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Your search keyword '"Alsaiari, Shahad"' showing total 9 results
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9 results on '"Alsaiari, Shahad"'

1. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines

Author

vander Straeten, Aurélien, Sarmadi, Morteza, Daristotle, John L., Kanelli, Maria, Tostanoski, Lisa H., Collins, Joe, Pardeshi, Apurva, Han, Jooli, Varshney, Dhruv, Eshaghi, Behnaz, Garcia, Johnny, Forster, Timothy A., Li, Gary, Menon, Nandita, Pyon, Sydney L., Zhang, Linzixuan, Jacob-Dolan, Catherine, Powers, Olivia C., Hall, Kevin, Alsaiari, Shahad K., Wolf, Morris, Tibbitt, Mark W., Farra, Robert, Barouch, Dan H., Langer, Robert, and Jaklenec, Ana

Published
2024
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2. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer

Author

Alsaiari, Shahad K., primary, Nadeef, Seba, additional, Daristotle, John L., additional, Rothwell, William, additional, Du, Bujie, additional, Garcia, Johnny, additional, Zhang, Linzixuan, additional, Sarmadi, Morteza, additional, Forster, Timothy A., additional, Menon, Nandita, additional, Lin, Stacey Qiaohui, additional, Tostanoski, Lisa H., additional, Hachmann, Nicole, additional, Wang, Erika Yan, additional, Ventura, John D., additional, Barouch, Dan H., additional, Langer, Robert, additional, and Jaklenec, Ana, additional

Published
2024
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3. On‐Patient Temporary Medical Record for Accurate, Time‐Sensitive Information at the Point of Care

Author

Collins, Joe, primary, Han, Jooli, additional, Sarmadi, Morteza, additional, Allison‐Logan, Stephanie, additional, Straeten, Aurelien vander, additional, Perkinson, Collin F., additional, Acolaste, Sarah, additional, Kanelli, Maria, additional, Daristotle, John, additional, Karchin, Ari, additional, Henderson, Mitchell, additional, Cruz, Mache, additional, Artzi, Dolev, additional, Alsaiari, Shahad K., additional, Zhang, Linzixuan, additional, Levy, Lauren, additional, Wood, Lowell, additional, Jing, Lihong, additional, McHugh, Kevin J., additional, Bawendi, Moungi G., additional, Langer,, Robert, additional, and Jaklenec, Ana, additional

Published
2024
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4. A microneedle vaccine printer for thermostable COVID-19 mRNA vaccines

Author

vander Straeten, Aurélien, primary, Sarmadi, Morteza, additional, Daristotle, John L., additional, Kanelli, Maria, additional, Tostanoski, Lisa H., additional, Collins, Joe, additional, Pardeshi, Apurva, additional, Han, Jooli, additional, Varshney, Dhruv, additional, Eshaghi, Behnaz, additional, Garcia, Johnny, additional, Forster, Timothy A., additional, Li, Gary, additional, Menon, Nandita, additional, Pyon, Sydney L., additional, Zhang, Linzixuan, additional, Jacob-Dolan, Catherine, additional, Powers, Olivia C., additional, Hall, Kevin, additional, Alsaiari, Shahad K., additional, Wolf, Morris, additional, Tibbitt, Mark W., additional, Farra, Robert, additional, Barouch, Dan H., additional, Langer, Robert, additional, and Jaklenec, Ana, additional

Published
2023
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5. A Machine Learning-optimized system for on demand, pulsatile, photo- and chemo-therapeutic treatment using near-infrared responsive MoS2-based microparticles in a breast cancer model

Author

Kanelli, Maria, primary, Bardhan, Neelkanth M., additional, Sarmadi, Morteza, additional, Alsaiari, Shahad, additional, Rothwell, William T., additional, Pardeshi, Apurva, additional, De Fiesta, Dominique C., additional, Mak, Howard, additional, Spanoudaki, Virginia, additional, Henning, Nicole, additional, Han, Jooli, additional, Belcher, Angela M., additional, Langer, Robert S., additional, and Jaklenec, Ana, additional

Published
2023
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7. A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS2-Based Microparticles in a Breast Cancer Model

Author

Kanelli, Maria, Bardhan, Neelkanth M., Sarmadi, Morteza, Eshaghi, Behnaz, Alsaiari, Shahad K., Rothwell, William T., Pardeshi, Apurva, Varshney, Dhruv, De Fiesta, Dominique C., Mak, Howard, Spanoudaki, Virginia, Henning, Nicole, Kumar, Ashutosh, Han, Jooli, Belcher, Angela M., Langer, Robert, and Jaklenec, Ana

Abstract

Multimodal cancer therapies are often required for progressive cancers due to the high persistence and mortality of the disease and the negative systemic side effects of traditional therapeutic methods. Thus, the development of less invasive modalities for recurring treatment cycles is of clinical significance. Herein, a light-activatable microparticle system was developed for localized, pulsatile delivery of anticancer drugs with simultaneous thermal ablation by applying controlled ON–OFF thermal cycles using near-infrared laser irradiation. The system is composed of poly(caprolactone) microparticles of 200 μm size containing molybdenum disulfide (MoS2) nanosheets as the photothermal agent and hydrophilic doxorubicin or hydrophobic violacein, as model drugs. Upon irradiation, the nanosheets heat up to ≥50 °C leading to polymer softening and release of the drug. MoS2nanosheets exhibit high photothermal conversion efficiency and require low-power laser irradiation. A machine learning algorithm was applied to acquire the optimal laser operation conditions. In a mouse subcutaneous model of 4T1 triple-negative breast cancer, 25 microparticles were intratumorally administered, and after 3-cycle laser treatment, the system conferred synergistic phototherapeutic and chemotherapeutic effects. Our on-demand, pulsatile synergistic treatment resulted in increased median survival up to 39 days post start of treatment compared to untreated mice, with complete eradication of the tumors at the primary site. Such a system is therapeutically relevant for patients in need of recurring cycles of treatment on small tumors, since it provides precise localization and low invasiveness and is not cross-resistant with other treatments.

Published
2024
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8. A Machine Learning-Optimized System for Pulsatile, Photo- and Chemotherapeutic Treatment Using Near-Infrared Responsive MoS 2 -Based Microparticles in a Breast Cancer Model.

Author

Kanelli M, Bardhan NM, Sarmadi M, Eshaghi B, Alsaiari SK, Rothwell WT, Pardeshi A, Varshney D, De Fiesta DC, Mak H, Spanoudaki V, Henning N, Kumar A, Han J, Belcher AM, Langer R, and Jaklenec A

Abstract

Multimodal cancer therapies are often required for progressive cancers due to the high persistence and mortality of the disease and the negative systemic side effects of traditional therapeutic methods. Thus, the development of less invasive modalities for recurring treatment cycles is of clinical significance. Herein, a light-activatable microparticle system was developed for localized, pulsatile delivery of anticancer drugs with simultaneous thermal ablation by applying controlled ON-OFF thermal cycles using near-infrared laser irradiation. The system is composed of poly(caprolactone) microparticles of 200 μm size containing molybdenum disulfide (MoS 2 ) nanosheets as the photothermal agent and hydrophilic doxorubicin or hydrophobic violacein, as model drugs. Upon irradiation, the nanosheets heat up to ≥50 °C leading to polymer softening and release of the drug. MoS 2 nanosheets exhibit high photothermal conversion efficiency and require low-power laser irradiation. A machine learning algorithm was applied to acquire the optimal laser operation conditions. In a mouse subcutaneous model of 4T1 triple-negative breast cancer, 25 microparticles were intratumorally administered, and after 3-cycle laser treatment, the system conferred synergistic phototherapeutic and chemotherapeutic effects. Our on-demand, pulsatile synergistic treatment resulted in increased median survival up to 39 days post start of treatment compared to untreated mice, with complete eradication of the tumors at the primary site. Such a system is therapeutically relevant for patients in need of recurring cycles of treatment on small tumors, since it provides precise localization and low invasiveness and is not cross-resistant with other treatments.

Published
2024
Full Text
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9. A Machine Learning-optimized system for on demand, pulsatile, photo- and chemo-therapeutic treatment using near-infrared responsive MoS 2 -based microparticles in a breast cancer model.

Author

Kanelli M, Bardhan NM, Sarmadi M, Alsaiari S, Rothwell WT, Pardeshi A, De Fiesta DC, Mak H, Spanoudaki V, Henning N, Han J, Belcher AM, Langer RS, and Jaklenec A

Abstract

Cancer therapy research is of high interest because of the persistence and mortality of the disease and the side effects of traditional therapeutic methods, while often multimodal treatments are necessary based on the patient's needs. The development of less invasive modalities for recurring treatment cycles is thus of critical significance. Herein, a light-activatable microparticle system was developed for localized, pulsatile delivery of anticancer drugs with simultaneous thermal ablation, by applying controlled ON-OFF thermal cycles using near-infrared laser irradiation. The system is composed of poly(caprolactone) microparticles of 200 μm size with incorporated molybdenum disulfide (MoS 2 ) nanosheets as the photothermal agent and hydrophilic doxorubicin or hydrophobic violacein, as model drugs. Upon irradiation the nanosheets heat up to ≥50 °C leading to polymer matrix melting and release of the drug. MoS 2 nanosheets exhibit high photothermal conversion efficiency and allow for application of low power laser irradiation for the system activation. A Machine Learning algorithm was applied to acquire optimal laser operation conditions; 0.4 W/cm 2 laser power at 808 nm, 3-cycle irradiation, for 3 cumulative minutes. In a mouse subcutaneous model of 4T1 triple-negative breast cancer, 25 microparticles were intratumorally administered and after 3-cycle laser treatment the system conferred synergistic phototherapeutic and chemotherapeutic effect. Our on-demand, pulsatile synergistic treatment resulted in increased median survival up to 40 days post start of treatment compared to untreated mice, with complete eradication of the tumors at the primary site. Such a system could have potential for patients in need of recurring cycles of treatment on subcutaneous tumors.

Published
2023
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