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Purpose: According to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator for gliomas. Therefore, imaging-based prediction of IDH mutation status is of high interest for individual patient management. We compared and evaluated the diagnostic value of radiomics derived from dual positron emission tomography (PET) and magnetic resonance imaging (MRI) data to predict the IDH mutation status non-invasively. Methods: Eighty-seven glioma patients at initial diagnosis who underwent PET targeting the translocator protein (TSPO) using [18F]GE-180, dynamic amino acid PET using [18F]FET, and T1-/T2-weighted MRI scans were examined. In addition to calculating tumor-to-background ratio (TBR) images for all modalities, parametric images quantifying dynamic [18F]FET PET information were generated. Radiomic features were extracted from TBR and parametric images. The area under the receiver operating characteristic curve (AUC) was employed to assess the performance of logistic regression (LR) classifiers. To report robust estimates, nested cross-validation with five folds and 50 repeats was applied. Results: TBRGE-180 features extracted from TSPO-positive volumes had the highest predictive power among TBR images (AUC 0.88, with age as co-factor 0.94). Dynamic [18F]FET PET reached a similarly high performance (0.94, with age 0.96). The highest LR coefficients in multimodal analyses included TBRGE-180 features, parameters from kinetic and early static [18F]FET PET images, age, and the features from TBRT2 images such as the kurtosis (0.97). Conclusion: The findings suggest that incorporating TBRGE-180 features along with kinetic information from dynamic [18F]FET PET, kurtosis from TBRT2, and age can yield very high predictability of IDH mutation status, thus potentially improving early patient management. [ABSTRACT FROM AUTHOR]

This qualitative study was conducted with participants from a previous investigation that explored the applicability and perceived impact of a program based on yoga, mindfulness, emotional intelligence, and positive psychology, to enhance student musicians' health and well-being during the lockdown. This program is named CRAFT, the acronym of which stands for the following Spanish terms that constitute its 5 elements: Consciencia, Relajación, Atención, Felicidad, and Transcendencia. The current study aimed to gain a greater understanding of participants' CRAFT-based practice implementation experience and their perceived benefits derived from it during the lockdown. Participants were higher education student musicians (n = 26) attending CRAFT-based elective subjects of Mindfulness and Emotional Intelligence, once a week for 1 hr throughout the academic year 2019/2020; at a Royal Conservatory of Music in Spain. Participants' responses to an open-ended question were content analyzed following a deductive approach guided by the framework of the 5 CRAFT elements. The content analysis revealed 6 overarching themes, 1 for each CRAFT element and an additional 1 labeled "other." Participants' perceived benefits aligned with the 5 CRAFT elements and included developments such as enhanced conscious awareness, emotional self-regulation, psychological distress, mind clearance, relaxation, concentration, wellness, vitality, hope, transforming attitudes, equanimity, positivity, and resilience. These findings suggest that curricular exposure with the CRAFT program was beneficial among higher education student musicians to cope with their health and well-being lockdown demands, having thus relevant implications in both higher education and clinical settings for health and well-being promotion, support, and prevention during stressful pandemic times. [ABSTRACT FROM AUTHOR]