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With applications across chemistry, physics and medicine, nuclear magnetic resonance is a proven, uniquely versatile and powerful spectroscopic technique. The success of NMR and its constant redevelopment means that the literature is vast and wide-ranging. Each chapter in this volume is a distillation of the key recent literature in different areas, covering the spectrum of NMR theory and practice, and including theory and computation of nuclear shielding, NMR of soft matter, hyperpolarisation techniques and NMR of living systems. These reports are invaluable both for new researchers wishing to engage with literature for the first time, and for seasoned practitioners, particularly service managers, needing to keep in touch with the ever-expanding ways in which NMR is used.

Drawing together the latest research on migration, gender and COVID-19, this erudite Research Handbook contributes to a better understanding of the immediate and longer-term implications of the pandemic on gender dynamics and roles in international migration. Providing a wealth of expert critical analysis, it considers post-COVID-19 realities and assesses the future scope of research in this interdisciplinary field of study.Capturing multi-disciplinary insights and diverse geographies, the Research Handbook explores migration in all of its facets, from displacement and internal and international mobility to return migration and labour mobility. Chapters address topical issues relating to the policy and programmatic implications of the COVID-19 pandemic for migration and migrants from a gender perspective. Marie McAuliffe and Céline Bauloz, alongside leading researchers and academics, present a major contribution to scholarly inquiry which is crucial for informing inclusive and sustainable responses to improve migrants'wellbeing and protection.Offering a state-of-the-art review of the implications of COVID-19 on migration through the lens of gender, this Research Handbook will provide a thought-provoking resource for students and researchers in demography, migration studies, geography, political science, sociology and international law. Its critical examination of policy and programmatic interventions designed to address gender inequalities in migration will also be of significant interest to policymakers and practitioners.

Sumerian was the first language to be put into writing (ca. 3200–3100 BCE), and it is the language for which the cuneiform script was originally developed. Even after it was supplanted by Akkadian as the primary spoken language in ancient Mesopotamia, Sumerian continued to be used as a scholarly written language until the end of the first millennium BCE. This volume presents the first comprehensive English-language scholarly lexicon of Sumerian.This dictionary covers all the nuances of meaning for Sumerian terms found in historical inscriptions and literary, administrative, and lexical texts dating from about 2500 BCE to the first century BCE. The entries are organized by transcription and are accompanied by the transliteration and translation of passages in which the term occurs and, where relevant, a discussion of the word's treatment in other publications. Main entries bring together all the parts of speech and compound forms for the Sumerian term and present each part of speech individually. All possible Akkadian equivalents and variant syllabic renderings are listed for lexical attestations of a word, and a meaningful sample of occurrences is given for literary and economic passages. Entries of homonyms with different orthographies and unrelated words with the same orthography are grouped together, each being assigned a unique identifier, and the dictionary treats the phoneme /dr/ as a separate consonant.Written by one of the foremost scholars in the field, An Annotated Sumerian Dictionary is an essential reference for Sumerologists and Assyriologists and a practical help to students of ancient cultures.

Het is algemeen bekend dat de rechtshandhaving niet uitsluitend een strafrechtelijke aangelegenheid is. Er is ook een belangrijke rol weggelegd voor de bestuursrechtelijke handhaving. Dit boek handelt over het gebied waar strafrecht en bestuursrecht elkaar ontmoeten in de rechtshandhaving, namelijk de bestuursstrafrechtspleging. Hierin wordt vanuit een juridisch en sociaalwetenschappelijk perspectief nagegaan hoe verschillende actoren in de bestuursstrafrechtsketen invulling geven aan hun taken en hoe deze zich hebben ontwikkeld, gelet op veranderende verwachtingen in de samenleving over het bestuursstrafrecht. Het gaat om onderzoek naar (ontwikkelingen in) het empirisch functioneren van het bestuursstrafrecht en de bestuursstrafrechtsketen, en naar effecten van bestuursstrafrechtelijke interventies. Bestuursstrafrechtspleging bestaat uit vier verschillende delen. Het eerste deel is een introductie, waarin inzichtelijk wordt gemaakt wat precies wordt verstaan onder bestuursstrafrechtspleging en welke empirische onderzoeksmethoden voorkomen. Het tweede deel handelt over de actoren in de bestuursstrafrechtspleging, namelijk de burgemeester, het Openbaar Ministerie, de boetfunctionaris en de politie. In het derde deel wordt vanuit een juridisch perspectief een overzicht gegeven van het landschap van de bestuursstrafrechtspleging, terwijl in het vierde deel juridisch empirische perspectieven centraal staan. De bijdragen in deze bundel zijn geschreven door strafrecht en bestuursrechtjuristen, maar ook door criminologen en bestuurskundigen. Dit boek kan worden gebruikt in het (academische) onderwijs, maar is ook geschikt voor degenen die werkzaam zijn in de praktijk van het bestuursstrafrecht. Dit is een publicatie in de reeks van het Montaigne Centrum voor Rechtsstaat en Rechtspleging, Universiteit Utrecht.

This detailed and comprehensive study examines nutrition and health in the World Health Organization (WHO) Eastern Mediterranean Region, presenting the six game-changing food systems actions proposed by the WHO and the progress of their implementation in the region. The WHO Eastern Mediterranean Region is a particularly complex place to study: an area of economic contrasts with changing dietary patterns and stark differences between high levels of malnutrition and a prevalence of overweight and obesity. As a result, actions to improve the nutritional situation of the population are urgently sought. The strategies explored in this book offer a unique opportunity to change food systems all over the world, addressing aspects including sustainable food production, the impact of marketing and labelling on behaviour, and the effect of global events such as climate change, war and the COVID-19 pandemic. Reshaping Food Systems is an essential read at a time when malnutrition in all its forms, including undernourishment, micronutrient deficiencies and overweight and obesity, pose a serious threat to global health, and is of particular interest for policymakers working in nutrition and public health.

New insights into the changing human attitudes towards wild nature through the depiction of wolves in human culture and heritage.Few animals arouse such strong opinion as the wolf. It occupies a contested, ambiguous, yet central role in human culture and heritage. It appears as both an inspirational emblem of the wild and an embodiment of evil. Offering a mirror to different human attitudes, beliefs, and values, the wolf is, arguably, the species that plays the greatest role in shaping our views on what nature is or should be. North America and, more recently, Europe have witnessed a remarkable return of the grey wolf (Canis lupus, and its close relative the Eurasian wolf, Canis lupus lupus) to eco-systems. The essays collected here explore aspects of this recovery, and consider the history, literature and myth surrounding this iconic species. There are chapters on wolf taxonomy, including the coywolf, the red wolf, and the many faces of the dingo. We also meet the Tasmanian wolf and encounter Nazi Werewolves from Outer Space. The book explores the challenges of separating fact from fiction and superstition, and our willingness to co-exist with large carnivores in the twenty-first century. Biologists, historians, anthropologists, cultural theorists, conservationists and museologists will all find riches in the detail presented in this wolf collection.

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics

This volume includes seven chapters that describe recent advances in health and disease. Chapter One discusses the distribution and functions of toll-like receptors with a focus on the signaling pathways and interaction with different receptors in response to bacterial ligands. Chapter Two examines the relationship between oral health and nutrition of Arab refugees in Greece. Chapter Three summarizes the present data regarding the role of toll-like receptors, their endogenous ligands and receptor signaling pathways in the initiation and development of acute kidney injury. Chapter Four addresses the role of the NOD-like receptor pyrin containing 3 inflammasome in the pathogenesis of major depressive disorder and the potential therapeutic strategies targeting the negative modulation of this complex. Chapter Five describes types of laparoscopic approaches for the treatment of abdominal wall hernias. Chapter Six deals with the synthesis and characterization of arptine-lysine co crystals for the enhanced dissolution rate of asprin. Finally, Chapter Seven presents the optimal surgical management of goiter.

This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics.Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research.The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.