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One correction is noted for the paper. The branching fraction (Formula presented.) was not included in the conversion of the observed cross-section limit, (Formula presented.) to the coupling constants κugt and κcgt and the branching fractions B(t → ug) and B(t → cg). The inclusion leads to weaker observed exclusion limits on the coupling constants divided by the scale of new physics of (Formula presented.) and (Formula presented.) and on the branching fractions B(t → ug) < 1.2×10−4 and B(t → cg) < 6.4×10−4. The predicted exclusion limits on the coupling constants divided by the scale of newphysics are (Formula presented.) and (Formula presented.) and on the branching fractions B(t → ug) < 1.1 × 10−4 and B(t → cg) < 5.7 × 10−4. Updated distributions of the observed upper limits on the coupling constants for combinations of cgt and ugt channels are shown in Figure 10a and on the branching fractions in Figure 10b.

This study is a quantitative study that aims to see whether there is an effect on the problem solving abilities of students who are taught by a project-based learning model with photonovelas media on global warming materials. this study used in this study was a multiple choice test to measure students’ problem solving abilities. The population taken in this study was seventh grade students of SMP Negeri Bongomeme. The sample used was 50 students, namely, 26 students in the experimental class and 24 students in the control class. The analysis used in this study uses Rasch modeling SPSS 16.0 applications, namely hypothesis testing with the Wilcoxon test. Introduction

This study aims to study the quantitative relationship between molecular structure and biological activity (QSAR) of the 7-O-amide hesperetine derivative compounds and to design new compounds which are more potential as anti-inflammatory. This research was theoretically exploratory by using computational chemical methods. The object of this research was 23 derivative compounds of 7-O-Amide Hesperetine with their anti-inflammatory biological activity (IC50) values. The research data were obtained from the results of quantum chemistry calculations assist with computational chemistry code and statistical analysis of multiple linear regressions. The QSAR equation obtained was log IC50 = -2581,151 + (3127,454 × qC2) + (1884,436 × qC3) + (-1581,855 × qC11) + (8181,049 × qC8) + (-2166,325 ×qC4), where n = 23, R2 = 0.679, SEE = 0.092, Fcount /Ftable = 7189, and PRESS = 0.144. The best QSAR model was used to design and predict 23 new anti-inflammatory compounds of derived from 7-O-amide hesperetine with higher activity. The calculation results showed that the proposed anti-inflammatory compound with the highest activity to prevent inflammation was (S)-5-hydroxy-2-(3hidroxy-4-methoxyphenyl)-7-(2-oxo-2-(piperazine-1-yl)ethoxy )chroman-4-one (compound 38) with an IC50 value of 1.194 or 15.66 nM.