1. Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment.
- Author
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Yusefi M, Shameli K, Lee-Kiun MS, Teow SY, Moeini H, Ali RR, Kia P, Jie CJ, and Abdullah NH
- Subjects
- Humans, Cellulose chemistry, Drug Delivery Systems, Fluorouracil pharmacology, Magnetic Phenomena, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction, Drug Liberation, Chitosan chemistry, Colorectal Neoplasms drug therapy, Nanocomposites chemistry
- Abstract
Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe
3 O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 ± 3.46 nm and +23 ± 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/5FU nanocomposites with an average diameter of 37.16 ± 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity., Competing Interests: Declaration of competing interest We have no conflicts of interest to disclose., (Copyright © 2023 Elsevier B.V. All rights reserved.)- Published
- 2023
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