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Your search keyword '"Ahmed, Zamal"' showing total 14 results
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14 results on '"Ahmed, Zamal"'

3. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

Author

Ye, Zu, primary, Xu, Shengfeng, additional, Shi, Yin, additional, Cheng, Xueqian, additional, Zhang, Yuan, additional, Roy, Sunetra, additional, Namjoshi, Sarita, additional, Longo, Michael A., additional, Link, Todd M., additional, Schlacher, Katharina, additional, Peng, Guang, additional, Yu, Dihua, additional, Wang, Bin, additional, Tainer, John A., additional, and Ahmed, Zamal, additional

Published
2024
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7. Regulation of microRNA expression by the adaptor protein GRB2

Author

Stainthorp, Amy K, Lin, Chi-Chuan, Wang, Dapeng, Medhi, Ragini, Ahmed, Zamal, Suen, Kin Man, Miska, Eric A, Whitehouse, Adrian, Ladbury, John E, and Apollo - University of Cambridge Repository

Subjects
MicroRNAs, Base Sequence, Argonaute Proteins, Gene Silencing, GRB2 Adaptor Protein
Abstract

Protein interactions with the microRNA (miRNA)-mediated gene silencing protein Argonaute 2 (AGO2) control miRNA expression. miRNA biogenesis starts with the production of precursor transcripts and culminates with the loading of mature miRNA onto AGO2 by DICER1. Here we reveal an additional component to the regulatory mechanism for miRNA biogenesis involving the adaptor protein, growth factor receptor-bound protein 2 (GRB2). The N-terminal SH3 domain of GRB2 is recruited to the PAZ domain of AGO2 forming a ternary complex containing GRB2, AGO2 and DICER1. Using small-RNA sequencing we identified two groups of miRNAs which are regulated by the binding of GRB2. First, mature and precursor transcripts of mir-17~92 and mir-221 miRNAs are enhanced. Second, mature, but not precursor, let-7 family miRNAs are diminished suggesting that GRB2 directly affects loading of these miRNAs. Notably, the resulting loss of let-7 augments expression of oncogenic targets such as RAS. Thus, a new role for GRB2 is established with implications for cancer pathogenesis through regulation of miRNA biogenesis and oncogene expression.

Published
2023

8. Data from Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

Author

Yuan, Xiangliang, primary, Duan, Yimin, primary, Xiao, Yi, primary, Sun, Kai, primary, Qi, Yutao, primary, Zhang, Yuan, primary, Ahmed, Zamal, primary, Moiani, Davide, primary, Yao, Jun, primary, Li, Hongzhong, primary, Zhang, Lin, primary, Yuzhalin, Arseniy E., primary, Li, Ping, primary, Zhang, Chenyu, primary, Badu-Nkansah, Akosua, primary, Saito, Yohei, primary, Liu, Xianghua, primary, Kuo, Wen-Ling, primary, Ying, Haoqiang, primary, Sun, Shao-Cong, primary, Chang, Jenny C., primary, Tainer, John A., primary, and Yu, Dihua, primary

Published
2023
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9. Supplementary Data from Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

Author

Yuan, Xiangliang, primary, Duan, Yimin, primary, Xiao, Yi, primary, Sun, Kai, primary, Qi, Yutao, primary, Zhang, Yuan, primary, Ahmed, Zamal, primary, Moiani, Davide, primary, Yao, Jun, primary, Li, Hongzhong, primary, Zhang, Lin, primary, Yuzhalin, Arseniy E., primary, Li, Ping, primary, Zhang, Chenyu, primary, Badu-Nkansah, Akosua, primary, Saito, Yohei, primary, Liu, Xianghua, primary, Kuo, Wen-Ling, primary, Ying, Haoqiang, primary, Sun, Shao-Cong, primary, Chang, Jenny C., primary, Tainer, John A., primary, and Yu, Dihua, primary

Published
2023
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10. Data from An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Author

Indarte, Martin, primary, Puentes, Roisin, primary, Maruggi, Marco, primary, Ihle, Nathan T., primary, Grandjean, Geoffrey, primary, Scott, Michael, primary, Ahmed, Zamal, primary, Meuillet, Emmanuelle J., primary, Zhang, Shuxing, primary, Lemos, Robert, primary, Du-Cuny, Lei, primary, Layng, Fabiana I.A.L., primary, Correa, Ricardo G., primary, Bankston, Laurie A., primary, Liddington, Robert C., primary, Kirkpatrick, Lynn, primary, and Powis, Garth, primary

Published
2023
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11. Supplemental Information from An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors

Author

Indarte, Martin, primary, Puentes, Roisin, primary, Maruggi, Marco, primary, Ihle, Nathan T., primary, Grandjean, Geoffrey, primary, Scott, Michael, primary, Ahmed, Zamal, primary, Meuillet, Emmanuelle J., primary, Zhang, Shuxing, primary, Lemos, Robert, primary, Du-Cuny, Lei, primary, Layng, Fabiana I.A.L., primary, Correa, Ricardo G., primary, Bankston, Laurie A., primary, Liddington, Robert C., primary, Kirkpatrick, Lynn, primary, and Powis, Garth, primary

Published
2023
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12. Epigenetic–Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer

Author

Das, Chandrima, primary, Adhikari, Swagata, additional, Bhattacharya, Apoorva, additional, Chakraborty, Sanjukta, additional, Mondal, Payel, additional, Yadav, Shalini S., additional, Adhikary, Santanu, additional, Hunt, Clayton R., additional, Yadav, Kamlesh K., additional, Pandita, Shruti, additional, Roy, Siddhartha, additional, Tainer, John A., additional, Ahmed, Zamal, additional, and Pandita, Tej K., additional

Published
2023
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13. Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

Author

Yuan, Xiangliang, primary, Duan, Yimin, additional, Xiao, Yi, additional, Sun, Kai, additional, Qi, Yutao, additional, Zhang, Yuan, additional, Ahmed, Zamal, additional, Moiani, Davide, additional, Yao, Jun, additional, Li, Hongzhong, additional, Zhang, Lin, additional, Yuzhalin, Arseniy E., additional, Li, Ping, additional, Zhang, Chenyu, additional, Badu-Nkansah, Akosua, additional, Saito, Yohei, additional, Liu, Xianghua, additional, Kuo, Wen-Ling, additional, Ying, Haoqiang, additional, Sun, Shao-Cong, additional, Chang, Jenny C., additional, Tainer, John A., additional, and Yu, Dihua, additional

Published
2022
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14. PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer

Author

Jeung, Hei-Cheul, primary, Puentes, Roisin, additional, Aleshin, Alexander, additional, Indarte, Martin, additional, Correa, Ricardo G., additional, Bankston, Laurie A., additional, Layng, Fabiana I.A.L., additional, Ahmed, Zamal, additional, Wistuba, Ignacio, additional, Yao, Yong, additional, Duenas, Daniela G., additional, Zhang, Shuxing, additional, Meuillet, Emmanuelle J., additional, Marassi, Francesca, additional, Liddington, Robert C., additional, Kirkpatrick, Lynn, additional, and Powis, Garth, additional

Published
2021
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