1. Loss of stromal cell Thy-1 plays a critical role in lipopolysaccharide induced chronic lung allograft dysfunction
- Author
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Atsushi Hata, Yizhan Guo, Andrew E. Miller, Mika Hata, Zhongcheng Mei, Amir Manafi, Dongge Li, Anirban Banerjee, Eric Lazear, Christine Lau, Andrew E. Gelman, Daniel Kreisel, Ichiro Yoshino, David Wilkes, Thomas H. Barker, and Alexander Sasha Krupnick
- Subjects
Lipopolysaccharides ,Mice, Inbred C57BL ,Pulmonary and Respiratory Medicine ,Mice ,Transplantation ,Animals ,Surgery ,Stromal Cells ,Allografts ,Cardiology and Cardiovascular Medicine ,Fibrosis ,Lung ,Lung Transplantation - Abstract
Long-term survival of lung transplants lags behind other solid organs due to early onset of a fibrotic form of chronic rejection known as chronic lung allograft dysfunction (CLAD). Preventing CLAD is difficult as multiple immunologic and physiologic insults contribute to its development. Targeting fibroblast activation, which is the final common pathway leading to CLAD, offers the opportunity to ameliorate fibrosis irrespective of the initiating insult. Thy-1 is a surface glycoprotein that controls fibroblast differentiation and activation.To study the role of Thy-1 in CLAD, we utilized the minor antigen mismatched C57BL/6 (B6More severe CLAD was evident in B6Our findings suggest that the loss of Thy-1 on fibroblasts is a previously unrecognized cause of CLAD and its replacement may offer therapeutic applications for amelioration of this disease post-transplantation in the setting of infectious stress responses.
- Published
- 2022
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