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Objective To investigate the application effect of analysis of Healthcare Failure Mode and Effect Analysis（HFMEA) in the risk management of emergency intravenous thrombolysis in acute ischemic stroke (AIS) patients. Methods A total of 100 AIS patients admitted in this hospital from June to December2018 were selected as the control group. The HFMEA was used to review,discuss,and evaluate the whole process of emergency intravenous thrombolysis in AIS patients,and to select failure modes with RPN>125 or S>9 in emergency intravenous thrombolysis in this hospital, and to develop targeted improvement measures to intervene. From January to June 2019, 100 patients with AIS treated in the emergency department of this hospital after the implementation of HFMEA were selected as the observation group. The RPN value of emergency intravenous thrombolysis, the time of completing various examinations and intravenous thrombolysis after arriving at the emergency department of the two groups were observed to compare the effect before and after the implementation of HFMEA. Results After the implementation of HEMEA, the RPN scores of all aspects of emergency intravenous thrombolysis in AIS patients in the observation group were lower than those in the control group (before the implementation). And after the implementation of HEME A, the time of completing various examinations and intravenous thrombolysis after arriving at the emergency department decreased. The differences were statistically significant (P <0.05). Conclusion Applying HFMEA to the risk management of emergency intravenous thrombolysis in AIS patients can optimize the process related to the operation of emergency intravenous thrombolysis according to the actual situation of the hospital, reduce the risk of emergency thrombolysis in AIS patients, increase patient safety, and reflect patient-centeredness throughout the process, which can effectively improve the patient’s medical experience and establish a good image of the hospital and medical staff. [ABSTRACT FROM AUTHOR]

BACKGROUND: At present, the construction of engineered adipose tissue through seed cells, scaffold materials and extracellular microenvironment is one of the most potential directions for use in soft-tissue defect reconstructions. However, graft resorption attributed to lack of effective vascular network and blood supply is a major limitation for wider application of adipose tissue engineering. OBJECTIVE: To review the related research on how to establish a blood vessel network and effective engineered adipose tissue vascularization based on hydrogel scaffold. METHODS: The computer was used to search for articles on CNKI, Wanfang, and PubMed databases from January 2010 to June 2020. The search terms were “tissue engineering, adipose tissue, adipose-derived stem cell, hydrogel, vascularization” in Chinese and English. Relevant articles were summarized and finally 88 articles were included to analyze the results. RESULTS AND CONCLUSION: There are four main vascularization strategies for tissue engineered fat constructed with hydrogel materials: Tissue engineering chamber model; adipose-derived stem cells co-cultured with vascular endothelial cells; hydrogel scaffolds loaded with cytokines; application of suitable hydrogel scaffold with angiogenic properties. Therefore, the application of hydrogel materials to establish highly biomimetic adipose tissue units, combined with effective vascularization techniques, will further improve the efficiency of soft tissues repair and reconstruction. [ABSTRACT FROM AUTHOR]

Copyright of Forest Research is the property of Forest Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)