22 results on '"ARMAGAN, Berkan"'
Search Results
2. The burden of face affected questionnaire in patients with systemic sclerosis: Translation, cross-cultural adaptation and psychometric properties in the Turkish version
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Sari, Fulden, Apaydin, Zilan B, Apaydin, Hakan A, Kayaalp, Mehmet, Erden, Abdulsamet, Güven, Serdar C, Armağan, Berkan, Omma, Ahmet, Küçükşahin, Orhan, and Erten, Şükran
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- 2024
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Catalog
3. Mortality risk factors in primary Sjögren syndrome: a real-world, retrospective, cohort study
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Arends, S., Treppo, E., Longhino, S., Manfrè, V., Rizzo, M., Baldini, C., Bombardieri, S., Bandeira, M., Silvéiro-António, M., Seror, R., Mariette, X., Nordmark, G., Danda, D., Wiland, P., Gerli, R., Kwok, S.K., Park, S.H., Kvarnstrom, M., Wahren-Herlenius, M., Downie-Doyle, S., Sene, D., Isenberg, D., Valim, V., Devauchelle-Pensec, V., Saraux, A., Morel, J., Morcillo, C., Díaz Cuiza, P.E., Herrera, B.E., González-de-Paz, L., Sisó-Almirall, A., Brito-Zerón, Pilar, Flores-Chávez, Alejandra, Horváth, Ildiko Fanny, Rasmussen, Astrid, Li, Xiaomei, Olsson, Peter, Vissink, Arjan, Priori, Roberta, Armagan, Berkan, Hernandez-Molina, Gabriela, Praprotnik, Sonja, Quartuccio, Luca, Inanç, Nevsun, Özkızıltaş, Burcugül, Bartoloni, Elena, Sebastian, Agata, Romão, Vasco C., Solans, Roser, Pasoto, Sandra G., Rischmueller, Maureen, Galisteo, Carlos, Suzuki, Yasunori, Trevisani, Virginia Fernandes Moça, Fugmann, Cecilia, González-García, Andrés, Carubbi, Francesco, Jurcut, Ciprian, Shimizu, Toshimasa, Retamozo, Soledad, Atzeni, Fabiola, Hofauer, Benedikt, Melchor-Díaz, Sheila, Gheita, Tamer, López-Dupla, Miguel, Fonseca-Aizpuru, Eva, Giacomelli, Roberto, Vázquez, Marcos, Consani, Sandra, Akasbi, Miriam, Nakamura, Hideki, Szántó, Antónia, Farris, A. Darise, Wang, Li, Mandl, Thomas, Gattamelata, Angelica, Kilic, Levent, Pirkmajer, Katja Perdan, Abacar, Kerem, Tufan, Abdurrahman, de Vita, Salvatore, Bootsma, Hendrika, and Ramos-Casals, Manuel more...
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- 2023
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4. Association between oxygen delivery and digital ulcers in systemic sclerosis
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Akdogan, Ali, Sari, Alper, Sener, Yusuf Ziya, Oksul, Metin, Armagan, Berkan, Kilic, Levent, Karadag, Omer, Bilgen, Sule Apras, Kaya, Ergun Baris, Kiraz, Sedat, and Ertenli, Ali Ihsan
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- 2023
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5. Neurological involvement in patients with primary Sjogren's syndrome: A retrospective cross-sectional study
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Konak, Hatice, Gök, Kevser, Armagan, Berkan, Güven, Serdar, Atalar, Ebru, Apaydin, Hakan, Maras, YüKsel, and Erten, SüKran
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Medical research ,Medicine, Experimental ,Neurophysiology ,Health - Abstract
Byline: Hatice. Konak, Kevser. Gök, Berkan. Armagan, Serdar. Güven, Ebru. Atalar, Hakan. Apaydin, Yüksel. Maras, Sükran. Erten Background: To determine the rate and types of neurological involvement in patients with [...] more...
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- 2023
6. Age-Related Variations in Treatment Patterns for Axial Spondyloarthritis.
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Erdogan, Esra Kayacan, Orhan, Kevser, Ulucakoy, Rezan Kocak, Ulusoy, Bahar Ozdemir, Guven, Serdar Can, Atalar, Ebru, Armagan, Berkan, and Babaoglu, Hakan
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CROSS-sectional method ,CONSERVATIVE treatment ,ADRENOCORTICAL hormones ,ANKYLOSIS ,DISEASE management ,METHOTREXATE ,LEFLUNOMIDE ,SEX distribution ,AGE distribution ,COLCHICINE ,ANTIRHEUMATIC agents ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,CHI-squared test ,PHYSICIAN practice patterns ,SULFONAMIDES ,ANALYSIS of variance ,SPONDYLOARTHROPATHIES ,DATA analysis software ,PATIENTS' attitudes ,COMORBIDITY ,DRUG utilization ,INTERLEUKINS ,TUMOR necrosis factors ,CHEMICAL inhibitors - Abstract
Aim: This study examines treatment patterns and preferences among patients diagnosed with Axial Spondyloarthritis (AxSpA) across different age groups. Material and Method: Ankara Bilkent City Hospital registry enabled a comprehensive cross-sectional analysis of 2,811 patients stratified into three age groups: 18-40, 41-55, and over 55 years. These groups were compared in terms of their treatments. Results: Our findings indicate an increasing prevalence of female patients and comorbidities with age. Medication usage patterns showed a trend towards increased use of Methotrexate and Colchicine with age, while Sulfasalazine and Leflunomide were more commonly prescribed in older age groups. Notably, the use of biologic Disease-Modifying Anti-Rheumatic Drugs (bDMARDs), including anti-Tumor Necrosis Factor (anti-TNF)", "anti-Interleukin (anti-IL) agents, demonstrated a declining trend with advancing age, though not reaching statistical significance. This trend was also reflected in gender-specific treatment distributions, where no significant difference was found in bDMARDs administration among patients over 55 years, contrasting with a higher usage rate in younger male patients. Conclusion: Our study highlights a shift towards more conservative treatment approaches, such as increased conventional synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) use in older patients, likely due to their safety profile and the specific challenges associated with treating older adults, including higher comorbidity rates and medication side effects. These findings emphasize the need for personalized treatment strategies and suggest potential adjustments in clinical practices to better accommodate the aging population, advocating for ongoing research to optimize treatment efficacy and safety for elderly patients with AxSpA. [ABSTRACT FROM AUTHOR] more...
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- 2024
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7. A disease to consider in the differential diagnosis of lower back pain: Celiac disease and related autoimmune disorders
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Karakaş, Özlem, primary, Armagan, Berkan, additional, Taş Kılıç, Diler, additional, Özdemir Ulusoy, Bahar, additional, Atalar, Ebru, additional, Köseoğlu, Hasan Tankut, additional, Yuksel, Mahmut, additional, Kalkan, Cagdas, additional, Akın, Fatma Ebru, additional, Altiparmak, Emin, additional, and Erten, Şükran, additional more...
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- 2024
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8. Baseline capillaroscopy provides no evidence of microvascular changes to predict long-COVID syndrome.
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OZDEMIR ULUSOY, Bahar, BABAOGLU, Hakan, ARMAGAN, Berkan, AYPAK ALTUNSOY, Adalet, AKINCI, Esragul, KUCUKSAHIN, Orhan, OMMA, Ahmet, ERTEN, Sukran, and ERDEN, Abdulsamet
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POST-acute COVID-19 syndrome ,COVID-19 ,COVID-19 testing ,COVID-19 pandemic ,CAPILLAROSCOPY - Abstract
BACKGROUND: Long-COVID refers to a variety of symptoms that continue for at least 4 weeks following the onset of acute COVID-19 infection. "Microclots/microvasculopathy" is a potential cutting-edge theory. Nailfold capillaroscopy is a non-invasive method used to assess microvascularity. In this study, we aimed to compare baseline characteristics and capillaroscopic findings of patients with and without long-COVID syndrome. METHODS: Baseline clinical characteristics of 53 patients who tested positive for SARS-CoV-2 were recorded. At the time of COVID-19 diagnosis, patients underwent nailfold capillaroscopy. One year later, patients were rescreened for long-COVID symptoms. Comparisons were made between patients with and without long-COVID syndrome in terms of their baseline characteristics and capillaroscopic findings. RESULTS: There were 35 individuals (66%) with long-COVID syndrome. The most common symptoms related to long-COVID were fatigue (43.4%), myalgia (34%), arthralgia (20.8%), dyspnea (20.8%). In total, 22 patients (41.5%) had abnormal capillaroscopy findings. Like other baseline characteristics, the proportion of patients with abnormal capillaroscopic findings (40% vs 44%, p=0.76) was similar between patients with and without long-COVID syndrome. CONCLUSION: Microvasculopathy and microthrombotic vascular damage are among the strongest hypotheses discussed in this regard. Our results may suggest that factors, rather than baseline microvasculopathy, may drive pathophysiological mechanism underlying the poorly understood long-COVID syndrome [ABSTRACT FROM AUTHOR] more...
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- 2024
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9. Impact of the Long-Term Hydroxychloroquine Use on COVID-19 Severity in Patients with Autoimmune Rheumatic Disease.
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Erdogan, Esra Kayacan, Karakas, Hakan Apaydin1,Özlem, Ulusoy, Bahar Özdemir, Armagan, Berkan, and Kucuksahin, Orhan
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HYDROXYCHLOROQUINE ,SARS-CoV-2 ,AUTOIMMUNE diseases ,THROMBOEMBOLISM ,RHEUMATOLOGY - Abstract
Copyright of Acibadem Saglik Bilimleri Dergisi is the property of Acibadem University Medical School and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
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- 2024
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10. Treatment patterns of rheumatoid arthritis across different age groups.
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Ulusoy, Bahar Ozdemir, Erdogan, Esra Kayacan, Armagan, Berkan, Karakas, Ozlem, Apaydin, Hakan, Orhan, Kevser, Kocak, Rezan, Atalar, Ebru, Dagli, Pinar Akyuz, Konak, Hatice Ecem, Polat, Bunyamin, and Babaoglu, Hakan more...
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RHEUMATOID arthritis treatment ,DISEASE incidence ,TUMOR necrosis factors ,METHOTREXATE ,ANTIRHEUMATIC agents ,OLDER patients - Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a higher incidence in older adults. We aimed to analyze the differences in the choice of RA treatment regimens across various age groups. A retrospective cohort study using data from the Ankara Bilkent City Hospital Registry was conducted, involving 3,475 RA patients categorized into three age groups: 18-49, 50-64, and over 65 years. Key variables examined included demographics, comorbidities, and utilization of various treatment modalities, including disease-modifying antirheumatic drugs (DMARDs), tumor necrosis factor-alpha inhibitors (TNFi), targeted synthetic DMARDs (tsDMARDs), and other biological treatments. Statistical analysis was done with Jamovi software. The study found significant differences in drug prescriptions among age groups. Older patients (>65 years) were less likely to be prescribed methotrexate and sulfasalazine but more likely to receive leflunomide and colchicine. A decline in the use of TNFi and tsDMARDs with age was noted, while other biologics were consistently used across all ages. Our findings underscore the impact of age on treatment choices in RA, revealing a tendency towards less aggressive treatment approaches in older patients. We emphasize the importance of re-evaluating current treatment protocols to better accommodate the health needs of the aging RA population and enhance their quality of life. [ABSTRACT FROM AUTHOR] more...
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- 2024
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11. Exposure to air pollution as an environmental determinant of how Sjögren's disease is expressed at diagnosis
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Brito-Zerón, Pilar, primary, Flores-Chávez, Alejandra, additional, Ng, Wan-Fai, additional, Fanny Horváth, Ildiko, additional, Rasmussen, Astrid, additional, Priori, Roberta, additional, Baldini, Chiara, additional, Armagan, Berkan, additional, Özkiziltaş, Burcugül, additional, Praprotnik, Sonja, additional, Suzuki, Yasuori, additional, Quartuccio, Luca, additional, Hernandez-Molina, Gabriela, additional, Abacar, Kerem, additional, Bartoloni, Elena, additional, Rischmueller, Maureen, additional, Reis-de Oliveira, Fabiola, additional, Fernandes Moça Trevisani, Virginia, additional, Jurcut, Ciprian, additional, Fugmann, Cecilia, additional, Carubbi, Francesco, additional, Hofauer, Benedikt, additional, Valim, Valeria, additional, Pasoto, Sandra G., additional, Retamozo, Soledad, additional, Atzeni, Fabiola, additional, Fonseca-Aizpuru, Eva, additional, López-Dupla, Miguel, additional, Giacomelli, Roberto, additional, Nakamura, Hideki, additional, Akasbi, Miriam, additional, Thompson, Kyle, additional, Szántó, Antónia, additional, Farris, A. Darise, additional, Villa, Martina, additional, Bombardieri, Stefano, additional, Kilic, Levent, additional, Tufan, Abdurrahman, additional, Perdan Pirkmajer, Katja, additional, Fujisawa, Yuhei, additional, de Vita, Salvatore, additional, Inanc, Nevsun, additional, and Ramos-Casals, Manuel, additional more...
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- 2023
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12. Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome
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Flores-Chávez, Alejandra, primary, Brito-Zerón, Pilar, additional, Ng, Wan-Fai, additional, Szántó, Antónia, additional, Rasmussen, Astrid, additional, Priori, Roberta, additional, Baldini, Chiara, additional, Armagan, Berkan, additional, Özkiziltaş, Burcugül, additional, Praprotnik, Sonja, additional, Suzuki, Yasunori, additional, Quartuccio, Luca, additional, Hernández-Molina, Gabriela, additional, Inanc, Nevsun, additional, Bartoloni, Elena, additional, Rischmueller, Maureen, additional, Reis-de Oliveira, Fabiola, additional, Fernandes Moça Trevisani, Virginia, additional, Jurcut, Ciprian, additional, Nordmark, Gunnel, additional, Carubbi, Francesco, additional, Hofauer, Benedikt, additional, Valim, Valeria, additional, Pasoto, Sandra G., additional, Retamozo, Soledad, additional, Atzeni, Fabiola, additional, Fonseca-Aizpuru, Eva, additional, López-Dupla, Miguel, additional, Giacomelli, Roberto, additional, Nakamura, Hideki, additional, Akasbi, Miriam, additional, Thompson, Kyle, additional, Fanny Horváth, Ildiko, additional, Farris, A. Darise, additional, Simoncelli, Edoardo, additional, Bombardieri, Stefano, additional, Kilic, Levent, additional, Tufan, Abdurrahman, additional, Perdan Pirkmajer, Katja, additional, Fujisawa, Yuhei, additional, De Vita, Salvatore, additional, Abacar, Kerem, additional, and Ramos-Casals, Manuel, additional more...
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- 2023
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13. Mortality risk factors in primary Sjögren syndrome: a real-world, retrospective, cohort study
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Brito-Zerón, Pilar, primary, Flores-Chávez, Alejandra, additional, Horváth, Ildiko Fanny, additional, Rasmussen, Astrid, additional, Li, Xiaomei, additional, Olsson, Peter, additional, Vissink, Arjan, additional, Priori, Roberta, additional, Armagan, Berkan, additional, Hernandez-Molina, Gabriela, additional, Praprotnik, Sonja, additional, Quartuccio, Luca, additional, Inanç, Nevsun, additional, Özkızıltaş, Burcugül, additional, Bartoloni, Elena, additional, Sebastian, Agata, additional, Romão, Vasco C., additional, Solans, Roser, additional, Pasoto, Sandra G., additional, Rischmueller, Maureen, additional, Galisteo, Carlos, additional, Suzuki, Yasunori, additional, Trevisani, Virginia Fernandes Moça, additional, Fugmann, Cecilia, additional, González-García, Andrés, additional, Carubbi, Francesco, additional, Jurcut, Ciprian, additional, Shimizu, Toshimasa, additional, Retamozo, Soledad, additional, Atzeni, Fabiola, additional, Hofauer, Benedikt, additional, Melchor-Díaz, Sheila, additional, Gheita, Tamer, additional, López-Dupla, Miguel, additional, Fonseca-Aizpuru, Eva, additional, Giacomelli, Roberto, additional, Vázquez, Marcos, additional, Consani, Sandra, additional, Akasbi, Miriam, additional, Nakamura, Hideki, additional, Szántó, Antónia, additional, Farris, A. Darise, additional, Wang, Li, additional, Mandl, Thomas, additional, Gattamelata, Angelica, additional, Kilic, Levent, additional, Pirkmajer, Katja Perdan, additional, Abacar, Kerem, additional, Tufan, Abdurrahman, additional, de Vita, Salvatore, additional, Bootsma, Hendrika, additional, Ramos-Casals, Manuel, additional, Arends, S., additional, Treppo, E., additional, Longhino, S., additional, Manfrè, V., additional, Rizzo, M., additional, Baldini, C., additional, Bombardieri, S., additional, Bandeira, M., additional, Silvéiro-António, M., additional, Seror, R., additional, Mariette, X., additional, Nordmark, G., additional, Danda, D., additional, Wiland, P., additional, Gerli, R., additional, Kwok, S.K., additional, Park, S.H., additional, Kvarnstrom, M., additional, Wahren-Herlenius, M., additional, Downie-Doyle, S., additional, Sene, D., additional, Isenberg, D., additional, Valim, V., additional, Devauchelle-Pensec, V., additional, Saraux, A., additional, Morel, J., additional, Morcillo, C., additional, Díaz Cuiza, P.E., additional, Herrera, B.E., additional, González-de-Paz, L., additional, and Sisó-Almirall, A., additional more...
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- 2023
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14. Mortality risk factors in primary Sjögren syndrome : a real-world, retrospective, cohort study
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Brito-Zerón, Pilar, Flores-Chávez, Alejandra, Horváth, Ildiko Fanny, Rasmussen, Astrid, Li, Xiaomei, Olsson, Peter, Vissink, Arjan, Priori, Roberta, Armagan, Berkan, Hernandez-Molina, Gabriela, Praprotnik, Sonja, Quartuccio, Luca, Inanc, Nevsun, Özkiziltas, Burcugül, Bartoloni, Elena, Sebastian, Agata, Romão, Vasco C., Solans, Roser, Pasoto, Sandra G., Rischmueller, Maureen, Galisteo, Carlos, Suzuki, Yasunori, Fernandes Moca Trevisani, Virginia, Fugmann, Cecilia, González-García, Andrés, Carubbi, Francesco, Jurcut, Ciprian, Shimizu, Toshimasa, Retamozo, Soledad, Atzeni, Fabiola, Hofauer, Benedikt, Melchor-Díaz, Sheila, Gheita, Tamer, López-Dupla, Miguel, Fonseca-Aizpuru, Eva, Giacomelli, Roberto, Vázquez, Marcos, Consani, Sandra, Akasbi, Miriam, Nakamura, Hideki, Szántó, Antónia, Farris, A. Darise, Wang, Li, Mandl, Thomas, Gattamelata, Angelica, Kilic, Levent, Perdan Pirkmajer, Katja, Abacar, Kerem, Tufan, Abdurrahman, de Vita, Salvatore, Bootsma, Hendrika, Ramos-Casals, Manuel, Brito-Zerón, Pilar, Flores-Chávez, Alejandra, Horváth, Ildiko Fanny, Rasmussen, Astrid, Li, Xiaomei, Olsson, Peter, Vissink, Arjan, Priori, Roberta, Armagan, Berkan, Hernandez-Molina, Gabriela, Praprotnik, Sonja, Quartuccio, Luca, Inanc, Nevsun, Özkiziltas, Burcugül, Bartoloni, Elena, Sebastian, Agata, Romão, Vasco C., Solans, Roser, Pasoto, Sandra G., Rischmueller, Maureen, Galisteo, Carlos, Suzuki, Yasunori, Fernandes Moca Trevisani, Virginia, Fugmann, Cecilia, González-García, Andrés, Carubbi, Francesco, Jurcut, Ciprian, Shimizu, Toshimasa, Retamozo, Soledad, Atzeni, Fabiola, Hofauer, Benedikt, Melchor-Díaz, Sheila, Gheita, Tamer, López-Dupla, Miguel, Fonseca-Aizpuru, Eva, Giacomelli, Roberto, Vázquez, Marcos, Consani, Sandra, Akasbi, Miriam, Nakamura, Hideki, Szántó, Antónia, Farris, A. Darise, Wang, Li, Mandl, Thomas, Gattamelata, Angelica, Kilic, Levent, Perdan Pirkmajer, Katja, Abacar, Kerem, Tufan, Abdurrahman, de Vita, Salvatore, Bootsma, Hendrika, and Ramos-Casals, Manuel more...
- Abstract
Background What baseline predictors would be involved in mortality in people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the baseline characteristics collected at the time of diagnosis of SjS associated with mortality and to identify mortality risk factors for all-cause death and deaths related to systemic SjS activity measured by the ESSDAI score. Methods In this international, real-world, retrospective, cohort study, we retrospectively collected data from 27 countries on mortality and causes of death from the Big Data Sjögren Registry. Inclusion criteria consisted of fulfilling 2002/2016 SjS classification criteria, and exclusion criteria included chronic HCV/HIV infections and associated systemic autoimmune diseases. A statistical approach based on a directed acyclic graph was used, with all-cause and Sjögren-related mortality as primary endpoints. The key determinants that defined the disease phenotype at diagnosis (glandular, systemic, and immunological) were analysed as independent variables. Findings Between January 1st, 2014 and December 31, 2023, data from 11,372 patients with primary SjS (93.5% women, 78.4% classified as White, mean age at diagnosis of 51.1 years) included in the Registry were analysed. 876 (7.7%) deaths were recorded after a mean follow-up of 8.6 years (SD 7.12). Univariate analysis of prognostic factors for all-cause death identified eight Sjögren-related variables (ocular and oral tests, salivary biopsy, ESSDAI, ANA, anti-Ro, anti-La, and cryoglobulins). The multivariate CPH model adjusted for these variables and the epidemiological features showed that DAS-ESSDAI (high vs no high: HR = 1.68; 95% CI, 1.27–2.22) and cryoglobulins (positive vs negative: HR = 1.72; 95% CI, 1.22–2.42) were independent predictors of all-cause death. Of the 640 deaths with available information detailing the specific cause of death, 14% were due to systemic SjS. Univariate analysis of prognostic factors for Sjögren-c, Title in Web of Science: Mortality risk factors in primary Sjogren syndrome: a real-world, retrospective, cohort study more...
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- 2023
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15. Safety and immunogenicity of inactive vaccines as booster doses for COVID-19 in Türkiye: A randomized trial
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Omma, Ahmet, primary, Batirel, Ayse, additional, Aydin, Mehtap, additional, Yilmaz Karadag, Fatma, additional, Erden, Abdulsamet, additional, Kucuksahin, Orhan, additional, Armagan, Berkan, additional, Güven, Serdar Can, additional, Karakas, Ozlem, additional, Gokdemir, Selim, additional, Altunal, Lutfiye Nilsun, additional, Buber, Aslihan Ayse, additional, Gemcioglu, Emin, additional, Zengin, Oguzhan, additional, Inan, Osman, additional, Sahiner, Enes Seyda, additional, Korukluoglu, Gulay, additional, Sezer, Zafer, additional, Ozdarendeli, Aykut, additional, Kara, Ates, additional, and Ates, Ihsan, additional more...
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- 2022
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16. Long-Term Results of Immunogenicity of Booster Vaccination against SARS-CoV-2 (Hybrid COV-RAPEL TR Study) in Turkiye: A Double-Blind, Randomized, Controlled, Multicenter Phase 2 Clinical Study.
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Ates, Ihsan, Batirel, Ayse, Aydin, Mehtap, Karadag, Fatma Yilmaz, Erden, Abdulsamet, Kucuksahin, Orhan, Armagan, Berkan, Guven, Serdar Can, Karakas, Ozlem, Gokdemir, Selim, Altunal, Lutfiye Nilsun, Buber, Aslihan Ayse, Gemcioglu, Emin, Zengin, Oguzhan, Inan, Osman, Sahiner, Enes Seyda, Korukluoglu, Gulay, Sezer, Zafer, Ozdarendeli, Aykut, and Omma, Ahmet more...
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BOOSTER vaccines ,IMMUNE response ,SARS-CoV-2 Delta variant ,VACCINE immunogenicity ,COVID-19 vaccines ,NEUTRALIZATION tests - Abstract
The immunogenicity of vaccines decreases over time, causing a need for booster doses. This study aimed to present the long-term (Day 84) immunogenicity results of the double-blind, randomized, controlled, phase II Hybrid COV-RAPEL TR Study (NCT04979949), in which the TURKOVAC or CoronaVac vaccines were used as a booster after the second dose of primary vaccination with CoronaVac. A total of 190 participants from the Hybrid COV-RAPEL TR Study, who had both Day 28 and Day 84 immunogenicity results, were included. The immunogenicity on Day 84, regarding the neutralizing antibody positivity (Wuhan and Delta variants) and anti-spike immunoglobulin (Ig) G (IgG) antibody positivity, was compared between TURKOVAC and CoronaVac vaccine arms according to sex and age groups. Overall, antibody positivity showed a slight decrease on Day 84 vs. Day 28, but was not different between TURKOVAC and CoronaVac arms either for sexes or for age groups. However, TURKOVAC produced better antibody response against the Delta variant than CoronaVac, while CoronaVac was superior over TURKOVAC regarding neutralizing antibody positivity in the 50–60 years age group, regardless of the variant. A single booster dose, after the completion of the primary vaccination, increases antibody positivity on Day 28 which persists until Day 84 with a slight decrease. However, an additional booster dose may be required thereafter, since the decrease in antibody titer may be faster over time. [ABSTRACT FROM AUTHOR] more...
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- 2023
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17. Secukinumab in the treatment of psoriatic arthritis or ankylosing spondyloarthritis with multiple sclerosis: a case series with literature review
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Eksin, Mehmet Akif, primary, Erden, Abdulsamet, additional, Güven, Serdar Can, additional, Armagan, Berkan, additional, Ozdemir, Bahar, additional, Karakas, Ozlem, additional, Omma, Ahmet, additional, and Kucuksahin, Orhan, additional more...
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- 2022
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18. The clinical significance of antiphospholipid antibodies in COVID-19 infection
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Atalar, Ebru, primary, Erden, Abdulsamet, additional, Guven, Serdar Can, additional, Armagan, Berkan, additional, Ates, İhsan, additional, Küçüksahin, Orhan, additional, and Omma, Ahmet, additional
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- 2022
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19. Performance of the systemic lupus erythematosus risk probability index in a cohort of undifferentiated connective tissue disease.
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Erden, Abdulsamet, Apaydın, Hakan, Fanouriakis, Antonis, Güven, Serdar Can, Armagan, Berkan, Dağlı, Pınar Akyüz, Konak, Hatice Ecem, Polat, Bünyamin, Atalar, Ebru, Esmer, Serdar, Karakaş, Özlem, Özdemir, Bahar, Eksin, Mehmet Akif, Omma, Ahmet, Kücüksahin, Orhan, Bertsias, George K, and Boumpas, Dimitrios T more...
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SYSTEMIC lupus erythematosus diagnosis ,CONNECTIVE tissue diseases ,DESCRIPTIVE statistics ,EARLY diagnosis - Abstract
Objectives We sought to evaluate the performance of the SLE Risk Probability Index (SLERPI) for identification of SLE in a large cohort of patients with UCTD. Methods The SLERPI was applied in a cohort of patients who met classification criteria for UCTD and did not fulfil any classification criteria for other defined CTD including SLE. Patients with a SLERPI score of >7 were 'diagnosed' as SLE. Patients diagnosed with SLE and those not were compared in terms of disease characteristics and index parameters. Results A total of 422 patients with UCTD were included in the study. Median (interquartile range) SLERPI was 4.25 (2.5) points, while 39 (9.2%) patients had a SLERPI score >7 and were diagnosed as SLE. Patients with younger age (P = 0.026) and presence of malar rash (P < 0.0001), mucosal ulcer (P < 0.0001), alopecia (P < 0.0001), ANA positivity (P < 0.0001), low C3 and C4 (P = 0.002), proteinuria >500 mg/24 h (P = 0.001), thrombocytopenia (P = 0.009) or autoimmune haemolytic anaemia (P < 0.0001) were more likely to fulfil criteria for SLE by the SLERPI. Conclusion SLERPI enabled a significant proportion of patients to be identified as SLE in our UCTD cohort. This new probability index may be useful for early identification of SLE among patients with signs of CTD without fulfilling any definite criteria set. [ABSTRACT FROM AUTHOR] more...
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- 2022
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20. Evaluation of Serum Total Antioxidant Level, Nutritional Status and Mediterranean Diet Adherence of Adult Women with Rheumatoid Arthritis: A Case-Control Study.
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Bekar C, Armagan B, Sari A, and Ayaz A
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Rheumatoid arthritis (RA) is characterized by chronic inflammation in joints. Obesity, stress, being women, and dietary pattern are important in pathogenesis. The joint damage in RA is accelerated by oxidative stress. The aim of this study was to examine the serum total antioxidant level, nutritional status, and Mediterranean diet adherence of adult women with RA. 35 adult women RA patients and 35 healthy control subjects participated in this study (45.4 ± 11.61 and 42.5 ± 8.50 years, respectively). Nutritional status, physical activity levels, and adherence to the Mediterranean diet were questioned. Physicians assessed the disease activity score of patients with RA. Serum total antioxidant (TAS) and oxidant status (TOS) were analysed. The serum TAS of the control group was higher, whereas the oxidative stress index (OSI) and TOS were lower than that of RA group. Dietary protein, fiber, eicosapentaenoic acid (EPA), retinol, iron, zinc, and total antioxidant intake in the RA group were lower than the control group (p < 0.05). Individuals with higher fiber intake showed a significantly lower risk for RA after adjusted for potential confounding factors (OR = 0.845, 95% CI = 0.773-0.923, p < 0.001). The mean physical activity level of the control group was higher than that of the RA group (1.59 ± 0.10 and 1.53 ± 0.13, respectively) (p = 0.01). In conclusion, serum antioxidant parameters and dietary antioxidant intake are decreased in patients with RA. Therefore, medical treatment for these patients should be supplemented with medical nutrition therapy to achieve optimal nutritional status. more...
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- 2025
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21. The Role of Central Sensitization in Autoimmune Connective Tissue Diseases: A Comparative Cross-Sectional Study.
- Author
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Bazancir-Apaydin Z, Apaydin H, Armagan B, Orhan K, and Erten S
- Subjects
- Humans, Female, Cross-Sectional Studies, Male, Middle Aged, Adult, Case-Control Studies, Comorbidity, Autoimmune Diseases epidemiology, Autoimmune Diseases immunology, Autoimmune Diseases diagnosis, Autoimmune Diseases blood, Aged, Sjogren's Syndrome blood, Sjogren's Syndrome immunology, Sjogren's Syndrome diagnosis, Sjogren's Syndrome epidemiology, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic immunology, Lupus Erythematosus, Systemic blood, Lupus Erythematosus, Systemic epidemiology, Arthritis, Rheumatoid immunology, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid epidemiology, Arthritis, Rheumatoid blood, Connective Tissue Diseases immunology, Connective Tissue Diseases diagnosis, Connective Tissue Diseases epidemiology, Connective Tissue Diseases blood
- Abstract
Objective: To investigate the central sensitization (CS) in patients with autoimmune connective tissue diseases (ACTDs) and its relationship with disease activity, laboratory findings, medical treatments, organ involvements, and comorbidity., Methods: One hundred and eleven patients with ACTDs and 40 healthy individuals were included. All patients were divided into three groups in terms of their diseases: Sjögren's syndrome (SS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). The CS was assessed using the central sensitization inventory (CSI-A and CSI-B scores). The disease activity, laboratory findings, medical treatments, organ involvements, and comorbidity of all patients were evaluated., Results: Overall, 41.4% patients with ACTDs had CS. SS group had the highest CS positivity (n = 21, 58.3%) compared to the RA (n = 14, 36.8%) and SLE (n = 11, 29.7%) groups. The SS group had a significantly higher CSI-A score (p < 0.016) than the RA and SLE group, which had similar scores. CSI-A (p = 0.008, r = -0.63) and CSI-B (p = 0.001, r = -0.76) scores were moderately to high correlated with vitamin D3 levels in SLE group. CSI-B score was moderately correlated with folic acid levels (p = 0.03, r = 0.50) and TSH (p = 0.005, r = 0.55) in SS group. The CSI-A score ≥ 40 subgroup had more female gender, frequency of COPD or asthma, more coexisting fibromyalgia, higher VAS score, more common exocrine gland involvement, and higher corticosteroid dose compared to the CSI score < 40 subgroup., Conclusions: CS is commonly seen in patients with ACTDs, especially in SS. CS is associated with vitamin D3, folic acid, and TSH levels in ACTD subgroups and the patients with clinical CS have a specific profile., (© 2025 The Author(s). International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.) more...
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- 2025
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22. Quality of life, disease activity and preferences for administration routes in rheumatoid arthritis: a multicentre, prospective, observational study.
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Direskeneli H, Karadag O, Ates A, Tufan A, Inanc N, Koca SS, Cetin GY, Akar S, Cinar M, Yilmaz S, Yilmaz N, Dalkilic E, Bes C, Yilmazer B, Sahin A, Ersözlü D, Tezcan ME, Sen N, Keser G, Kalyoncu U, Armagan B, Hacibedel B, Helvacioglu K, Cesur TY, Basibuyuk CS, Alkan S, and Gunay LM more...
- Abstract
Objective: We aimed to evaluate quality of life (QoL), disease activity, compliance to treatment, patient and physician preferences for route of administration (RoA), status of health and pain in RA patients starting advanced treatments or needing a switch, and the factors associated with patient preferences., Methods: A multicentre, prospective, observational and 1-year follow-up study was conducted, between 2015 and 2020, in adult RA patients using advanced treatments for the first time or needing a switch in their current treatments. All the data collected were entered into electronic case report forms. DAS in 28 joints with ESR [DAS28-4(ESR)], EuroQol 5-Dimensional Questionnaire (EQ-5D), HAQ Disability Index (HAQ-DI), Compliance Questionnaire for Rheumatology (CQR-19), Work Productivity and Activity Impairment Instrument (WPAI) and Patient Global Assessment-Visual Analogue Scale (PGA-VAS) questionnaires were used for longitudinal assessments., Results: Four hundred and fifty-nine patients were enrolled. Three hundred and eight patients (67.1%) attended the final study visit at 12 months and were included for comparative analyses. Irrespective of RoA, the disease activity and QoL improved significantly at 12 months, whereas compliance worsened. At baseline and 12 months, EQ-5D and DAS28-4(ESR) scores were significantly correlated ( P < 0.001). The WPAI scores changed significantly in favour of better outcomes over 12 months after initiation of advanced treatment or switching ( P < 0.001). A higher proportion of patients preferred an oral RoA, in comparison to physicians (53.6% vs 31.4%; P < 0.001). Patient and physician RoA preferences were independent of gender, age, disease duration, advanced treatment type and the EQ-5D-3L, DAS28-4(ESR), HAQ-DI, PGA-VAS and CQR-19 scores at baseline., Conclusion: The oral route was more frequently preferred by patients compared with physicians, although patients' preference rates showed a slight increase towards the end of the treatment, which might be an important factor for RA outcomes. Better control of disease activity and QoL were achieved at 12 months, regardless of RoA., (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.) more...
- Published
- 2022
- Full Text
- View/download PDF
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