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1. Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia

Author

Asken, Breton M, Bove, Jessica M, Bauer, Russell M, Tanner, Jeremy A, Casaletto, Kaitlin B, Staffaroni, Adam M, VandeVrede, Lawren, Alosco, Michael L, Mez, Jesse B, Stern, Robert A, Miller, Bruce L, Grinberg, Lea T, Boxer, Adam L, Gorno-Tempini, Maria Luisa, Rosen, Howie J, Rabinovici, Gil D, and Kramer, Joel H

Subjects
Biomedical and Clinical Sciences, Health Sciences, Aging, Mental Health, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Rare Diseases, Traumatic Head and Spine Injury, Traumatic Brain Injury (TBI), Clinical Research, Acquired Cognitive Impairment, Neurodegenerative, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Aphasia, Frontotemporal Dementia (FTD), Physical Injury - Accidents and Adverse Effects, Behavioral and Social Science, 2.1 Biological and endogenous factors, Neurological, Good Health and Well Being, Humans, Male, Female, Frontotemporal Dementia, Aged, Aphasia, Primary Progressive, Middle Aged, Craniocerebral Trauma, Neuropsychological Tests, Frontotemporal dementia, Primary progressive aphasia, Repetitive head impacts, Risk factor, Traumatic brain injury, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundTraumatic brain injury (TBI) and repetitive head impacts (RHI) have been linked to increased risk for multiple types of neurodegenerative disease, higher dementia risk, and earlier age of dementia symptom onset, suggesting transdiagnostic implications for later-life brain health. Frontotemporal dementia (FTD) and primary progressive aphasia (PPA) represent a spectrum of clinical phenotypes that are neuropathologically diverse. FTD/PPA diagnoses bring unique challenges due to complex cognitive and behavioral symptoms that disproportionately present as an early-onset dementia (before age 65). We performed a detailed characterization of lifetime head trauma exposure in individuals with FTD and PPA compared to healthy controls to examine frequency of lifetime TBI and RHI and associated clinical implications.MethodsWe studied 132 FTD/PPA (age 68.9 ± 8.1, 65% male) and 132 sex-matched healthy controls (HC; age 73.4 ± 7.6). We compared rates of prior TBI and RHI (contact/collision sports) between FTD/PPA and HC (chi-square, logistic regression, analysis of variance). Within FTD/PPA, we evaluated associations with age of symptom onset (analysis of variance). Within behavioral variant FTD, we evaluated associations with cognitive function and neuropsychiatric symptoms (linear regression controlling for age, sex, and years of education).ResultsYears of participation were greater in FTD/PPA than HC for any contact/collision sport (8.5 ± 6.7yrs vs. 5.3 ± 4.5yrs, p = .008) and for American football (6.2yrs ± 4.3yrs vs. 3.1 ± 2.4yrs; p = .003). Within FTD/PPA, there were dose-dependent associations with earlier age of symptom onset for TBI (0 TBI: 62.1 ± 8.1, 1 TBI: 59.9 ± 6.9, 2 + TBI: 57.3 ± 8.4; p = .03) and years of American football (0yrs: 62.2 ± 8.7, 1-4yrs: 59.7 ± 7.0, 5 + yrs: 55.9 ± 6.3; p = .009). Within bvFTD, those who played American football had worse memory (z-score: -2.4 ± 1.2 vs. -1.4 ± 1.6, p = .02, d = 1.1).ConclusionsLifetime head trauma may represent a preventable environmental risk factor for FTD/PPA. Dose-dependent exposure to TBI or RHI influences FTD/PPA symptom onset and memory function in bvFTD. Clinico-pathological studies are needed to better understand the neuropathological correlates linking RHI or TBI to FTD/PPA onset and symptoms.

Published
2024

2. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE

Author

Alexander, Abigail, Alvarez, Victor E., Huber, Bertrand R., Alosco, Michael L., Mez, Jesse, Tripodis, Yorghos, Nicks, Raymond, Katz, Douglas I., Dwyer, Brigid, Daneshvar, Daniel H., Martin, Brett, Palmisano, Joseph, Goldstein, Lee E., Crary, John F., Nowinski, Christopher, Cantu, Robert C., Kowall, Neil W., Stern, Robert A., Delalle, Ivana, McKee, Ann C., and Stein, Thor D.

Published
2024
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3. Optimal blood tau species for the detection of Alzheimer’s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study

Author

Montoliu-Gaya, Laia, Alosco, Michael L., Yhang, Eukyung, Tripodis, Yorghos, Sconzo, Daniel, Ally, Madeline, Grötschel, Lana, Ashton, Nicholas J., Lantero-Rodriguez, Juan, Sauer, Mathias, Gomes, Bárbara, Nilsson, Johanna, Brinkmalm, Gunnar, Sugarman, Michael A., Aparicio, Hugo J., Martin, Brett, Palmisano, Joseph N., Steinberg, Eric G., Simkin, Irene, Turk, Katherine W., Budson, Andrew E., Au, Rhoda, Farrer, Lindsay, Jun, Gyungah R., Kowall, Neil W., Stern, Robert A., Goldstein, Lee E., Qiu, Wei Qiao, Mez, Jesse, Huber, Bertrand Russell, Alvarez, Victor E., McKee, Ann C., Zetterberg, Henrik, Gobom, Johan, Stein, Thor D., and Blennow, Kaj

Published
2024
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5. Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts

Author

Alosco, Michael L, Ly, Monica, Mosaheb, Sydney, Saltiel, Nicole, Uretsky, Madeline, Tripodis, Yorghos, Martin, Brett, Palmisano, Joseph, Delano-Wood, Lisa, Bondi, Mark W, Meng, Gaoyuan, Xia, Weiming, Daley, Sarah, Goldstein, Lee E, Katz, Douglas I, Dwyer, Brigid, Daneshvar, Daniel H, Nowinski, Christopher, Cantu, Robert C, Kowall, Neil W, Stern, Robert A, Alvarez, Victor E, Mez, Jesse, Huber, Bertrand Russell, McKee, Ann C, and Stein, Thor D

Subjects
Biological Psychology, Psychology, Acquired Cognitive Impairment, Brain Disorders, Neurodegenerative, Neurosciences, Neurological, Good Health and Well Being, myelin, cerebrovascular disease, chronic traumatic encephalopathy, repetitive head impacts, white matter, Clinical sciences, Biological psychology
Abstract

American football players and other individuals exposed to repetitive head impacts can exhibit a constellation of later-life cognitive and neuropsychiatric symptoms. While tau-based diseases such as chronic traumatic encephalopathy can underpin certain symptoms, contributions from non-tau pathologies from repetitive head impacts are increasingly recognized. We examined cross-sectional associations between myelin integrity using immunoassays for myelin-associated glycoprotein and proteolipid protein 1 with risk factors and clinical outcomes in brain donors exposed to repetitive head impacts from American football. Immunoassays for myelin-associated glycoprotein and proteolipid protein 1 were conducted on dorsolateral frontal white matter tissue samples of 205 male brain donors. Proxies of exposure to repetitive head impacts included years of exposure and age of first exposure to American football play. Informants completed the Functional Activities Questionnaire, Behavior Rating Inventory of Executive Function-Adult Version (Behavioral Regulation Index), and Barratt Impulsiveness Scale-11. Associations between myelin-associated glycoprotein and proteolipid protein 1 with exposure proxies and clinical scales were tested. Of the 205 male brain donors who played amateur and professional football, the mean age was 67.17 (SD = 16.78), and 75.9% (n = 126) were reported by informants to be functionally impaired prior to death. Myelin-associated glycoprotein and proteolipid protein 1 correlated with the ischaemic injury scale score, a global indicator of cerebrovascular disease (r = -0.23 and -0.20, respectively, Ps < 0.01). Chronic traumatic encephalopathy was the most common neurodegenerative disease (n = 151, 73.7%). Myelin-associated glycoprotein and proteolipid protein 1 were not associated with chronic traumatic encephalopathy status, but lower proteolipid protein 1 was associated with more severe chronic traumatic encephalopathy (P = 0.03). Myelin-associated glycoprotein and proteolipid protein 1 were not associated with other neurodegenerative disease pathologies. More years of football play was associated with lower proteolipid protein 1 [beta = -2.45, 95% confidence interval (CI) [-4.52, -0.38]] and compared with those who played

Published
2023

6. Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players

Author

Alosco, Michael L, Su, Yi, Stein, Thor D, Protas, Hillary, Cherry, Jonathan D, Adler, Charles H, Balcer, Laura J, Bernick, Charles, Pulukuri, Surya Vamsi, Abdolmohammadi, Bobak, Coleman, Michael J, Palmisano, Joseph N, Tripodis, Yorghos, Mez, Jesse, Rabinovici, Gil D, Marek, Kenneth L, Beach, Thomas G, Johnson, Keith A, Huber, Bertrand Russell, Koerte, Inga, Lin, Alexander P, Bouix, Sylvain, Cummings, Jeffrey L, Shenton, Martha E, Reiman, Eric M, McKee, Ann C, and Stern, Robert A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Aging, Physical Injury - Accidents and Adverse Effects, Acquired Cognitive Impairment, Brain Disorders, Alzheimer's Disease, Dementia, Neurosciences, Neurodegenerative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurological, Humans, Alzheimer Disease, Autopsy, Brain, Brain Injuries, Traumatic, Chronic Traumatic Encephalopathy, Death, Football, Positron-Emission Tomography, tau Proteins, Biomarkers, Chronic traumatic encephalopathy, Neurodegenerative disease, Positron emission tomography imaging, Repetitive head impacts, Tau, Flortaucipir, DIAGNOSE C. T. E. Research Project, Other Physical Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

PurposeFlourine-18-flortaucipir tau positron emission tomography (PET) was developed for the detection for Alzheimer's disease. Human imaging studies have begun to investigate its use in chronic traumatic encephalopathy (CTE). Flortaucipir-PET to autopsy correlation studies in CTE are needed for diagnostic validation. We examined the association between end-of-life flortaucipir PET and postmortem neuropathological measurements of CTE-related tau in six former American football players.MethodsThree former National Football League players and three former college football players who were part of the DIAGNOSE CTE Research Project died and agreed to have their brains donated. The six players had flortaucipir (tau) and florbetapir (amyloid) PET prior to death. All brains from the deceased participants were neuropathologically evaluated for the presence of CTE. On average, the participants were 59.0 (SD = 9.32) years of age at time of PET. PET scans were acquired 20.33 (SD = 13.08) months before their death. Using Spearman correlation analyses, we compared flortaucipir standard uptake value ratios (SUVRs) to digital slide-based AT8 phosphorylated tau (p-tau) density in a priori selected composite cortical, composite limbic, and thalamic regions-of-interest (ROIs).ResultsFour brain donors had autopsy-confirmed CTE, all with high stage disease (n = 3 stage III, n = 1 stage IV). Three of these four met criteria for the clinical syndrome of CTE, known as traumatic encephalopathy syndrome (TES). Two did not have CTE at autopsy and one of these met criteria for TES. Concomitant pathology was only present in one of the non-CTE cases (Lewy body) and one of the CTE cases (motor neuron disease). There was a strong association between flortaucipir SUVRs and p-tau density in the composite cortical (ρ = 0.71) and limbic (ρ = 0.77) ROIs. Although there was a strong association in the thalamic ROI (ρ = 0.83), this is a region with known off-target binding. SUVRs were modest and CTE and non-CTE cases had overlapping SUVRs and discordant p-tau density for some regions.ConclusionsFlortaucipir-PET could be useful for detecting high stage CTE neuropathology, but specificity to CTE p-tau is uncertain. Off-target flortaucipir binding in the hippocampus and thalamus complicates interpretation of these associations. In vivo biomarkers that can detect the specific p-tau of CTE across the disease continuum are needed.

Published
2023

7. Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study

Author

Tao, Qiushan, Akhter-Khan, Samia C, Ang, Ting Fang Alvin, DeCarli, Charles, Alosco, Michael L, Mez, Jesse, Killiany, Ronald, Devine, Sherral, Rokach, Ami, Itchapurapu, Indira Swetha, Zhang, Xiaoling, Lunetta, Kathryn L, Steffens, David C, Farrer, Lindsay A, Greve, Douglas N, Au, Rhoda, and Qiu, Wei Qiao

Subjects
Health Services and Systems, Public Health, Health Sciences, Alzheimer's Disease, Acquired Cognitive Impairment, Depression, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Biomedical Imaging, Behavioral and Social Science, Brain Disorders, Neurodegenerative, Mental Illness, Clinical Research, Basic Behavioral and Social Science, Mental Health, Dementia, Aetiology, 2.3 Psychological, social and economic factors, Mental health, Neurological, Social isolation, Alzheimer?s disease, Neuroimaging, Cohort study, Brain health, Alzheimer's disease, Clinical sciences, Health services and systems, Public health
Abstract

BackgroundIt remains unclear whether persistent loneliness is related to brain structures that are associated with cognitive decline and development of Alzheimer's disease (AD). This study aimed to investigate the relationships between different loneliness types, cognitive functioning, and regional brain volumes.MethodsLoneliness was measured longitudinally, using the item from the Center for Epidemiologic Studies Depression Scale in the Framingham Heart Study, Generation 3, with participants' average age of 46·3 ± 8·6 years. Robust regression models tested the association between different loneliness types with longitudinal neuropsychological performance (n = 2,609) and regional magnetic resonance imaging brain data (n = 1,829) (2002-2019). Results were stratified for sex, depression, and Apolipoprotein E4 (ApoE4).FindingsPersistent loneliness, but not transient loneliness, was strongly associated with cognitive decline, especially memory and executive function. Persistent loneliness was negatively associated with temporal lobe volume (β = -0.18, 95%CI [-0.32, -0.04], P = 0·01). Among women, persistent loneliness was associated with smaller frontal lobe (β = -0.19, 95%CI [-0.38, -0.01], P = 0·04), temporal lobe (β = -0.20, 95%CI [-0.37, -0.03], P = 0·02), and hippocampus volumes (β = -0.23, 95%CI [-0.40, -0.06], P = 0·007), and larger lateral ventricle volume (β = 0.15, 95%CI [0.02, 0.28], P = 0·03). The higher cumulative loneliness scores across three exams, the smaller parietal, temporal, and hippocampus volumes and larger lateral ventricle were evident, especially in the presence of ApoE4.InterpretationPersistent loneliness in midlife was associated with atrophy in brain regions responsible for memory and executive dysfunction. Interventions to reduce the chronicity of loneliness may mitigate the risk of age-related cognitive decline and AD.FundingUS National Institute on Aging.

Published
2022

8. Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project

Author

Stern, Robert A., Trujillo-Rodriguez, Diana, Tripodis, Yorghos, Pulukuri, Surya V., Alosco, Michael L., Adler, Charles H., Balcer, Laura J., Bernick, Charles, Baucom, Zachary, Marek, Kenneth L., McClean, Michael D., Johnson, Keith A., McKee, Ann C., Stein, Thor D., Mez, Jesse, Palmisano, Joseph N., Cummings, Jeffrey L., Shenton, Martha E., and Reiman, Eric M.

Published
2023
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10. Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males

Author

Daneshvar, Daniel H., Nair, Evan S., Baucom, Zachary H., Rasch, Abigail, Abdolmohammadi, Bobak, Uretsky, Madeline, Saltiel, Nicole, Shah, Arsal, Jarnagin, Johnny, Baugh, Christine M., Martin, Brett M., Palmisano, Joseph N., Cherry, Jonathan D., Alvarez, Victor E., Huber, Bertrand R., Weuve, Jennifer, Nowinski, Christopher J., Cantu, Robert C., Zafonte, Ross D., Dwyer, Brigid, Crary, John F., Goldstein, Lee E., Kowall, Neil W., Katz, Douglas I., Stern, Robert A., Tripodis, Yorghos, Stein, Thor D., McClean, Michael D., Alosco, Michael L., McKee, Ann C., and Mez, Jesse

Published
2023
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11. Neuropsychological test performance of former American football players

Author

Alosco, Michael L., Barr, William B., Banks, Sarah J., Wethe, Jennifer V., Miller, Justin B., Pulukuri, Surya Vamsi, Culhane, Julia, Tripodis, Yorghos, Adler, Charles H., Balcer, Laura J., Bernick, Charles, Mariani, Megan L., Cantu, Robert C., Dodick, David W., McClean, Michael D., Au, Rhoda, Mez, Jesse, Turner, II, Robert W., Palmisano, Joseph N., Martin, Brett, Hartlage, Kaitlin, Cummings, Jeffrey L., Reiman, Eric M., Shenton, Martha E., and Stern, Robert A.

Published
2023
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12. Examination of parkinsonism in former elite American football players

Author

Alosco, Michael L., Adler, Charles H., Dodick, David W., Tripodis, Yorghos, Balcer, Laura J., Bernick, Charles, Banks, Sarah J., Barr, William B., Wethe, Jennifer V., Palmisano, Joseph N., Martin, Brett, Hartlage, Kaitlin, Cantu, Robert C., Geda, Yonas E., Katz, Douglas I., Mez, Jesse, Cummings, Jeffery L., Shenton, Martha E., Reiman, Eric M., and Stern, Robert A.

Published
2024
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14. Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis

Author

Nicks, Raymond, Clement, Nathan F., Alvarez, Victor E., Tripodis, Yorghos, Baucom, Zachery H., Huber, Bertrand R., Mez, Jesse, Alosco, Michael L., Aytan, Nurgul, Cherry, Jonathan D., Cormier, Kerry A., Kubilius, Carol, Mathias, Rebecca, Svirsky, Sarah E., Pothast, Morgan J., Hildebrandt, Audrey M., Chung, Jaeyoon, Han, Xudong, Crary, John F., McKee, Ann C., Frosch, Matthew P., and Stein, Thor D.

Published
2023
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17. Multimodal deep learning for Alzheimer’s disease dementia assessment

Author

Qiu, Shangran, Miller, Matthew I., Joshi, Prajakta S., Lee, Joyce C., Xue, Chonghua, Ni, Yunruo, Wang, Yuwei, De Anda-Duran, Ileana, Hwang, Phillip H., Cramer, Justin A., Dwyer, Brigid C., Hao, Honglin, Kaku, Michelle C., Kedar, Sachin, Lee, Peter H., Mian, Asim Z., Murman, Daniel L., O’Shea, Sarah, Paul, Aaron B., Saint-Hilaire, Marie-Helene, Alton Sartor, E., Saxena, Aneeta R., Shih, Ludy C., Small, Juan E., Smith, Maximilian J., Swaminathan, Arun, Takahashi, Courtney E., Taraschenko, Olga, You, Hui, Yuan, Jing, Zhou, Yan, Zhu, Shuhan, Alosco, Michael L., Mez, Jesse, Stein, Thor D., Poston, Kathleen L., Au, Rhoda, and Kolachalama, Vijaya B.

Published
2022
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18. A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease

Author

Turk, Katherine W., Geada, Alexandra, Alvarez, Victor E., Xia, Weiming, Cherry, Jonathan D., Nicks, Raymond, Meng, Gaoyuan, Daley, Sarah, Tripodis, Yorghos, Huber, Bertrand R., Budson, Andrew E., Dwyer, Brigid, Kowall, Neil W., Cantu, Robert C., Goldstein, Lee E., Katz, Douglas I., Stern, Robert A., Alosco, Michael L., Mez, Jesse, McKee, Ann C., and Stein, Thor D.

Published
2022
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19. Substantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy.

Author

Adams, Jason W., Kirsch, Daniel, Calderazzo, Samantha M., Tuz-Zahra, Fatima, Tripodis, Yorghos, Mez, Jesse, Alosco, Michael L., Alvarez, Victor E., Huber, Bertrand R., Kubilus, Caroline, Cormier, Kerry A., Nicks, Raymond, Uretsky, Madeline, Nair, Evan, Kuzyk, Eva, Aytan, Nurgul, Cherry, Jonathan D., Crary, John F., Daneshvar, Daniel H., and Nowinski, Christopher J.

Published
2024
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20. Neurodegenerative biomarkers in different chambers of the eye relative to plasma: an agreement validation study.

Author

Sampani, Konstantina, Ness, Steven, Tuz-Zahra, Fatima, Aytan, Nurgul, Spurlock, Elizabeth E., Alluri, Sreevardhan, Chen, Xuejing, Siegel, Nicole H., Alosco, Michael L., Xia, Weiming, Tripodis, Yorghos, Stein, Thor D., and Subramanian, Manju L.

Subjects
GLIAL fibrillary acidic protein, VITREOUS humor, AQUEOUS humor, TAU proteins, ALZHEIMER'S disease
Abstract

Background: Protein biomarkers have been broadly investigated in cerebrospinal fluid and blood for the detection of neurodegenerative diseases, yet a clinically useful diagnostic test to detect early, pre-symptomatic Alzheimer's disease (AD) remains elusive. We conducted this study to quantify Aβ40, Aβ42, total Tau (t-Tau), hyperphosphorylated Tau (ptau181), glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in eye fluids relative to blood. Methods: In this cross-sectional study we collected vitreous humor, aqueous humor, tear fluid and plasma in patients undergoing surgery for eye disease. All six biomarkers were quantitatively measured by digital immunoassay. Spearman and Bland–Altman correlation analyses were performed to assess the agreement of levels between ocular fluids and plasma. Results: Seventy-nine adults underwent pars-plana vitrectomy in at least one eye. Of the 79, there were 77 vitreous, 67 blood, 56 tear fluid, and 51 aqueous samples. All six biomarkers were quantified in each bio-sample, except GFAP and NfL in tear fluid due to low sample volume. All six biomarkers were elevated in vitreous humor compared to plasma samples. T-Tau, ptau181, GFAP and NfL were higher in aqueous than in plasma, and t-Tau and ptau181 concentrations were higher in tear fluid than in plasma. Significant correlations were found between Aβ40 in plasma and tears (r = 0.5; p = 0.019), t-Tau in plasma and vitreous (r = 0.4; p = 0.004), NfL in plasma and vitreous (r = 0.3; p = 0.006) and plasma and aqueous (r = 0.5; p = 0.004). No significant associations were found for Aβ42, ptau181 and GFAP among ocular fluids relative to plasma. Bland–Altman analysis showed aqueous humor had the closest agreement to plasma across all biomarkers. Biomarker levels in ocular fluids revealed statistically significant associations between vitreous and aqueous for t-Tau (r = 0.5; p = 0.001), GFAP (r = 0.6; p < 0.001) and NfL (r = 0.7; p < 0.001). Conclusion: AD biomarkers are detectable in greater quantities in eye fluids than in plasma and show correlations with levels in plasma. Future studies are needed to assess the utility of ocular fluid biomarkers as diagnostic and prognostic markers for AD, especially in those at risk with eye disease. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy

Author

Culhane, Julia E., primary, Jackson, Colleen E., additional, Tripodis, Yorghos, additional, Nowinski, Christopher J., additional, Dams-O'Connor, Kristen, additional, Pettway, Erika, additional, Uretsky, Madeline, additional, Abdolmohammadi, Bobak, additional, Nair, Evan, additional, Martin, Brett, additional, Palmisano, Joseph, additional, Katz, Douglas I., additional, Dwyer, Brigid, additional, Daneshvar, Daniel H., additional, Goldstein, Lee E., additional, Kowall, Neil W., additional, Cantu, Robert C., additional, Stern, Robert A., additional, Huber, Bertrand Russell, additional, Crary, John F., additional, Mez, Jesse, additional, Stein, Thor D., additional, McKee, Ann C., additional, and Alosco, Michael L., additional

Published
2024
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23. Brain morphometry in former American football players: Findings from the DIAGNOSE CTE research project

Author

Arciniega, Hector, primary, Baucom, Zachary H, additional, Tuz-Zahra, Fatima, additional, Tripodis, Yorghos, additional, John, Omar, additional, Carrington, Holly, additional, Kim, Nicholas, additional, Knyazhanskaya, Evdokiya E, additional, Jung, Leonard B, additional, Breedlove, Katherine, additional, Wiegand, Tim L T, additional, Daneshvar, Daniel H, additional, Rushmore, R Jarrett, additional, Billah, Tashrif, additional, Pasternak, Ofer, additional, Coleman, Michael J, additional, Adler, Charles H, additional, Bernick, Charles, additional, Balcer, Laura J, additional, Alosco, Michael L, additional, Koerte, Inga K, additional, Lin, Alexander P, additional, Cummings, Jeffrey L, additional, Reiman, Eric M, additional, Stern, Robert A, additional, Shenton, Martha E, additional, and Bouix, Sylvain, additional

Published
2024
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24. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy

Author

Alosco, Michael L., primary, White, Micaela, additional, Bell, Carter, additional, Faheem, Farwa, additional, Tripodis, Yorghos, additional, Yhang, Eukyung, additional, Baucom, Zachary, additional, Martin, Brett, additional, Palmisano, Joseph, additional, Dams-O’Connor, Kristen, additional, Crary, John F., additional, Goldstein, Lee E., additional, Katz, Douglas I., additional, Dwyer, Brigid, additional, Daneshvar, Daniel H., additional, Nowinski, Christopher, additional, Cantu, Robert C., additional, Kowall, Neil W., additional, Stern, Robert A., additional, Alvarez, Victor E., additional, Huber, Bertrand Russell, additional, Stein, Thor D., additional, McKee, Ann C., additional, and Mez, Jesse, additional

Published
2024
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25. Examination of plasma YKL‐40 as a clinical biomarker for Alzheimer’s disease

Author

Sugarman, Michael A, primary, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Karikari, Thomas K, additional, Pase, Matthew P., additional, Himali, Jayandra Jung, additional, Beiser, Alexa S., additional, Seshadri, Sudha, additional, Budson, Andrew E, additional, O'Connor, Maureen K., additional, Au, Rhoda, additional, Goldstein, Lee E, additional, Qiu, Wei Qiao, additional, Kowall, Neil W, additional, Stern, Robert A, additional, McKee, Ann C., additional, Mez, Jesse B., additional, Alosco, Michael L, additional, and Aparicio, Hugo J, additional

Published
2023
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26. Characterizing Cerebrovascular Pathologies in Brain Donors Exposed to Repetitive Head Impacts

Author

Emrani, Sheina, primary, Koutures, Anne, additional, Tripodis, Yorghos, additional, Uretsky, Madeline, additional, Abdolmohammadi, Bobak, additional, Nowinski, Christopher, additional, Daneshvar, Daniel H, additional, Katz, Douglas I, additional, Goldstein, Lee E, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Dams‐O'Connor, Kristen, additional, Crary, John F., additional, Mez, Jesse B., additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, McKee, Ann C., additional, Stein, Thor D., additional, and Alosco, Michael L, additional

Published
2023
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28. MAPT subhaplotypes and chronic traumatic encephalopathy

Author

Han, Xudong, primary, Petrosky, Jillian, additional, Bald, Sarah, additional, Zhang, Yichi, additional, Sherva, Richard, additional, Chung, Jaeyoon, additional, Abdolmohammadi, Bobak, additional, Durape, Shruti, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Farrell, Kurt W., additional, Farrell, John, additional, Cherry, Jonathan D, additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Alosco, Michael L, additional, Tripodis, Yorghos, additional, Stern, Robert A, additional, Stein, Thor D., additional, Farrer, Lindsay A., additional, Crary, John F., additional, McKee, Ann C., additional, and Mez, Jesse B., additional

Published
2023
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29. White matter hyperintensities: A long‐term consequence of repetitive head impacts?

Author

Alosco, Michael L, primary, Ly, Monica T., additional, Tuz‐Zahra, Fatima, additional, Tripodis, Yorghos, additional, Adler, Charles, additional, Balcer, Laura, additional, Bernick, Charles B., additional, Peskind, Elaine R, additional, Mariani, Megan, additional, Au, Rhoda, additional, Banks, Sarah J, additional, Barr, William, additional, Wethe, Jennifer, additional, Bondi, Mark W., additional, Delano‐Wood, Lisa, additional, Cantu, Robert, additional, Coleman, Michael J, additional, Dodick, David W., additional, McClean, Michael D, additional, Mez, Jesse B., additional, Palmisano, Joseph N, additional, Martin, Brett M, additional, Lin, Alexander P, additional, Koerte, Inga, additional, Cummings, Jeffrey L., additional, Reiman, Eric M., additional, Shenton, Martha E, additional, Stern, Robert A, additional, and Bouix, Sylvain, additional

Published
2023
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30. Identifying Optimal Blood Tau Epitopes for the Detection of Alzheimer’s Disease Neuropathology: An Immunoprecipitation Mass Spectrometry and Autopsy Study

Author

Montoliu‐Gaya, Laia, primary, Alosco, Michael L, additional, Yhang, Eukyung, additional, Tripodis, Yorghos, additional, Ashton, Nicholas J., additional, Rodriguez, Juan Lantero, additional, Aparicio, Hugo J, additional, Sugarman, Michael A, additional, Ally, Madeline, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Steinberg, Eric, additional, Simkin, Irene, additional, Turk, Katherine W, additional, Budson, Andrew E, additional, Au, Rhoda, additional, Farrer, Lindsay A., additional, Jun, Gyungah R, additional, Kowall, Neil W, additional, Stern, Robert A, additional, Killiany, Ronald J, additional, Goldstein, Lee E, additional, Qiu, Wei Qiao, additional, Huber, Bertrand R., additional, Mez, Jesse B., additional, McKee, Ann C., additional, Zetterberg, Henrik, additional, Gobom, Johan, additional, and Stein, Thor D., additional

Published
2023
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31. Age of dementia onset and death in chronic traumatic encephalopathy

Author

Ryder, Megan H., primary, Abdolmohammadi, Bobak, additional, Daneshvar, Daniel H, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Tripodis, Yorghos, additional, Stein, Thor D., additional, Alosco, Michael L, additional, McKee, Ann C., additional, and Mez, Jesse B., additional

Published
2023
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33. Investigating Potential Racial Differences in Dementia‐Related Plasma Biomarkers

Author

Pettway, Erika C, primary, Labonte, Jacob, additional, II, Robert W Turner, additional, Bragg, Tahlia, additional, Turner, Arlener, additional, Banks, Sarah J, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Karikari, Thomas K, additional, Tripodis, Yorghos, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Stern, Robert A, additional, Killiany, Ronald J, additional, Aparicio, Hugo J, additional, Goldstein, Lee E, additional, Qiu, Wendy, additional, Budson, Andrew E, additional, Mez, Jesse B., additional, and Alosco, Michael L, additional

Published
2023
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34. Association of Traumatic Brain Injury, Mild Cognitive Impairment and Dementia in the Framingham Heart Study

Author

Durape, Shruti, primary, Joshi, Prajakta S., additional, Burton, Rebecca, additional, Chien‐Young, Kurtis, additional, Price, Eden, additional, Yhang, Eukyung, additional, Liu, Yulin, additional, Ang, Ting Fang Alvin, additional, Devine, Sherral A., additional, Gurnani, Ashita S, additional, Katz, Douglas I, additional, Tripodis, Yorghos, additional, Alosco, Michael L, additional, Dams‐O'Connor, Kristen, additional, Au, Rhoda, additional, and Mez, Jesse B., additional

Published
2023
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35. Sex Differences on Tau, Astrocytic and Neurodegeneration Plasma Biomarkers

Author

Labonte, Jacob, primary, Pettway, Erika C, additional, Sugarman, Michael, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Karikari, Thomas K, additional, Tripodis, Yorghos, additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Stern, Robert A, additional, Killiany, Ronald J, additional, Aparicio, Hugo J, additional, Goldstein, Lee E, additional, Qiu, Wendy, additional, Mez, Jesse B., additional, Banks, Sarah J, additional, and Alosco, Michael L, additional

Published
2023
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36. Fluid Biomarkers for Neurobehavioral Dysregulation in Former American Football Players

Author

van Amerongen, Suzan, primary, Pulukuri, Surya V, additional, Tripodis, Yorghos, additional, Bernick, Charles B., additional, Geda, Yonas E., additional, Wethe, Jennifer, additional, Katz, Douglas I, additional, Alosco, Michael L, additional, Mez, Jesse B., additional, Palmisano, Joseph N, additional, Tuz‐Zahra, Fatima, additional, Adler, Charles, additional, Balcer, Laura, additional, Ashton, Nicholas J., additional, Blennow, Kaj, additional, Iliff, Jeffrey J, additional, Li, Ge, additional, Zetterberg, Henrik, additional, Peskind, Elaine R, additional, Reiman, Eric M., additional, Shenton, Martha E, additional, Cummings, Jeffrey L., additional, and Stern, Robert A, additional

Published
2023
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37. Cognitive, functional, and neuropsychiatric correlates of regional tau in autopsy‐confirmed chronic traumatic encephalopathy

Author

Faheem, Farwa, primary, Alosco, Michael L, additional, White, Micaela, additional, Bell, Carter, additional, Tripodis, Yorghos, additional, Yhang, Eukyung, additional, Baucom, Zachary H., additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Goldstein, Lee E, additional, Katz, Douglas I, additional, Dwyer, Brigid, additional, Daneshvar, Daniel H, additional, Nowinski, Christopher, additional, Cantu, Robert, additional, Kowall, Neil W, additional, Stern, Robert A, additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Stein, Thor D., additional, McKee, Ann C., additional, and Mez, Jesse B., additional

Published
2023
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38. Frequency of repetitive head impacts and influence on clinical variability among male patients with Alzheimer’s disease and frontotemporal dementia

Author

Asken, Breton M., primary, Tanner, Jeremy A., additional, Soleimani‐Meigooni, David N., additional, Knudtson, Marguerite V., additional, Grinberg, Lea T., additional, Miller, Bruce L, additional, Kramer, Joel H., additional, Mez, Jesse B., additional, Alosco, Michael L, additional, and Rabinovici, Gil D., additional

Published
2023
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40. Relative Contributions of Mixed Pathologies to Cognitive and Functional Symptoms in Brain Donors Exposed to Repetitive Head Impacts

Author

Saltiel, Nicole, primary, Tripodis, Yorghos, additional, Menzin, Talia, additional, Olaniyan, Aliyah, additional, Baucom, Zach, additional, Yhang, Eukyung, additional, Palmisano, Joseph N., additional, Martin, Brett, additional, Uretsky, Madeline, additional, Nair, Evan, additional, Abdolmohammadi, Bobak, additional, Shah, Arsal, additional, Nicks, Raymond, additional, Nowinski, Christopher, additional, Cantu, Robert C., additional, Daneshvar, Daniel H., additional, Dwyer, Brigid, additional, Katz, Douglas I., additional, Stern, Robert A., additional, Alvarez, Victor E., additional, Huber, Bertrand, additional, Boyle, Patricia A., additional, Schneider, Julie A., additional, Mez, Jesse, additional, McKee, Ann C., additional, Alosco, Michael L., additional, and Stein, Thor D., additional

Published
2023
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41. Examination of parkinsonism in former elite American football players

Author

Alosco, Michael L., primary, Adler, Charles H., additional, Dodick, David W., additional, Tripodis, Yorghos, additional, Balcer, Laura J., additional, Bernick, Charles, additional, Banks, Sarah J., additional, Barr, William B., additional, Wethe, Jennifer V., additional, Palmisano, Joseph N., additional, Martin, Brett, additional, Hartlage, Kaitlin, additional, Cantu, Robert C., additional, Geda, Yonas E., additional, Katz, Douglas I., additional, Mez, Jesse, additional, Cummings, Jeffery L., additional, Shenton, Martha E., additional, Reiman, Eric M., additional, and Stern, Robert A., additional

Published
2023
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42. 64 Neuroimaging Evidence of Neurodegenerative Disease in Former Professional American Football Players Who “Fail” Validity Testing: A Case Series

Author

Shankar, Ranjani, primary, Culhane, Julia, additional, Iaccarino, Leonardo, additional, Nowinski, Chris, additional, Mundada, Nidhi, additional, Smith, Karen, additional, Tanner, Jeremy, additional, Windon, Charles, additional, Tripodis, Yorghos, additional, Mercier, Gustavo, additional, Stein, Thor D, additional, McKee, Anne C, additional, Stern, Robert A, additional, Kowall, Neil, additional, Miller, Bruce L, additional, Mez, Jesse, additional, Killiany, Ron, additional, Rabinovici, Gil D, additional, Alosco, Michael L, additional, and Asken, Breton M, additional

Published
2023
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43. 4 Risk Factor and Biomarker Correlates of FLAIR White Matter Hyperintensities in Former American Football Players

Author

Ly, Monica T, primary, Tuz-Zahra, Fatima, additional, Tripodis, Yorghos, additional, Adler, Charles H, additional, Balcer, Laura J, additional, Bernick, Charles, additional, Peskind, Elaine, additional, Mariani, Megan L, additional, Au, Rhoda, additional, Banks, Sarah J, additional, Barr, William B, additional, Wethe, Jennifer V, additional, Bondi, Mark W, additional, Delano-Wood, Lisa, additional, Cantu, Robert C, additional, Coleman, Michael J, additional, Dodick, David W, additional, McClean, Michael D, additional, Mez, Jesse, additional, Palmisano, Joseph N, additional, Martin, Brett, additional, Hartlage, Kaitlin, additional, Lin, Alexander P, additional, Koerte, Inga K, additional, Cummings, Jeffrey L, additional, Reiman, Eric M, additional, Shenton, Martha E, additional, Stern, Robert A, additional, Bouix, Sylvain, additional, and Alosco, Michael L, additional

Published
2023
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44. 6 Association Between American Football Play and Parkinson's Disease: Analysis of the Fox Insight Data Set

Author

Bruce, Hannah, primary, Tripodis, Yorghos, additional, McClean, Michael, additional, Korell, Monica, additional, Tanner, Caroline M, additional, Contreras, Brittany, additional, Gottesman, Joshua, additional, Kirsch, Leslie, additional, Karim, Yasir, additional, Martin, Brett, additional, Palmisano, Joseph, additional, Stein, Thor D, additional, Mez, Jesse, additional, Stern, Robert A, additional, Adler, Charles H, additional, Nowinski, Chris, additional, McKee, Ann C, additional, and Alosco, Michael L, additional

Published
2023
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45. 57 Traumatic Brain Injury and Concussion in Patients with Frontotemporal Dementia Spectrum Diagnoses

Author

Bove, Jessica, primary, Knudtson, Marguerite, additional, You, Michelle, additional, Alosco, Michael L, additional, Mez, Jesse, additional, Miller, Bruce L, additional, Rosen, Howie J, additional, Gorno-Tempini, Maria Luisa, additional, Seeley, William W, additional, Kramer, Joel H, additional, Bauer, Russell M, additional, and Asken, Breton M, additional

Published
2023
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46. 5 Antemortem Plasma GFAP Predicts Alzheimer’s Disease Neuropathological Changes

Author

Ally, Madeline, primary, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Karikari, Thomas K., additional, Aparicio, Hugo, additional, Sugarman, Michael A., additional, Frank, Brandon, additional, Tripodis, Yorghos, additional, Martin, Brett, additional, Palmisano, Joseph N., additional, Steinberg, Eric G., additional, Simkina, Irene, additional, Farrer, Lindsay, additional, Jun, Gyungah, additional, Turk, Katherine W., additional, Budson, Andrew E., additional, O’Connor, Maureen K., additional, Au, Rhoda, additional, Qiu, Wei Qiao, additional, Goldstein, Lee E., additional, Killiany, Ronald, additional, Kowall, Neil W., additional, Stern, Robert A., additional, Mez, Jesse, additional, Huber, Bertran R., additional, McKee, Ann C., additional, Stein, Thor D., additional, and Alosco, Michael L., additional

Published
2023
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47. 4 Evaluating Plasma GFAP for the Detection of Alzheimer’s Disease Dementia

Author

Ally, Madeline, primary, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Ashton, Nicholas J., additional, Karikari, Thomas K., additional, Aparicio, Hugo, additional, Sugarman, Michael A., additional, Frank, Brandon, additional, Tripodis, Yorghos, additional, McKee, Ann C., additional, Stein, Thor D., additional, Martin, Brett, additional, Palmisano, Joseph N., additional, Steinberg, Eric G., additional, Simkina, Irene, additional, Farrer, Lindsay, additional, Jun, Gyungah, additional, Turk, Katherine W., additional, Budson, Andrew E., additional, O’Connor, Maureen K., additional, Au, Rhoda, additional, Qiu, Wei Qiao, additional, Goldstein, Lee E., additional, Killiany, Ronald, additional, Kowall, Neil W., additional, Stern, Robert A., additional, Mez, Jesse, additional, and Alosco, Michael L., additional

Published
2023
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48. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE

Author

Alosco, Michael L., Mian, Asim Z., Buch, Karen, Farris, Chad W., Uretsky, Madeline, Tripodis, Yorghos, Baucom, Zachary, Martin, Brett, Palmisano, Joseph, Puzo, Christian, Ang, Ting Fang Alvin, Joshi, Prajakta, Goldstein, Lee E., Au, Rhoda, Katz, Douglas I., Dwyer, Brigid, Daneshvar, Daniel H., Nowinski, Christopher, Cantu, Robert C., Kowall, Neil W., Huber, Bertrand Russell, Alvarez, Victor E., Stern, Robert A., Stein, Thor D., Killiany, Ronald J., McKee, Ann C., and Mez, Jesse

Published
2021
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49. Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts

Author

Uretsky, Madeline, Bouix, Sylvain, Killiany, Ronald J., Tripodis, Yorghos, Martin, Brett, Palmisano, Joseph, Mian, Asim Z, Buch, Karen, Farris, Chad, Daneshvar, Daniel H, Dwyer, Brigid, Goldstein, Lee, Katz, Douglas, Nowinski, Christopher, Cantu, Robert, Kowall, Neil, Huber, Bertrand Russell, Stern, Robert A, Alvarez, Victor E, Stein, Thor D, McKee, Ann, Mez, Jesse, and Alosco, Michael L

Published
2021
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50. Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.

Author

Su, Yi, Protas, Hillary, Luo, Ji, Chen, Kewei, Alosco, Michael L., Adler, Charles H., Balcer, Laura J., Bernick, Charles, Au, Rhoda, Banks, Sarah J., Barr, William B., Coleman, Michael J., Dodick, David W., Katz, Douglas I., Marek, Kenneth L., McClean, Michael D., McKee, Ann C., Mez, Jesse, Daneshvar, Daniel H., and Palmisano, Joseph N.

Abstract

INTRODUCTION: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project. METHOD: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same‐age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES). RESULTS: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups. DISCUSSION: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI. [ABSTRACT FROM AUTHOR]

Published
2024
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