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Post-dural puncture headache (PDPH) is a common complication following spinal procedures, particularly lumbar punctures and epidural anesthesia. This systematic review aims to evaluate and compare the effectiveness of various management strategies for PDPH. A comprehensive search was conducted across major databases for relevant articles published up to January 2024. The inclusion criteria comprised studies assessing interventions for post-dural puncture headache (PDPH) management in adult populations. Data extraction and quality evaluation were conducted independently by two reviewers. Analysis involved 34 studies meeting the inclusion criteria. The results indicate that conservative approaches, including bed rest, hydration, caffeine, and analgesics, continue to serve as the fundamental components of PDPH management. Additionally, epidural blood patch (EBP) emerged as the most effective intervention for refractory cases. However, further research is needed to optimize treatment protocols and explore emerging therapies.

Cancer-related pain represents a serious challenge in oncological care, often refractory to conventional analgesics and significantly impacting patients' quality of life. In recent years, medical marijuana (cannabis) has emerged as a potential adjunctive or alternative therapy for managing pain in oncological patients. This narrative review critically evaluates the existing literature on the efficacy, safety, and underlying mechanisms of action of medical marijuana in alleviating pain associated with cancer. Drawing upon a synthesis of preclinical and clinical studies, as well as meta-analyses and systematic reviews, this review provides insights into the scientific basis and clinical implications of utilizing medical marijuana in oncological pain management.

Introduction: Tension-type headache (TTH) is a common neurological disorder characterized by bilateral head pain and muscle tension, affecting up to 78% of the population. Despite its prevalence, TTH has historically received less attention than migraines. However, recent years have seen increased interest in understanding its pathophysiology and treatment options. This review comprehensively analyzes TTH management, covering non-pharmacological and pharmacological approaches to guide clinical practice and future research effectively. State of Knowledge: TTHs manifest as bilateral, pressing, encircling head pain, profoundly affecting individuals' quality of life. Recent years have witnessed increased interest in TTH understanding and treatment. Non-pharmacological interventions, including behavioral modifications, exercise, dietary adjustments, sleep hygiene, physical therapy, psychotherapy, and pharmacological treatments like over-the-counter medications, prophylactic drugs, psychedelics, and botulinum toxin A, have shown promise in alleviating symptoms. Conclusion: This review highlights the multifaceted management of TTH. Non-pharmacological interventions, including behavioral modifications and psychotherapy, offer symptom relief. Body awareness therapy, exercise, and psychotherapy benefit TTH symptoms and quality of life. Paracetamol, ibuprofen, and amitriptyline are standard treatments, with emerging options like psychedelics and botulinum toxin A. Personalizing treatment and understanding TTH mechanisms pose challenges. A multidisciplinary approach is essential for enhancing management and outcomes. More research is required to identify optimal treatments and long-term efficacy. Despite challenges, progress in TTH management brings hope for better patient care.

Introduction: In today’s world, we know how important it is to keep healthy habits because many diseases begin with daily lifestyle choices. Dry eye disease is a disease of the ocular surface and there are many risk factors, that lead to developing this disorder. As the possible factors we can underline deficiency of vitamin D or Omega-3 fatty acids, lack of physical exercise, long screen time, or smoking tobacco. Aim of the study: This review seeks to highlight the issue of dry eye disease linked to everyday routines by examining clinical trial outcomes. Furthermore, it offers an analysis of potential strategies to prevent ocular alterations by critically evaluating the existing data. State of knowledge: The listed lifestyle choices cause a higher risk of developing dry eye disease and affect ocular health on many levels, leading to unpleasant feelings and affecting people’s lives. However, with some lifestyle changes, the risk of developing this disease can be decreased, and negative symptoms can be minimized. It is important to remember vitamin D, and Omega-3 supplementation, daily physical activity, minimalization of the time spent in front of the visual display terminals, and quitting smoking. Conclusions: Many daily habits are connected to developing dry eye disease, and it is very important to remember about the small daily changes, which can decrease the risk of the disease.

Diabetic retinopathy, also defined as diabetic eye disease is one of the main causes of eye complications and blindless in the world therefore leads to irreversible vision disorder and vision loss. A pregnant women as a patient is always a real challenge for doctors of various specialties. During this period, numerous systemic changes occur, such as increased blood pressure in the third trimester, increased blood volume insulin resistance with worsening glycemic control and excessive coagulation. The above complication may be reflected in the image of the fundus of the eye. Pregnancy may induce retinal disease such as diabetic retinopathy. This review article presents the incidence, pathogenesis and risk factors associated with diabetic retinopathy during pregnancy. More over in the following paper discussed management of diabetic retinopathy in pregnancy and guidelines are recommended based on the achievable evidence.

Episcleritis is an inflammatory condition affecting the episclera of the eye, which is the tissue between the sclera and conjunctiva. It manifests as unilateral or bilateral redness and discomfort. Despite its typically benign course, it may signal underlying systemic disorders, necessitating comprehensive evaluation and personalized management. While most cases are idiopathic, autoimmune diseases and infections may play contributory roles. Epidemiological studies reveal a predilection for young to middle-aged females, with episcleritis being less common in children. Diagnostically, characteristic features include sectoral redness and mild discomfort, distinguishing it from conjunctivitis and scleritis. Treatment primarily focuses on symptomatic relief, utilizing topical steroids, oral NSAIDs, and artificial tears. The prognosis is generally favourable, with spontaneous resolution within weeks; however, recurrent, or chronic cases may necessitate further evaluation for underlying systemic conditions. This comprehensive review aims to elucidate etiology, epidemiology, diagnosis, management strategies, prognosis of episcleritis, and clinical nuances, drawing upon recent literature from 1976 to the present. By consolidating contemporary knowledge, this review provides valuable insights for clinicians on how to treat this ocular condition effectively.

Introduction: Vitamin D is a steroid hormone that can modulate immune and inflammatory responses. Recent investigations have shed light on its potential role in the pathogenesis of many diseases affecting the eyes. Aim of the study: This paper aims to provide a comprehensive review of the existing findings on the relationship between vitamin D and ocular diseases. The intention is to present new perspectives that will contribute to a better understanding of the complicated nature of this aspect. Material and methods: This review included relevant papers from PubMed database using specified keywords. Analysis of the literature: The role of vitamin D in ocular and visual health has been observed in many studies. A deficiency of vitamin D may play a significant role in the development of many ocular diseases such as dry eye disease, myopia, diabetic retinopathy, keratoconus, and thyroid eye disease. Conclusions: Adequate vitamin D levels are significant for maintaining ocular health. Recognition of the pivotal role of vitamin D in ocular diseases opens new possibilities for potential therapeutic interventions. Ongoing research is needed to further investigate that aspect. Supplementation of vitamin D may prevent or modulate many diseases affecting the eyes.

Withania somnifera, commonly known as ashwagandha, has gained popularity in recent years among individuals interested in healthy lifestyles, natural medicine, and sports. This review aims to summarize the current knowledge regarding the effects of ashwagandha supplementation on various aspects of physical performance, particularly in the context of resistance training. Studies have shown that ashwagandha can positively impact muscle strength, with significant increase of muscle force and power output. Additionally, it has demonstrated potential in modulating body composition, with reduction of body fat percentage noted in certain populations. However, results of studies on ashwagandha’s effect on muscle size remain inconclusive and may depend on various factors such as training status and individual responses. In terms of endurance, ashwagandha supplementation has been associated with improvement in maximal oxygen uptake, indicating enhanced aerobic capacity and delayed exhaustion during endurance activities. Furthermore, ashwagandha was shown to aid muscle recovery by reducing exercise-induced muscle damage and inflammatory response, potentially accelerating the muscle regeneration process. Ashwagandha may also influence hormone levels, such as testosterone and cortisol, with potential implications for muscle growth and recovery. However, further research is needed to fully understand the mechanisms underlying these effects. Overall, ashwagandha supplementation appears to hold promise for enhancing physical performance and overall well-being. Further research is needed to elucidate optimal dosages, long-term safety, and potential interactions with other supplements or medications.