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Your search keyword '"Li, Guan"' showing total 2 results
Start Over Author "Li, Guan" Topic meta-analysis Publication Year Range Last 3 years
2 results on '"Li, Guan"'

1. Prevalence and risk factors of depression in Chinese patients with type 2 diabetes mellitus: a protocol of systematic review and meta-analysis

Author

Xiaobo Liu, Jun Zhang, Hong Jiang, Yuxi Li, Juan Li, Chao Dong, Dongling Zhong, Li Guan, Huiling Zhang, Jin Fan, and Rongjiang Jin

Subjects
China, Funnel plot, medicine.medical_specialty, endocrine system diseases, MEDLINE, Medicine (miscellaneous), Cochrane Library, Meta-Analysis as Topic, Type 2 diabetes mellitus, Protocol, Prevalence, Humans, Medicine, Depression, business.industry, Publication bias, Odds ratio, Study heterogeneity, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Risk factors, Meta-analysis, Family medicine, Observational study, business, Systematic Reviews as Topic
Abstract

Background The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Depression is a significant complication of T2DM, leading to poor management of T2DM. Thus, early detection and treatment of depression in patients with T2DM are essential and effective. Therefore, we plan to conduct a systematic review and meta-analysis to evaluate the prevalence of depression in Chinese patients with T2DM and explore potential risk factors of depression in T2DM. Methods We will search literatures recorded in MEDLINE, EMBASE, the Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and WanFang Database from their inception onwards. We will manually search gray literatures, reference lists of identified studies, relevant websites, and consult experts in this field. We will include population-based, cross-sectional surveys that investigated the prevalence of depression in Chinese patients with T2DM or/and the possible risk factors of depression in T2DM. Two reviewers will screen studies, extract data, and evaluate risk of bias independently. Agency for Healthcare Research and Quality methodology checklist will be used to assess the risk of bias. If feasible, we will conduct random effects meta-analysis of observational data to summarize the pooled prevalence, and use odds ratio for categorical data to explore potential risk factors. Prevalence estimates will be stratified according to age, gender, and other factors. Statistical heterogeneity will be estimated using Cochran’s Q and I2 index. We will conduct meta-regression to investigate the potential sources of heterogeneity, sensitivity analyses to assess robustness of the synthesized results, and funnel plots and Egger’s test to assess publication bias. Discussion This systematic review and meta-analysis will provide comprehensive evidence of the prevalence and potential risk factors of depression in Chinese patients with T2DM. We expect to provide evidence for healthcare practitioners and policy makers to pay attention to the mental health of patients with T2DM. Our data will highlight the need and importance of early detection and intervention for depression in patients with T2DM. Systematic review registration PROSPERO CRD42020182979.

Published
2021

2. The Comparison of Spinopelvic Parameters, Complications, and Clinical Outcomes After Spinal Fusion to S1 with or without Additional Sacropelvic Fixation for Adult Spinal Deformity: A Systematic Review and Meta-analysis.

Author

Bo Han, Peng Yin, Yong Hai, Yunzhong Cheng, Li Guan, Yuzeng Liu, Han, Bo, Yin, Peng, Hai, Yong, Cheng, Yunzhong, Guan, Li, and Liu, Yuzeng

Subjects
*TREATMENT effectiveness, *SPINAL fusion, *SPINE abnormalities, *ADULTS, *ODDS ratio, *PSEUDARTHROSIS, *LUMBAR vertebrae surgery, *RESEARCH, *META-analysis, *RESEARCH methodology, *SYSTEMATIC reviews, *RETROSPECTIVE studies, *MEDICAL cooperation, *EVALUATION research, *KYPHOSIS, *COMPARATIVE studies, *LORDOSIS, *LUMBAR vertebrae
Abstract

Study Design: Systematic review and meta-analysis.Objective: The purpose of the study was to compare the outcomes and after spinal fusion with or without iliac screw (IS) insertion for patients with adult spinal deformity (ASD).Summary Of Background Data: The number of patients undergoing multilevel spinal stabilization for the treatment of ASD is growing. However, the selection of spinopelvic fixation for ASD patients with long fusion is controversial.Methods: A comprehensive literature search was performed without time restriction according to the guidelines from the Cochrane Collaboration in May 2020 using PubMed, EMBASE, and the Cochrane Library. The comparison of the two types of fixation was evaluated by spinopelvic parameters, incidence rate of complications, rate of revision, and clinical outcomes at the last follow-up.Results: The literature search identified 422 records, of which eight studies were included for meta-analysis with a total of 439 patients. All the included studies provided level III evidence. There was no significant difference in the sagittal vertical axis, pelvic incidence, the proximal junctional kyphosis rates, the pseudarthrosis rates, the revision rates, and the clinical outcomes at the last follow-up between those who receive sacrum fixation and sacropelvic fixation. Nevertheless, greater lumbar lordosis (LL) (weighted mean difference [WMD], 4.15; 95% confidence interval [CI] 2.46-5.84, P < 0.01), greater sacral slope (SS) (WMD, 2.32; 95% CI 1.21-3.43, P < 0.01), and lower rate of the distal instrumentation instability (odds ratio, 0.25; 95% CI 0.10-0.61, P = 0.002) were observed in IS group between the comparison.Conclusion: The clinical outcomes in the IS group were similar to those in the non-IS group, but the application of the IS significantly restored LL, prevented decompensation, and reduced the occurrence of the distal instrumentation instability. Therefore, the IS may be a good choice for the operative treatment of ASD patients with sagittal malalignment and other risks of lumbosacral fracture, metal breakage, and screw pullout.Level of Evidence: 3. [ABSTRACT FROM AUTHOR]

Published
2021
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