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We present a new pipeline developed to detect and characterize faint astronomical companions at small angular separation from the host star using sets of wide-field imaging observations not specifically designed for high-contrast imaging analysis. The core of the pipeline relies on Karhunen–Loéve truncated transformation of the reference point-spread function (PSF) library to perform PSF subtraction and identify candidates. Tests of reliability of detections and characterization of companions are made through simulation of binaries and generation of receiver operating characteristic curves for false-positive/true-positive analysis. The algorithm has been successfully tested on large HST/ACS and WFC3 data sets acquired for two HST Treasury Programs on the Orion Nebula Cluster. Based on these extensive numerical experiments we find that, despite being based on methods designed for observations of a single star at a time, our pipeline performs very well on mosaic space-based data. In fact, we are able to detect brown-dwarf-mass companions almost down to the planetary-mass limit. The pipeline is able to reliably detect signals at separations as close as ≳0.″1 with a completeness of ≳10%, or ∼0.″2 with a completeness of ∼30%. This approach can potentially be applied to a wide variety of space-based imaging surveys, from data in the existing HST archive to near-future JWST mosaics and future wide-field Roman images.

Supplementary data associated with this article can befound, in the online version, at https://doi.org/10.1016/j.medcli.2021.06.015, Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe COVID- 19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19. Methods: We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleed- ing, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death. Results: 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p = 0.003; 52 (34.4%) vs 35 (23.2%), p = 0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding. Conclusions: AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk., Antecedentes y objetivos: La fibrilación auricular (FA) es frecuente en pacientes ingresados por COVID-19 grave. Sin embargo, los datos sobre el manejo de la anticoagulación crónica en estos pacientes son escasos. Analizamos la anticoagulación y la incidencia de episodios cardiovasculares mayores en pacientes con FA ingresados por la COVID-19. Métodos: Retrospectivamente, se identificaron todos los pacientes con FA ingresados por la COVID-19 entre marzo y mayo de 2020, en 9 hospitales espa ̃noles. Se seleccionó un grupo control de pacientes ingresados consecutivamente por la COVID-19 sin FA. Se compararon las características basales, inci- dencia de hemorragias mayores, episodios trombóticos y mortalidad. Para reducir potenciales factores de confusión se realizó un emparejamiento por puntuación de propensión, así como un análisis multivariante para predecir hemorragia mayor y mortalidad. Resultados: Se incluyeron 305 pacientes con FA ingresados por la COVID-19. Tras el emparejamiento por puntuación de propensión, 151 pacientes con FA fueron emparejados con 151 controles. Durante el ingreso, la heparina de bajo peso molecular fue el principal anticoagulante y la incidencia de hemorragia mayor y mortalidad fue mayor en el grupo de FA (16[10,6%] vs. 3[2%], p = 0,003; 52[34,4%] vs. 35[23,2%], p = 0,03, respectivamente). El análisis multivariante demostró la presencia de FA como predictor indepen- diente de sangrados y mortalidad intrahospitalaria en los pacientes con la COVID-19. En el grupo de FA, un segundo análisis multivariante identificó valores elevados de dímero-D como predictor independiente de hemorragia mayor intrahospitalaria. Conclusiones: Los pacientes con FA ingresados por la COVID-19 representan una población de alto riesgo de sangrado y mortalidad durante el ingreso. Parece recomendable individualizar la anticoagulación durante el ingreso, considerando el riesgo específico de sangrado y trombosis.

We present a kinematic study of six dwarf spheroidal galaxies (dSph) satellites of the Milky Way (MW), namely Carina, Draco, Fornax, Sculptor, Sextans, and Ursa Minor. We combine proper motions (PMs) from the $Gaia$ Data Release 3 (DR3) and line-of-sight velocities ($v_{\mathrm{los}}$) from the literature to derive their 3D internal kinematics and to study the presence of internal velocity gradients. We find velocity gradients along the line-of-sight for Carina, Draco, Fornax, and Ursa Minor, at $\geq 1\sigma$ level of significance . The value of such gradients appears to be related to the orbital history of the dwarfs, indicating that the interaction with the MW is causing them. Dwarfs that are close to the MW and moving towards their orbits pericentres show, on average, larger velocity gradients. On the other hand, dwarfs that have recently left their orbits pericentres show no significant gradients. Lastly, dwarfs located at large Galactocentric distances show gradients with an intermediate intensity. Our results would indicate that the torque caused by the strong tidal forces exerted by the MW induces a strong velocity gradient when the dwarfs approach their orbits pericentres. During the pericentre passage, the rapid change in the forces direction would disrupt such gradient, which may steadily recover as the galaxies recede. We assess our findings by analysing dwarfs satellites from the TNG50 simulation. We find a significant increase in the intensity of the detected gradients as the satellites approach their pericentre, followed by a sharp drop as they abandon it, supporting our results for the dSphs of the MW., Comment: 13 pages, 9 figures, 1 table. Accepted for publication in MNRAS

A number of studies based on data collected by the $\textit{Hubble Space Telescope}$ ($\textit{HST}$) GO-13297 program "HST Legacy Survey of Galactic Globular Clusters: Shedding UV Light on Their Populations and Formation" have investigated the photometric properties of a large sample of Galactic globular clusters and revolutionized our understanding of their stellar populations. In this paper, we expand previous studies by focusing our attention on the stellar clusters' internal kinematics. We computed proper motions for stars in 56 globular and one open clusters by combining the GO-13297 images with archival $\textit{HST}$ data. The astro-photometric catalogs released with this paper represent the most complete and homogeneous collection of proper motions of stars in the cores of stellar clusters to date, and expand the information provided by the current (and future) $\textit{Gaia}$ data releases to much fainter stars and into the crowded central regions. We also census the general kinematic properties of stellar clusters by computing the velocity-dispersion and anisotropy radial profiles of their bright members. We study the dependence on concentration and relaxation time, and derive dynamical distances. Finally, we present an in-depth kinematic analysis of the globular cluster NGC 5904., Comment: 33 pages, 19 figures, 6 tables. Accepted for publication on ApJ. Astro-photometric catalogs, velocity-dispersion values and profiles are available at https://archive.stsci.edu/hlsp/hacks