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Democratic backsliding and autocratisation tendencies raise the question of what liberal democracy can do to defend itself. Of particular concern are populists, who are often perceived to have an ambiguous commitment to the principles of liberal democracy. The defence of liberal democracy has often been conceived in legal terms, for example, with party bans and propaganda restrictions. However, legal means are criticized for being elitist because they are directed against irrational and emotionally driven masses and because they allegedly violate the very values that they are supposed to protect by limiting the democratic freedom of some groups. Instead, critics have proposed cultural and socio-economic means as non-elitist and non-exclusionary alternatives more in line with the values of democracy. This article discusses whether the employment of cultural and socio-economic means against groups – in casu populists – who are perceived as a challenge to liberal democracy can avoid the charge of elitism and exclusion by analysing whether these means are consistent with the publicity constraint. It finds that the use of education and money to defend democracy against such groups relies on a form of elitism and exclusion similar to the one that the defence by legal means is charged with. [ABSTRACT FROM AUTHOR]

While the literature has widely explored the organisational strategies of populist radical right parties (PRRPs) on the fringes, little is known about the grassroots activism of mainstream PRRPs. We focus on the Italian League and the Swiss People's Party (SVP), two mainstream PRRPs that have a long pedigree of government experience, to investigate if, how and why they invest in extensive activities at the local level to reach the public, despite their pivotal position in the national political scene. Methodologically, we rely on 120 interviews with members and representatives of these two PRRPs to identify the key grassroots activities they carry out at the local level and their perceived goals. The analysis reveals that despite their mainstream status, both the League and SVP still perceive to suffer from stigmatisation and demonisation, as they are not fully accepted as legitimate actors by the public. For this reason, they engage in grassroots activities and activism at the local level, the one closest to the everyday life and concerns of ordinary citizens. Grassroots activism aims to improve the legitimacy of PRRPs, by delivering the idea that their members and activists are normal people committed to help the local communities and not extremists. [ABSTRACT FROM AUTHOR]

Although a burgeoning literature explores the international dimensions of populism, we still know little about how populist leaders gain international popularity. This paper describes how Viktor Orbán, the Prime Minister of Hungary, has emerged as the role model of international right-wing populism. It demonstrates that Orbán actively supplied himself as an example that like-minded politicians should follow. We draw on the concept of legitimation strategies to illustrate why Orbán markets himself as the leader of an international movement against liberal ideologues (Wajner, 2022). At the same time, populists in many countries have searched abroad for a successful model to follow. Orbán's anti-migration policies and his defense of conservative family values constitute chapters of an illiberal playbook that right-wing populists are eager to implement. We use the concept of authoritarian learning to develop this demand-side perspective (Hall and Ambrosio, 2017). Empirically, we demonstrate our argument through an analysis of speeches delivered at a leading gathering of right-wing populists and moral conservatives: the Hungarian editions of the Conservative Political Action Conference (CPAC) that took place in Budapest in 2022 and 2023. [ABSTRACT FROM AUTHOR]

This study aims to explore the effect of social media use on fundraising by nonprofit organizations (NPOs). To do so, we analyze the accounts of 83 Spanish nongovernmental development organizations on Facebook, Twitter, YouTube, and Instagram over a 5-week period. Our results show that social media can be a useful tool for NPO fundraising. Specifically, although mere presence on social media has no effect on the donations raised by the organization, the size of the NPO's network (followers), its social media activity (posts), content (posts explicitly requesting donations), and follower engagement do influence fundraising. This study helps to highlight the usefulness of social media as a fundraising tool and to show the differences among platforms, format, and content of posts. In particular, NPOs who intend to increase fundraising should actively participate in social media—especially Twitter and YouTube—not overuse stories and increase posts that solicit donations. [ABSTRACT FROM AUTHOR]

This study comprehensively investigates the stress distribution and aging effects in Ethylene Propylene Diene Monomer (EPDM) and Liquid Silicone Rubber (LSR) gasket materials through a novel integration of hyperelastic modeling and advanced machine learning techniques. By employing the Mooney–Rivlin, Ogden, and Yeoh hyperelastic models, we evaluated the mechanical behavior of EPDM and LSR under conditions of no aging, heat aging, and combined heat- and sulfuric-acid exposure. Each model revealed distinct sensitivities to stress distribution and material deformation, with peak von Mises stress values indicating that LSR experiences higher internal stress than EPDM across all conditions. For instance, without aging, LSR shows a von Mises stress of 24.17 MPa compared to 14.96 MPa for EPDM, while under heat and sulfuric acid exposure, LSR still exhibits higher stress values, showcasing its resilience under extreme conditions. Additionally, the ensemble learning approach achieved a classification accuracy of 98% for LSR and 84% for EPDM in predicting aging effects, underscoring the robustness of our predictive framework. These findings offer practical implications for selecting suitable gasket materials and developing predictive maintenance strategies in industrial applications, such as fuel cells, where material integrity under stress and aging is paramount. [ABSTRACT FROM AUTHOR]

Citizen science represents an important opportunity for school students to make real-world connections with science through context-based learning with the potential to increase their engagement, enjoyment and understanding of science. However, to date, citizen science has not experienced wide uptake in school settings and there is a paucity of information about its implementation in the classroom. Here we present a mixed-method approach investigating teachers' knowledge and use of citizen science in Australian classrooms. We explored teachers' experience and perceptions of citizen science, and opportunities and barriers to incorporate citizen science as an educational approach through an online questionnaire. Among the teachers surveyed, 45% (n = 295) had personally participated in citizen science outside of school and 41% (n = 283) had incorporated citizen science projects in classroom lessons. Teachers (45%, n = 295) reported participating in citizen science initiatives multiple times. Also, most projects that teachers were involved in (77%, n = 292) were related to ecological studies, such as species monitoring. Citizen science was reported to be a relatively new approach; used by teachers for less than a year on average. The main challenges included a lack of knowledge, time, confidence, and clarity regarding citizen science project alignment with the Australian curriculum. Additionally, 92% of respondents said they would be more encouraged to use citizen science in classrooms if projects were aligned to the curriculum. Identifying ways to increase teachers' openness to incorporate citizen science in their classrooms is crucial to its successful widespread, long-term, and meaningful implementation. Encouraging broader participation of teachers in citizen science based on their previous experiences could address their expectations and increase their confidence and feeling of ownership. These research findings suggest that meaningful and applicable citizen science programs could be co-created by addressing resource limitations and curriculum alignment challenges. Implementing solutions to these barriers is likely to contribute to the development of sustainable school-inclusive citizen science projects, with potential to positively impact science education in the long-term. [ABSTRACT FROM AUTHOR]

This study looks into the message frames, emotional appeals, and approaches used in the We Can Do This COVID-19 vaccine campaign by the U.S. Department of Health and Human Services (HHS). A quantitative content analysis of 145 audio-visual campaign elements was guided by framing theory. Results indicate that the campaign messages primarily focused on vaccine benefits and used an informational approach to messaging. Consistent use of hope is observed alongside frames, such as vaccine information, facts and findings, and preventive measures. The moral obligation frame uses a more negative appeal (i.e., guilt) across the campaign elements. Additionally, while informational messages incorporate a more fear appeal, sadness, guilt, and hope remain the consistent emotional appeals in the transformational message approach. The findings of this study can serve as a valuable resource for the U.S. Government authorities and other healthcare experts in the implementation of comparable vaccination campaigns. [ABSTRACT FROM AUTHOR]

COVID-19 offers many valuable lessons, many of which could be found in unique societies like Hong Kong. The metropolis is special for its drastically varying—good and bad—COVID-19 performances. Hong Kong was widely considered a pandemic control and containment success for maintaining a remarkably low number of COVID-19 infections and deaths, until it was not. In March 2022, for instance, Hong Kong had the world's highest COVID-19 infection rates. As Hong Kong shares many similarities with other metropolises around the world, it is important to learn the hard-earned lessons from its failure to control infections. Drawing insights from the literature and our own research, this analysis aims to identify key lessons societies could gain from Hong Kong's COVID-19 responses to ensure better preparation for future pandemics. [ABSTRACT FROM AUTHOR]

Copyright of International Sociology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Renal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann–Pick C1-Like 1 (NPC1L1) plays a crucial role in cholesterol absorption and has been implicated in cancer progression across various cancers. However, its expression patterns and prognostic significance in RCC remain unclear. Methods: In this study, NPC1L1 expression in normal and RCC tissues, including subtypes, was compared using TCGA, GEPIA2, and The Human Protein Atlas. Clinical correlations were assessed, and the impact of NPC1L1 on overall survival (OS) and progression-free survival (PFS) was evaluated. Gene effect scores were analyzed using the DepMap tool to determine the involvement of NPC1L1 in RCC progression. Results: NPC1L1 expression was significantly lower in RCC tissues compared to normal tissues, particularly in the clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC) subtypes, but increased in advanced tumor stages. Higher NPC1L1 expression was associated with worse OS and PFS in RCC patients. Multivariable Cox regression confirmed NPC1L1 as an independent prognostic marker. Additionally, gene effect scores showed that NPC1L1 is essential for the survival of specific RCC cell lines. Conclusions: This study determines NPC1L1 as an independent prognostic indicator in RCC, with higher expression associated with poor survival outcomes. These findings suggest that NPC1L1 could serve as a valuable marker for identifying high-risk RCC patients. Further research is required to investigate the molecular mechanisms underlying the role of NPC1L1 in RCC progression. [ABSTRACT FROM AUTHOR]

Purpose: Charitable giving in China has moved from being subjected to government attention and public skepticism to receiving government encouragement and public support. The role played by political connections in philanthropy is indisputable, although very few studies have explored their association from the perspective of the country's first Charity Law of 2016. This study aims to contribute to the ongoing debate about the 2016 Charity Law and offers an understanding of the future trends in corporate charitable giving. Design/methodology/approach: Using empirical analysis of data collected from listed companies in China, this study analyzes the impact of political connections on corporate charitable giving before and after the 2016 Charity Law. The study adopts three leading theories from previous research into corporate charitable giving and political connections: corporate social responsibility, resource dependence theory and stakeholder theory. A conceptual framework is outlined, and hypotheses are formulated accordingly. Findings: The results show that political connections have a substantial positive impact on corporate charitable giving, both before and after the implementation of the 2016 Charity Law, which has significantly promoted and increased the amount and proportion of charitable giving. Although the 2016 Charity Law attempted to weaken the political connections of enterprises, the influence of political connections on corporate charitable giving has proved difficult to diminish or eliminate, as charity is dominated by the state. Originality/value: This study explores the association between political connections and corporate charitable giving from the perspective of China's Charity Law of 2016. [ABSTRACT FROM AUTHOR]

The Fused Filament Fabrication is an economic 3D printing process to produce lightweight polymersbased structures. Therefore, it is drawing a consistently increasing interest from industry and researchers. Flexural and impact properties are two of the critical performance measures for gauging the integrity of the printed structures. Since 2014, numerous studies have been carried out on this topic, however, their holistic overview with a focus on the flexural and impact properties has been barely presented in the literature. The current article reviews the relationship between the process parameters, both operating and geometrical, and these properties in detail. The cause-effect relationship is thoroughly examined considering material effect. This allows the identification of the complex interactive effects and conducive ranges of the important parameters to effectively control the process for achieving the desired mechanical properties. The review establishes that the crystallinity of post-printed polymers is a crucial factor in controlling the mechanical properties, and filled polymers generally offer better properties than unfilled ones if the right filler given the desired properties is chosen. Topology optimization, recyclability of polymers through FFF, and retention of polymer properties after printing are also discussed as innovative trends. Finally, limitations and research gaps are identified, and the latest ideas are proposed as a way forward for further development of the FFF technology. [ABSTRACT FROM AUTHOR]

Heart failure (HF) is a leading cause of mortality, morbidity, and financial burden worldwide. The emergence of advanced artificial intelligence (AI) technologies, particularly Generative Pre-trained Transformer (GPT) systems, presents new opportunities to enhance HF management. In this review, we identified and examined existing studies on the use of ChatGPT in HF care by searching multiple medical databases (PubMed, Google Scholar, Medline, and Scopus). We assessed the role of ChatGPT in HF prevention, diagnosis, and management, focusing on its influence on clinical decision-making and patient education. However, ChatGPT faces limited training data, inherent biases, and ethical issues that hinder its widespread clinical adoption. We review these limitations and highlight the need for improved training approaches, greater model transparency, and robust regulatory compliance. Additionally, we explore the effectiveness of ChatGPT in managing HF, particularly in reducing hospital readmissions and improving patient outcomes with customized treatment plans while addressing social determinants of health (SDoH). In this review, we aim to provide healthcare professionals and policymakers with an in-depth understanding of ChatGPT's potential and constraints within the realm of HF care. [ABSTRACT FROM AUTHOR]

This article explores how different anti-establishment parties (AEPs) can themselves strategically enact an image of both distinctiveness and 'normality' behind their political offer. For this purpose, we directly measure and map diverse anti-establishment normalisation strategies by analysing 142 social media campaigns of radical right, left, and 'centrist' AEPs and their conventional competitors during 23 elections in Europe during 2010–2019. We find that while AEPs presented themselves as fundamentally distinct from 'politics as usual', they simultaneously attempted to normalise their contestation supply across and within two dimensions: mainstreaming and streamlining. Using regression analysis, we further find that the degree to which AEPs rhetorically normalised their supply was positively and significantly associated with their broader electoral appeal ceteris paribus, controlling for substantive issue positions, parliamentary experience and position in government. Concurrently, the effects of particular normalisation strategies and their specific calibration varied for the radical right and left. The findings deepen our comparative understanding of diverse anti-establishment strategies used in party competition. [ABSTRACT FROM AUTHOR]

CoCrW can be produced using Additive Manufacturing (AM), while casting methods are commonly used for applications such as dental prostheses. However, rapid heating and cooling during AM production can lead to internal defects, micro-cracks, and shrinkage. Micro-milling can help enhance the material's structure and impart micro-scale properties. This study aimed to investigate the micro-milling properties of CoCrW products manufactured using AM and compare them with materials produced by casting. Numerical models and experimental studies were conducted to examine the differences. Results showed that CoCr alloys produced with AM exhibited 25%–30% lower burr formations, while CoCrW produced by casting had 2%–5% lower surface roughness. Micro-milling experiments demonstrated that a feed rate of 2.5 μm/tooth resulted in 35%–40% more burr formation and surface roughness compared to a feed rate of 5 µm/tooth in both SLM and casting methods, attributed to the cutting edge radius. The cutting temperature and top burr height were analyzed using finite element simulations and experimental methods. It was observed that the maximum temperature in CoCrW produced by casting was 6%–15% higher than that in the SLM method. The finite element analyses and experiments revealed a difference of 4%–7% in maximum temperatures and top burr height. [ABSTRACT FROM AUTHOR]

In the last decade, the appointment of technocratic ministers has become more common than ever before in Europe. Yet, scholarly attention has mostly focused on the economic determinants that lead to the appointment of such political outsiders in governments. In contrast, political determinants have not been fully examined. This article aims to investigate the role of economic determinants, as well as institutional factors (e.g. electoral system), party-system characteristics (e.g. volatility, polarization) and cabinet-related factors (e.g. intra-cabinet heterogeneity, the strength of populist parties within the government). Using a novel data set comprising data for more than 7000 ministers, including around 900 technocrats, our analysis shows that the share of populist parties within the cabinets has the strongest effect on the likelihood of appointing technocrats in national government. However, institutional-level variables appear to have no effect on the levels of technocratic appointments. [ABSTRACT FROM AUTHOR]

After Trump and Brexit, a dominant narrative emerged that portrayed the rise of right-wing populism as a backlash to neoliberalism. While it is true that right-wing populism emerged during the heydays of neoliberal globalization in the 1980s and 1990s, the relationship between the two is more complex than often assumed. In a series of countries, right-wing populism emerged with, rather than against neoliberalism. The particular combination of "neoliberal populism," however, is still underexplored. Studying this political discourse can help us understand the role of neoliberal ideology in the rise of right-wing populism. As a contribution to this end, this article offers an in-depth analysis of the ideological evolution of the Dutch neoliberal populist Pim Fortuyn (1948–2002). It places the development of his ideas against the backdrop of the Dutch neoliberal turn and shows how his populist establishment critique emerged out of a neoliberal critique of the Dutch corporatist welfare state. [ABSTRACT FROM AUTHOR]

The Russian-Ukrainian war (RUW) is responsible for extensive individual suffering and a socio-economic impact on the world and is reshaping global affairs. Many studies have focused on direct exposure to conflict and several public health policies have been devised. Nonetheless, indirect exposure through media has received minimal attention and there is limited evidence that mental health symptoms and disorders may arise as a result. We explored the role of voluntary or involuntary media-based exposure to the RUW on individuals' mental health including stress symptoms, coping strategies, daily functioning, and worries across demographic variables. In our sample, subjects with involuntary and higher amount of exposure seem to have higher stress symptoms. Also, those who had previous ruminations on war issues could be at risk of developing more post-traumatic stress symptoms. Therefore, media appears to be a conduit that spreads negative consequences of community trauma beyond directly affected communities. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic initiated new and unprecedented challenges that required organizations to curate timely, accurate and engaging public health information to communicate to local communities during a health crisis. Guided by the social media typology, content analysis was used to analyze tweets from six organizations located in a predominantly Hispanic community responsible for managing the pandemic. Findings revealed that these organizations have actively used Twitter (now known as "X") to inform local residents about COVID- 19 at the beginning of the pandemic and guided them how to respond to this health crisis by providing content with health-related actions. The analysis indicated that redundant digital content without using the local language of the community did not help public health officials communicate effectively to their citizens, thereby increasing their level of engagement and eliciting behavior changes. We suggest that public organizations, government, and healthcare organizations within a minority community need adopt social media strategies that incorporate the local community's language in content generation to foster ongoing conversations, mobilize actions, and elicit behavioral changes within their local communities. [ABSTRACT FROM AUTHOR]

Prolonged use of atypical antipsychotics (AAPs) is commonly associated with increased cardiovascular disease risk. While weight gain and related health issues are generally considered the primary contributors to this risk, direct interference with mitochondrial bioenergetics, particularly in the liver where these drugs are metabolized, is emerging as an additional contributing factor. Here, we compared the effects of two AAPs with disparate metabolic profiles on the response of Fao hepatoma cells to oxidative stress: olanzapine (OLA), which is obesogenic, and aripiprazole (ARI), which is not. Results showed that cells treated with ARI exhibited resistance to H2O2-induced oxidative stress, while OLA treatment had the opposite effect. Despite enhanced survival, ARI-treated cells exhibited higher apoptotic rates than OLA-treated cells when exposed to H2O2. Gene expression analysis of pro- and anti-apoptotic factors revealed that ARI-treated cells had a generally blunted response to H2O2, contrasting with a heightened response in OLA-treated cells. This was further supported by the reduced activation of MAPKs and STAT3 in ARI-treated cells in response to H2O2, whereas OLA pre-treatment enhanced their activation. The loss of stress response in ARI-treated cells was consistent with the observed increase in the mitochondrial production of O2•-, a known desensitizing factor. The physiological relevance of O2•- in ARI-treated cells was demonstrated by the increase in mitophagy flux, likely related to mitochondrial damage. Notably, OLA treatment protected proteasome activity in Fao cells exposed to H2O2, possibly due to the better preservation of stress signaling and mitochondrial function. In conclusion, this study highlights the underlying changes in cell physiology and mitochondrial function by AAPs. ARI de-sensitizes Fao cells to stress signaling, while OLA has the opposite effect. These findings contribute to our understanding of the metabolic risks associated with prolonged AAP use and may inform future therapeutic strategies. [ABSTRACT FROM AUTHOR]

Background: Glycemic disorder is closely related to the risk of pancreatic cancer, but previous studies focused on the influence of diabetes. The aim of this meta-analysis was to investigate the influence of prediabetes, an intermediate state between normoglycemia and diabetes, on the risk of pancreatic cancer. Methods: Relevant longitudinal observational studies were identified through a search of Medline, Embase, and Web of Science databases. To minimize the influence of between-study heterogeneity, a randomized-effects model was used to pool the results. Results: Nine cohort studies including 26,444,624 subjects were available for the meta-analysis. Among them, 2,052,986 (7.8%) had prediabetes at baseline, and the participants were followed for a mean duration of 5.9 years. It was found that, compared to people with normoglycemia, those with prediabetes had a higher incidence of pancreatic cancer (risk ratio [RR]: 1.42, 95% confidence interval: 1.36 to 1.49, p<0.001) with no statistical heterogeneity (I2 = 0%). Sensitivity analysis performed by excluding one dataset at a time did not significantly change the results (RR: 1.38 to 1.45, p all <0.05). Subgroup analyses indicated that the association between prediabetes and increased risk of pancreatic cancer was not significantly impacted by study characteristics such as study design, location, age, and sex of participants, definition of prediabetes, duration of follow-up, or adjustment for alcohol intake (p for subgroup difference all >0.05). Conclusions: Prediabetes may be associated with an increased risk of pancreatic cancer compared to normoglycemia. [ABSTRACT FROM AUTHOR]

Two novel rare earth-substituted tungstoantimonates [H2N(CH3)2]8Na12[Dy2(H2O)6(tar)(Sb2W21O72)]2·40H2O (DySbW) and [H2N(CH3)2]6Na14[Ho2(H2O)6(tar)(Sb2W21O72)]2·25H2O (HoSbW) (H4tar = tartaric acid) were synthesized. The meso-polyanions are alternately linked by {Na3(H2O)3} clusters and DL-tar ligands to form 1D chains. Notably, HoSbW exhibits excellent catalytic activity and high stability for the synthesis of isoindolinones using EtOH as a green solvent. [ABSTRACT FROM AUTHOR]

This research explores the role of the 12 sustainability competences outlined in the European GreenComp and three sustainability pillars within the practice of the science capital teaching approach. This study considers the dimensions constituting an individual's science capital which shape the approach's pedagogical foundation. We conducted a document study of the science capital teaching approach, comprising six modules, by analyzing 208 documents for the presence of the GreenComp sustainability competences and three sustainability pillars: environment, society, and economy. The data revealed a distribution pattern describing the teaching approach's efficacy, indicating eight competence trends differentiated into three extracted levels and four trends related to the pillars. A subsequent thematic analysis of five semi-structured interviews helped to identify decisive categories defining the derived trends. Overall, the results showed a consistent presence of sustainability competences, with some deviations, and the integration of all pillars, despite an irregular distribution unfavorably affecting the economic perspective. [ABSTRACT FROM AUTHOR]

Hans Kelsen was one of the most important legal thinkers of the 20th century, and he is known for mounting an elaborate defense of liberal party democracy at a time when the latter was hardly the most popular form of regime. This article examines how Kelsen responded to two major political movements he experienced in his intellectual prime: political Catholicism, which he was confronted with in interwar Austria, and Christian Democracy, which became a hegemonic political force in Western Europe after World War II, when Kelsen was already in exile. The article reconstructs Kelsen's complex critique of these two religious movements and ends by reflecting on what we can learn from his arguments about current attempts to revive Christian political thought. [ABSTRACT FROM AUTHOR]

Chinese international students' well-being is an important part to notice with the rapid number of Chinese international students (CIS) in the U.S. and the increasing number of depressions in college. A systematic review of articles using analytical methods was conducted following the PRISMA guidelines. 1600 studies were initially reviewed from EBSCO, ProQuest, etc. After examining inclusive and exclusive criteria, 30 studies were included in the full review. 19 psychological factors associated with CIS's well-being were found. Results showed that social support is positively associated with CIS's well-being and is correlated with acculturative adjustment for improving psychological well-being. This research revealed the importance of considering cultural psychology in mental health professions, such as acculturation, language issues, and social support. When this population reports depression, anxiety, or academic stress symptoms, mental health providers need to be aware of these impacts and provide psychoeducation for counseling services in the U.S. college. [ABSTRACT FROM AUTHOR]

Recidivism in Australia is high, especially in the Australian Capital Territory (ACT). While high-quality stable housing has been shown to reduce recidivism, people released from prison face many barriers in obtaining housing. This paper reports on a qualitative study exploring the housing experiences of 11 people released from prison in the ACT. Participants felt the importance of housing for reintegration and avoiding recidivism, but reported many challenges, including issues relating to lack of pre-release planning, income and employment, drug use, difficulties and delays with accessing social housing, and complying with parole or bail conditions. We recommend increased investment in services to assist people in prison with organizing housing before release. Furthermore, as housing is a foundational need for reintegration and drug use is high among the prison population in the ACT, Housing First initiatives may be the most appropriate model for providing accommodation and reducing recidivism. [ABSTRACT FROM AUTHOR]

Purpose: This paper aims to investigate whether the two dominant financial reporting regimes, US Generally Accepted Accounting Principles (US GAAP) and International Financial Reporting Standards (IFRS), are associated with audit pricing and audit report lags. Design/methodology/approach: In 2007, the US SEC eliminated the requirement for foreign registrants to reconcile their financial statements to US GAAP from IFRS. In this post-reconciliation setting in the USA, the authors use panel ordinary least square regressions to examine a sample of foreign firms cross-listed in the USA reporting under IFRS and US domestic firms reporting under US GAAP during the fiscal year 2007–2019. Findings: The authors find that the firms reporting under IFRS have longer audit report lags than firms reporting under US GAAP. In addition, the authors find that firms reporting under IFRS pay higher audit fees than their US GAAP counterparts. The results are robust after controlling for the firm- and country-specific characteristics as well as using propensity-score matching. Originality/value: To the best of the authors' knowledge, this study is the first to provide empirical evidence that the differences between the two reporting regimes are associated with auditor behavior, possibly through additional audit efforts and audit complexity associated with auditing the principle-based IFRS relative to the rule-based US GAAP. [ABSTRACT FROM AUTHOR]

The global outbreak of COVID-19 in 2020 has led to the dominance of COVID-19 prevention information on all media channels. Drawing on the ability–motivation model of information processing, this study examined how such an information overabundance hampered individuals' ability and motivation to process in the era of COVID-19. With a survey conducted from 493 participants, we found that less message elaboration of COVID-19 prevention information was predicted by greater message fatigue, a state of low motivation due to information overabundance. In addition, greater message fatigue was accompanied by greater information overload, a state of low ability due to information overabundance. Moreover, certain motivation-related (i.e. health status, trait reactance and frequency of information seeking) and ability–related factors (i.e. health literacy, health status, trait anxiety and information quality) were found to be associated with message fatigue and information overload, respectively. The theoretical and practical implications are discussed. [ABSTRACT FROM AUTHOR]

Background/Objectives: The experience of the COVID-19 pandemic has turned the spotlight on the importance of public health measures and disease prevention. Despite this, the acceptance of influenza vaccination has remained low in most countries (and far from the 75% target set by the World Health Organization). The objective of this study has been to investigate how attitudes and behaviors regarding influenza vaccination in the Spanish adult population have changed over the last three years (from 2021 to 2024) in order to analyze trends in influenza vaccination. Methods: To this end, a cross-sectional study was conducted through 2206 telephone interviews, and the results were compared with those obtained in previous campaigns. Results: The findings indicate a significant decline in overall vaccination intent. Healthcare professionals remain the most influential factor in encouraging vaccination, yet there is a notable increase in the lack of vaccine recommendations, contributing to the decision not to vaccinate. This study also reveals low awareness of the influenza vaccine campaign, emphasizing the need for improved public health communication. Conclusions: To counteract these trends, this study recommends intensifying awareness campaigns, strengthening the role of healthcare providers in vaccine advocacy, and tailoring communication strategies. These efforts are crucial to enhancing vaccination coverage and protecting vulnerable populations against influenza. [ABSTRACT FROM AUTHOR]

Background and aim: The COVID-19 pandemic has led to a significant adverse effect on the mental health of healthcare professionals. This study aims to assess the effects of the prolonged pandemic on burnout and mood disorders and to evaluate the influence of positive vaccination beliefs on these factors at a medical center during the extended COVID-19 pandemic. Methods: This retrospective study analyzed the results of an online questionnaire survey including burnout status and mood disorders from 2020 to 2022. The factors related to mood moderate/severe disorders and the impact of the positive vaccine belief were also explored. Results: The initial analysis revealed that healthcare professionals continued to experience significant levels of personal and work-related burnout, along with mood disorders. However, the scores and the percentage of moderate to severe burnout gradually decreased. Notably, the percentage of individuals with moderate to severe mood disorders also gradually declined (2020: 13.4%, 2021: 12.3%, 2022: 11.1%). The number of participants who need professional interventions decreased from 56.2% in 2020 to 45.9% in 2021, and 46% in 2022. Multivariate analysis revealed a positive vaccine belief was associated with a lower risk of moderate/severe mood disorders, with odd ratios (OR) and 95% confidence intervals (95% CI) of 0.38 (0.28 -- 0.52) and 0.41 (0.30 -- 0.52) in the 2021 and 2022 cohorts, respectively. Further investigation revealed that age over 50 was linked to a positive vaccine belief in 2021 and 2022. Within the 2022 cohort, working as nurses was identified as the independent factor associated with a less positive belief, with the OR and 95% CI of 0.49 (0.27 -- 0.90). Conclusion: The findings of the present study suggest burnout and mood disorders are still significant during the pandemic. A positive vaccine belief may mitigate pandemic-related mental distress. Further interventions to enhance the belief combined with other supporting measures are important in a long fight against the pandemic. [ABSTRACT FROM AUTHOR]

This investigation focuses on the influence of thin films on laser-induced periodic surface structures (TF-LIPSSs) formed on soda-lime glass using femtosecond laser pulses with a wavelength of 515 nm. In this study, we introduce a new framework involving a combined metal thin film of chromium and silver (Cr:30 nm + Ag:100 nm) deposited onto soda-lime glass by DC magnetron sputtering. Due to their better coupling by heat accumulation, metal thin film enables a more efficient transfer of energy to the dielectric glass substrate, leading to the formation of periodic structures. The thin-metal-film-deposited glass substrate is irradiated with the second-harmonic generator of a Satsuma laser source to create the LIPSS at high repetition rates ranging from 10 to 250 kHz. We observe simultaneously low-spatial-frequency LIPSS (LSFL) with a spatial period (Λ) of 400 nm and high-spatial-frequency LIPSS (HSFL) with a spatial period of about 110 nm on thin film and glass substrate, respectively. Interestingly, at 10 μJ and 100 kHz, the HSFL observed on the glass substrate are significantly smaller than half of the irradiation wavelength. In the center region, the HSFL⊥ are perpendicular to the laser beam polarization. In the transitioned region between the impact center and the melted area, the HSFLII are parallel to the polarization. Furthermore, when the energy was increased from 10 to 15 μJ, the irradiated zone geometry changed from a regular circular shape to an elliptical one due to an uneven energy distribution over the ablated area, resulting in the formation of irregular surface structures. Finally, a comparative analysis of surface modifications on a metal thin-film-coated glass substrate using different repetition rates and energy levels revealed dissimilar morphological structures. [ABSTRACT FROM AUTHOR]

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Cancer stem cells drive tumor initiation, invasion, metastasis and recurrence. In the present study, we have evaluated the role of ERRα in the maintenance of breast cancer stem cells (BCSCs) using breast cancer cell lines. The inhibition of ERRα with the inverse agonist, XCT-790, or the knockdown of ERRα in breast cancer cells significantly reduced the mammosphere formation efficiency and mammosphere size along with a significant reduction in the CD44 + /CD24 - BCSCs. Treatment with XCT-790 significantly downregulated expression of the transcription factors involved in stem cell maintenance such as Oct4, Klf4, Sox2, Nanog and c-Myc in the mammosphere forming stem cells of MCF7 and MDA-MB-231. In addition, XCT-790 induced cell cycle arrest and apoptosis in the mammosphere-forming cells. The knockdown or inhibition of ERRα downregulated the expression of Notch1 and β-catenin, whereas the overexpression of ERRα in MCF7 cells upregulated the expression of these proteins. Moreover, the inhibition of ERRα synergistically enhanced the efficacy of paclitaxel in inhibiting the BCSCs. These results show that ERRα is crucial for the maintenance of BCSCs and suggest that ERRα could be a potential target for breast cancer treatment., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

27-hydroxycholesterol (27-HC) is an oxysterol that acts as an endogenous selective estrogen receptor modulator (SERM), and its adverse effects on breast cancer via the estrogen receptor (ER) have provided new insights into the pathology of cholesterol-linked breast cancer. Our earlier in vitro experiments showed that the methanolic extract of pomegranate could exhibit SERM properties and compete with 27-HC. The major constituents of pomegranate are ellagitannins and ellagic acid, which are converted into urolithins by the colonic microbiota. In recent years, urolithins, especially urolithin A (UA) and urolithin B (UB), have been reported to have a plethora of advantageous effects, including antiproliferative and estrogenic activities. In this study, we attempted to determine the potential of urolithins in antagonizing and counteracting the adverse effects of 27-HC in breast cancer cells. Our findings suggested that UA had an antiproliferative capacity and attenuated the proliferative effects of 27-HC, resulting in subsequent loss of membrane potential and apoptosis in breast cancer cells. Further, UA induced estrogen response element (ERE) transcriptional activity and modulated estrogen-responsive genes, exhibiting a SERM-like response concerning receptor binding. Our in vivo hollow fiber assay results showed a loss of cell viability in breast cancer cells upon UA consumption, as well as a reduction in 27-HC-induced proliferative activity. Additionally, it was shown that UA did not induce uterine proliferation or alter blood biochemical parameters. Based on these findings, we can conclude that UA has the potential to act as a potent estrogen receptor alpha (ERα) modulator and 27-HC antagonist. UA is safe to consume and is very well tolerated. This study further opens up the potential of UA as ER modulator and its benefits in estrogen-dependent tissues., (© 2023 John Wiley & Sons Ltd.)

New parties are a key mechanism behind party system innovation as voters are offered new choices. To explain party entry (i.e. participation in a lower house election for the first time), the state-of-the-art has typically focused on domestic determinants. This, however, assumes that party entry takes place in an international vacuum. Building on the policy diffusion literature, we explore how party family members abroad influence party entry in the focal country. Based on a new dataset on the evolution of each party family in 17 Western European party systems between 1961 and 2016, including 2191 new parties, our mixed-methods approach combining spatial econometric models with pathway case analysis demonstrates that party entry is influenced by the entry and electoral success of their party family abroad. This has important implications for the literature on party entry and the international diffusion of policy platforms. [ABSTRACT FROM AUTHOR]

Introduction: The Health Belief Model (HBM) has been widely studied, but it is unclear how social media post creators use HBM constructs to influence the public's awareness of health topics, particularly for COVID-19 preventative health behaviors. Moreover, there is limited knowledge about how content creators enhance user engagement with COVID-19 vaccine tweets. Methods: A content analysis of COVID-19 vaccine tweets (n = 362) examined how HBM constructs were used in social media posts and their relationship to content creator characteristics (e.g., race, education level) and user engagement behaviors (e.g., number of favorites). Findings: Content creators' tweets about COVID-19-related topics generally centered on two HBM constructs—benefits and barriers—while fewer tweets emphasized perceived susceptibility or self-efficacy; tweets containing these constructs were retweeted less often. Findings revealed that tweets from politicians, health experts, and white and Asian sources emphasized the perceived benefits of the COVID-19 vaccine. Individual tweets, especially from Black individuals and celebrities, generated more user engagement. Conclusions: Understanding the factors that contribute to social media user engagement with health-related content is important for designing more focused and impactful health communication campaigns and promoting healthier habits and perspectives. Thus, by demonstrating the possible relevance of the HBM to digital communication strategies or health campaigns, our study provides useful guidance for health promoters and policymakers who use social media to raise public health awareness. [ABSTRACT FROM AUTHOR]

Background: Stromal inflammatory cells in malignant tissue have recently gained increasing interest. Unlike the extensive research on tumor‐infiltrating lymphocytes, published data about tumor‐infiltrating eosinophils in breast cancer are scarce. Furthermore, similar studies have yet to be conducted in Iraq. Aims: The objective of this study is to examine the presence of eosinophilic infiltration by direct visualization using light microscopy and to analyze its relationship with other histological parameters in a group of Iraqi women diagnosed with invasive mammary cancer. Methods and material: A retrospective study enrolled 90 histological samples of invasive mammary carcinoma provided by core needle biopsy from a single center, together with their immunohistochemical results for ER and HER2‐NEU. Data reviewing, direct morphological visualizations, and counting eosinophilic infiltration in tissue sections were done by two independent pathologists using light microscopy. The results were statistically correlated with the grade, ER, HER2‐NEU, calcification, and axillary lymph node status at presentation. Results: Out of the entire sample size (90), 40 (44%) showed the presence of eosinophilic infiltration in the tissue, both intratumoral and stromal. Further analysis revealed that most eosinophilic infiltrates had an intermediate score (4−19) per 10 consecutive high‐power fields. A strong and meaningful statistical relationship was seen between tissue eosinophilic infiltration and HER2/NEU status. A statistically insignificant correlation was seen between tissue eosinophilic infiltration and histological grade, ER receptor status, calcification, and axillary lymph node status at presentation. Conclusions: Eosinophils are tumor‐infiltrating cells in breast cancer, both intratumoral and stromal. The presence of tissue eosinophilic infiltration can predict HER2/NEU negativity in breast cancer. [ABSTRACT FROM AUTHOR]

This scoping review provides an overview of the conduct, origin and distribution of previous peer-reviewed research on children's and adolescents' social media use. Searches were conducted in electronic databases Scopus, Web of Science, and ACM Digital Library, identifying 244 studies that met the inclusion criteria. The review reveals a steady increase in publications over the years, with most originating from the United States, the United Kingdom, Australia, and Canada. Among these studies, 174 employ quantitative methods, 30 utilize qualitative approaches, 19 use mixed methods, and 21 are review studies. The research predominantly falls within the disciplines of medicine and health, and psychology. The findings highlight a significant imbalance between qualitative and quantitative research, with quantitative, cross-sectional studies relying on self-reported questionnaire results being the most common. However, quantitative studies do not adequately capture the details of the complex and varied nature of social media use, nor do the common cross-sectional nature of those studies enable insights to be drawn on changes and variations over time or establish causal relationships. This scoping review reveals a growing interest in this topic, but also highlights the need for greater geographical and disciplinary diversity, varied methodological approaches, and more heterogeneous participant involvement in future research. This review suggests a pressing need for more empirical, qualitative research that examines situated social media use from the perspectives of children and adolescents. Moreover, additional longitudinal studies are necessary to offer causal explanations and a deeper understanding of the evolving dynamics of social media use among younger populations. [ABSTRACT FROM AUTHOR]

This study explored the influence of COVID-19 stigma on the city image of Wuhan by adopting the associative group analysis method. The collected data were free associations of the word "Wuhan" from 39 non-Chinese participants residing outside of China. It found that there were 12 meaning categories related to the city image of Wuhan, half of which were related to COVID-19, and the other half were related to Wuhan city. 56.45% of the associated words were related to COVID-19 and 43.55% to Wuhan city. The results demonstrated that the city image of Wuhan was impacted by the COVID-19 pandemic, mediated by personal experience and perceived media reports. The associated words have constructed a "Wuhan-COVID-19" stereotype, including "Wuhan-birthplace of COVID" and "Wuhan-eating wild animals". This reflected that the city image of Wuhan endured stigma in the global community. The study provided implications for eliminating stigma and reconstructing group relationships in the global community. [ABSTRACT FROM AUTHOR]

Background: Antipsychotic medications are effective treatments for schizophrenia (SZ) and bipolar I disorder (BD-I), but when presented with different treatment options, there are tradeoffs that individuals make between clinical improvement and adverse effects. As new options become available, understanding the attributes of antipsychotic medications that are valued and the tradeoffs that individuals consider when choosing among them is important. Methods: A discrete-choice experiment (DCE) was administered online to elicit preferences across 5 attributes of oral antipsychotics: treatment efficacy (i.e., improvement in symptom severity), weight gain over 6 months, sexual dysfunction, sedation, and akathisia. Eligible respondents were aged 18–64 years with a self-reported clinician diagnosis of SZ or BD-I. Results: In total, 144 respondents with SZ and 152 with BD-I completed the DCE. Of those with SZ, 50% identified themselves as female and 69.4% as White, with a mean (SD) age of 41.0 (10.1) years. Of those with BD-I, most identified themselves as female (69.7%) and as White (77.6%), with a mean (SD) age of 40.0 (10.7) years. In both cohorts, respondents preferred oral antipsychotics with better efficacy, less weight gain, no sexual dysfunction or akathisia, and lower risk of sedation. Treatment efficacy was the most important attribute, with a conditional relative importance (CRI) of 31.4% for respondents with SZ and 31.0% for those with BD-I. Weight gain (CRI = 21.3% and 23.1%, respectively) and sexual dysfunction (CRI = 23.4% and 19.2%, respectively) were adverse effects in this study that respondents most wanted to avoid. Respondents with SZ were willing to accept 9.8 lb of weight gain or > 25% risk of sedation for symptom improvement; those with BD-I were willing to accept 8.5 lb of weight gain or a > 25% risk of sedation. Conclusions: In this DCE, treatment efficacy was the most important attribute of oral antipsychotic medications among respondents with SZ and BD-I. Weight gain and sexual dysfunction were the adverse effects respondents most wanted to avoid; however, both cohorts were willing to accept some weight gain or sedation to obtain better efficacy. These results highlight features that patients value in antipsychotic medications and how they balance benefits and risks when choosing among treatments. [ABSTRACT FROM AUTHOR]

The study assessed and compared the psychological impact of the COVID-19 pandemic before and during lockdown periods among the general population in Saudi Arabia. Methods: A validated and reliable General Anxiety Disorder (GAD)-7 instrument was used to quantify stress levels by measuring anxiety. Nonprobability snowball sampling was used to collect data from 516 participants residing in Saudi Arabia. The difference in scores for each of the seven related questions of GAD-7 was determined using a non-parametric Wilcoxon rank test. Results: A mild level of anxiety was consistently observed both before and during the lockdown, as indicated by GAD-7 scores of 6.17 (SD = 5.5) before the lockdown and 6.42 (SD = 5.7) during the lockdown. There were no differences in GAD-7 scores before 6.17 (SD = 5.5) and during 6.42 (SD = 5.7) the lockdown periods. However, levels of moderate anxiety increased by 5% during the lockdown period. Anxiety levels before and during lockdown were significantly associated with gender (χ 2 (3, n = 516) =11.23 p = 0.01) and employment status (χ 2 (3, n = 516) = 9.41 p = 0.024). Among the GAD-7 questionnaire items, item number 1 ("Feeling nervous, anxious, or on edge") (p= 0.00) and item number 7 ("Feeling afraid as if something awful might happen") (p= 0.025) showed a significant association with anxiety levels before and during the lockdown periods. Conclusion: The enduring prevalence of mild anxiety, persisting both before and during the lockdown periods, underscores the profound impact of COVID-19 on the mental health of the general population in Saudi Arabia. Plain Language Summary: This study aimed to understand how the COVID-19 pandemic affected the mental well-being of people in Saudi Arabia, specifically looking at anxiety levels before and during lockdown. We used a survey with 516 participants and found that, overall, people reported mild anxiety both before and during the lockdown. However, there was a 5% increase in moderate anxiety during the lockdown. Interestingly, we discovered that gender and employment status were linked to anxiety levels. Women and those with certain employment statuses reported different anxiety levels. Specific questions in the survey, such as feeling nervous or afraid, were mainly associated with anxiety during both periods. In conclusion, even though anxiety levels were generally mild, some groups and specific concerns showed differences. This information can help us understand how to better support people's mental health during challenging times like a pandemic. [ABSTRACT FROM AUTHOR]

Diabetes mellitus (DM) is a chronic metabolic disorder that can affect the balance of bone metabolism and bone microenvironment, leading to impaired fracture healing. There are several underlying mechanisms which contributing to the impaired diabetic bone microenvironment such as hyperglycemia, the production of advanced glycation end products (AGEs), inflammation, and oxidative stress, etc. Recent studies have achieved great progress in developing novel smart biomaterials in improving the diabetic bone microenvironment to promote diabetic fracture healing. In this paper, we reviewed the mechanisms on DM-induced impaired fracture healing. Meanwhile, we also summarized the smart biomaterials used to improve the local microenvironment of diabetic fractures healing, which provides a novel perspective for the future treatment of fractures in diabetic patients. [ABSTRACT FROM AUTHOR]

A ballad is a type of poetry that is presented with music. This type of literature has always existed throughout history; But before the constitutional revolution, its theme was love and inner emotions. With the emergence of the constitutional movement and along with the changes in various aspects of the society, the poem also took on a social theme and served to express the thoughts of intellectuals. Speech analysis or discourse analysis is a type of interdisciplinary study that analyzes speech and leads to a deep reading of literary works. This research, based on its critical discourse analysis, tries to investigate and analyze the national patriotic works of Malek al-Shoarai Bahar and his criticisms and clarifications during the constitutional movement. With the components of liberalism, socialism, nationalism, parliamentarism and democracy, this discourse finds its political subject and challenges the hegemony of the ruling discourse. The discourse of naturalism and liberalism covers the centrality of all works. The method of this research is descriptive-analytical, and the data of the research has been examined using the method of content analysis and the method of library and document analysis. [ABSTRACT FROM AUTHOR]

Introduction: Trauma is considered as one of the important causes of maternal death, which imposes a large financial burden on the medical system. During the recent few years, the mortality of pregnant mothers following direct complications of pregnancy and delivery has decreased, but the mortality due to trauma is increasing. The present study was designed with aim to investigate the etiology and prognosis of trauma in pregnant women. Methods: In this cross-sectional descriptive study conducted in 2023 in Hasheminezhad hospital of Mashhad, the frequency of trauma in 122 pregnant women referring to the accident emergency room of Mashhad Hasheminezhad Hospital was investigated. To study the etiology and outcome of pregnant women with complain of trauma, demographic information and the information related to the etiology and outcome of patients were extracted from the trauma registry. Data were analyzed by SPSS software (version 26). P<0.05 was considered significant. Results: The mean age of patients was 30.60 ± 7.51 years. The most common cause of trauma was traffic accidents in 65 cases (53.3%) and most of them were in the second trimester of pregnancy. The most common site of injury was abdomen (80.4%) and the most common complication was abortion (5.73%) and placental abruption (4.91%). There were 13 (10.3%) patients who lost their pregnancy. Conclusion: In this study, the most common cause of trauma was car accidents and most of the patients were young, who may have multiple pregnancies by the end of their childbearing years. Therefore, providing educational content to this group in the future may reduce maternal and fetal complications caused by trauma. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to evaluate and compare the quality of work life (QWL) of nurses, in pre- and post-COVID-19 pandemic situations. Design/methodology/approach: The study adopts a descriptive research design. Data were collected during the pre- and post-pandemic periods. The target sampling unit of the study comprises nurses working in Bangalore city, Karnataka, India. The minimum sample size was determined (Bartlett et al., 2001) as 385. The scale validation is carried out. The factors for the present study were explored using exploratory factor analysis and confirmed by confirmatory factor analysis. Model fitness (proposed measurement model) is ensured by using fit indices. The linear regression method was used to measure the level of QWL of nurses. Findings: The present study noted that key factors that affects the QWL of nursing staff are work condition; work environment; work-life balance; compensation and reward; career development; job satisfaction and security; organization culture; relationship among co-workers and stress. Further, it is noticed that QWL of nurses pre-COVID-19 pandemic is 87.2%, while post-COVID-19 pandemic, it is 67%. Research limitations/implications: Present study can be extended to address the same research question by considering sampling unit such as therapist, technicians and sanitarians who have equally undergone tremendous pressure during pandemic. Practical implications: The study outcome provides references for organizations engaged in health services to understand the extreme job conditions posed by pandemic. The constructive inspiration (physio-social and organizational support) reinforces the nurses to continue in their professions by decreasing negative impact. Originality/value: The research paper extends the contributions of Hwang (2002), Nikeghbal et al. (2021), Howie–Esquivel et al. (2022) and Rania et al. (2023) and add to the existing body of the QWL literature. The outcome of the research records the prevailing conditions of pandemic and its effect on changes in work environment with specific reference to health-care sector. [ABSTRACT FROM AUTHOR]

Increased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have not been well elucidated. In this study, we found that plasma TIMP‐1 levels were significantly higher in COVID‐19 and H1N1 patients compared with those in healthy subjects (n = 25). TIMP‐1 concentrations were significantly different between males and females in each disease group. Among female but not male patients, TIMP‐1 levels significantly correlated with the PaO2/FiO2 ratio and hospital length of stay. Using the mouse model of ALI induced by the H1N1 virus, we found that TIMP‐1 is strikingly induced in PDGFRα‐positive cells in the murine lungs. Moreover, female mice showed a higher Timp‐1 expression in the lungs on day 3 postinfection. Mechanistically, we observed that estrogen can upregulate TIMP‐1 expression in lung fibroblasts, not epithelial cells. In addition, overexpression of estrogen receptor α (ERα) increased the TIMP‐1 promoter activity. In summary, TIMP‐1 is an estrogen‐responsive gene, and its promoter activity is regulated by ERα. Circulating TIMP‐1 may serve as a sex‐specific marker, reflecting the severity and worst outcomes in female patients with SARS‐CoV2‐ and IAV‐related ALI. [ABSTRACT FROM AUTHOR]

We study determinants of COVID-19 vaccine donations from recipients' perspective, especially considering supply chain and institutional weakness (corruption) aspects. Results, based on data from more than 130 nations, show that strengthened supply chains reduced donations. The impacts of corruption and logistics performance likely persisted from pre-COVID times. More corrupt nations received fewer donations per capita, ceteris paribus. The results with respect to economic prosperity support efforts to end vaccine apartheid, and island nations received more donations, as did nations with more bilateral vaccine deals. Finally, donations received through COVAX were driven by qualitatively similar factors, except corruption did not matter. [ABSTRACT FROM AUTHOR]