1. An elevated level of interleukin-17A in a Senegalese malaria cohort is associated with rs8193038 IL-17A genetic variant
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Fatou Thiam, Gora Diop, Cedric Coulonges, Celine Derbois, Alassane Thiam, Abou Abdallah Malick Diouara, Mame Ndew Mbaye, Mamadou Diop, Cheikh Momar Nguer, Yakhya Dieye, Babacar Mbengue, Jean-Francois Zagury, Jean-Francois Deleuze, and Alioune Dieye
- Subjects
Plasmodium falciparum ,Cytokines ,Single nucleotide polymorphism ,Severe malaria ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Malaria infection is a multifactorial disease partly modulated by host immuno-genetic factors. Recent evidence has demonstrated the importance of Interleukin-17 family proinflammatory cytokines and their genetic variants in host immunity. However, limited knowledge exists about their role in parasitic infections such as malaria. We aimed to investigate IL-17A serum levels in patients with severe and uncomplicated malaria and gene polymorphism’s influence on the IL-17A serum levels. In this research, 125 severe (SM) and uncomplicated (UM) malaria patients and 48 free malaria controls were enrolled. IL-17A serum levels were measured with ELISA. PCR and DNA sequencing were used to assess host genetic polymorphisms in IL-17A. We performed a multivariate regression to estimate the impact of human IL-17A variants on IL-17A serum levels and malaria outcomes. Elevated serum IL-17A levels accompanied by increased parasitemia were found in SM patients compared to UM and controls (P
- Published
- 2024
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