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Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper introduced the design and application of patient wristband with post-it label for identification of infectious diseases. This wristband is easy to use, with a post-it label which can stick to the wristband, helping nurses indentify the disease condition of the patient and carry out following prevention to reduce the risk of infection. Furthermore, the application of wristband with post-it label can protect patient privacy. (本研究介绍了一款住院患者腕带“便利贴”式传染病标识的设计与应用方法, 其制作简单, 使用时仅需粘贴在患者手腕带上即可, 有助于医护人员快速有效识别患者信息, 做好防护, 降低感染风险, 且该标识隐私性好, 减轻了患者诊治压力, 值得临床参考应用。)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The human telomeric i-motif (htel-iM) is a unique higher-order DNA structure formed by the cytosine-rich (C) sequences at the end of human telomeres. Studies have shown that htel-iM plays a significant role in the transcriptional regulation of telomeric repeat-containing RNA (TERRA), maintenance of telomere function and inhibition of telomerase activity. Thus, it is closely related to the development and progression of many cancers and is a promising new target for cancer treatment therapy. Compared to other nucleic acid higher-order structures such as G-quadruplexes, the stability of htel-iM is much weaker and affected by many factors like buffer pH, ionic conditions and molecular crowding environments. Therefore the existence of the iM structures in near neutral physiological conditions has been uncertain for a long time. Recently, using in-vitro screened small molecule ligands to selectively recognize and stabilize htel-iM provides a new strategy for the exploration of the biological relevance of htel-iM. Thus it has become a research hotspot to take telomere as a cancer treatment target. However, so far the reported small molecule ligands selectively targeting the htel-iM are far from sufficient compared with those targeting other higher-order nucleic acid structures. In this review, the discovery and the characteristic of the iM structures are briefly described, with an emphasis on the in-vitro affecting factors of the htel-iM structure, the reported htel-iM ligands and its biological relevance and regulation mechanisms, which will be helpful in further exploration of the htel-iM structure and ligand screening in near physiological conditions, and understanding the mechanism and developing novel therapeutic strategies for cancer treatment targeting the htel-iM structures. [ABSTRACT FROM AUTHOR]

This review summarizes commonly used hospital-based healthcare quality evaluation systems at home and abroad, and focuses on evaluation indicators regarding patient safety. Through the comparative analysis between different evaluation systems, it tries to shed light on China’s healthcare quality evaluation system, especially the indicators related to patient safety. The purpose of this review is to understand and learn from foreign evaluation systems on patient safety, which can help further improve the quality of healthcare in China. [ABSTRACT FROM AUTHOR]

Copyright of Operations Research Transactions / Yunchouxue Xuebao is the property of Editorial office of Operations Research Transactions and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the clinical features, immunophenotype, gene mutation sites, and diagnosis and treatment of primary immunodeficiency disease (PID) caused by tyrosine kinase 2 (TYK2) gene mutation. Methods The clinical data, molecular genetic test results, and treatment of a child with PID caused by Tyk2 gene mutations were retrospectively analyzed, and a review of the relevant literature was conducted. Results The patient was a 1-year and 8-month-old girl, who suffered from repeated pulmonary infection, eczema, and BCG-related complications after birth. The genetic test revealed compound heterozygous mutations in the TYK2 (c. 209_delGCTT; p. C70Sfs21/c. 1507C>T; p. R503X). After anti-infection therapy, the patient improved and was discharged from the hospital, and human immunoglobulin was infused regularly after discharge. A total of 11 relevant literatures were retrieved, and 18 patients with PID caused by TYK2 gene mutation were reported. The main clinical phenotype of patients with TYK2 gene mutation was intracellular bacterial (especially mycobacterial) infection and/or viral infection. Immunologically, the number of lymphocytes and immunoglobulins were basically normal, but there were multiple cytokine signaling defects. TYK2 gene mutation caused elevated serum IgE in some PID patients. Conventional anti-infective regimens were effective for most of the children, and some children required anti-mycobacterial therapy. Conclusions When the patient suffers from repeated bacterial infection (especially intracellular bacteria), viral infection, eczema or atopic dermatitis, with or without elevated serum IgE, the possibility of PID caused by TYK2 gene mutation should be considered. Gene sequence analysis can assist in early diagnosis. [ABSTRACT FROM AUTHOR]