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Compelling evidence proved that coronavirus disease (COVID-19) disproportionately affects minorities. The goal of the present study was to explore the effects of intersected discrimination and discrimination types on COVID-19, mental health, and cognition. A sample of 542 Iraqis, 55.7% females, age ranged from 18 to 73, with (M = 31.16, SD = 9.77). 48.7% were Muslims, and 51.3% were Christians (N = 278). We used measures for COVID-19 stressors, executive functions, intersected discrimination (gender discrimination, social groups-based discrimination, sexual orientation discrimination, and genocidal discrimination), posttraumatic stress disorder (PTSD), depression, anxiety, status and death, existential anxieties, and health. We conducted independent samples t test between Muslims and Christians. We conducted hierarchical regression analyses using the Christian minority subsample to see if intersected discrimination is predictive of COVID-19 hospitalization. We conducted two-path analyses, one with intersected discrimination as an independent variable and the second with the different discrimination types as independent variables. Intersected discrimination predicted COVID-19 hospitalization. The primary discrimination type for Christians was genocidal discrimination. Christians had higher existential anxiety about status and death than Muslims. Intersected discrimination and discrimination types had a significant association with mental health, health, and cognition variables, with intersected discrimination, had a higher impact than each. Existential anxiety about the person's social and economic status was the critical outcome of intersected discrimination that trickles down to other variables. COVID-19 stressors had significant effects on depression, PTSD, generalized anxiety, and Status existential annihilation anxiety (EAA). COVID-19 hospitalization and stressors are associated with inhibition and working memory deficits. We discussed the conceptual and clinical implications of the results. Public Policy Relevance Statement: The current found empirical evidence that intersected discrimination is a significant predictor of coronavirus disease (COVID-19) hospitalization in Iraqi Christians and underlies the disproportionate impact of COVID-19 on discrimination victims. Intersected discrimination triggered the existential anxiety about the person's social and economic status (status EAA) that trickled down to adverse health, mental health, and cognitive outcomes. The primary discrimination type for Iraqi Christians exposed to Islamic State of Iraq and Syria (ISIS) was genocidal discrimination, one of the worst discrimination types. COVID-19 stressors had significant effects on higher status EAA and adverse effects on mental health and cognition. The present study results highlighted the primacy of addressing intersected discrimination and the advocacy for social justice and support for victims of discrimination. [ABSTRACT FROM AUTHOR]