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A series of (E)-1-methyl-3-((substituted phenylimino)methyl)quinolin-2(1H)-one schiff bases (3a-j) bearing quinoline moiety synthesized successfully in ethanol by condensation of starting material 1-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (1) with various substituted anilines (2a-j). The structure of the newly synthesized compounds was confirmed by proton (1H) and carbon (13C) nuclear magnetic resonance spectroscopy, Fourier transformation infrared (FT-IR), Mass spectroscopic study and elemental analysis. The in-vitro antimicrobial activity of the synthesized compounds was undertaken by agar well diffusion method against gram positive bacteria (Bacillus licheniformis and Bacillus cereus) gram negative bacteria (Escherichia coli and Acetobactor sp.) and antifungal activity against (Aspergillus Flavus and Pichnanomala). Further the compounds which shows good activity (3b, 3c, 3d, 3f, 3g and 3j) are screened for in-vitro antitubercular activity by Micro-plate alamar blue assay (MABA) method against mycobacterium tuberculosis H37Rv strain provided important information about activity against these strains. The structure activities of the synthesized compounds were also discussed. Compounds 3a, 3c, 3d, 3f and 3g show good argument with the different substituent attached to the phenyl ring.

The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic action against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Salmonella. Typhi, and Shigella sp. On the other hand, compound 4h had significant antifungal activity against Candida albicans and Aspergillus fusarium and was a highly promising agent when compared to standard nystatin.

In the present work, we have synthesized thiazole-hydrazone conjugates 5(a–h) and characterized them using various analytical techniques such as UV, IR, NMR, and mass spectrometry. Solvatochromic properties were evaluated in ten solvents with different polarity and quantum chemical parameters using a DFT study. The antibacterial activity results revealed that compounds 5c, 5d and 5g exhibited good efficacy and that the remaining compounds displayed significant activity. The synthesized compounds were screened for their cytotoxic activity against HepG2 and MCF-7 cell lines, and all the synthesized compounds exhibited significant potency towards the screened cancer cell lines. The anti-inflammatory efficacy of the synthesized thiazole derivatives was determined against MMP-2 and MMP-9, and some of the compounds showed significant activity. Furthermore, the in silico molecular docking was performed with the COX-2 receptor.