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Abstract Background Pulmonary embolism (PE) is a lethal type of venous thromboembolic disease. Right ventricular (RV) failure is not an uncommon complication of PE leading to higher adverse outcomes. The tricuspid annular peak systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio as a surrogate for RV–pulmonary artery coupling has proven to be among the predictor of clinical outcomes in multiple patient groups. We evaluated in this study the role of TAPSE/PASP ratio in predicting adverse clinical outcomes in patients with acute PE. Results Among patients with established diagnosis of acute PE admitted to the coronary care unit, echocardiography was done within 12 h of admission and TAPSE/PASP ratio was calculated. The patients were followed during hospitalization and after discharge for 3 months for development of adverse outcomes including rehospitalization due to heart failure, recurrent PE and mortality. A total of fifty-five consecutive patients were recruited with mean age 58.3 ± 6.9 years and nearly equal male-to-female ratio. The mean ratio of TAPSE/PASP was 0.479 ± 0.206. In-hospital and 3-month follow-up showed that 10.9% needed rehospitalization with heart failure, 14.5% developed recurrent pulmonary embolism, and mortality was 9.1%. TAPSE/PASP ratio was significantly lower among the patients who developed adverse outcomes. TAPSE/PASP ratio was among the independent predictors of rehospitalization with heart failure, recurrent pulmonary embolism but not mortality at 3-month follow-up. TAPSE/PASP ratio predicted rehospitalization with heart failure at a cutoff point ≤ 0.325, with 100% sensitivity and 79.6% specificity, and predicted recurrent pulmonary embolism at a cutoff point ≤ 0.325, with 75% sensitivity and 78.7% specificity. Conclusion TAPSE/PASP ratio is a noninvasive tool that can predict the development of early adverse outcomes in patients with acute PE including rehospitalization with heart failure and recurrent pulmonary embolism.

Abstract Background Instantaneous wave-free ratio (iwFR) is a well-validated method for functional evaluation of intermediate coronary lesions. A recently developed Murray law-based QFR (µQFR) allows wire-free FFR estimation using a high-quality single angiographic projection. We aim to determine the diagnostic accuracy of µQFR as compared to wire-based iwFR for physiological assessment of coronary lesions in a sample of Egyptian patients. Results Over a one-year period, patients who previously underwent iwFR assessment of an intermediate coronary stenosis (40–90%) were retrospectively included. μQFR analysis was then performed offline using a dedicated artificial intelligence (AI)-aided computation software. All the measurements were performed blinded to iwFR results, and the agreement between iwFR and μQFR values was tested. Forty-nine patients (mean age 57.9 ± 9 years, 72.9% males) were included. Mean value of iwFR and μQFR was 0.90 ± 0.075 and 0.79 ± 0.129, respectively. There was a significant moderate positive linear correlation between μQFR and iwFR (r = 0.47, p = 0.001; 95% CI 0.22–0.68) with moderate-to-substantial agreement between the two methods (Kappa 0.6). In assessing the diagnostic accuracy of μQFR, the receiver operating characteristic (ROC) curve yielded an area under the curve (AUC) of 0.84 (95% CI 0.717–0.962) for predicting functionally significant lesions defined as iwFR

Abstract Background The reported prevalence of patent foramen ovale (PFO) in the general population is variable. It ranges between 8.6 and 42% according to the population studied and the imaging technique used. We aim to prospectively assess the prevalence and characteristics of PFO and interatrial septum (IAS) abnormalities as well as the related clinical manifestations in a sample of Egyptian population. Results This study comprised 1000 patients who were referred for CT coronary angiography (CTCA). Mean age was 52.5 ± 10.9 years. The prevalence of PFO among the studied population was 16.3%; closed PFO (grade I) 44.2%, open PFO (grade II) 50.9%, and open PFO with jet (grade III) 4.9%. Anatomical high-risk PFO features—defined as the presence of at least 2 or more of the following (diameter ≥ 2 mm, length ≥ 10 mm, septal aneurysm “ASA”, or redundant septum)—were found in 51.5% of PFOs’ population. Other IAS abnormalities as redundant septum (8.6%), ASA (5.3%), Bachmann’s bundle (4.5%), microaneurysm (2.6%), and atrial septal defect (ASD) (0.4%) were detected. There was a lower rate of coexistence of ASA with PFO (p = 0.031). Syncope was significantly higher in patients with PFO compared to those without PFO (6.7% vs. 1.6%, p = 0.001). Stroke, transient ischaemic attacks (TIA), and dizziness were similar in both groups. TIA, dizziness, and syncope were significantly higher in patients with IAS abnormalities including PFO compared to those without IAS abnormalities. Syncope was also significantly higher in PFO with high-risk anatomical features compared to those with non-high-risk PFO population (p = 0.02). Conclusion The prevalence of PFO in our study was approximately 16.3%, almost half of them showed anatomical high-risk features for stroke. Dizziness, syncope and TIA were significantly higher in patients with IAS abnormalities including PFO.

Life cycle assessment (LCA) is a widely recognized tool for environmental assessment, which has experienced a strong development both in methodology and applications. This paper aimed to perform a bibliometric analysis of LCA research during 2000-2022, considering publication types, publication trends, subject categories, journals, institutions, countries, and author keywords. Social Network Analysis was applied to recognize mapping trends, status, and hot spots in LCA research and to discover co-authorship relations and international collaborations among countries worldwide. The results of this study showed that the number of LCA publications has remarkably increased by more than tenfold over the study period. The United States, with 5885 publications (17.3%), was the most productive country in terms of the number of publications. The keywords "sustainability," "environmental impact," "carbon footprint," "circular economy," "recycling," and "climate change" were the most occurred keywords in the literature. The keyword "sustainability," growing from 221 in 2000-2011 to 2013 in 2011-2022, was the most trending keyword. The keywords "water footprint," "biogas," and "GHG emissions" exhibited the highest increase in frequency, with growth rates of 18.5, 11.2, and 7.1 times, respectively. The outcomes of this study showed the cumulative progression of the literature, thereby establishing a framework for future works in LCA research. [ABSTRACT FROM AUTHOR]

HLA-DR/DQ haplotypes largely define genetic susceptibility to type 1 diabetes (T1D). The DQB1*06:02-positive haplotype (DR15-DQ602) common in individuals of European ancestry is very rare among children with T1D. Among 4,490 children with T1D in the Finnish Pediatric Diabetes Register, 57 (1.3%) case patients with DQB1*06:02 were identified, in comparison with 26.1% of affected family-based association control participants. There were no differences between DQB1*06:02-positive and -negative children with T1D regarding sex, age, islet autoantibody distribution, or autoantibody levels, but significant differences were seen in the frequency of second class II HLA haplotypes. The most prevalent haplotype present with DQB1*06:02 was DRB1*04:04-DQA1*03-DQB1*03:02, which was found in 27 (47.4%) of 57 children, compared with only 797 (18.0%) of 4,433 among DQB1*06:02-negative case patients (P < 0.001 by χ2 test). The other common risk-associated haplotypes, DRB1*04:01-DQA1*03-DQB1*03:02 and (DR3)-DQA1*05-DQB1*02, were less prevalent in DQB1*06:02-positive versus DQB1*06:02-negative children (P < 0.001). HLA-B allele frequencies did not differ by DQB1*06:02 haplotype between children with T1D and control participants or by DRB1*04:04-DQA1*03-DQB1*03:02 haplotype between DQB1*06:02-positive and -negative children with T1D. The increased frequency of the DRB1*04:04 allele among DQB1*06:02-positive case patients may indicate a preferential ability of the DR404 molecule to present islet antigen epitopes despite competition by DQ602. Article Highlights: The common HLA-DQB1*06:02 allele is strongly protective against type 1 diabetes (T1D), although few DQB1*06:02-positive individuals have been found. We compared the distribution of the second class II haplotypes in DQB1*06:02-positive children with T1D with the distribution of haplotypes found in in other children with T1D. HLA-DRB1*04:04-DQA1*03-DQB1*03:02 was the most common second haplotype in DQB1*06:02-positive children with T1D, whereas DRB1*04:01-DQA1*03-DQB1*03:02 was most frequent in other children with T1D. This finding suggests that the islet-specific epitopes presented by DRB1*04:04 can more efficiently avoid binding to DQB1*06:02 than epitopes presented by other risk-associated haplotypes. [ABSTRACT FROM AUTHOR]

Due to the higher production cost of the monolithic carbide tools as well as their brittle nature, cemented carbides such as WC-Co are frequently joined to tool steel. To overcome the joining complications that arise due to notable differences in thermal expansions between the components and the poor wettability, various investigators have used copper-based and silver-based filler metals to dissimilarly braze the cemented carbides to steels. However, researchers do not agree about the selection of filler material. This research investigates the use of pure copper, brass, and silver-based filler metals to join the WC-Co cemented carbide to AISI 1045 steel. In this regard, microstructural features and mechanical properties including microhardness and shear strength were studied. The results indicate the formation of Cu(Fe,Co) solid solution and η carbides at the joint interfaces as well as the development of various precipitated phases in the joint area comprising Fe-Zn and Co-Zn intermetallic compounds. The reaction layers at both sides of the joints accompanied by cobalt-depleted zone on the hard metal side were observed. While using the α−β brass interlayer, the increase in hardness of the joint area through the presence of (Cu,Zn) solid solution compared to pure copper, the joint shear strength was enhanced from 161 to 173 MPa. On the other hand, the utilization of silver-based filler alloy with a distribution of hard copper-rich solid solution phase (182 HV) embedded in a silver-rich ductile matrix (88 HV), presenting a dispersion hardening effect, improved the shear strength of the joint to 203 MPa.

Although the bibliometric method has been widely used in a large number of sciences, no bibliometric study has been presented on the VOSviewer application as the most prominent software in this area. This study aimed to achieve a bibliometric analysis of research using VOSviewer, emphasizing "environment" and "energy" areas. Various features, including language, chronological trends, source types, subject categories, countries, source titles, affiliations, authors, and author keywords were systematically investigated. The countries' cooperation, authors' collaborations based on citations, the author keywords' occurrences were constructed, visualized, and assessed through the VOSviewer. The study indicated that the number of VOSviewer-related publications has grown significantly. More than 97% of the total publication were journal articles and conference papers, while all publications in the mentioned fields have been in the form of articles. China was the leading country in publications, followed by Spain, Brazil, Italy, and the UK. As well, the USA and Spain had a large number of cooperation with other countries. Li, J., and Li, H. from China were the most cited authors. "Energy", and "Environmental Science" were widely used areas in the most productive journals, as "Sustainability" published the most VOSviewer articles, followed by "International Journal of Environmental Research And Public Health" and "Journal of Cleaner Production". Among the author keywords, "sustainability", "sustainable development", and "circular economy" could be recognized. Based on database comparison, the number of publications using the "Web of Science" database is higher than "Scopus". However, the increase of articles published in the "Scopus" database is more. [ABSTRACT FROM AUTHOR]

In this research, the effect of RSW parameters including current intensity, welding time and welding force (coded by A, B and C) on the radius, thickness and area of ​​the nugget and the radius of the HAZ of TRIP steel joints was investigated by DOE and RSM. A 3D coupled thermal-electrical-structural FEM was used to model RSW. To validate the FE model, two TRIP steel sheets were welded experimentally. During welding, the temperature was measured and the results were compared with the FE results and a good agreement was obtained. The boundaries of the welding zones were determined according to the critical temperatures and the responses in all samples were calculated. Using analysis of variance, direct, quadratic and interaction effects of parameters on the responses were studied and a mathematical model was obtained for each response. The direct linear effects of all parameters on all responses were significant. But among the interaction effects, the effect of B×C on the nugget radius, the effect of A×B on the nugget thickness, the effect of A×B on the nugget area and the effects of A×B and B×C on the HAZ radius were significant. Also, current intensity had the greatest effect on all responses.

The diffusion couple method is an appreciated experimental approach in taking in phase relations in multi-component systems. To investigate the growth mechanism of the phases and the diffusion of the components, Ni–Ti diffusion couple experiments are carried out at four different temperatures of 750, 800, 850, and 900 °C up to 24 h. Microstructural observations using scanning electron microscopy equipped with energy dispersive spectroscopy at the interface of the nickel-titanium indicates formation of three major intermetallic compounds by the sequence of NiTi2, Ni3Ti and NiTi. Using typical marker tests with incremental diffusion couples, data about mobilities of elemental type intermetallic phase media can be attained, and tracer diffusion coefficients can be presumed. By using of cerium oxide particles as an inert marker, it is shown that the diffusion of nickel atoms toward titanium is faster than the diffusion of titanium atoms through the compound layers. The marker plane is detected at the interface of Ni/Ni3Ti.The ratio of intrinsic diffusivities indicates that Ni is the predominant diffusing element in this system. The activation energies for the formation and growth of NiTi2, NiTi, Ni3Ti, and the total interfacial layers are found to be respectively 204, 151, 38, and 154 kJ/mol. In addition, the integrated diffusion coefficients are calculated by use of Wagner method. The activation energies for the integrated diffusion coefficient of NiTi2, NiTi and Ni3Ti are calculated as 168,149 and 78 kJ/mol, respectively.

Polypropylene (PP)/acrylonitrile butadiene rubber (NBR) composite plates reinforced with halloysite nanotubes (HNTs) were manufactured in the presence of dual compatibilizers: PP-grafted maleic anhydride (PP-g-MA) and styrene ethylene butylene styrene-grafted maleic anhydride (SEBS-g-MA). The mechanical characteristics and microstructure of the PP/NBR/HNT nanocomposites were investigated as a function of NBR content (10, 20, and 30 wt.%) and HNTs content (3, 5, and 7 wt.%). The results demonstrated that the rubber particles were well dispersed over the PP matrix and that the HNTs were partly agglomerated at contents above 5%. Friction stir welding (FSW) was used to join the nanocomposite plates. A significant reduction in scattered NBR droplet size was seen in the FS-welded specimens containing 80/20 (wt/wt) PP/NBR composites in the presence of a dual compatibilizer. Considerable improvement in particle dispersion was observed in the case of PP/NBR blends filled 80/20 (wt/wt) with HNTs joined using FSW, leading to enhanced mechanical properties in the joints. This was due to the stirring action of the FSW tool. Suitable agreement between anticipated and confirmed values was observed in experiments.

Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

Ni–Mn–Ga Heusler alloys are multifunctional materials that demonstrate macroscopic strain under an externally applied magnetic field through the motion of martensite twin boundaries within the microstructure. This study sought to comprehensively characterize the microstructural, mechanical, thermal, and magnetic properties near the solidus in binder-jet 3D printed 14M Ni50Mn30Ga20. Neutron diffraction data were analyzed to identify the martensite modulation and observe the grain size evolution in samples sintered at temperatures of 1080 °C and 1090 °C. Large clusters of high neutron-count pixels in samples sintered at 1090 °C were identified, suggesting Bragg diffraction of large grains (near doubling in size) compared to 1080 °C sintered samples. The grain size was confirmed through quantitative stereology of polished surfaces for differently sintered and heat-treated samples. Nanoindentation testing revealed a greater resistance to plasticity and a larger elastic modulus in 1090 °C sintered samples (relative density ~95%) compared to the samples sintered at 1080 °C (relative density ~80%). Martensitic transformation temperatures were lower for samples sintered at 1090 °C than 1080 °C, though a further heat treatment step could be added to tailor the transformation temperature. Microstructurally, twin variants ≤10 μm in width were observed and the presence of magnetic anisotropy was confirmed through magnetic force microscopy. This study indicates that a 10 °C sintering temperature difference can largely affect the microstructure and mechanical properties (including elastic modulus and hardness) while still allowing for the presence of magnetic twin variants in the resulting modulated martensite.