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Background: Cosmetic adverse reactions (CARs) are becoming widespread in China. However, a comprehensive analysis of data is lacking. Objective: To analyse the clinical characteristics of patients with reported adverse reactions to cosmetics in Chongqing, China. Methods: Cases with CARs reported to the Chongqing Adverse Drug Reaction Monitoring Centre System from 2017 to 2021 were analysed. Results: A total of 23 245 cases were identified, of which 94.5% were women. Contact dermatitis (84.3%) was the most common diagnosis of CARs, followed by acne (3.1%). The most frequently reported clinical signs were erythema (70.1%), followed by papules (35.5%). The majority of CARs were reported to be due to ordinary cosmetics (87.9%), of which 81.0% were skin care products and 7.1% were makeup products. Cosmetics with special functions constituted 12.2%, of these, skin whitening (54.0%) and sunscreen (28.0%) products were most frequently reported. Conclusion: Our results suggest that adverse reactions to cosmetics are of concern in China, and dermatologists should actively identify and diagnose CARs. In addition, we should establish a convenient and effective model for collecting, reporting, and evaluating CARs. [ABSTRACT FROM AUTHOR]

Fagopyrum dibotrys, being native to southwest China, is widely distributed in Yunnan, Guizhou Provinces and Chongqing City. However, the quality of medicinal materials growing in different origins varies greatly, and cannot meet the market demand for high-quality F. dibotrys. In this study, 648 metabolites were identified, and phenolic compounds of F. dibotrys from different origins were clearly separated by principal component analysis (PCA). Our results suggested that the medicinal differences of F. dibotrys from different origins can be elucidated via the variations in the abundance of the phenolic and flavonoid compounds. We found that the epicatechin, total flavonoids and total tannin content in Yunnan Qujing (YQ) and Yunnan Kunming (YK) were higher than those in Chongqing Shizhu (CS), Chongqing Fuling (CF) and Guizhou Bijie (GB), suggesting that Yunnan Province can be considered as one of the areas that produce high-quality medicinal materials. Additionally, 1,6-di-O-galloyl-β-D-glucose, 2,3-di-O-galloyl-D-glucose and gallic acid could be used as ideal marker compounds for the quality control of F. dibotrys from different origins caused by metabolites, and the F. dibotrys planted in Yunnan Province is well worth exploiting. [ABSTRACT FROM AUTHOR]