67 [43-128] h, p = 0.007), and in multivariable linear regression lower phosphatemia at admission was associated with longer LOMV (p < 0.001) after controlling for severity (PELOD2 score) and weight., Conclusion: Hypophosphatemia was frequent in infants with severe bronchiolitis admitted to a PICU and was associated with a longer LOMV., (© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
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- 2023
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32. Alveolar target ventilation and dead space in children under anaesthesia: The proventiped cohort study.
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Gardon A, De Queiroz Siqueira M, Cerceuil E, Bouhamri N, Chassard D, and Baudin F
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- Humans, Child, Cohort Studies, Respiration, Artificial, Tidal Volume, Carbon Dioxide, Respiratory Dead Space physiology, Anesthesia
- Abstract
Introduction: Ventilator settings in children under anaesthesia remain difficult because of the changes in the physiology and the high dead space., Objective: To determine the alveolar minute-volume to sustain normocapnia in children under mechanical ventilation., Design: A prospective observational study., Settings: This study was performed between May and October 2019 in a tertiary care children's hospital., Patients: Children between 2 months and 12 years, weighing between 5 and 40 kg, admitted for general anaesthesia., Intervention: Volumetric capnography was used to estimate the alveolar and dead space volume (Vd)., Main Outcome Measures: Total and alveolar minute ventilation in (ml kg -1 min -1 ) over 100 breaths., Results: Sixty patients were included comprising 20 per group: 5 to 10 kg (group 1), 10 to 20 kg (group 2), 20 to 40 kg (group 3). Seven patients were excluded for aberrant capnographic curves. After normalisation to weight, the median [IQR] tidal volume per kilogram was similar between the three groups: 6.5 ml kg -1 [6.0 to 7.5 ml kg -1 ], 6.4 ml kg -1 [5.7 to 7.3 ml kg -1 ], 6.4 ml kg -1 [5.3 to 6.8 ml kg -1 ]; P = 0.3. Total Vd (in ml kg -1 ) was negatively correlated to weight ( r = -0.62, 95% confidence interval -0.41 to -0.76, P < 0.001). The total normalised minute ventilation (ml kg -1 min -1 ) to obtain normocapnia was higher in group 1 than in group 2 and in group 3; 203 ml kg -1 min -1 [175 to 219 ml kg -1 min -1 ], 150 ml kg -1 min -1 [139 to 181 ml kg -1 min -1 ] and 128 ml kg -1 min -1 [107 to 157 ml kg -1 min -1 ]; P < 0.001 (mean ± SD), but (mean ± SD) alveolar minute ventilation was similar between the three groups; 68 ± 21 ml kg -1 min -1 ., Conclusion: Total dead space volume (including apparatus dead space) represents a major component of tidal volume in children less than 30 kg, when using large heat and moisture exchanger filters. The total minute ventilation necessary to achieve normocapnia decreased with increasing weight, while the alveolar minute ventilation remained constant., Trial Registration: ClinicalTrials.gov, identifier: NCT03901599., (Copyright © 2023 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.)
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- 2023
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33. Respiratory physiology during NAVA ventilation in neonates born with a congenital diaphragmatic hernia: The "NAVA-diaph" pilot study.
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Dreyfus L, Butin M, Plaisant F, Claris O, and Baudin F
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- Infant, Infant, Newborn, Humans, Pilot Projects, Prospective Studies, Diaphragm physiology, Respiratory Rate, Respiration, Artificial, Hernias, Diaphragmatic, Congenital surgery, Interactive Ventilatory Support
- Abstract
Background: Neurally adjusted ventilatory assist (NAVA) is a ventilatory mode that delivers synchronized ventilation, proportional to the electrical activity of the diaphragm (EAdi). Although it has been proposed in infants with a congenital diaphragmatic hernia (CDH), the diaphragmatic defect and the surgical repair could alter the physiology of the diaphragm., Aim: To evaluate, in a pilot study, the relationship between the respiratory drive (EAdi) and the respiratory effort in neonates with CDH during the postsurgical period under either NAVA ventilation or conventional ventilation (CV)., Methods: This prospective physiological study included eight neonates admitted to a neonatal intensive care unit with a diagnosis of CDH. EAdi, esophageal, gastric, and transdiaphragmatic pressure, as well as clinical parameters, were recorded during NAVA and CV (synchronized intermittent mandatory pressure ventilation) in the postsurgical period., Results: EAdi was detectable and there was a correlation between the ΔEAdi (maximal - minimal values) and the transdiaphragmatic pressure (r = 0.26, 95% confidence interval [CI] [0.222; 0.299]). There was no significant difference in terms of clinical or physiological parameters during NAVA compared to CV, including work of breathing., Conclusion: Respiratory drive and effort were correlated in infants with CDH and therefore NAVA is a suitable proportional mode in this population. EAdi can also be used to monitor the diaphragm for individualized support., (© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.)
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- 2023
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34. Risk of Admission to the Pediatric Intensive Care Unit for SARS-CoV-2 Delta and Omicron Infections.
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Recher M, Leteurtre S, Javouhey E, Morin L, Baudin F, Rambaud J, Mortamet G, Hubert H, Angoulvant F, and Levy M
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- Child, Humans, Aged, Intensive Care Units, Pediatric, SARS-CoV-2, COVID-19 diagnosis, COVID-19 epidemiology
- Abstract
Background: The severity of SARS-CoV-2-related diseases in children remains unclear. This study aimed to describe the incidence of French pediatric intensive care units (PICUs) admissions with acute COVID-19, incidental positive SARS-CoV-2 test result, and multisystem inflammatory syndrome in children (MIS-C) during the delta and omicron variant periods., Methods: This study used the French PICU registry to obtain data on all patients admitted to 41 French PICUs diagnosed with acute COVID-19, incidental positive SARS-CoV-2 test result, or MIS-C between August 30, 2021 and April 20, 2022. Data regarding the total number of positive SARS-CoV-2 polymerase chain reaction results according to the type of variants were obtained from the French National Public Health Agency., Results: Of 745 children, 244 (32.8%) were admitted for acute COVID-19, 246 (33.0%) for incidental positive SARS-CoV-2 test results, and 255 (34.2%) for MIS-C. The incidence of each group was higher with delta than with omicron. The incidence rate ratios with the delta variant were 7.47 (95% CI, 4.22-13.26) for acute COVID-19, 4·78 (95% CI, 2.30-9.94) for incidental positive SARS-CoV-2 test results, and 10.46 (95% CI, 5.98-18.31) for MIS-C compared to the omicron variant. The median age was 66 (7.7-126.8) months; 314 (42%) patients had comorbidities. Patients with acute COVID-19 and incidental positive SARS-CoV-2 test results had similar proportions of comorbidities. No patient with MIS-C died, whereas the mortality rates in the acute COVID-19 and incidental positive SARS-CoV-2 test results groups were 6.8% and 3.8%, respectively., Conclusions: The incidence of acute COVID-19, incidental positive SARS-CoV-2 test results, and MIS-C admitted to the PICU were significantly higher with the delta variant than with the omicron variant., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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35. Impact of COVID-19 lockdown on surgical procedures for retinal detachment in France: a national database study.
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Baudin F, Benzenine E, Mariet AS, Ben Ghezala I, Daien V, Gabrielle PH, Quantin C, and Creuzot-Garcher CP
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- Humans, Age Distribution, Communicable Disease Control, Incidence, France epidemiology, Retrospective Studies, Retinal Detachment epidemiology, Retinal Detachment surgery, Retinal Detachment etiology, COVID-19 epidemiology, COVID-19 complications
- Abstract
Background/aims: The COVID-19 crisis and the decisions made regarding population lockdown may have changed patient care. We aimed to investigate the incidence rate of rhegmatogenous retinal detachment (RRD) cases during the COVID-19 lockdown period., Methods: In this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France from 2017 to the lockdown period in 2020. The monthly hospital incidence rates of RRD procedures per 100 000 inhabitants before, during and after lockdown were computed for the whole country. Finally, we assessed the influence of viral incidence on the RRD incidence rate, comparing two regions with highly contrasting viral penetration., Results: From January to July, the average monthly national hospital incidence rate of RRD decreased from a mean of 2.59/100 000 inhabitants during 2017-2019 to 1.57/100 000 inhabitants in 2020. Compared with 2019, during the 8-week lockdown period in 2020, a 41.6% decrease in the number of RRD procedures was observed (p < 0.001) with the weekly incidence of RRD decreasing from 0.63/100 000 inhabitants in 2019 to 0.36/100 000 inhabitants. During the 4-month post-lockdown period, no increased activity related to postponed procedures was observed. No difference was found in the rate of RRD surgery when comparing two regions with highly contrasting viral incidence., Conclusion: Containment may have been responsible for a decrease in the number of surgical procedures for RRD, without any compensating post-lockdown activity in France. These results might help increase awareness of the management of RRD emergencies., Competing Interests: Competing interests: IBG, EB, A-SM and CQ have nothing to disclose. FB—consultant (Novartis and Théa). P-HG—consultant (Novartis, Bayer, Allergan and Horus). VD—consultant (Bayer, Novartis and Théa). CPC-G—consultant (Allergan, Bayer, Horus Pharma, Novartis, Roche and Théa)., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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36. Orthoparamyxovirinae C Proteins Have a Common Origin and a Common Structural Organization.
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Roy A, Chan Mine E, Gaifas L, Leyrat C, Volchkova VA, Baudin F, Martinez-Gil L, Volchkov VE, Karlin DG, Bourhis JM, and Jamin M
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- Scattering, Small Angle, X-Ray Diffraction, Immunity, Innate, RNA metabolism, Nipah Virus genetics, Nipah Virus metabolism
- Abstract
The protein C is a small viral protein encoded in an overlapping frame of the P gene in the subfamily Orthoparamyxovirinae. This protein, expressed by alternative translation initiation, is a virulence factor that regulates viral transcription, replication, and production of defective interfering RNA, interferes with the host-cell innate immunity systems and supports the assembly of viral particles and budding. We expressed and purified full-length and an N-terminally truncated C protein from Tupaia paramyxovirus (TupV) C protein (genus Narmovirus). We solved the crystal structure of the C-terminal part of TupV C protein at a resolution of 2.4 Å and found that it is structurally similar to Sendai virus C protein, suggesting that despite undetectable sequence conservation, these proteins are homologous. We characterized both truncated and full-length proteins by SEC-MALLS and SEC-SAXS and described their solution structures by ensemble models. We established a mini-replicon assay for the related Nipah virus (NiV) and showed that TupV C inhibited the expression of NiV minigenome in a concentration-dependent manner as efficiently as the NiV C protein. A previous study found that the Orthoparamyxovirinae C proteins form two clusters without detectable sequence similarity, raising the question of whether they were homologous or instead had originated independently. Since TupV C and SeV C are representatives of these two clusters, our discovery that they have a similar structure indicates that all Orthoparamyxovirine C proteins are homologous. Our results also imply that, strikingly, a STAT1-binding site is encoded by exactly the same RNA region of the P/C gene across Paramyxovirinae, but in different reading frames (P or C), depending on which cluster they belong to.
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- 2023
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37. IMPACT study: Impact of adherence to anti-VEGF intravitreal injections for macular disease during COVID 19-related confinement in France.
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Hurand V, Ducloyer JB, Baudin F, Aho S, Weber M, Kodjikian L, Devin F, Gabrielle PH, Creuzot-Garcher C, and Massin P
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- Humans, Female, Male, Ranibizumab, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Intravitreal Injections, Receptors, Vascular Endothelial Growth Factor, Communicable Disease Control, Retrospective Studies, Treatment Outcome, COVID-19 epidemiology, Retinal Diseases drug therapy, Retinal Diseases epidemiology, Wet Macular Degeneration drug therapy, Wet Macular Degeneration epidemiology
- Abstract
Purpose: The aim of this study was to evaluate the impact of adherence to French coronavirus disease 2019 (COVID 19)-related guidelines for intravitreal injection (IVI) practice on the visual outcomes of patients treated with anti-vascular endothelial growth factor (VEGF) agents for macular diseases during the first lockdown period., Methods: Observational multicentre study including all patients from 18 centres with an IVI initially planned during the lockdown. Visual acuity (VA, ETDRS) was recorded at 1 and 4 months after lockdown. French COVID 19-related guidelines recommended maintaining IVI practice. We defined three groups of patients: A, adherent to guidelines; NA+, non-adherent with delayed IVIs; and NA-, non-adherent without IVIs performed during the lockdown. Risk factors for non-adherence and visual loss were studied., Results: A total of 3020 eyes of 3020 patients, aged 77.8 ± 11.6 years, 59.8% women, were included. 59.3% were non-adherent(46.7% NA+, 12.6% NA-). A smaller decrease in VA at 4 months was observed in the A group than the NA+ and NA- group (-0.2 ± 6.7, -0.3 ± 6.9 and -1.5 ± 6.9, respectively [p < 0.001]). Factors associated with non-adherence were in multivariable analysis, older age, hospital practice, low-density population areas, high viral incidence areas, longer intervals between injection and treat and extent protocol. Factors associated with visual loss at 4 months in multivariable analysis were, being in the NA- group, older age, T&E and fixed regimens., Conclusion: Strict adherence to guidelines was associated with better visual outcome, although most of our patients did not attend as planned. Identification of patients at risk could help in the future in case of a new pandemic lockdown., (© 2022 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
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- 2023
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38. Effects of topical docosahexaenoic acid on postoperative fibrosis in an animal model of glaucoma filtration surgery.
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Carré C, Baudin F, Buteau B, Martine L, Grégoire S, Vasku G, Berdeaux O, Béduneau A, Pellequer Y, Jamoussi J, Desrumeaux C, Aho S, Bron AM, Acar N, Creuzot-Garcher C, and Gabrielle PH
- Subjects
- Animals, Rats, Disease Models, Animal, Docosahexaenoic Acids, Fibrosis, Intraocular Pressure, Mitomycin pharmacology, Filtering Surgery, Glaucoma surgery, Trabeculectomy
- Abstract
Purpose: The aim of this study was to evaluate docosahexaenoic acid (DHA) as a potential antifibrotic agent after glaucoma filtration surgery (GFS) in rats., Methods: A total of 36 10-week-old Brown Norway rats underwent GFS. Animals were equally divided into three groups: a control group, a DHA group and a mitomycin C (MMC) group. Intraocular pressure (IOP) was measured using a dynamic rebound tonometer, and a photograph of the surgical site was taken on days 1, 3, 7, 10, 14 and 17. The incorporation of DHA into fibroblasts was evaluated by gas chromatography. The expression of alfa-smooth muscle actin (α-SMA) and Smad proteins was assessed by Western blotting., Results: IOP decreased after surgery in animals from the three groups on day 1 after surgery. Over time, IOP remained lower in the DHA and MMC groups than in the control group (median [interquartile range] 8.0 [7.0-8.0] and 8.0 [7.3-8.0] mmHg vs. 9.0 [8.0-9.0] mmHg, respectively; p < 0.001). Bleb area in the DHA and MMC groups remained larger than that of the control group from day 7 to day 14 (3.9 [2.9-5.2] and 3.5 [2.3-4.4] mm
2 vs. 2.3 [2.0-2.8] mm2 , respectively; p = 0.0021). We did not observe any change in DHA concentrations in the fibroblasts of the DHA group compared with the other groups., Conclusion: The impact of DHA on IOP and bleb area was similar to that of MMC. The mechanisms of action of DHA in rat eye fibroblasts deserve further investigation., (© 2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)- Published
- 2023
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39. Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2).
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Emeriaud G, López-Fernández YM, Iyer NP, Bembea MM, Agulnik A, Barbaro RP, Baudin F, Bhalla A, Brunow de Carvalho W, Carroll CL, Cheifetz IM, Chisti MJ, Cruces P, Curley MAQ, Dahmer MK, Dalton HJ, Erickson SJ, Essouri S, Fernández A, Flori HR, Grunwell JR, Jouvet P, Killien EY, Kneyber MCJ, Kudchadkar SR, Korang SK, Lee JH, Macrae DJ, Maddux A, Modesto I Alapont V, Morrow BM, Nadkarni VM, Napolitano N, Newth CJL, Pons-Odena M, Quasney MW, Rajapreyar P, Rambaud J, Randolph AG, Rimensberger P, Rowan CM, Sanchez-Pinto LN, Sapru A, Sauthier M, Shein SL, Smith LS, Steffen K, Takeuchi M, Thomas NJ, Tse SM, Valentine S, Ward S, Watson RS, Yehya N, Zimmerman JJ, and Khemani RG
- Subjects
- Child, Humans, Respiration, Artificial methods, Consensus, Respiratory Distress Syndrome diagnosis, Respiratory Distress Syndrome therapy, Acute Lung Injury
- Abstract
Objectives: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed., Design: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science., Setting: Not applicable., Patients: Patients with or at risk for PARDS., Interventions: None., Measurements and Main Results: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%., Conclusions: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients., Competing Interests: Dr. Barbaro is currently receiving grant support (R01 HL153519; R01 HD015434) from the National Institutes of Health (NIH); he is currently Chair of the Extracorporeal Life Support Organization Registry. Dr. Bembea receives research funding to her institution from the NIH/National Institute of Neurological Disorders and Stroke (R01NS106292) and the Grifols Investigator Sponsored Research Grant. She serves as Chair of the Scientific Committee of the Pediatric Acute Lung Injury and Sepsis Investigators Research Network. Dr. Cheifetz is a medical consultant for Phillips and Medtronic. His institution receives research grant funding from the NIH. Dr. Cruces received funding from the Chilean Ministry of Sciences (Fondecyt 1220322). Dr. Curley received funding from the NIH (UH3HL141736, R01HD098269, R01HL149910, R01HL153519, R01HD104618). Dr. Dahmer received funding from the NIH (National Institute of Child Health and Human Development [NICHD], R21 HD097387; National Heart, Lung and Blood Institute [NHLBI] R01 HL149910). Dr. Dalton received funding from the Department of Defense (No. 13363072). She is a consultant for Innovative Extracorporeal Membrane Oxygenation Concepts, Hemocue, Entegrion, Medtronic, and advisory board member for Abiomed. Dr. Emeriaud’s research program is supported by the Fonds de Recherche du Québec-Santé and the Quebec Respiratory Health Network. Dr. Emeriaud is leading a study, which is financially supported by Maquet. Dr. Jouvet’s research program and salary is supported by the Fonds de Recherche du Québec-Santé and the Quebec Respiratory Health Network. Dr. Jouvet is leading studies, which is financially supported by VitalTracer, Dymedso and public financial agencies (Canadian Foundation for innovation, Institut TransMedTech, Quebec Ministry of Health, Sainte-Justine Hospital). Dr. Killien received funding from the NIH (NICHD K23HD100566). Dr. Kneyber received research funding from the NIH/NICHD (UG3 HL141736-01/U24 HL141723-01) and ZorgOnderzoek Nederland and the area Medical (848041002), Stichting Vrienden Beatrix Kinderziekenhuis, Fonds NutsOhra, University Medical Center Groningen, VU University Medical Center, and the Royal Academy of Dutch Sciences (TerMeulen stipend). Dr. Kneyber’s research program is technically supported by Vyaire, Applied Biosignals, and Timpl. Dr. Kneyber received honoraria from Vyaire. Dr. Kneyber serves as consultant for Metran and served as consultant for Vyaire. Dr. Kudchadkar received funding to her institution from the NIH/NICHD (R01HD103811 & R21HD093369) and the Donaghue Foundation. Dr. López-Fernández is funded by an academic grant from the Instituto de Salud Carlos III, Madrid, Spain (PI19/00141). Dr. Maddux received funding to her institution from the NIH/NICHD (K23HD096018). Dr. Morrow has received honoraria for Continuing Medical Education presentations from EduPro Health. Her research is part-funded by the National Research Foundation of South Africa, through the Incentive Funding for Rated Researchers program. Dr. Nadkarni receives unrestricted research grants to his institution from the NIH, U.S. Department of Defense, Agency for Healthcare Research and Quality, Laerdal Foundation, RQI Partners, Zoll Medical, Defibtech, HeartHero, and Nihon-Kohden. Dr. Nadkarni is an elected member of the Executive Committee (Council) of the Society of Critical Care Medicine. Dr. Napolitano research and consulting relationships with: Drager, Timpel, VERO-Biotech, Actuated Medical, and Philips/Respironics. Dr. Pons has been on the speaker’s bureau of Philips, ResMed and Fisher & Paykel; Hospital Sant Joan de Déu has received disposable material from these companies. Dr. Randolph receives funding from the Centers for Disease Control and Prevention, NIH (National Institute of Allergy and Infectious Diseases AI154470). Dr. Rowan receives funding from the NHLBI (NHLBI K23HL150244). Dr. Sanchez-Pinto received funding from the NIH (NICHD R01 HD105939). Dr. Sauthier research program and salary is supported by the Fonds de Recherche du Québec-Santé. Dr. Takeuchi receives funding from Japan Society for the Promotion of Science grant (KAKENHI 21K09063). Dr. Tse receives research funding to her institution from the Canadian Institute of Health Research and salary support from the Fonds de Recherche du Québec—Santé. Dr. Watson receives research funding to his institution from the NIH. Dr. Zimmerman received research funding from NIH and Biomedical Advanced Research and Development Authority; royalties from Elsevier Publishing. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
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- 2023
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40. Monitoring in Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.
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Bhalla A, Baudin F, Takeuchi M, and Cruces P
- Subjects
- Infant, Newborn, Child, Humans, Adolescent, Lung, Monitoring, Physiologic methods, Respiratory Rate, Respiratory Distress Syndrome diagnosis, Respiratory Distress Syndrome therapy, Acute Lung Injury diagnosis, Acute Lung Injury therapy
- Abstract
Objectives: Monitoring is essential to assess changes in the lung condition, to identify heart-lung interactions, and to personalize and improve respiratory support and adjuvant therapies in pediatric acute respiratory distress syndrome (PARDS). The objective of this article is to report the rationale of the revised recommendations/statements on monitoring from the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2)., Data Sources: MEDLINE (Ovid), Embase (Elsevier), and CINAHL Complete (EBSCOhost)., Study Selection: We included studies focused on respiratory or cardiovascular monitoring of children less than 18 years old with a diagnosis of PARDS. We excluded studies focused on neonates., Data Extraction: Title/abstract review, full-text review, and data extraction using a standardized data collection form., Data Synthesis: The Grading of Recommendations Assessment, Development and Evaluation approach was used to identify and summarize evidence and develop recommendations. We identified 342 studies for full-text review. Seventeen good practice statements were generated related to respiratory and cardiovascular monitoring. Four research statements were generated related to respiratory mechanics and imaging monitoring, hemodynamics monitoring, and extubation readiness monitoring., Conclusions: PALICC-2 monitoring good practice and research statements were developed to improve the care of patients with PARDS and were based on new knowledge generated in recent years in patients with PARDS, specifically in topics of general monitoring, respiratory system mechanics, gas exchange, weaning considerations, lung imaging, and hemodynamic monitoring., Competing Interests: Dr. Bhalla received support for article research from the National Institutes of Health. The remaining authors have disclosed that they do not have any potential conflicts of interest., (Copyright © 2023 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.)
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- 2023
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41. Clinical practice guidelines: management of severe bronchiolitis in infants under 12 months old admitted to a pediatric critical care unit.
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Milési C, Baudin F, Durand P, Emeriaud G, Essouri S, Pouyau R, Baleine J, Beldjilali S, Bordessoule A, Breinig S, Demaret P, Desprez P, Gaillard-Leroux B, Guichoux J, Guilbert AS, Guillot C, Jean S, Levy M, Noizet-Yverneau O, Rambaud J, Recher M, Reynaud S, Valla F, Radoui K, Faure MA, Ferraro G, and Mortamet G
- Subjects
- Humans, Infant, Child, Intensive Care Units, Pediatric, Hospitalization, Critical Care, Bronchiolitis diagnosis, Bronchiolitis therapy, Noninvasive Ventilation methods
- Abstract
Purpose: We present guidelines for the management of infants under 12 months of age with severe bronchiolitis with the aim of creating a series of pragmatic recommendations for a patient subgroup that is poorly individualized in national and international guidelines., Methods: Twenty-five French-speaking experts, all members of the Groupe Francophone de Réanimation et Urgence Pédiatriques (French-speaking group of paediatric intensive and emergency care; GFRUP) (Algeria, Belgium, Canada, France, Switzerland), collaborated from 2021 to 2022 through teleconferences and face-to-face meetings. The guidelines cover five areas: (1) criteria for admission to a pediatric critical care unit, (2) environment and monitoring, (3) feeding and hydration, (4) ventilatory support and (5) adjuvant therapies. The questions were written in the Patient-Intervention-Comparison-Outcome (PICO) format. An extensive Anglophone and Francophone literature search indexed in the MEDLINE database via PubMed, Web of Science, Cochrane and Embase was performed using pre-established keywords. The texts were analyzed and classified according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. When this method did not apply, an expert opinion was given. Each of these recommendations was voted on by all the experts according to the Delphi methodology., Results: This group proposes 40 recommendations. The GRADE methodology could be applied for 17 of them (3 strong, 14 conditional) and an expert opinion was given for the remaining 23. All received strong approval during the first round of voting., Conclusion: These guidelines cover the different aspects in the management of severe bronchiolitis in infants admitted to pediatric critical care units. Compared to the different ways to manage patients with severe bronchiolitis described in the literature, our original work proposes an overall less invasive approach in terms of monitoring and treatment., (© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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42. Bioenergetic control of soil carbon dynamics across depth.
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Henneron L, Balesdent J, Alvarez G, Barré P, Baudin F, Basile-Doelsch I, Cécillon L, Fernandez-Martinez A, Hatté C, and Fontaine S
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- Carbon Cycle, Agriculture, Rhizosphere, Soil Microbiology, Soil, Carbon
- Abstract
Soil carbon dynamics is strongly controlled by depth globally, with increasingly slow dynamics found at depth. The mechanistic basis remains however controversial, limiting our ability to predict carbon cycle-climate feedbacks. Here we combine radiocarbon and thermal analyses with long-term incubations in absence/presence of continuously
13 C/14 C-labelled plants to show that bioenergetic constraints of decomposers consistently drive the depth-dependency of soil carbon dynamics over a range of mineral reactivity contexts. The slow dynamics of subsoil carbon is tightly related to both its low energy density and high activation energy of decomposition, leading to an unfavourable 'return-on-energy-investment' for decomposers. We also observe strong acceleration of millennia-old subsoil carbon decomposition induced by roots ('rhizosphere priming'), showing that sufficient supply of energy by roots is able to alleviate the strong energy limitation of decomposition. These findings demonstrate that subsoil carbon persistence results from its poor energy quality together with the lack of energy supply by roots due to their low density at depth., (© 2022. The Author(s).)- Published
- 2022
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43. Prevention of submicron aerosolized particle dispersion: evaluation of an aerosol box using a pediatric simulation model.
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Tabone L, Rivest D, Levy A, Buyck M, Jouvet P, Aubin CE, François T, Robert E, and Baudin F
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- Humans, Child, SARS-CoV-2, Respiratory Aerosols and Droplets, Suction, Aerosolized Particles and Droplets, COVID-19 prevention & control
- Abstract
Background and Aim: The SplashGuard CG (SG) is a barrier enclosure developed to protect healthcare workers from SARS-CoV-2 transmission during aerosol-generating procedures. Our objective was to evaluate the protection provided by the SG against aerosolized particles (AP), using a pediatric simulation model of spontaneous ventilation (SV) and noninvasive ventilation (NIV). Methods: An aerosol generator was connected to the airways of a pediatric high-fidelity manikin with a breathing simulator. AP concentrations were measured both in SV and NIV in the following conditions: with and without SG, inside and outside the SG, with and without suction applied to the device. Results: In the SV simulated setting, AP peaks were lower with SG: 0.1 × 10
5 particles/L compared to without: 1.6 × 105 , only when the ports were closed and suction applied. In the NIV simulated setting, AP peaks outside the SG were lower than without SG (20.5 × 105 particles/L), whatever the situation, without suction (14.4 × 105 particles/L), with suction and ports open or closed: 10.3 and 0.7 × 105 particles/L. In SV and NIV simulated settings, the AP peaks measured within the SG were much higher than the AP peaks measured without SG, even when suction was applied to the device. Conclusions: The SG seems to decrease peak AP exposure in the 2 ventilation contexts, but only with closed port and suction in SV. However, high concentrations of AP remain inside even with suction and SG should be used cautiously.- Published
- 2022
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44. Incidence of Rhegmatogenous Retinal Detachment Following Macular Surgery in France Between 2006 and 2016.
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Ben Ghezala I, Mariet AS, Benzenine E, Gabrielle PH, Baudin F, Quantin C, and Creuzot-Garcher C
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- Humans, Male, Middle Aged, Incidence, Vitrectomy methods, Cohort Studies, Retrospective Studies, Postoperative Complications etiology, France epidemiology, Retinal Detachment epidemiology, Retinal Detachment surgery, Retinal Detachment etiology, Retinal Perforations epidemiology, Retinal Perforations surgery, Retinal Perforations complications, Epiretinal Membrane epidemiology, Epiretinal Membrane surgery, Epiretinal Membrane complications
- Abstract
Purpose: To report the incidence of postoperative rhegmatogenous retinal detachment after macular surgery in France between 2006 and 2016, and identify associated factors., Design: Nationwide, population-based, cohort study., Methods: All surgical procedures for an epiretinal membrane or a macular hole performed in France from January 1, 2006 to October 31, 2016 were identified in the French national administrative database (Programme de Médicalisation des Systèmes d'Information). The incidence of rhegmatogenous retinal detachment occurring within 90 days of a macular surgical procedure was investigated., Results: From January 1, 2006 to October 31, 2016, 152,034 macular surgical procedures for epiretinal membranes or macular holes were recorded in France. Of these, 3605 cases of rhegmatogenous retinal detachment occurring within 90 days of the procedure were found. The incidence of rhegmatogenous retinal detachment was 2.37% overall, 1.95% for epiretinal membrane surgery, and 3.43% for macular hole surgery. In multivariable Poisson regression analysis, rhegmatogenous retinal detachment was associated with macular hole surgery (incidence rate ratio [IRR], 1.76; 95% CI, 1.63-1.90; P < .001), history of cataract extraction in the previous year (IRR, 1.20; 95% CI, 1.08-1.34; P = .001), age <60 years (P < .001), and male sex (IRR, 1.63; 95% CI, 1.51-1.76; P < .001)., Conclusions: The incidence of rhegmatogenous retinal detachment within 90 days of macular surgery was 2.37% overall in France between 2006 and 2016, and it was higher for macular hole surgery than for epiretinal membrane surgery., (Copyright © 2022 Elsevier Inc. All rights reserved.)
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- 2022
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45. "Oris Duplicatio"-Duplication of the Oral Cavity a Rare Malformation in a 10-Month-Old Child: State of the Science and Management.
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Delay A, Morand B, Hacini L, Lewandowski M, Baudin F, and Bachelet JT
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- Humans, Infant, Mouth, Mouth Abnormalities
- Abstract
The authors report the case of a 10-month-old child with total oral duplication. The authors review this pathology and the diagnostic and treatment modality through the few cases described in scientific history. The discussed etiopathogeny of this rare malformation is detailed in this work., Competing Interests: The authors report no conflicts of interest., (Copyright © 2022 by Mutaz B. Habal, MD.)
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- 2022
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46. Epidemiology of Treated Diabetes Ocular Complications in France 2008-2018-The LANDSCAPE French Nationwide Study.
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Creuzot-Garcher C, Massin P, Srour M, Baudin F, Dot C, Nghiem-Buffet S, Girmens JF, Collin C, Ponthieux A, and Delcourt C
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Aim: LANDSCAPE aimed to estimate the annual incidence and prevalence of treated diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) between 2008 and 2018., Methods: This French nationwide observational study used data from the French National Health Insurance Databases covering 99% of the French population. Data about healthcare consumption were used to identify adults treated with anti-VEGFs or dexamethasone implants (for DME) and with pan-retinal photocoagulation (for PDR). All French patients newly treated between 2008 and 2018 were included. Incidence and prevalence of treated DME and PDR were estimated for the age-matched general population and the population with diabetes in France. Sociodemographic characteristics and medical history were described in both populations., Results: We identified 53,584 treated DME patients and 127,273 treated PDR patients between 2008 and 2018, and 11,901 DME and 11,996 PDR new incident patients in 2018. The treated DME incidence in 2018 was 2.5 per 10,000 in the general population and 37.3 per 10,000 in the population with diabetes. Prevalence in 2018 was 9.5 and 143.7 per 10,000 in the respective populations. Treated PDR incidence in 2018 was 2.3 per 10,000 in the general population and 31.2 per 10,000 in the population with diabetes. Prevalence in 2018 was 19.9 and 270.3 per 10,000 in the respective populations. Incidence and prevalence were not age-dependent. Incidence of treated PDR incidence was relatively stable from 2008-2018. Incidence of treated DME incidence rose from 2012-2018, probably due to widening access to newly available treatments, such as anti-VEGFs., Conclusions: We provide exhaustive nationwide data on the incidence and prevalence of treated diabetic ocular complications in France over a 10-year period.
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- 2022
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47. Topical Antibiotic Prophylaxis and Intravitreal Injections: Impact on the Incidence of Acute Endophthalmitis-A Nationwide Study in France from 2009 to 2018.
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Baudin F, Benzenine E, Mariet AS, Ghezala IB, Bron AM, Daien V, Gabrielle PH, Quantin C, and Creuzot-Garcher C
- Abstract
Background: The dramatic increase in intravitreal injections (IVTs) has been accompanied by a greater need for safer procedures. The ongoing debate about topical antibiotic prophylaxis after IVTs emphasizes the importance of large-scale studies. We aimed to study the role of topical antibiotic prophylaxis in reducing the risk of acute endophthalmitis after IVTs. Methods: Population-based cohort study, in France, from 2009 to 2018, including all French patients receiving IVTs of corticosteroids or anti-VEGF agents. Results: A total of 5,291,420 IVTs were performed on 605,434 patients. The rate of topical antibiotic prophylaxis after IVTs progressively decreased during the study period, with a sharp drop in 2014 (from 84.6% in 2009 to 27.4% in 2018). Acute endophthalmitis occurred in 1274 cases (incidence rate = 0.0241%). Although antibiotic prophylaxis did not alter the risk of endophthalmitis ( p = 0.06), univariate analysis showed an increased risk after fluoroquinolone and aminoglycoside prophylaxis. This increased risk was not found in multivariate analysis. However, we observed an increased risk related to the use of fixed combinations of fluoroquinolones and aminoglycosides with corticosteroids (IRR = 1.89; 95% CI = 1.57-2.27%, antibiotics combined with corticosteroids). Conclusion: These results are consistent with the literature. Endophthalmitis rates after IVTs did not decrease with topical antibiotic prophylaxis. The use of a combination of antibiotics and corticosteroids doubles the risk of endophthalmitis and should be avoided. Avoiding antibiotic prophylaxis would reduce the costs and the potential risks of antibiotic resistance.
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- 2022
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48. Association between Obstetric Complications and Intravitreal Anti-Vascular Endothelial Growth Factor Agents or Intravitreal Corticosteroids.
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Ben Ghezala I, Mariet AS, Benzenine E, Bardou M, Bron AM, Gabrielle PH, Baudin F, Quantin C, and Creuzot-Garcher C
- Abstract
This nationwide population-based cohort study aimed to describe the use of intravitreal injections (IVTs) of anti-vascular endothelial growth factor (anti-VEGF) agents and corticosteroids in pregnant women in France and to report on the incidence of obstetric and neonatal complications. All pregnant women in France who received any anti-VEGF or corticosteroid IVT during pregnancy or in the month preceding pregnancy from 1 January 2009 to 31 December 2018 were identified in the national medico-administrative databases. Between 2009 and 2018, there were 5,672,921 IVTs performed in France. Among these IVTs, 228 anti-VEGF or corticosteroid IVTs were administered to 139 women during their pregnancy or in the month preceding their pregnancy. Spontaneous abortion or the medical termination of pregnancy occurred in 10 women (16.1%) who received anti-VEGF agents and in one (3.1%) of the women who received corticosteroids ( p = 0.09). This is the first national cohort study of pregnant women treated with anti-VEGF or corticosteroid IVTs. We found a high incidence of obstetric complications in pregnant women treated with anti-VEGF or corticosteroid IVTs but could not demonstrate a statistically significant association between the intravitreal agents and these complications. These agents should continue to be used with great caution in pregnant women.
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- 2022
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49. Cystoid Macular Edema after Rhegmatogenous Retinal Detachment Repair with Pars Plana Vitrectomy: Rate, Risk Factors, and Outcomes.
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Merad M, Vérité F, Baudin F, Ghezala IB, Meillon C, Bron AM, Arnould L, Eid P, Creuzot-Garcher C, and Gabrielle PH
- Abstract
(1) Background: The aim was to describe the rate and outcomes of cystoid macular edema (CME) after pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment (RRD) and to identify risk factors and imaging characteristics. (2) Methods: A retrospective consecutive case study was conducted over a 5-year period among adult patients who underwent PPV for primary RRD repair. The main outcome measure was the rate of CME at 12 months following PPV. (3) Results: Overall, 493 eyes were included. The CME rate was 28% (93 patients) at 12 months. In multivariate analysis, eyes with worse presenting visual acuity (VA) (odds ratio [OR], 1.55; 95% CI, 1.07-2.25; p = 0.02) and grade C proliferative vitreoretinopathy (PVR) (OR, 2.88; 95% CI, 1.04-8.16; p = 0.04) were more at risk of developing CME 1 year after PPV. Endolaser retinopexy was associated with a greater risk of CME than cryotherapy retinopexy (OR, 3.06; 95% CI, 1.33-7.84; p = 0.01). Eyes undergoing cataract surgery within 6 months of the initial RRD repair were more likely to develop CME at 12 months (OR, 1.96; 95% CI, 1.06-3.63; p = 0.03). (4) Conclusions: CME is a common complication after PPV for primary RRD repair. Eyes with worse presenting VA, severe PVR at initial presentation, endolaser retinopexy, and cataract surgery within 6 months of initial RRD repair were risk factors for postoperative CME at 12 months.
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- 2022
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50. Incidence of rhegmatogenous retinal detachment in France from 2010 to 2016: seasonal and geographical variations.
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Ben Ghezala I, Mariet AS, Benzenine E, Gabrielle PH, Baudin F, Bron AM, Quantin C, and Creuzot-Garcher CP
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- Age Distribution, France epidemiology, Humans, Incidence, Retrospective Studies, Seasons, Sex Distribution, Retinal Detachment epidemiology, Retinal Detachment etiology
- Abstract
Aims: To investigate the annual and monthly hospital incidence rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 2016 in France at the national and regional levels., Methods: In this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France during 2010-2016 from the national administrative database. The annual and monthly hospital incidence rates of RRD per 100 000 population were calculated for the whole country and for each region., Results: The average annual national hospital incidence rate of RRD was 21.97±1.04 per 100 000 population. The annual national hospital incidence rate of RRD was the lowest in 2010 (20.91 per 100 000 population) after which it increased until 2015 (23.55 per 100 000 population). The average monthly national RRD hospital incidence rate was the highest in June (2.03±0.12 per 100 000 population) and the lowest in August (1.60±0.09). The average annual age-standardised and sex-standardised regional hospital incidence rate was the highest in Guadeloupe and Pays de la Loire (28.30±2.74 and 26.13±0.84 per 100 000 population, respectively) and the lowest in French Guiana and Martinique (15.51±3.50 and 17.29±2.12 per 100 000 population, respectively)., Conclusions: The average annual national hospital incidence rate of RRD increased from 2010 to 2015. The hospital incidence rate of RRD seemed to vary according to season and geographical location., Competing Interests: Competing interests: AMB is a consultant for Aerie, Allergan, Bausch Lomb, Santen and Théa. CPC-G is a consultant for Alcon, Allergan, Bausch Lomb, Bayer, Horus, Novartis, Roche and Théa., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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