11 results on '"Brown, David A."'
Search Results
2. Sociodemographic circumstances, health, and life experience shape posttraumatic distress trajectories among individuals exposed to smoke during a large‐scale coal mine fire.
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Smith, Catherine L., Campbell, Timothy C. H., Gao, Caroline X., Lane, Tyler J., Maybery, Darryl, Berger, Emily, Brown, David, Ikin, Jillian F., McFarlane, Alexander, Abramson, Michael J., and Carroll, Matthew
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COAL mining ,SMOKE ,PARTICULATE matter ,MENTAL health ,LIFE change events ,INHALATION injuries ,CHRONIC traumatic encephalopathy - Abstract
The 2014 Hazelwood coal mine fire in the Latrobe Valley, Australia, distributed toxic smoke into surrounding communities over 45 days. This study investigated risk and protective factors associated with four trajectories of posttraumatic distress (resilient, recovery, delayed‐onset, chronic) among exposed adults. Participants (N = 709) completed surveys in 2016–2017 and 2019–2020 assessing mine fire–related particulate matter (PM2.5) exposure; sociodemographic, physical, and mental health variables; and exposure to other traumatic and recent stressful events. Mine fire–related posttraumatic distress was measured using the IES‐R; trajectories were determined according to established clinical significance thresholds. Relative risk ratios (RRRs) were generated from multivariate multinomial regressions. The resilient trajectory was most common (77.0%). The chronic trajectory (8.5%) was associated with loneliness, RRR = 2.59, 95% CI [1.30, 5.16], and physical health diagnoses, RRR = 2.31, 95% CI [1.32, 4.02]. The delayed‐onset trajectory (9.1%) was associated with multiple recent stressful events, RRR = 2.51, 95% CI [1.37, 4.59]; mental health diagnoses, RRR = 2.30, 95% CI [1.25, 4.24]; loneliness, RRR = 2.05, 95% CI [1.09, 3.88]; and male gender, RRR = 2.01, 95% CI [1.18, 3.44]. Socioeconomic advantage protected against chronic, RRR = 0.68, 95% CI [0.53, 0.86], and delayed‐onset trajectory membership, RRR = 0.68, 95% CI [0.50, 0.94]; social support protected against chronic trajectory membership, RRR = 0.67, 95% CI [0.49, 0.92]. PM2.5 exposure did not determine trajectory. These findings enhance understanding of longer‐term posttraumatic responses to large‐scale smoke events and can inform mental health initiatives within at‐risk communities. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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3. «Love of home and country will always appeal to the man with a heart»: The impact of World War I on Italian communities in Australia 1914-1922.
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Brown, David
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WORLD War I , *WORLD War II , *ITALIANS , *IMMIGRANTS' rights - Abstract
This article addresses the role of nationalism and identity in relation to the experience of Italians in Australia, and more specifically, North Queensland, during World War One. Through a comparative study with the experience of Italians in the United States during World War One it is possible to comprehend further how the events of World War One impacted the Italian communities of Australia. World War One was a seminal event for the Italian communities in Australia as, unlike World War Two, the fact Italy and Australia were fighting on the same side gave Italians a sense of place in their new country they had not experienced before. However, when the Italian government attempted to forcibly conscript overseas Italians to fight on the Italian front, a policy they were helped with by the Australian government, it brought about challenging questions concerning citizenship, identity and the rights of immigrants residing in Australia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
4. Contrasting clinical characteristics and treatment patterns in women with newly diagnosed advanced-stage epithelial ovarian cancer in Australia, South Korea and Taiwan.
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Hung-Hsueh Chou, Fereday, Sian, DeFazio, Anna, Chih-Long Chang, Bowtell, David, Heng-Cheng Hsu, Traficante, Nadia, Soo Young Jeong, Wen-Fang Cheng, Ariyarantne, Dinuka, Teresa Tung, Rajadhyaksha, Viraj, Won-Hee Lee, Brown, David, and Byoung-Gie Kim
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OVARIAN epithelial cancer ,OVARIAN cancer ,CYTOREDUCTIVE surgery ,DIAGNOSIS ,PROGRESSION-free survival ,BEVACIZUMAB - Abstract
Objective: The real-world INFORM study analyzed sociodemographics, treatment patterns and clinical outcomes for patients with newly diagnosed advanced epithelial ovarian cancer (EOC) in Australia, South Korea (S.Korea) and Taiwan preceding incorporation of poly(ADPribose) polymerase inhibitors into clinical practice. Methods: Retrospective data from patients diagnosed with EOC (high-grade serous EOC for Taiwan) between January 2014 and December 2018 with =12 months follow-up from diagnosis were analyzed descriptively. Survival was evaluated by Kaplan-Meier with two-sided 95% confidence interval (CI). Results: Of the 987 patients (Australia, 223; S.Korea, 513; Taiwan, 251), 98% received platinum-based chemotherapy (CT). In S.Korea and Taiwan 76.0% and 78.9% respectively underwent primary cytoreductive surgery; in Australia, 56.5% had interval debulking surgery. Bevacizumab was included in primary/maintenance therapy for 22.4%, 14.6% and 6.8% of patients in Australia, S.Korea and Taiwan, respectively. Patients receiving bevacizumab were high-risk (reimbursement policy) and achieved similar real-world progression-free survival (PFS) compared with CT only. Overall, the median real-world PFS (months; 95% CI) was similar across Australia (16.0 [14.63-18.08]), S.Korea (17.7 [16.18-19.27]) and Taiwan (19.1 [17.56-22.29]). Conclusion: This study reveals poor prognosis despite differences in demographics and treatment patterns for patients with EOC across Asia-Pacific suggesting the need for biomarker-driven novel therapies to improve outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Considering the new minimum staffing standards for Australian residential aged care.
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Sutton, Nicole, Ma, Nelson, Yang, Jin Sug, Rawlings-Way, Olivia, Brown, David, McAllister, Gillian, Parker, Deborah, and Lewis, Rachael
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EVALUATION of organizational effectiveness ,STATISTICS ,HEALTH services accessibility ,GOVERNMENT regulation ,RETROSPECTIVE studies ,MEDICAL protocols ,RESIDENTIAL care ,NURSES ,DESCRIPTIVE statistics ,WORKING hours ,LOGISTIC regression analysis ,ELDER care - Abstract
Objective: To compare the historical staffing patterns and organisational characteristics of Australian residential aged care facilities (RACFs) against the new minimum staffing standards recommended by the Royal Commission into Aged Care Quality and Safety (RCACQS). Method: Retrospective data analysis was used to compare the staffing levels and characteristics of 1705 RACFs (for 4 years, 2016–19) with the three new mandatory staffing requirements. De-identified datasets were provided by the RCACQS, obtained under its legal authority. Results: Only 3.8% of RACFs have staffing levels at or above all three requirements. Although many (79.7%) already meet the requirement to have a registered nurse (RN) on-site for morning and afternoon shifts, few have staffing levels above requirements for total direct care per resident per day (10.4%) or care provided by an RN per resident per day (11.1%). Historical levels of on-site RNs, total direct care, and RN care vary significantly across facilities of different size, location and provider scale. Conclusion: The new staffing standards, to be mandatory by 2023, prescribe minimum requirements significantly higher than existing levels, particularly in care per resident per day. Each of the three requirements will likely have a differential effect for different types of RACFs. What is known about the topic?: International evidence suggests that introducing mandatory minimum staffing standards tends to increase the amount of care provided by staff in residential aged care facilities (RACFs). However, the impact of staffing standards is influenced by the stringency of the minimum threshold relative to existing staffing levels, the capacity of organisations to increase their staffing levels, and the specific way the regulation is formulated. What does this paper add?: This paper explores the potential implications of the three national minimum staffing standards, to be in force by October 2023, specifying total direct care, care received by a registered nurse (RN), and an RN on-site. By examining the existing staffing levels of Australian RACFs, it identifies the extent to which facilities already meet the new standards and the characteristics of facilities with staffing levels above and below the three requirements (individually and in combination). What are the implications for practitioners?: The study informs both policy and practice in relation to the likely effects of implementing the national minimum staffing standards for residential aged care in Australia. It demonstrates that the new minimum thresholds are likely to require substantial increases in staffing across the sector, both in terms of all direct care workers and RNs. It also shows that the three requirements are likely to have a differential effect for RACFs of different size, location and chain affiliation, thereby guiding policy about the future needs for Australia's aged care workforce. [ABSTRACT FROM AUTHOR]
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- 2022
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6. The impact of the Hazelwood coal mine fire smoke exposure on asthma.
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Taylor, Sasha, Borg, Brigitte, Gao, Caroline, Brown, David, Hoy, Ryan, Makar, Annie, McCrabb, Tom, Ikin, Jillian F., Thompson, Bruce R., and Abramson, Michael J.
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WHEEZE ,COAL mining ,ASTHMA ,PULMONARY function tests ,PARTICULATE matter - Abstract
In 2014, a fire at an open cut coal mine in South-eastern Australia burned for about 6 weeks. Residents of the adjacent town were exposed to high levels of fine particulate matter (PM
2.5 ) during this period. Three and a half years after the event, this study aimed to investigate potential long-term impacts of short-term exposure to coal mine fire smoke on asthma. A cross-sectional analysis was undertaken in a group of exposed participants with asthma from Morwell (n = 165) and a group of unexposed participants with asthma from the control town of Sale (n = 64). Exposure was determined by modeled PM2.5 data for the mine fire period. Respiratory symptoms were assessed with a validated respiratory health questionnaire and symptom severity score. Asthma control was assessed with a validated questionnaire. Lung function testing included spirometry, bronchodilator response, and fraction of exhaled nitric oxide. There was no evidence that exposed participants had more severe asthma symptoms, worse lung function, or more eosinophilic airway inflammation than unexposed participants. However, there was some evidence that Morwell participants had more uncontrolled than well-controlled asthma, compared to the participants from Sale (adjusted relative risk ratio 2.71 95% CI: 1.02, 7.21, p =.046). Three and a half years after exposure, coal mine fire smoke did not appear to be associated with more severe asthma symptoms or worse lung function but might be associated with poorer asthma control. [ABSTRACT FROM AUTHOR]- Published
- 2022
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7. Are e-cigarette use and vaping associated with increased respiratory symptoms and poorer lung function in a population exposed to smoke from a coal mine fire?
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Wai Kit Lee, Smith, Catherine L., Gao, Caroline X., Borg, Brigitte M., Nilsen, Kristopher, Brown, David, Makar, Annie, McCrabb, Thomas, Thompson, Bruce R., and Abramson, Michael J.
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ELECTRONIC cigarettes ,LUNGS ,SYMPTOMS ,COAL mining ,SMOKING ,WHEEZE - Abstract
Background and objective: E-cigarette use has become increasingly prevalent, but there is some evidence demonstrating potential harms with frequent use. We aimed to identify the profiles of e-cigarette users from a regional community in Australia and investigate the associations of e-cigarettes with respiratory symptoms and lung function. Methods: A total of 519 participants completed a cross-sectional study. Exposure to ecigarettes was collected via a validated questionnaire. Respiratory symptoms were evaluated via a self-reported questionnaire and lung function measured with spirometry and forced oscillation technique (FOT). Linear and logistic regression models were fitted to investigate the associations between e-cigarettes and outcomes, while controlling for confounders such as tobacco smoking. Results: Of the 519 participants, 46 (9%) reported e-cigarette use. Users tended to be younger (mean x SD 45.2 x 14.5 vs. 55.3 x 16.0 years in non-users), concurrently using tobacco products (63% vs. 12% in non-users), have a mental health diagnosis (67% vs. 37% in non-users) and have self-reported asthma (63% vs. 42% in nonusers). After controlling for known confounders, chest tightness (OR = 2.4, 95% CI 1.2-4.9, p = 0.02) was associated with e-cigarette use. Spirometry was not different after adjustment for confounding. However, FOT showed more negative reactance and a greater area under the reactance curve in e-cigarette users than non-users. Conclusion: E-cigarette use was associated with increased asthma symptoms and abnormal lung mechanics in our sample, supporting a potential health risk posed by these products. Vulnerable populations such as young adults and those with mental health conditions have higher usage, while there is high concurrent tobacco smoking. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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8. Use of adrenaline to manage suspected anaphylaxis following COVID-19 vaccination: An Australian retrospective cohort study.
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Deng, Lucy, Tapper, Kathryn, Thosar, Deepali, Goeman, Emma, Baker, Louise, Adelstein, Stephen, Boyle, Michael, Brown, David A, Evans, Louise, Katelaris, Connie, Lee, Frederick, Li, Jamma, Swaminathan, Sanjay, Taylor, Mark S, Wong, Melanie, and Wood, Nicholas
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ADRENALINE , *COVID-19 vaccines , *ANAPHYLAXIS , *COHORT analysis , *SYMPTOMS , *BOOSTER vaccines - Abstract
The rate of anaphylaxis following COVID-19 vaccinations is estimated to be 2–11 cases per million doses administered. However, adrenaline is occasionally used in individuals who are later diagnosed with immunisation stress-related responses, as their initial presenting signs and symptoms can appear similar to that of anaphylaxis. This study aims to describe the clinical profile of individuals who had received adrenaline following a COVID-19 vaccine and their subsequent revaccination outcomes. We examined notifications of cases who had received adrenaline following a COVID-19 vaccine in New South Wales, Australia. The cases were classified into Brighton Collaboration Case Definition (BCCD) for anaphylaxis, their clinical presentation, management and subsequent revaccination outcomes were compared. From 22 February 2021 to 30 September 2021, there were 222 cases where adrenaline was administered. Of these, 32 (14 %) fulfilled Level 1 BCCD, 59 (27%) Level 2, 2 (1%) Level 3, 97 (44%) Level 4 and 32 (14 %) Level 5. The most commonly reported symptoms were sensation of throat closure (n = 116, 52%), difficulty breathing (n = 82, 37%) and nausea (n = 55, 25 %). Of the 176 (79%) individuals who proceeded to further vaccination, 89 (51%) received the same vaccine formulation and only 14 (8%) experienced another allergic adverse event with 9 (5%) receiving adrenaline. Less than one in five individuals who received adrenaline met Level 1 BCCD criteria for anaphylaxis. Many reactions that were treated with adrenaline had little to no diagnostic certainty of anaphylaxis and in such cases repeat vaccination had a high likelihood of being tolerated. Increased awareness and education on objective signs and symptoms of anaphylaxis is required to ensure appropriate use of adrenaline. [ABSTRACT FROM AUTHOR]
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- 2023
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9. An exploration of the trajectory of psychological distress associated with exposure to smoke during the 2014 Hazelwood coal mine fire.
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Carroll, Matthew, Campbell, Timothy C.H., Smith, Catherine L., Gao, Caroline X., Maybery, Darryl, Berger, Emily, Brown, David, Allgood, Shantelle, Broder, Jonathan C., Ikin, Jillian, McFarlane, Alexander, Sim, Malcolm R., Walker, Judi, and Abramson, Michael J.
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COAL mining , *PSYCHOLOGICAL distress , *COAL mining accidents , *FIRE management , *SMOKE , *PARTICULATE matter , *SUMMER - Abstract
Due to climate change, catastrophic events such as landscape fires are increasing in frequency and severity. However, relatively little is known about the longer-term mental health outcomes of such events. Follow-up was conducted of 709 adults exposed to smoke from the 2014 Hazelwood mine fire in Morwell, Victoria, Australia. Participants completed two surveys evaluating posttraumatic distress, measured using the Impact of Events Scale-Revised (IES-R), three and six years after the mine fire. Mixed-effects regression models were used to evaluate longitudinal changes in distress. IES-R total scores increased on average by 2.6 points (95%CI: 1.2 to 3.9 points) between the two survey rounds, with increases across all three posttraumatic distress symptom clusters, particularly intrusive symptoms. This increase in distress was evident across all levels of fine particulate matter (PM2.5) exposure to the mine fire smoke. Age was an effect modifier between mine fire PM2.5 exposure and posttraumatic distress, with younger adults impacted more by exposure to the mine fire. Greater exposure to PM2.5 from the mine fire was still associated with increased psychological distress some six years later, with the overall level of distress increasing between the two survey rounds. The follow-up survey coincided with the Black Summer bushfire season in south-eastern Australia and exposure to this new smoke event may have triggered distress sensitivities stemming from exposure to the earlier mine fire. Public health responses to disaster events should take into consideration prior exposures and vulnerable groups, particularly younger adults. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Long-term impact of exposure to coalmine fire emitted PM2.5 on emergency ambulance attendances.
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Broder, Jonathan C., Gao, Caroline X., Abramson, Michael J., Wolfe, Rory, Dimitriadis, Christina, Ikin, Jillian, Sim, Malcolm R., Del Monaco, Anthony, Johnston, Fay H., Carroll, Matthew, Brown, David, Smith, Karen, and Guo, Yuming
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COAL mining accidents , *AMBULANCES , *MEDICAL care , *ATTENDANCE - Abstract
Little is known about the long-term health effects of coalmine fire smoke exposure. The 2014 Hazelwood coalmine fire event in southeast Australia released smoke into surrounding areas for 6 weeks. We aimed to investigate whether individual-level exposure to coalmine fire-related PM 2.5 was associated with a long-term increase in ambulance attendances following a coalmine fire event. A total of 2223 residents from the most exposed town of Morwell were assessed for ambulance attendances after the Hazelwood event from April 1, 2014 to December 31, 2017. PM 2.5 exposure was estimated for each individual using participant self-reported location diary data during the event and modelled PM 2.5 concentrations. Recurrent event survival analysis was used to evaluate the relationship between PM 2.5 exposure and ambulance attendances. For each 10 μg/m3 increase in mean coalmine fire-related PM 2.5 exposure, there was a 10% (adjusted hazard ratio [HR]:1.10, 95%CI:1.03–1.17) increase in the overall risk of ambulance attendances within 3.5 years after the coalmine fire. Exposure to PM 2.5 was also associated with increased risk of respiratory (HR: 1.21, 95%CI: 1.02–1.44) and cardiovascular (HR: 1.13, 95%CI: 1.01–1.28) related ambulance attendances. These results demonstrate that exposure to coalmine fire smoke during the Hazelwood event was associated with a long-term health risk post the fire event, specifically for respiratory and cardiovascular conditions. These findings are important for effective implementation of health care services following future extended coalmine fire PM 2.5 events. [Display omitted] • This is first to evaluate the long-term health impact of prolonged coalmine fire on ambulance attendances in individual level data. • Recurrent event survival analysis was used to evalute the impact of mine fire-related PM 2.5 on long-term risk of ambulance attendances. • Exposure to mire fire smoke was associated with increase in ambulance attendances, specifically for respiratory and cardiovascular conditions. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Granulomatous mastitis and immunosuppression: Case series at an Australian quaternary referral center.
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Liang I, Berglund LJ, Brown DA, Suan D, Meybodi F, Lee AYS, and Swaminathan S
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- Female, Humans, Australia, Immunosuppression Therapy, Immune Tolerance, Granulomatous Mastitis diagnosis, Granulomatous Mastitis drug therapy
- Published
- 2024
- Full Text
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