Search

New heterocyclic compounds (R1-R26) were synthesized, as oxazole derivatives (R7-R11) were synthesized from the cyclization of the compound (R1) with the compounds (R2-R6), then the oxazole derivatives (R7-R11) were used to synthesis the pyrimidine derivatives (R12-R16), imidazole derivatives (R17-R21), and pyrazole derivatives (R22-R26) from the reaction it's with different compounds, all compounds were characterized using infrared spectra, nuclear magnetic resonance, mass, and physical properties. Then the effectiveness of these compounds was tested on the inhibition of Acinetobacter baumannii isolated from swabs and urine of COVID-19 patients in Respiratory Care units in Iraq and the results showed that the compounds (R1-R26) with three concentrations (1000, 500, 250ppm), respectively, had an inhibitory effect on the isolated bacteria compared to the antibiotics used in the hospital, which did not show any effectiveness in inhibiting this type of bacteria. [ABSTRACT FROM AUTHOR]