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Omalizumab, a monoclonal anti-IgE antibody, has been used off-label in a few case series of bullous pemphigoids (BPs) with rapid efficacy and high safety profile. However, there is a lack of data to select patients who would get the most therapeutic benefit from omalizumab therapy. To assess if eosinophil-to-lymphocyte ratio (ELR), total serum IgE level, and serum eosinophil percentage would be useful in predicting response to omalizumab therapy in patients with BP. Medical records of 10 patients with BP treated with omalizumab were retrospectively analysed for clinical and laboratory data. ELRs, total serum IgE levels, and serum eosinophil percentages were compared between groups of complete responders and partial responders/flare-ups, but the results were not statistically significant. Studies with larger sample sizes should be done to predict the role of type 2 immunity markers in omalizumab therapy of BP patients. Keywords: Bullous pemphigoid, eosinophil, lymphocyte, omalizumab, type 2 immunity, Author(s): Gülfem Akin (corresponding author) [1]; Ceylan Avci [1]; Sevgi Akarsu [1] Introduction Bullous pemphigoid (BP) is an autoimmune blistering disease that occurs in elderly patients older than 60 years. [...]

Background: Previous studies have noted the link between rosacea severity and quality of life, but there is limited understanding of how disease perception impacts these aspects. Additionally, sun exposure is identified as a common trigger for rosacea flare‐ups, emphasizing the importance of sun protection practices in managing the condition. This cross‐sectional study aims to fill the gap in the literature by investigating the relationship between clinical severity, disease perception, quality of life, and sun protection behaviors in rosacea patients. Methods: Questionnaires assessing the quality of life, illness perception, sun protection behaviors, sun protection decisional balance, and its potential predictors were completed by 120 rosacea patients and 120 controls. Results: Patients exhibited a higher prevalence of sun protection behaviors than the control group (24.15 ± 5.76 vs. 17.63 ± 5.56, p < 0.001) and demonstrated greater determination in adhering to sun protection practices (13.43 ± 2.37 vs. 9.40 ± 3.09, p < 0.001). Hierarchical linear regression analyses showed that quality of life was related to clinical severity, illness perception (consequences, illness coherence, emotional representations), causal attribution (risk factors, immunity), and sun protection decisional balance variables (R2 = 0.45, F = 7.39, p < 0.001). Also, the perceived pros and cons of sun protection behaviors were predicted by illness perception (treatment control), causal attribution (risk factors, immunity, chance/accident), and quality of life variables (R2 = 0.24, F = 2.59, p = 0.004). Conclusions: Providing more information to rosacea patients can improve their disease perception and quality of life, increasing adherence to sun protection behaviors. [ABSTRACT FROM AUTHOR]

In this article, we studied the geometric properties of generalized Wright-Bessel functions. For this purpose, we determined sufficient conditions for univalency, convexity, starlikeness and close-to-convexity of the generalized Wright-Bessel functions in the open unit disk. [ABSTRACT FROM AUTHOR]