20 results on '"Andrianaivoarimanana, Voahangy"'
Search Results
2. Plague
- Author
-
Rajerison, Minoarisoa, primary, Andrianaivoarimanana, Voahangy, additional, and Olliaro, Piero, additional
- Published
- 2024
- Full Text
- View/download PDF
3. CONTRIBUTORS
- Author
-
Abahuje, Egide, primary, Abrahim, Orit, additional, Adetifa, Ifedayo M.O., additional, Ajjampur, Sitara S.R., additional, Alexander, Suceena, additional, PhD, Chiara Altare,, additional, Alves, Fabiana, additional, Andrianaivoarimanana, Voahangy, additional, Angelakis, Emmanouil, additional, Aronson, Jeffrey K., additional, Atukorala, Inoshi G., additional, Baily, Guy, additional, Baker, Stephen, additional, Barrett, Alan D.T., additional, Basnyat, Buddha, additional, Bastawrous, Andrew, additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Baxter, Cheryl, additional, Beare, Nicholas A.V., additional, Beeching, Nick J., additional, Bekker, Linda-Gail, additional, Berlin, Anita, additional, FRS, Zulfiqar A. Bhutta, additional, Bloom, David E., additional, Blumberg, Lucille, additional, Boelaert, Marleen, additional, Brett-Major, David, additional, Brooker, Simon J., additional, Brouwer, Matthijs C., additional, Brunetti, Enrico, additional, Bull, Susan, additional, Bundy, Donald A.P., additional, Burri, Christian, additional, Bustinduy, Amaya L., additional, Caillet, Céline, additional, Chai, Jong Yil, additional, Chang, Thashi, additional, Chappuis, François, additional, Chibi, Buyisile, additional, Chiodini, Peter L., additional, Chowdhury, Rajiv, additional, Chowdhury, Sudipta Dhar, additional, Clemens, John D., additional, Cooke, Graham S., additional, Cotton, Mark F., additional, Currie, Bart J., additional, Cusack, Tomas-Paul, additional, Dance, David A.B., additional, Davis, Emily H., additional, Day, Nicholas P.J., additional, Deen, Jacqueline, additional, Dondorp, Arjen M., additional, Dünser, Martin W., additional, Eitzen, Edward, additional, Chebib, Hassan El, additional, Enria, Delia, additional, Faust, Christina, additional, Fekadu, Abebaw, additional, Fink, Günther, additional, Fischer, Peter U., additional, Fletcher, Tom, additional, Franco-Paredes, Carlos, additional, French, Neil, additional, Frumkin, Howard, additional, Garcia, Hector H., additional, Gerada, Alessandro, additional, Glass, Roger I., additional, Gordon, Stephen B., additional, Gottstein, Bruno, additional, Goyal, Alpesh, additional, Grey, Jonathan, additional, Gupta, Yashdeep, additional, Haines, Andy, additional, Hampson, Katie, additional, Hanlon, Charlotte, additional, Harrison, Mark, additional, Haswell, Melissa R., additional, Hawkesworth, Sophie, additional, Hay, Roderick J., additional, Heckmann, Jeannine M., additional, Heimesaat, Markus M., additional, Henao-Martínez, Andrés F., additional, Hien, Tran Tinh, additional, Hoerauf, Achim, additional, Irfan, Omar, additional, PhD, Euzebiusz Jamrozik, additional, Jobe, Modou, additional, John, George T., additional, Jones, Nick K., additional, Jones, Malcolm K., additional, Junghanss, Thomas, additional, Kaewkes, Sasithorn, additional, Karim, Quarraisha Abdool, additional, Keiser, Jennifer, additional, Kelly, Paul, additional, Khan, Amira M., additional, King, Charles H., additional, Kishore, Sandeep P., additional, Lang, Trudie, additional, Le, Thuy, additional, Liesenfeld, Oliver, additional, Lockwood, Diana N.J., additional, Mabey, David C.W., additional, Madkour, M. Monir, additional, Manesh, Abi, additional, Masekela, Refiloe, additional, Mäser, Pascal, additional, Mayaud, Philippe, additional, Mbanya, Dora, additional, McCarthy, James S., additional, McCartney, Daniel J., additional, McGready, Rose, additional, McKee, Martin, additional, Mc, Namara, Paul S., additional, Meara, John G., additional, Meintjes, Graeme, additional, Merson, Laura, additional, Mola, Glen, additional, Morassutti, Alessandra L., additional, Morris-Jones, Rachael, additional, Mortimer, Kevin J., additional, Muliyil, Divya Elizabeth, additional, Mumcuoglu, Kosta Y., additional, Munoz, Flor M., additional, Murphy, Adrianna, additional, Mutabingwa, Theonest, additional, Nawa, Yukifumi, additional, Newton, Paul N., additional, Nightingale, Sam, additional, Nokes, D. James, additional, Nosten, François H., additional, O’Hea, Jennifer, additional, Olliaro, Piero, additional, Ong, Jason J., additional, Oommen, Anu Mary, additional, Parashar, Umesh D., additional, Paris, Daniel H., additional, Parker, Michael, additional, Pluschke, Gerd, additional, Preidis, Geoffrey A., additional, Prentice, Andrew M., additional, Quail, Geoffrey, additional, Quinn, Thomas C., additional, Rabie, Helena, additional, Rajashekharaiah, Harsha, additional, Rajerison, Minoarisoa, additional, Ranganathan, Kannan, additional, Raoult, Didier, additional, Rassi,, Anis, additional, Ravi, Vasanthapuram, additional, Reddy, K. Srinath, additional, Rees, Claire, additional, Reynolds, Steven J., additional, Richter, Joachim, additional, Rijken, Marcus J., additional, Riviello, Robert, additional, Robinson, Janet, additional, Salazar, Juan C., additional, Schultz, Marcus J., additional, Schwarz, Dan, additional, Sendagire, Ibrahim, additional, Sharma, Savitri, additional, Shawon, Shajedur Rahman, additional, Singh, Bhagteshwar, additional, Sithithaworn, Paiboon, additional, Siwila, Joyce, additional, Solomon, Tom, additional, Spiegel, Paul, additional, Sridhar, Devi, additional, Sripa, Banchob, additional, Srour, M. Leila, additional, Stojković, Marija, additional, Strader, Christopher, additional, Suárez, Jose A., additional, Sundar, Shyam, additional, Tamarozzi, Francesca, additional, Tandon, Nikhil, additional, Tate, Jacqueline E., additional, Thachil, Jecko, additional, Thomson, Madeleine C., additional, Thwaites, Guy, additional, Thwaites, C. Louise, additional, van Daalen, Kim R., additional, Beek, Diederik van de, additional, van Doorn, H. Rogier, additional, Vega-Lopez, Francisco, additional, von Seidlein, MD, PhD, Lorenz, additional, Wakeham, Katie, additional, Walker, Stephen L., additional, Wallace, Ryan M., additional, Ward, Honorine, additional, Warrell, David A., additional, Weber, Tim Frederik, additional, Weil, Gary J., additional, White, Nicholas J., additional, White, MB Ch, B, Graham B., additional, Wong, Vanessa, additional, Wood, Robin, additional, Wood, Georgina, additional, Wyllie, Sarah, additional, Yacoub, Sophie, additional, Yen, Lam Minh, additional, Young, Paul R., additional, and Zafren, Ken, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017
- Author
-
Rakotondrasoa, Andriniaina, Andrianonimiadana, Lova Maminirina, Rahajandraibe, Soloandry, Razafimahatratra, Solohery, Andrianaivoarimanana, Voahangy, Rahelinirina, Soanandrasana, Crucitti, Tania, Brisse, Sylvain, Jeannoda, Victor, Rajerison, Minoarisoa, and Collard, Jean-Marc
- Published
- 2022
- Full Text
- View/download PDF
5. Review of genotyping methods for Yersinia pestis in Madagascar.
- Author
-
Randriantseheno, Lovasoa Nomena, Andrianaivoarimanana, Voahangy, Pizarro-Cerdá, Javier, Wagner, David M., and Rajerison, Minoarisoa
- Subjects
- *
YERSINIA pestis , *HORIZONTAL gene transfer , *RESTRICTION fragment length polymorphisms , *WHOLE genome sequencing , *RODENT populations , *PARACOCCIDIOIDOMYCOSIS , *TULAREMIA - Abstract
Background: Plague, a zoonotic disease caused by Yersinia pestis, was responsible for 3 historical human pandemics that killed millions of people. It remains endemic in rodent populations in Africa, Asia, North America, and South America but human plague is rare in most of these locations. However, human plague is still highly prevalent in Madagascar, which typically records a significant part of all annual global cases. This has afforded an opportunity to study contemporary human plague in detail using various typing methods for Y. pestis. Aim: This review aims to summarize the methods that have been used to type Y. pestis in Madagascar along with the major discoveries that have been made using these approaches. Methods: Pubmed and Google Scholar were used to search for the keywords: "typing Yersinia pestis Madagascar," "evolution Yersinia pestis Madagascar," and "diversity Yersinia pestis Madagascar." Eleven publications were relevant to our topic and further information was retrieved from references cited in those publications. Results: The history of Y. pestis typing in Madagascar can be divided in 2 periods: the pre-genomics and genomics eras. During the pre-genomics era, ribotyping, direct observation of plasmid content and plasmid restriction fragment length polymorphisms (RFLP) were employed but only revealed a limited amount of diversity among Malagasy Y. pestis strains. Extensive diversity only started to be revealed in the genomics era with the use of clustered regularly interspaced palindromic repeats (CRISPR), multiple-locus variable number tandem repeats (VNTR) analysis (MLVA), and single-nucleotide polymorphisms (SNPs) discovered from whole genome sequences. These higher-resolution genotyping methods have made it possible to highlight the distribution and persistence of genotypes in the different plague foci of Madagascar (Mahajanga and the Central and Northern Highlands) by genotyping strains from the same locations across years, to detect transfers between foci, to date the emergence of genotypes, and even to document the transmission of antimicrobial resistant (AMR) strains during a pneumonic plague outbreak. Despite these discoveries, there still remain topics that deserve to be explored, such as the contribution of horizontal gene transfer to the evolution of Malagasy Y. pestis strains and the evolutionary history of Y. pestis in Madagascar. Conclusions: Genotyping of Y. pestis has yielded important insights on plague in Madagascar, particularly since the advent of whole-genome sequencing (WGS). These include a better understanding of plague persistence in the environment, antimicrobial AMR and multi-drug resistance in Y. pestis, and the person-to-person spread of pneumonic plague. Considering that human plague is still a significant public health threat in Madagascar, these insights can be useful for controlling and preventing human plague in Madagascar and elsewhere, and also are relevant for understanding the historical pandemics and the possible use of Y. pestis as a biological weapon. Author summary: Plague remains a major public health concern in Madagascar and has been since its introduction to the country in 1898. The scale and rapid spread of the 2017 pneumonic plague epidemic in urban settings in Madagascar reminds us of the relevance of improving our understanding of this disease as well as its monitoring. In this review, we revisit the studies conducted in Madagascar that utilized genotyping approaches to understand the evolution, geographic distribution, and emergence of Y. pestis, the etiologic agent of plague. These studies greatly contributed to the comprehension of the origin, the transmission and the dynamics of the circulation of plague in Madagascar, providing useful information for preparing for future plague outbreaks in Madagascar and elsewhere. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague
- Author
-
Shattock, Robin John, primary, Andrianaivoarimanana, Voahangy, additional, McKay, Paul F., additional, Randriantseheno, Lovasoa Nomena, additional, Murugaiah, Valarmathy, additional, Samnuan, K., additional, Rogers, Paul, additional, Tregoning, John S., additional, Rajerison, Minoarisoa, additional, Moore, Kristoffer M., additional, Laws, Thomas Robert, additional, and Williamson, E. Diane, additional
- Published
- 2023
- Full Text
- View/download PDF
7. An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial—an update to the published protocol
- Author
-
Randremanana, Rindra Vatosoa, Raberahona, Mihaja, de Dieu Randria, Mamy Jean, Bourner, Josephine, Zadonirina, Gabriella, Razananaivo, Hanitra, Mayouya-Gamana, Théodora, Mangahasimbola, Reziky, Pesonel, Elise, Gillesen, Annelies, Rajerison, Minoarisoa, Andrianaivoarimanana, Voahangy, Edwards, Tansy, Horby, Peter, and Olliaro, Piero
- Subjects
CIPROFLOXACIN ,RESEARCH protocols ,SAFETY - Abstract
This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October 2019. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
8. Phylogenetic analysis of the origin and spread of plague in Madagascar
- Author
-
Esquivel Gomez, Luis Roger, primary, Savin, Cyril, additional, Andrianaivoarimanana, Voahangy, additional, Rahajandraibe, Soloandry, additional, Randriantseheno, Lovasoa Nomena, additional, Zhou, Zhemin, additional, Kocher, Arthur, additional, Didelot, Xavier, additional, Rajerison, Minoarisoa, additional, and Kühnert, Denise, additional
- Published
- 2023
- Full Text
- View/download PDF
9. 40 - Plague
- Author
-
Rajerison, Minoarisoa, Andrianaivoarimanana, Voahangy, and Olliaro, Piero
- Published
- 2024
- Full Text
- View/download PDF
10. Analytical framework to evaluate and optimize the use of imperfect diagnostics to inform outbreak response: Application to the 2017 plague epidemic in Madagascar
- Author
-
ten Bosch, Quirine, primary, Andrianaivoarimanana, Voahangy, additional, Ramasindrazana, Beza, additional, Mikaty, Guillain, additional, Rakotonanahary, Rado J. L., additional, Nikolay, Birgit, additional, Rahajandraibe, Soloandry, additional, Feher, Maxence, additional, Grassin, Quentin, additional, Paireau, Juliette, additional, Rahelinirina, Soanandrasana, additional, Randremanana, Rindra, additional, Rakotoarimanana, Feno, additional, Melocco, Marie, additional, Rasolofo, Voahangy, additional, Pizarro-Cerdá, Javier, additional, Le Guern, Anne-Sophie, additional, Bertherat, Eric, additional, Ratsitorahina, Maherisoa, additional, Spiegel, André, additional, Baril, Laurence, additional, Rajerison, Minoarisoa, additional, and Cauchemez, Simon, additional
- Published
- 2022
- Full Text
- View/download PDF
11. Analytical framework to evaluate and optimize the use of imperfect diagnostics to inform outbreak response : Application to the 2017 plague epidemic in Madagascar
- Author
-
ten Bosch, Quirine, Andrianaivoarimanana, Voahangy, Ramasindrazana, Beza, Mikaty, Guillain, Rakotonanahary, Rado J.L., Nikolay, Birgit, Rahajandraibe, Soloandry, Feher, Maxence, Grassin, Quentin, Paireau, Juliette, Rahelinirina, Soanandrasana, Randremanana, Rindra, Rakotoarimanana, Feno, Melocco, Marie, Rasolofo, Voahangy, Pizarro-Cerdá, Javier, Le Guern, Anne Sophie, Bertherat, Eric, Ratsitorahina, Maherisoa, Spiegel, André, Baril, Laurence, Rajerison, Minoarisoa, Cauchemez, Simon, ten Bosch, Quirine, Andrianaivoarimanana, Voahangy, Ramasindrazana, Beza, Mikaty, Guillain, Rakotonanahary, Rado J.L., Nikolay, Birgit, Rahajandraibe, Soloandry, Feher, Maxence, Grassin, Quentin, Paireau, Juliette, Rahelinirina, Soanandrasana, Randremanana, Rindra, Rakotoarimanana, Feno, Melocco, Marie, Rasolofo, Voahangy, Pizarro-Cerdá, Javier, Le Guern, Anne Sophie, Bertherat, Eric, Ratsitorahina, Maherisoa, Spiegel, André, Baril, Laurence, Rajerison, Minoarisoa, and Cauchemez, Simon
- Abstract
During outbreaks, the lack of diagnostic "gold standard" can mask the true burden of infection in the population and hamper the allocation of resources required for control. Here, we present an analytical framework to evaluate and optimize the use of diagnostics when multiple yet imperfect diagnostic tests are available. We apply it to laboratory results of 2,136 samples, analyzed with 3 diagnostic tests (based on up to 7 diagnostic outcomes), collected during the 2017 pneumonic (PP) and bubonic plague (BP) outbreak in Madagascar, which was unprecedented both in the number of notified cases, clinical presentation, and spatial distribution. The extent of these outbreaks has however remained unclear due to nonoptimal assays. Using latent class methods, we estimate that 7% to 15% of notified cases were Yersinia pestis-infected. Overreporting was highest during the peak of the outbreak and lowest in the rural settings endemic to Y. pestis. Molecular biology methods offered the best compromise between sensitivity and specificity. The specificity of the rapid diagnostic test was relatively low (PP: 82%, BP: 85%), particularly for use in contexts with large quantities of misclassified cases. Comparison with data from a subsequent seasonal Y. pestis outbreak in 2018 reveal better test performance (BP: specificity 99%, sensitivity: 91%), indicating that factors related to the response to a large, explosive outbreak may well have affected test performance. We used our framework to optimize the case classification and derive consolidated epidemic trends. Our approach may help reduce uncertainties in other outbreaks where diagnostics are imperfect.
- Published
- 2022
12. Phylogenetic analysis of the origin and spread of plague in Madagascar
- Author
-
Esquivel Gomez, Luis Roger, primary, Savin, Cyril, additional, Andrianaivoarimanana, Voahangy, additional, Rahajandraibe, Soloandry, additional, Randriantseheno, Lovasoa Nomena, additional, Zhou, Zhemin, additional, Kocher, Arthur, additional, Rajerison, Minoarisoa, additional, Didelot, Xavier, additional, and Kühnert, Denise, additional
- Published
- 2022
- Full Text
- View/download PDF
13. Proteomic Signatures of Antimicrobial Resistance in Yersinia pestis and Francisella tularensis
- Author
-
Deatherage Kaiser, Brooke L., primary, Birdsell, Dawn N., additional, Hutchison, Janine R., additional, Thelaus, Johanna, additional, Jenson, Sarah C., additional, Andrianaivoarimanana, Voahangy, additional, Byström, Mona, additional, Myrtennäs, Kerstin, additional, McDonough, Ryelan F., additional, Nottingham, Roxanne D., additional, Sahl, Jason W., additional, Schweizer, Herbert P., additional, Rajerison, Minoarisoa, additional, Forsman, Mats, additional, Wunschel, David S., additional, and Wagner, David M., additional
- Published
- 2022
- Full Text
- View/download PDF
14. The impact of COVID-19 on clinical research for Neglected Tropical Diseases (NTDs): A case study of bubonic plague
- Author
-
Rasoanaivo, Tsinjo Fehizoro, primary, Bourner, Josephine, additional, Randriamparany, Ravaka Niaina, additional, Gamana, Théodora Mayouya, additional, Andrianaivoarimanana, Voahangy, additional, Raherivelo, Mily Harijaona, additional, Randriamampionona, Harivelo, additional, Rajerison, Minoarisoa, additional, Raberahona, Mihaja, additional, Salam, Alex Paddy, additional, Edwards, Tansy, additional, Olliaro, Piero L., additional, and Randremanana, Rindra Vatosoa, additional
- Published
- 2021
- Full Text
- View/download PDF
15. Evaluating and optimizing the use of diagnostics during epidemics: Application to the 2017 plague outbreak in Madagascar
- Author
-
Bosch, Quirine, primary, Andrianaivoarimanana, Voahangy, additional, Ramasindrazana, Beza, additional, Mikaty, Guillain, additional, Rakotonanahary, Rado JL, additional, Nikolay, Birgit, additional, Rahajandraibe, Soloandry, additional, Feher, Maxence, additional, Grassin, Quentin, additional, Paireau, Juliette, additional, Rahelinirina, Soanandrasana, additional, Randremanana, Rindra, additional, Rakotoarimanana, Feno, additional, Melocco, Marie, additional, Rasolofo, Voahangy, additional, Pizarro-Cerda, Javier, additional, Le Guern, Anne-Sophie, additional, Bertherat, Eric, additional, Ratsitorahina, Maherisoa, additional, Spiegel, Andre, additional, Baril, Laurence, additional, Rajerison, Minoarisoa, additional, and Cauchemez, Simon, additional
- Published
- 2021
- Full Text
- View/download PDF
16. Transmission of Antimicrobial Resistant Yersinia pestis During a Pneumonic Plague Outbreak.
- Author
-
Andrianaivoarimanana, Voahangy, Wagner, David M, Birdsell, Dawn N, Nikolay, Birgit, Rakotoarimanana, Faniry, Randriantseheno, Lovasoa N, Vogler, Amy J, Sahl, Jason W, Hall, Carina M, Somprasong, Nawarat, Cauchemez, Simon, Schweizer, Herbert P, Razafimandimby, Harimahefa, Rogier, Christophe, and Rajerison, Minoarisoa
- Subjects
- *
PREVENTION of infectious disease transmission , *PREVENTION of epidemics , *ANTIFUNGAL agents , *GENETIC mutation , *RETROSPECTIVE studies , *GENETIC testing , *PLAGUE , *DRUG resistance in microorganisms , *COMBINED modality therapy , *BACTERIA - Abstract
Background Pneumonic plague (PP), caused by Yersinia pestis , is the most feared clinical form of plague due to its rapid lethality and potential to cause outbreaks. PP outbreaks are now rare due to antimicrobial therapy. Methods A PP outbreak in Madagascar involving transmission of a Y. pestis strain resistant to streptomycin, the current recommended first-line treatment in Madagascar, was retrospectively characterized using epidemiology, clinical diagnostics, molecular characterization, and animal studies. Results The outbreak occurred in February 2013 in the Faratsiho district of Madagascar and involved 22 cases, including 3 untreated fatalities. The 19 other cases participated in funeral practices for the fatal cases and fully recovered after combination antimicrobial therapy: intramuscular streptomycin followed by oral co-trimoxazole. The Y. pestis strain that circulated during this outbreak is resistant to streptomycin resulting from a spontaneous point mutation in the 30S ribosomal protein S12 (rpsL) gene. This same mutation causes streptomycin resistance in 2 unrelated Y. pestis strains, one isolated from a fatal PP case in a different region of Madagascar in 1987 and another isolated from a fatal PP case in China in 1996, documenting this mutation has occurred independently at least 3 times in Y. pestis. Laboratory experiments revealed this mutation has no detectable impact on fitness or virulence, and revertants to wild-type are rare in other species containing it, suggesting Y. pestis strains containing it could persist in the environment. Conclusions Unique antimicrobial resistant (AMR) strains of Y. pestis continue to arise in Madagascar and can be transmitted during PP outbreaks. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Local‐scale diversity of Yersinia pestis: A case study from Ambohitromby, Ankazobe District, Madagascar.
- Author
-
Ramasindrazana, Beza, Parany, Mamionah N. J., Rasoamalala, Fanohinjanaharinirina, Rasoanoro, Mercia, Rahajandraibe, Soloandry, Vogler, Amy J., Sahl, Jason W., Andrianaivoarimanana, Voahangy, Rajerison, Minoarisoa, and Wagner, David M.
- Subjects
YERSINIA pestis ,PLAGUE ,RATTUS rattus ,RATS ,ZOONOSES ,PUBLIC health - Abstract
Plague is a re‐emerging zoonotic disease and a major public health concern in several portions of the world, especially in Madagascar. We report on the presence of different subtypes of Yersinia pestis co‐occurring in the same locality. After confirmation of a human plague case in Ambohitromby Commune (Ankazobe District) via isolation of Y. pestis, we undertook small mammal trapping to identify the circulation of Y. pestis amongst rodents in this locality; blood samples were collected from rodents for seroprevalence analysis. Of the 60 individuals of Rattus rattus captured, one yielded an isolate of Y. pestis, 13 others were positive for F1 antigen of Y. pestis using a rapid diagnostic test, and 4 were PCR positive targeting the caf1 and pla genes; 28/60 (46.7%) of the captured R. rattus were seropositive for Y. pestis. Whole‐genome SNP analyses revealed that the two isolates obtained from the human case, and the R. rattus belonged to two different subtypes of Y. pestis (s05 and s13, respectively) that were circulating concurrently in Ambohitromby in 2016. Three Y. pestis subtypes (s03, s05 and s13) have now been isolated from Ambohitromby. Subtype s05 had been persisting there for >10 years but one or both of the other subtypes may have been introduced from the Central Highlands region as they were not observed in previous years (s13) or only observed once previously (s03). High seroprevalence against Y. pestis in R. rattus suggests that a portion of the local murine population may have acquired resistance to Y. pestis. Future research should focus on genomically characterizing Y. pestis strains circulating in Ankazobe District and other plague‐endemic regions of Madagascar to better understand the overall phylogeography of Y. pestis. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
18. Field assessment of dog as sentinel animal for plague in endemic foci of Madagascar.
- Author
-
RAJERISON, Minoarisoa, ANDRIANAIVOARIMANANA, Voahangy, RATSITORAHINA, Maherisoa, RAHELINIRINA, Soanandrasana, CHANTEAU, Suzanne, TELFER, Sandra, and RAHALISON, Lila
- Subjects
- *
ENDEMIC animals , *PLAGUE , *YERSINIA pestis , *CANIS , *RODENTS , *SEROCONVERSION , *CARNIVOROUS animals , *DOGS - Abstract
The epidemiology of Yersinia pestis, the causative agent of plague, involves vectors and reservoirs in its transmission cycle. The passive plague surveillance in Madagascar targets mainly rodent and fleas. However, carnivores are routinely surveyed as sentinels of local plague activity in some countries. The aim of this study is to assess the use of domestic dog (Canis familiaris) as sentinel animal for field surveillance of plague in a highly endemic area in Madagascar. Cross‐sectional surveys of plague antibody prevalence in C. familiaris were conducted in endemic areas with contrasting histories of plague cases in humans, as well as a plague free area. Rodent capture was done in parallel to evaluate evidence for Y. pestis circulation in the primary reservoirs. In 2 sites, dogs were later re‐sampled to examine evidence of seroconversion and antibody persistence. Biological samplings were performed between March 2008 and February 2009. Plague antibody detection was assessed using anti‐F1 ELISA. Our study showed a significant difference in dog prevalence rates between plague‐endemic and plague‐free areas, with no seropositive dogs detected in the plague free area. No correlation was found between rodents and dog prevalence rates, with an absence of seropositive rodents in some area where plague circulation was indicated by seropositive dogs. This is consistent with high mortality rates in rodents following infection. Re‐sampling dogs identified individuals seropositive on both occasions, indicating high rates of re‐exposure and/or persistence of plague antibodies for at least 9 months. Seroconversion or seropositive juvenile dogs indicated recent local plague circulation. In Madagascar, dog surveillance for plague antibody could be useful to identify plague circulation in new areas or quiescent areas within endemic zones. Within active endemic areas, monitoring of dog populations for seroconversion (negative to positive) or seropositive juvenile dogs could be useful for identifying areas at greatest risk of human outbreaks. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
19. Rodent control to fight plague: field assessment of methods based on rat density reduction.
- Author
-
RAHELINIRINA, Soanandrasana, SCOBIE, Kathryn, RAMASINDRAZANA, Beza, ANDRIANAIVOARIMANANA, Voahangy, RASOAMALALA, Fanohinjanaharinirina, RANDRIANTSEHENO, Lovasoa Nomena, RAKOTONIAINA, Jerry Sylvio, GORGÉ, Olivier, LAMBIN, Xavier, VALADE, Eric, TELFER, Sandra, and RAJERISON, Minoarisoa
- Subjects
RODENT control ,PLAGUE ,RATS ,MICE ,RATTUS rattus ,RODENT populations ,FOOD security - Abstract
Rodents represent a serious threat to food security and public health. The extent to which rodent control can mitigate the risk from rodent‐borne disease depends on both the effectiveness of control in reducing rodent abundance and the impact on disease epidemiology. Focusing on a plague‐endemic region of Madagascar, this study compared the effectiveness of 3 methods: live‐traps, snap‐traps, and rodenticides. Control interventions were implemented inside houses between May and October 2019. Tracking tiles monitored rodent abundance. Rodent fleas, the vector involved in plague transmission, were collected. Rodent populations consisted of Rattus rattus and Mus musculus. In terms of trap success, we found that our live‐trap regime was more effective than snap‐traps. While all 3 control strategies appeared to reduce in‐house rodent activity in the short term, we found no evidence of a longer‐term effect, with in‐house rodent abundance in treated sites comparable to non‐treatment sites by the following month. Endemic flea, Synopsyllus fonquerniei, is a key plague vector usually found on rats living outdoors. Although we found no evidence that its abundance inside houses increased following control, this may have been due to a lack of power caused by significant variation in S. fonquerniei abundance. The presence of S. fonquerniei in houses was more likely when S. fonquerniei abundance on outdoor rats was higher, which in turn correlated with high rat abundance. Our results emphasize that control strategies need to consider this connectivity between in‐house rat–flea populations and the outdoor populations, and any potential consequences for plague transmission. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
20. Potential human immunotherapeutics for plague.
- Author
-
Andrianaivoarimanana V, Randriantseheno LN, Moore KM, Walker NJ, Lonsdale SG, Kempster S, Almond NA, Rajerison M, and Williamson ED
- Abstract
Two monoclonal antibodies directed to the V antigen of Yersinia pestis have been tested for protective efficacy in a murine model of bubonic plague. Mice were infected with a current clinical isolate from Madagascar, designated Y. pestis 10-21/S. Mab7.3, delivered to mice intra-periteoneally at either 24 h prior to, or 24 h post-infection, was fully protective, building on many studies which have demonstrated the protective efficacy of this Mab against a number of different clinical isolates of Y. pestis . Mab 29.3, delivered intra-peritoneally at either -24 h or +24 h, protected 4/5 mice in either condition; this has demonstrated the protective efficacy of this Mab in vivo for the first time. These results add to the cumulative data about Mab7.3, which is currently being humanized and highlight its potential as a human immunotherapeutic for plague, which is an enduring endemic disease in Madagascar and other regions of Africa, Asia, and South America., (© Crown copyright 2021.)
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.