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Ultra-High-Strength Steel (UHSS) offers several advantages over normal carbon steel, promoting exceptional strength, reducing self-weight, improving fire resistance, enhancing durability, and reducing material consumption. These advantages result in cost savings and sustainable engineering construction. The 3D numerical model is based on Geometrical and Materially Nonlinear Imperfection Analysis (GMNIA) and determines the fire resistance of different cross-section columns. The model is validated with experimental tests, with a maximum relative error of 11%. A parametric analysis is presented, based on 252 simulations, assuming three heating rates, two different cross-sections, two different thicknesses, three lengths, and seven load levels. The fire resistance depends on the heating rate, but the critical temperature is almost equal and independent of the heating rate, if one assumes implicit creep in the constitutive material model. The fire resistance decreases with the load level, as expected. The thickness effect of the hollow section is almost negligible in the fire resistance of UHSS columns. The fire resistance decreases more in higher load levels for slender columns. Columns with Circular Hollow Sections (CHSs) generally show higher fire resistance than hybrid columns in longer columns, but the hybrid columns are subject to much higher loads. New design formulas are presented for the critical temperature of UHSS columns, depending on the load level and slenderness of two different cross-sections.