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Your search keyword '"Aitken-Buck, Hamish M."' showing total 9 results
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9 results on '"Aitken-Buck, Hamish M."'

3. An arrhythmogenic metabolite in atrial fibrillation

Author

Krause, Julia, Nickel, Alexander, Madsen, Alexandra, Aitken-Buck, Hamish M., Stoter, A. M. Stella, Schrapers, Jessica, Ojeda, Francisco, Geiger, Kira, Kern, Melanie, Kohlhaas, Michael, Bertero, Edoardo, Hofmockel, Patrick, Hübner, Florian, Assum, Ines, Heinig, Matthias, Müller, Christian, Hansen, Arne, Krause, Tobias, Park, Deung-Dae, Just, Steffen, Aïssi, Dylan, Börnigen, Daniela, Lindner, Diana, Friedrich, Nele, Alhussini, Khaled, Bening, Constanze, Schnabel, Renate B., Karakas, Mahir, Iacoviello, Licia, Salomaa, Veikko, Linneberg, Allan, Tunstall-Pedoe, Hugh, Kuulasmaa, Kari, Kirchhof, Paulus, Blankenberg, Stefan, Christ, Torsten, Eschenhagen, Thomas, Lamberts, Regis R., Maack, Christoph, Stenzig, Justus, and Zeller, Tanja

Published
2023
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6. Study of amphipathic metabolites in cardiac pathophysiology: Insights gained from long‐chain acylcarnitines and calcium handling.

Author

Aitken‐Buck, Hamish M., Khaing, Ei Phyo, Lamberts, Regis R., and Jones, Peter P.

Subjects
RYANODINE receptors, ARRHYTHMIA, CALCIUM, INTRACELLULAR calcium, PATHOLOGICAL physiology
Abstract

This article discusses the role of long-chain acylcarnitines (LCACs) in cardiac pathophysiology. Metabolomics studies have identified associations between LCACs and cardiovascular diseases such as heart failure and cardiac arrhythmias. The article focuses on the effects of LCACs on the ryanodine receptor (RyR2), a calcium release channel in cardiomyocytes. The study found that LCACs promote spontaneous calcium release and intracellular calcium accumulation, potentially through increased cytosolic calcium levels. The article also highlights the importance of considering methodological limitations and membrane perturbation effects when studying LCACs. The findings have implications for future research on LCACs and their potential as therapeutic targets for cardiovascular diseases. [Extracted from the article]

Published
2023
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9. Preparation of Human Atrial Trabeculae for Ex Vivo Analysis of Human Myocardial Function.

Author

Aitken-Buck HM, Bingham KT, and Lamberts RR

Subjects
Humans, Myocardial Contraction physiology, Atrial Function physiology, Dissection methods, Heart Atria metabolism, Heart Atria cytology, Myocardium metabolism, Myocardium cytology
Abstract

Human myocardial function can be investigated in the laboratory using human atrial trabeculae. These multicellular preparations provide a translatable model for assessing the ex vivo contractility, electrophysiology, and ionic and metabolic underpinnings of human cardiac muscle. Here, we detail the materials and methods required to determine the baseline function of a human atrial trabecula, from dissection to stimulation. This method is also adaptable for additional non-human myocardial applications., (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2025
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