25 results on '"Ackermann, Katharina'
Search Results
2. Perpetrators and victims of cyberbullying among youth with conduct disorder
- Author
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Baumann, Sarah, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Herpertz-Dahlmann, Beate, Freitag, Christine, Konrad, Kerstin, and Kohls, Gregor
- Published
- 2023
- Full Text
- View/download PDF
3. Machine learning classification of conduct disorder with high versus low levels of callous-unemotional traits based on facial emotion recognition abilities
- Author
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Pauli, Ruth, Kohls, Gregor, Tino, Peter, Rogers, Jack C., Baumann, Sarah, Ackermann, Katharina, Bernhard, Anka, Martinelli, Anne, Jansen, Lucres, Oldenhof, Helena, Gonzalez-Madruga, Karen, Smaragdi, Areti, Gonzalez-Torres, Miguel Angel, Kerexeta-Lizeaga, Iñaki, Boonmann, Cyril, Kersten, Linda, Bigorra, Aitana, Hervas, Amaia, Stadler, Christina, Fernandez-Rivas, Aranzazu, Popma, Arne, Konrad, Kerstin, Herpertz-Dahlmann, Beate, Fairchild, Graeme, Freitag, Christine M., Rotshtein, Pia, and De Brito, Stephane A.
- Published
- 2023
- Full Text
- View/download PDF
4. Zufriedenheit mit (teil-)stationärer psychiatrischer Behandlung: Effekte auf die physische und psychische Gesundheit
- Author
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Ackermann, Katharina, Ueberberg, Bianca, and Assion, Hans-Jörg
- Published
- 2023
- Full Text
- View/download PDF
5. Neuroendocrine Stress Response in Female and Male Youths With Conduct Disorder and Associations With Early Adversity
- Author
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Bernhard, Anka, Ackermann, Katharina, Martinelli, Anne, Chiocchetti, Andreas G., Vllasaliu, Leonora, González-Madruga, Karen, Batchelor, Molly, Raschle, Nora M., Oldenhof, Helena, Jansen, Lucres M.C., Kohls, Gregor, Konrad, Kerstin, Popma, Arne, Stadler, Christina, Fairchild, Graeme, and Freitag, Christine M.
- Published
- 2022
- Full Text
- View/download PDF
6. START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder – a randomized clinical trial
- Author
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Stadler, Christina; https://orcid.org/0000-0003-2178-0635, Freitag, Christine M; https://orcid.org/0000-0001-9676-4782, Popma, Arne; https://orcid.org/0000-0003-2170-3023, Nauta‐Jansen, Lucres; https://orcid.org/0000-0001-8475-4050, Konrad, Kerstin; https://orcid.org/0000-0001-9039-2615, Unternaehrer, Eva, Ackermann, Katharina; https://orcid.org/0000-0001-6443-7680, Bernhard, Anka; https://orcid.org/0000-0001-8864-1360, Martinelli, Anne; https://orcid.org/0000-0002-7158-9778, Oldenhof, Helena; https://orcid.org/0000-0002-7210-1519, Gundlach, Malou, Kohls, Gregor; https://orcid.org/0000-0003-2408-2939, Prätzlich, Martin, Kieser, Meinhard, Limprecht, Ronald, Raschle, Nora Maria; https://orcid.org/0000-0002-3160-5999, Vriends, Noortje, Trestman, Robert L, Kirchner, Marietta, Kersten, Linda, Stadler, Christina; https://orcid.org/0000-0003-2178-0635, Freitag, Christine M; https://orcid.org/0000-0001-9676-4782, Popma, Arne; https://orcid.org/0000-0003-2170-3023, Nauta‐Jansen, Lucres; https://orcid.org/0000-0001-8475-4050, Konrad, Kerstin; https://orcid.org/0000-0001-9039-2615, Unternaehrer, Eva, Ackermann, Katharina; https://orcid.org/0000-0001-6443-7680, Bernhard, Anka; https://orcid.org/0000-0001-8864-1360, Martinelli, Anne; https://orcid.org/0000-0002-7158-9778, Oldenhof, Helena; https://orcid.org/0000-0002-7210-1519, Gundlach, Malou, Kohls, Gregor; https://orcid.org/0000-0003-2408-2939, Prätzlich, Martin, Kieser, Meinhard, Limprecht, Ronald, Raschle, Nora Maria; https://orcid.org/0000-0002-3160-5999, Vriends, Noortje, Trestman, Robert L, Kirchner, Marietta, and Kersten, Linda
- Abstract
Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive‐behavioral, dialectical behavior therapy‐oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi‐center, parallel group, quasi‐randomized, controlled phase III trial, which tested the efficacy of START NOW (n = 72) compared with standard care (treatment as usual, TAU, n = 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (±1.5) years on average (range: 12–20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post‐treatment (T3), and (2) between T1 and 12‐week follow‐up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW = −4.87, −2.49; TAU = −4.94, −2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU (−0.056; 95% CI = −1.860, 1.749; Hedge's g = −0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 (−2.326; 95% CI = −4.274, −0.378; Hedge's g = −0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent‐reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post‐treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow‐up with a medium effect size, which indicates a clinically meaningful delayed treatment effect.
- Published
- 2024
7. Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp.
- Author
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Jannik Stemler, Christina Többen, Cornelia Lass-Flörl, Jörg Steinmann, Katharina Ackermann, Peter-Michael Rath, Michaela Simon, Oliver Andreas Cornely, and Philipp Koehler
- Subjects
invasive aspergillosis ,epidemiology ,invasive fungal disease ,immunocompromised host ,surgery ,antifungal treatment ,Biology (General) ,QH301-705.5 - Abstract
With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus Aspergillus spp.—namely A. flavus, A. terreus, A. niger and A. nidulans—including diagnostic and therapeutic differences and similarities to A. fumigatus. A. flavus is the second most common Aspergillus spp. isolated in patients with IA and the predominant species in subtropical regions. Treatment is complicated by its intrinsic resistance against amphotericin B (AmB) and high minimum inhibitory concentrations (MIC) for voriconazole. A. nidulans has been frequently isolated in patients with long-term immunosuppression, mostly in patients with primary immunodeficiencies such as chronic granulomatous disease. It has been reported to disseminate more often than other Aspergillus spp. Innate resistance against AmB has been suggested but not yet proven, while MICs seem to be elevated. A. niger is more frequently reported in less severe infections such as otomycosis. Triazoles exhibit varying MICs and are therefore not strictly recommended as first-line treatment for IA caused by A. niger, while patient outcome seems to be more favorable when compared to IA due to other Aspergillus species. A. terreus-related infections have been reported increasingly as the cause of acute and chronic aspergillosis. A recent prospective international multicenter surveillance study showed Spain, Austria, and Israel to be the countries with the highest density of A. terreus species complex isolates collected. This species complex seems to cause dissemination more often and is intrinsically resistant to AmB. Non-fumigatus aspergillosis is difficult to manage due to complex patient histories, varying infection sites and potential intrinsic resistances to antifungals. Future investigational efforts should aim at amplifying the knowledge on specific diagnostic measures and their on-site availability, as well as defining optimal treatment strategies and outcomes of non-fumigatus aspergillosis.
- Published
- 2023
- Full Text
- View/download PDF
8. The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors.
- Author
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Andreas G Chiocchetti, Afsheen Yousaf, Regina Waltes, Anka Bernhard, Anne Martinelli, Katharina Ackermann, Denise Haslinger, Björn Rotter, Nico Krezdorn, Kerstin Konrad, Gregor Kohls, Agnes Vetro, Amaia Hervas, Aranzazu Fernández-Rivas, and Christine M Freitag
- Subjects
Medicine ,Science - Abstract
Conduct Disorder (CD) is an impairing psychiatric disorder of childhood and adolescence characterized by aggressive and dissocial behavior. Environmental factors such as maternal smoking during pregnancy, socio-economic status, trauma, or early life stress are associated with CD. Although the number of females with CD is rising in Western societies, CD is under-researched in female cohorts. We aimed at exploring the epigenetic signature of females with CD and its relation to psychosocial and environmental risk factors. We performed HpaII sensitive genome-wide methylation sequencing of 49 CD girls and 50 matched typically developing controls and linear regression models to identify differentially methylated CpG loci (tags) and regions. Significant tags and regions were mapped to the respective genes and tested for enrichment in pathways and brain developmental processes. Finally, epigenetic signatures were tested as mediators for CD-associated risk factors. We identified a 12% increased methylation 5' of the neurite modulator SLITRK5 (FDR = 0.0046) in cases within a glucocorticoid receptor binding site. Functionally, methylation positively correlated with gene expression in lymphoblastoid cell lines. At systems-level, genes (uncorr. P < 0.01) were associated with development of neurons, neurite outgrowth or neuronal developmental processes. At gene expression level, the associated gene-networks are activated perinatally and during early childhood in neocortical regions, thalamus and striatum, and expressed in amygdala and hippocampus. Specifically, the epigenetic signatures of the gene network activated in the thalamus during early childhood correlated with the effect of parental education on CD status possibly mediating its protective effect. The differential methylation patterns identified in females with CD are likely to affect genes that are expressed in brain regions previously indicated in CD. We provide suggestive evidence that protective effects are likely mediated by epigenetic mechanisms impairing specific brain developmental networks and therefore exerting a long-term effect on neural functions in CD. Our results are exploratory and thus, further replication is needed.
- Published
- 2022
- Full Text
- View/download PDF
9. START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder – a randomized clinical trial.
- Author
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Stadler, Christina, Freitag, Christine M., Popma, Arne, Nauta‐Jansen, Lucres, Konrad, Kerstin, Unternaehrer, Eva, Ackermann, Katharina, Bernhard, Anka, Martinelli, Anne, Oldenhof, Helena, Gundlach, Malou, Kohls, Gregor, Prätzlich, Martin, Kieser, Meinhard, Limprecht, Ronald, Raschle, Nora M., Vriends, Noortje, Trestman, Robert L., Kirchner, Marietta, and Kersten, Linda
- Subjects
RESEARCH ,CONFIDENCE intervals ,RESEARCH methodology ,PSYCHOSOCIAL functioning ,BEHAVIOR disorders ,PSYCHOLOGY of women ,OPPOSITIONAL defiant disorder in children ,AGGRESSION (Psychology) ,COGNITIVE therapy ,MOTOR ability ,SOCIAL disabilities ,LONGITUDINAL method ,ADOLESCENCE - Abstract
Background: Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive‐behavioral, dialectical behavior therapy‐oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods: A total of 127 girls were included in this prospective, cluster randomized, multi‐center, parallel group, quasi‐randomized, controlled phase III trial, which tested the efficacy of START NOW (n = 72) compared with standard care (treatment as usual, TAU, n = 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (±1.5) years on average (range: 12–20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post‐treatment (T3), and (2) between T1 and 12‐week follow‐up (T4). Results: Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW = −4.87, −2.49; TAU = −4.94, −2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU (−0.056; 95% CI = −1.860, 1.749; Hedge's g = −0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 (−2.326; 95% CI = −4.274, −0.378; Hedge's g = −0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent‐reported irritability at post assessment. Conclusions: Although START NOW did not result in greater symptom reduction from baseline to post‐treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow‐up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder – a randomized clinical trial
- Author
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Stadler, Christina, primary, Freitag, Christine M., additional, Popma, Arne, additional, Nauta‐Jansen, Lucres, additional, Konrad, Kerstin, additional, Unternaehrer, Eva, additional, Ackermann, Katharina, additional, Bernhard, Anka, additional, Martinelli, Anne, additional, Oldenhof, Helena, additional, Gundlach, Malou, additional, Kohls, Gregor, additional, Prätzlich, Martin, additional, Kieser, Meinhard, additional, Limprecht, Ronald, additional, Raschle, Nora M., additional, Vriends, Noortje, additional, Trestman, Robert L., additional, Kirchner, Marietta, additional, and Kersten, Linda, additional
- Published
- 2023
- Full Text
- View/download PDF
11. Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp.
- Author
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Stemler, Jannik, primary, Többen, Christina, additional, Lass-Flörl, Cornelia, additional, Steinmann, Jörg, additional, Ackermann, Katharina, additional, Rath, Peter-Michael, additional, Simon, Michaela, additional, Cornely, Oliver Andreas, additional, and Koehler, Philipp, additional
- Published
- 2023
- Full Text
- View/download PDF
12. Zufriedenheit mit (teil-)stationärer psychiatrischer Behandlung: Effekte auf die physische und psychische Gesundheit
- Author
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Katharina Ackermann, Bianca Ueberberg, and Hans-Jörg Assion
- Subjects
Health Policy ,Medicine (miscellaneous) ,Education - Published
- 2023
13. Emotion processing in maltreated boys and girls: Evidence for latent vulnerability
- Author
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Bianca Diaconu, Gregor Kohls, Jack C. Rogers, Ruth Pauli, Harriet Cornwell, Anka Bernhard, Anne Martinelli, Katharina Ackermann, Nikola Fann, Aranzazu Fernandez-Rivas, Miguel Angel Gonzalez-Torres, Maider Gonzalez de Artaza-Lavesa, Amaia Hervas, Christina Stadler, Kerstin Konrad, Christine M. Freitag, Graeme Fairchild, Pia Rotshtein, and Stephane A. De Brito
- Subjects
Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,General Medicine - Abstract
Evidence of alterations in emotion processing in maltreated youth has been hypothesized to reflect latent vulnerability for psychopathology. However, previous studies have not systematically examined the influence of psychopathology on the results. Here, we examined emotion recognition and learning in youth who differed in terms of presence vs. absence of maltreatment and psychopathology and tested for potential sex effects. Maltreatment and psychopathology were assessed in 828 youth (514 females) aged 9–18 years using diagnostic interviews and self- and parent-report questionnaires. Emotion recognition was assessed via identification of morphed facial expressions of six universal emotions. For emotion learning, reward and punishment values were assigned to novel stimuli and participants had to learn to correctly respond/withhold response to stimuli to maximize points. A three-way interaction of maltreatment by psychopathology by emotion indicated that when psychopathology was low, maltreated youth were less accurate than non-maltreated youth for happy, fear and disgust. A three-way interaction of sex, maltreatment and emotion indicated that maltreated girls and boys were impaired for fear, but girls showed an impairment for happy, while boys for disgust. There were no effects of maltreatment, psychopathology, or sex on reward learning. However, a two-way interaction between sex and maltreatment showed that maltreated girls were worse at learning from punishment relative to non-maltreated girls, while maltreated boys were better than non-maltreated boys. The study provides the first clear evidence of latent-vulnerability in emotion recognition in maltreated youth and suggests that girls and boys might be characterized by distinct profiles of emotion recognition and learning following maltreatment.
- Published
- 2023
14. Validation of the Network of Relationship Inventory in Female and Male Adolescents
- Author
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Ackermann, Katharina, Martinelli, Anne, Bernhard, Anka, Ueno, Kathrin, Freitag, Christine M., Büttner, Gerhard, Schmiedek, Florian, and Schwenck, Christina
- Abstract
Abstract.Friendships and their different qualities have been shown to be important for adolescents’ socio-emotional development and psychological adjustment. In empirical research on such friendship qualities, the Network of Relationship Inventory – Relationship Quality Version (NRI-RQV) is a widely used questionnaire. Here, we conduct an extensive validation of a German version of the NRI-RQV, investigating its factor structure, reliability, and concurrent validity, in a sample of N= 679 adolescents aged 13–18 years. Applying multigroup confirmatory factor analysis, we further test whether the factor structure of the friendship quality construct holds across groups of males and females. Results showed that a structure with nine correlated first-order factors fit the data well, indicating nine distinct friendship qualities in males and females. Measurement invariance testing suggested the same underlying friendship quality construct, albeit differences in mean scores per gender. As evidence for concurrent validity, closeness and discordant friendship qualities showed expected correlations with empathy and social problems, respectively, but not with aggressive behavior. Overall, results indicate good psychometric properties for the German version of the NRI-RQV as a measure of friendship qualities in both males and females.
- Published
- 2024
- Full Text
- View/download PDF
15. Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp
- Author
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Stemler, Jannik, Többen, Christina, Lass-Flörl, Cornelia, Steinmann, Jörg, Ackermann, Katharina, Rath, Peter-Michael, Simon, Michaela, Cornely, Oliver Andreas, and Koehler, Philipp
- Subjects
Medizin - Abstract
With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus Aspergillus spp.—namely A. flavus, A. terreus, A. niger and A. nidulans—including diagnostic and therapeutic differences and similarities to A. fumigatus. A. flavus is the second most common Aspergillus spp. isolated in patients with IA and the predominant species in subtropical regions. Treatment is complicated by its intrinsic resistance against amphotericin B (AmB) and high minimum inhibitory concentrations (MIC) for voriconazole. A. nidulans has been frequently isolated in patients with long-term immunosuppression, mostly in patients with primary immunodeficiencies such as chronic granulomatous disease. It has been reported to disseminate more often than other Aspergillus spp. Innate resistance against AmB has been suggested but not yet proven, while MICs seem to be elevated. A. niger is more frequently reported in less severe infections such as otomycosis. Triazoles exhibit varying MICs and are therefore not strictly recommended as first-line treatment for IA caused by A. niger, while patient outcome seems to be more favorable when compared to IA due to other Aspergillus species. A. terreus-related infections have been reported increasingly as the cause of acute and chronic aspergillosis. A recent prospective international multicenter surveillance study showed Spain, Austria, and Israel to be the countries with the highest density of A. terreus species complex isolates collected. This species complex seems to cause dissemination more often and is intrinsically resistant to AmB. Non-fumigatus aspergillosis is difficult to manage due to complex patient histories, varying infection sites and potential intrinsic resistances to antifungals. Future investigational efforts should aim at amplifying the knowledge on specific diagnostic measures and their on-site availability, as well as defining optimal treatment strategies and outcomes of non-fumigatus aspergillosis. CA extern
- Published
- 2023
16. Neuroendocrine Stress Response in Female and Male Youths With Conduct Disorder and Associations With Early Adversity
- Author
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Christine M. Freitag, Karen D. González-Madruga, Helena Oldenhof, Christina Stadler, Molly Batchelor, Andreas G. Chiocchetti, Katharina Ackermann, Nora Maria Raschle, Leonora Vllasaliu, Graeme Fairchild, Gregor Kohls, Anka Bernhard, Anne Martinelli, Arne Popma, Kerstin Konrad, Lucres M. C. Jansen, VU University medical center, APH - Mental Health, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), University of Zurich, and Bernhard, Anka
- Subjects
Conduct Disorder ,Male ,medicine.medical_specialty ,Adolescent ,Hydrocortisone ,Neuropeptide ,cortisol ,Oxytocin ,Fight-or-flight response ,2738 Psychiatry and Mental Health ,SDG 3 - Good Health and Well-being ,Internal medicine ,oxytocin ,Trier social stress test ,medicine ,Developmental and Educational Psychology ,Humans ,Testosterone ,Child ,Saliva ,3204 Developmental and Educational Psychology ,conduct disorder ,10093 Institute of Psychology ,business.industry ,stress response ,medicine.disease ,Psychiatry and Mental health ,Endocrinology ,Prosocial behavior ,Conduct disorder ,testosterone ,Female ,150 Psychology ,business ,Stress, Psychological ,10190 Jacobs Center for Productive Youth Development ,Hormone ,medicine.drug - Abstract
Objective: Conduct disorder (CD) involves aggressive and antisocial behavior and is associated with blunted cortisol stress response in male youths. Far less is known about cortisol stress responsivity in female youths with CD or other neuroendocrine responses in both sexes. Although CD is linked to early adversity, the possibility that neuroendocrine alterations may mediate the relationship between early adversity and CD has not been systematically investigated. Method: Within the European FemNAT-CD multi-site study, salivary cortisol, testosterone, the testosterone/cortisol ratio, oxytocin, and psychological stress response to a standardized psychosocial stress test (the Trier Social Stress Test [TSST]), together with common pre- and postnatal environmental risk factors, were investigated in 130 pubertal youths with CD (63% female, 9-18 years of age) and 160 sex-, age-, and puberty-matched healthy controls (HCs). Results: The TSST induced psychological stress in both CD and HCs. In contrast, female and male youths with CD showed blunted cortisol, testosterone, oxytocin, and testosterone/cortisol stress responses compared to HCs. These blunted stress responses partly mediated the relationship between environmental risk factors and CD. Conclusion: Findings from this unique sample, including many female youths with CD, provide evidence for a widespread attenuated stress responsivity of not only stress hormones, but also sex hormones and neuropeptides in CD and its subgroups (eg, with limited prosocial emotions). Results are the first to demonstrate blunted neuroendocrine stress responses in both female and male youths with CD. Early adversity may alter neuroendocrine stress responsivity. Biological mechanisms should be investigated further to pave the way for personalized intervention, thereby improving treatments for CD.
- Published
- 2022
17. Perpetrators and victims of cyberbullying among youth with conduct disorder
- Author
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Sarah Baumann, Anka Bernhard, Anne Martinelli, Katharina Ackermann, Beate Herpertz-Dahlmann, Christine Freitag, Kerstin Konrad, and Gregor Kohls
- Subjects
Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,ddc:610 ,General Medicine - Abstract
European child & adolescent psychiatry (2022). doi:10.1007/s00787-022-01973-0, Published by Steinkopff, Darmstadt
- Published
- 2022
18. The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors
- Author
-
Geburtig-Chiocchetti, Andreas, Yousaf, Afsheen, Waltes, Regina, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Haslinger, Denise, Rotter, Björn, Krezdorn, Nico, Konrad, Kerstin, Kohls, Gregor, Vetro, Agnes, Hervás, Amaia, Fernández-Rivas, Aranzazu, Freitag, Christine M., Geburtig-Chiocchetti, Andreas, Yousaf, Afsheen, Waltes, Regina, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Haslinger, Denise, Rotter, Björn, Krezdorn, Nico, Konrad, Kerstin, Kohls, Gregor, Vetro, Agnes, Hervás, Amaia, Fernández-Rivas, Aranzazu, and Freitag, Christine M.
- Abstract
Conduct Disorder (CD) is an impairing psychiatric disorder of childhood and adolescence characterized by aggressive and dissocial behavior. Environmental factors such as maternal smoking during pregnancy, socio-economic status, trauma, or early life stress are associated with CD. Although the number of females with CD is rising in Western societies, CD is under-researched in female cohorts. We aimed at exploring the epigenetic signature of females with CD and its relation to psychosocial and environmental risk factors. We performed HpaII sensitive genome-wide methylation sequencing of 49 CD girls and 50 matched typically developing controls and linear regression models to identify differentially methylated CpG loci (tags) and regions. Significant tags and regions were mapped to the respective genes and tested for enrichment in pathways and brain developmental processes. Finally, epigenetic signatures were tested as mediators for CD-associated risk factors. We identified a 12% increased methylation 5’ of the neurite modulator SLITRK5 (FDR = 0.0046) in cases within a glucocorticoid receptor binding site. Functionally, methylation positively correlated with gene expression in lymphoblastoid cell lines. At systems-level, genes (uncorr. P < 0.01) were associated with development of neurons, neurite outgrowth or neuronal developmental processes. At gene expression level, the associated gene-networks are activated perinatally and during early childhood in neocortical regions, thalamus and striatum, and expressed in amygdala and hippocampus. Specifically, the epigenetic signatures of the gene network activated in the thalamus during early childhood correlated with the effect of parental education on CD status possibly mediating its protective effect. The differential methylation patterns identified in females with CD are likely to affect genes that are expressed in brain regions previously indicated in CD. We provide suggestive evidence that protective effects are likely me
- Published
- 2022
19. Perpetrators and victims of cyberbullying among youth with conduct disorder
- Author
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Baumann, Sarah, primary, Bernhard, Anka, additional, Martinelli, Anne, additional, Ackermann, Katharina, additional, Herpertz-Dahlmann, Beate, additional, Freitag, Christine, additional, Konrad, Kerstin, additional, and Kohls, Gregor, additional
- Published
- 2022
- Full Text
- View/download PDF
20. Firefly Ultra Dense Networks: Design von linearen und nichtlinearen Verarbeitungsstrategien
- Author
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Ackermann, Katharina
- Subjects
ddc:600 - Abstract
Firefly ultra dense networks combine the promising properties of centralized processing and ultra dense deployment. We consider the uplink of the network, where a large number of remote radio units, referred to as firefly nodes (FNs), are spatially distributed over an area. In this coverage area, several mobile devices (MDs) are simultaneously connected to all FNs via sub-6 GHz radio frequency links. In contrast to the cloud radio access network (C-RAN) architecture, the FNs in firefly ultra dense networks forward the MDs’ data through multi-hop millimeter-wave (mmWave) links to one or multiple root nodes, since the coverage radius of an individual mmWave link is limited. These root nodes then forward the data over optical fiber links further to a central unit (CU), where the MDs’ signals are decoded. The amount of data that is received at each FN is potentially huge, and therefore efficient signal processing is required at each FN before the received signals can be forwarded to other FNs. Thus, in this thesis, we propose several linear processing strategies and a nonlinear processing strategy. First, by deploying linear processing schemes, all received signal streams are linearly filtered at each FN before being forwarded over an available mmWave link. Our simulation results show significant performance improvement compared to a baseline scheme. Furthermore, we propose a nonlinear processing strategy that quantizes the received signals at each FN. In particular, for the nonlinear forwarding at the FNs, we formulate an optimization problem for a local design strategy and present an optimal solution by utilizing strong duality and using the Lagrangian method to transform the optimization problem into an unconstrained problem via its dual formulation. A bisection algorithm for finding the optimal dual variables and a closed-form solution for the primal variables are presented. In addition, based on the cut-set bound, we develop an upper bound of the achievable sum rate for the considered firefly network. It is shown that the proposed nonlinear forwarding strategy outperforms several linear forwarding strategies and approaches the performance upper bound in relevant transmit power regimes at the expense of higher computational complexity. Our simulation results reveal that having more root nodes in the topology improves the performance of linear and nonlinear forwarding but also requires additional optical fiber links to the CU. Firefly-Ultra-Dense-Netzwerke vereinen die vielversprechenden Eigenschaften von Centralized-Processing und Ultra-Dense-Deployment. Wir betrachten den Uplink des Netzwerkes, bei dem eine große Anzahl von Remote-Radio-Units, die als Firefly Nodes (FN) bezeichnet werden, räumlich über ein Gebiet verteilt ist. In diesem Abdeckungsgebiet sind mehrere Mobilgeräte (MDs) gleichzeitig mit allen FNs über das sub-6-GHz-Frequenzband verbunden. Im Gegensatz zur Cloud-Radio-Access-Network (C-RAN) Architektur, leiten die FNs in Firefly-Ultra-Dense-Netzwerken die Daten der MDs über Multihop-Millimeter-Wellen (mmWave) Verbindungen an einen oder mehrere Wurzelknoten weiter, da der Abdeckungsradius der einzelnen mmWave-Verbindung begrenzt ist. Diese Wurzelknoten wiederum leiten die Daten mittels Glasfaserleitungen zu einer Central-Unit (CU) weiter, bei der die Signale der MDs dekodiert werden. Die Datenmenge, die an jeder FN empfangen wird, ist potenziell groß, weshalb eine effiziente Signalverarbeitung an jeder FN erforderlich ist, bevor die empfangenen Signale an andere FNs weitergeleitet werden können. Daher stellen wir in dieser Arbeit mehrere lineare Verarbeitungsstrategien und eine nichtlineare Verarbeitungsstrategie vor. Mithilfe von linearer Verarbeitung werden alle empfangenen Signalströme an jeder FN linear gefiltert und anschließend über vorhandene mmWave Verbindungen weitergeleitet. Verglichen mit einem Vergleichsverfahren, zeigen unsere Simulationsergebnisse eine signifikante Leistungsverbesserung auf. Des Weiteren stellen wir eine nichtlineare Verarbeitungsstrategie vor, welche die empfangenen Signale an jeder FN quantisiert. Insbesondere wird ein Optimierungsproblem für eine lokale Designstrategie der nichtlinearen Weiterleitung formuliert und eine optimale Lösung präsentiert, wobei wir die starke Dualität und die Lagrangesche-Methode verwenden, um das Optimierungsproblem über seine duale Formulierung in ein einfacheres Problem umwandeln. Es wird ein Bisektionsalgorithmus zur Ermittlung der optimalen dualen Variablen und eine geschlossene Lösung für die primären Variablen vorgestellt. Darüber hinaus entwickeln wir auf der Grundlage der Cut-Set-Bound eine obere Schranke der erreichbaren Summenrate für das betrachtete Firefly-Netzwerk. Die vorgeschlagene nichtlineare Verarbeitungsstrategie übertrifft mehrere lineare Verarbeitungsstrategien und erreicht die obere Leistungsschranke in relevanten Sendeleistungsbereichen auf Kosten einer höhereren Berechnungskomplexität. Die Simulationsergebnisse zeigen, dass das Vorhandensein von mehr Wurzelknoten in der Topologie die Leistung der linearen und nichtlinearen Weiterleitung verbessert, jedoch weitere Glasfaserverbindungen zur CU nötig macht.
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- 2022
21. The methylome in females with adolescent Conduct Disorder: Neural pathomechanisms and environmental risk factors
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Chiocchetti, Andreas G., Yousaf, Afsheen, Kohls, Gregor, Vetro, Agnes, Hervas, Amaia, Fernández-Rivas, Aranzazu, Freitag, Christine M., Waltes, Regina, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Haslinger, Denise, Rotter, Björn, Krezdorn, Nico, and Konrad, Kerstin
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Environmental Impacts ,Conduct Disorder ,Cell biology ,Computer and Information Sciences ,Adolescent ,Epidemiology ,Science ,Gene Identification and Analysis ,Social Sciences ,Genetic Networks ,Biochemistry ,Methylation ,Hippocampus ,Cell Line ,Epigenesis, Genetic ,Epigenome ,Risk Factors ,Genetics ,Medicine and Health Sciences ,Psychology ,Humans ,Gene Regulatory Networks ,ddc:610 ,Behavior ,DNA methylation ,Biology and life sciences ,Ecology and Environmental Sciences ,Chemical Reactions ,DNA ,Chromatin ,Nucleic acids ,Aggression ,Chemistry ,Medical Risk Factors ,Physical Sciences ,Medicine ,Epigenetics ,Female ,Gene expression ,DNA modification ,Chromatin modification ,Network Analysis ,Research Article ,Chromosome biology ,Genome-Wide Association Study - Abstract
PLOS ONE 17(1), 1-7 (2022). doi:10.1371/journal.pone.0261691, Published by PLOS, San Francisco, California, US
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- 2022
22. Machine learning classification of conduct disorder with high versus low levels of callous-unemotional traits based on facial emotion recognition abilities
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Pauli, Ruth, primary, Kohls, Gregor, additional, Tino, Peter, additional, Rogers, Jack C., additional, Baumann, Sarah, additional, Ackermann, Katharina, additional, Bernhard, Anka, additional, Martinelli, Anne, additional, Jansen, Lucres, additional, Oldenhof, Helena, additional, Gonzalez-Madruga, Karen, additional, Smaragdi, Areti, additional, Gonzalez-Torres, Miguel Angel, additional, Kerexeta-Lizeaga, Iñaki, additional, Boonmann, Cyril, additional, Kersten, Linda, additional, Bigorra, Aitana, additional, Hervas, Amaia, additional, Stadler, Christina, additional, Fernandez-Rivas, Aranzazu, additional, Popma, Arne, additional, Konrad, Kerstin, additional, Herpertz-Dahlmann, Beate, additional, Fairchild, Graeme, additional, Freitag, Christine M., additional, Rotshtein, Pia, additional, and De Brito, Stephane A., additional
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- 2021
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23. Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder.
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Konrad, Kerstin, Kohls, Gregor, Baumann, Sarah, Bernhard, Anka, Martinelli, Anne, Ackermann, Katharina, Smaragdi, Areti, Gonzalez‐Madruga, Karen, Wells, Amy, Rogers, Jack C., Pauli, Ruth, Clanton, Roberta, Baker, Rosalind, Kersten, Linda, Prätzlich, Martin, Oldenhof, Helena, Jansen, Lucres, Kleeven, Anneke, Bigorra, Aitana, and Hervas, Amaia
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RESEARCH methodology ,BORDERLINE personality disorder ,INTERVIEWING ,POST-traumatic stress disorder ,BEHAVIOR disorders in children ,SEX distribution ,COMPARATIVE studies ,ATTENTION-deficit hyperactivity disorder ,MENTAL depression ,AGE factors in disease ,PATHOLOGICAL psychology ,ANXIETY ,COMORBIDITY - Abstract
Background: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed‐onset pathway' hypotheses of female CD. Methods: As part of the FemNAT‐CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9–18 years), compared to 864 sex‐ and age‐matched typically developing controls. Results: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post‐traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention‐deficit/hyperactivity disorder. In line with the 'gender paradox' hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age‐of‐onset subtypes of CD (i.e. fewer girls with childhood‐onset CD). In line with the 'delayed‐onset pathway' hypothesis, girls with adolescent‐onset CD showed similar levels of dimensional psychopathology like boys with childhood‐onset CD, while boys with adolescent‐onset CD had the lowest levels of internalizing psychopathology. Conclusions: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the 'gender paradox' and 'delayed‐onset pathway' hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex‐specific clinical profiles of CD will be critical in informing intervention and prevention programmes. [ABSTRACT FROM AUTHOR]
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- 2022
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24. [Patient satisfaction with psychiatric day-care and inpatient treatment: Effects on physical and mental health].
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Ackermann K, Ueberberg B, and Assion HJ
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- Humans, Female, Male, Inpatients, Prospective Studies, Germany, Patient Satisfaction, Mental Health
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Introduction: Quality assessment from the patient's point of view makes it possible to identify negative quality developments at an early stage. The focus is not on the medical result, but on what the patient wants. Correlations between patient satisfaction and physical and psychological treatment outcome were already shown in the 1990s. However, studies using rather unspecific satisfaction measures are scarce. The aim of this study was to investigate the influence of patient satisfaction with the treatment and the therapies offered on the extent of recovery., Methods: In this prospective study, a questionnaire developed for the differentiated recording of patient satisfaction with the therapy offerings of the LWL-Klinik Dortmund was used in a day-care/hospital setting. The structure of the questionnaire was tested by means of explorative factor analysis. The factors generated in this way served as the basis for the hierarchical regression analyses in the further course. In addition to important treatment aspects from the patient's point of view, the subjective health status was recorded by means of SF-36., Results: 105 patients participated in the study (64% female, 84% diagnosed with depression). Significant predictors for physical health were well-being after exercise therapy and satisfaction with the weekly structure of services. Significant predictors for mental health were age at onset of illness, age, perceived benefits from exercise therapy as well as occupational therapy, treatment duration and setting., Discussion: The demonstrated impact of patient satisfaction on mental health highlights the relevance of treatment quality improvement to recovery., (Copyright © 2023. Published by Elsevier GmbH.)
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- 2023
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25. Psychophysiological responses to sadness in girls and boys with conduct disorder.
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Oldenhof H, Jansen L, Ackermann K, Baker R, Batchelor M, Baumann S, Bernhard A, Clanton R, Dochnal R, Fehlbaum LV, Fernandez-Rivas A, Goergen S, Gonzalez de Artaza-Lavesa M, Gonzalez-Madruga K, Gonzalez-Torres MA, Gundlach M, Lotte van der Hoeven M, Kalogerakis Z, Kapornai K, Kieser M, Konsta A, Martinelli A, Pauli R, Rogers J, Smaragdi A, Sesma-Pardo E, Siklósi R, Steppan M, Tsiakoulia F, Vermeiren R, Vriends N, Werner M, Herpertz-Dahlmann B, Kohls G, De Brito S, Konrad K, Stadler C, Fairchild G, Freitag CM, and Popma A
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- Adolescent, Antisocial Personality Disorder, Emotions physiology, Humans, Sadness, Conduct Disorder, Respiratory Sinus Arrhythmia physiology
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Reduced responsiveness to emotions is hypothesized to contribute to the development of conduct disorder (CD) in children and adolescents. Accordingly, blunted psychophysiological responses to emotions have been observed in boys with CD, but this has never been tested in girls. Therefore, this study compared psychophysiological responses to sadness in girls and boys with and without CD, and different clinical phenotypes of CD: with versus without limited prosocial emotions (LPE), and with versus without comorbid internalizing disorders (INT). Nine-hundred and 27 girls (427 CD, 500 controls) and 519 boys (266 CD, 253 controls) aged 9-18 years participated. Psychophysiological responses were measured while participants watched two validated sad film clips, specifically: heart rate (HR), respiratory sinus arrhythmia (RSA; indexing parasympathetic activity), preejection period (PEP; indexing sympathetic activity). Girls and boys with CD showed larger HR responses to sadness than controls. This effect was rendered nonsignificant, however, after controlling for covariates. We observed aberrant RSA responses to sadness in CD compared with controls. Similarly, we found a significant positive association between RSA responsivity and antisocial behavior when assessed dimensionally. The effects were very small, though. Results were similar for boys and girls. We found no evidence for emotional underresponsiveness in CD in the largest psychophysiological study to date in this field. More research is needed to explore whether this is specific to sadness or generalizes to other emotions. Furthermore, we recommend that studies on emotion processing in CD assess different physiological measures to help disentangle CD-related effects on sympathetic and parasympathetic activity. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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- 2022
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