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Methimazole or thiamazole is the most commonly used remedy in the medical management of hyperthyroidism, an endocrine disorder with growing prevalence, particularly in geriatric feline patients. Unfortunately, veterinarians have little, or most often, no access to the transdermal conditionings. The novelty of this research is that very few. transdermal formulations that include methimazole are studied yet in the veterinary field, and most often, the efficacy of methimazole is studied using pluronic lecithin organogel or lipophilic formulations as a vehicle in healthy or hyperthyroid cats. In this aim, our study followed a formulation of topical methimazole that includes a human base cream as a vehicle. Five healthy cats were included in this study and received 0.1 mL cream containing 10 mg methimazole over 15 days. The ointment was applied to the hairless portions of the inner pinna and: the body weight, hematological, biochemical parameters, the adverse effects, and total thyroxin serum concentration were monitored on day 0 and day 16. Topical reactions were observed after treatment, on day 14, after 15 days of topical methimazole application. Thyroxin serum concentration was significantly lower compared to the concentrations seen on day 0, allowing us to conclude that, the incorporation of methimazole in a dermatological cream base induces, at the same dose of 10 mg × 0.1 mL-1, a significant change in total thyroxin levels, changes comparable to those acquired by other authors using PLO or lipophilic gel.