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Your search keyword '"Aleksandra Tarasiuk"' showing total 6 results
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6 results on '"Aleksandra Tarasiuk"'

1. Interactions between neurotrophins, mood, and physical activity under the conditions of sleep deprivation

Author

Marcin Sochal, Marta Ditmer, Agata Binienda, Aleksandra Tarasiuk, Piotr Białasiewicz, Szymon Turkiewicz, Filip Franciszek Karuga, Fichna Jakub, and Agata Gabryelska

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Sleep deprivation (DS) is the forced elimination of sleep. While brain-derived neurotrophic factor (BDNF) has been extensively studied in the context of in mood changes following DS, the role of other neurotrophins remains elusive. This study explores the impact of DS on BDNF, glial cell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4) at mRNA and protein level, considering their potential links to mood disturbances. The study involved 81 participants subjected to polysomnography (PSG) and DS. Blood samples, mood assessments, and actigraphy data were collected twice, after PSG and DS. NT mRNA expression and serum protein concentrations of BDNF, GDNF, NT3, and NT4 were measured. Participants were divided into Responders and Non-Responders based on mood improvement after DS. DS reduced BDNF mRNA expression in all participants, with no change in serum BDNF protein. GDNF protein decreased in Non-Responders, while Responders exhibited reduced GDNF mRNA. NT3 protein increased in both groups, while NT3 mRNA decreased in Respondents. NT4 protein rose universally post-DS, but NT4 mRNA remained unchanged. Physical activity (PA) negatively correlated with mRNA expression of BDNF, GDNF, and NT3 post-DS. The study’s short DS duration and exclusion of immature NT forms limit comprehensive insights. GDNF, together with NT3, might play an important role in mood response to DS. PA during DS seems to impair the mRNA expression of NTs in leukocytes. Future studies on the subject of sleep deprivation might consider investigating the relationship between BDNF and NT4 in the context of their apparent redundancy.

Published
2024
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3. Putative molecular targets for vitamin A in neutralizing oxidative stress in acute and chronic pancreatitis — a systematic review

Author

Jacek Burzyński, Jakub Fichna, and Aleksandra Tarasiuk

Subjects
Pharmacology, General Medicine
Abstract

Acute pancreatitis (AP) and chronic pancreatitis (CP) are debilitating diseases of gastrointestinal tract and constitute great threat for human health in high-income countries. Recent studies emphasize the impact of oxidative stress on development of these pathologies, and numerous authors evaluate the effect of the antioxidant therapy on the course of AP and CP. Though several antioxidative agents were discovered in the past decades, vitamins remain canonical antioxidants. Despite the fact that vitamin A is known for its antioxidative effect, there is little data about the impact of vitamin A on oxidative stress in the pathogenesis of AP and CP. The scope of the review is to evaluate molecular targets for vitamin A, which may be involved in oxidative stress occurring in the course of AP and CP. Our research of available literature revealed that several mechanisms are responsible for attenuation of oxidative stress in AP and CP, including Nrf2, MAPK, AMPK, TLR3, and TLR4. Furthermore, these factors are at least partially expressed in vitamin A-dependent manner, though further investigations are required for elucidating in detail the role of vitamin A in defense against reactive oxygen species. Our review revealed that vitamin A might influence the expression of several molecular pathways involved in antioxidative defense and cytoprotection; thus, its administration during AP and CP may change the course of the disease.

Published
2023
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4. Contributors

Author

Francesca Algieri, Luiz Domingues de Almeida-Junior, Mariana da Rocha Alves, Henrique Silvano Arruda, Maria de Lourdes Setsuko Ayrizono, Rafaela de Carvalho Baptista, Levi Nascimento Bellinazzi, Joana Breves, Fabíola Vieira de Carvalho, Hugo Dugolin Ceccato, Karina Nascimento da Silva, Luiz Claudio Di Stasi, Cilene Bicca Dias, Patricia Diez-Echave, Elizabethe Adriana Esteves, Marciane Milanski Ferreira, Julio Galvez, Livia Moreira Genaro, Marina Villar Geraldi, Luis Eduardo Miani Gomes, Laura Hidalgo-Garcia, Raquel Franco Leal, Amanda Pereira Lima, Dyana Carla Lima, Ana Paula da Fonseca Machado, Juliana Kelly da Silva Maia, Mario Roberto Maróstica Junior, Carlos Augusto Real Martinez, Fábio Perez de Mello, Jose Alberto Molina-Tijeras, Andréa Cristina de Moraes Malinverni, Lauane Gomes Moreno, Ludmilla David de Moura, Roberto de Paula do Nascimento, Nathan Hargreaves Noguera, Mariah Zajankauskas Orçati, Ana Paula Ribeiro Paiotti, José Aires Pereira, Gabriele Polezi, Cíntia Lacerda Ramos, Lívia Mateus Reguengo, Beatriz Elias Ribeiro, Daniel Araki Ribeiro, Julia Soto Rizzato, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, Maria Jesús Rodríguez-Sojo, Antonio Jesús Ruiz-Malagón, Maciej Salaga, Débora Salles, Julian Furtado Silva, Carina de Sousa Santos, Heitor Siffert Pereira de Souza, Karine Mariane Steigleder, Mikołaj Świerczyński, Aleksandra Tarasiuk, and Teresa Vezza

Published
2023
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