1. Fucus vesiculosus polysaccharide alleviates type 2 diabetes in rats via remodeling gut microbiota and regulating glycolipid metabolism-related gene expression.
- Author
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Zheng, Qianwen, Zheng, Yang, Jia, Rui-Bo, Luo, Donghui, Chen, Chong, and Zhao, Mouming
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FUCUS vesiculosus , *POLYSACCHARIDES , *TYPE 2 diabetes , *GLYCOLIPIDS , *GUT microbiome , *GENE expression , *INSULIN - Abstract
The antidiabetic activity and underlying mechanisms of Fucus vesiculosus polysaccharide (FVP) were studied in type 2 diabetic rats. Our results exhibited that FVP intervention reversed body weight loss, alleviated hyperglycemia and insulin resistance in diabetic rats. FVP also had the potential to ameliorate dyslipidemia, liver and kidney dysfunction, decrease oxidative stress, promote glycogen synthesis, and boost short-chain fatty acid production and total bile acid excretion. 16S rRNA gene sequencing analysis suggested that FVP interfered with the gut microbiota in a beneficial manner. Moreover, RT-qPCR results demonstrated that the antidiabetic activity of FVP in connection with the acceleration of blood glucose absorption and glycogen synthesis, the inhibition of gluconeogenesis, and the regulation of lipid metabolism in the liver. These findings suggested that FVP had antidiabetic effects on high-fat diet and STZ-induced diabetic rats and could be a potential resource for treating type 2 diabetes mellitus. [Display omitted] • FVP promoted glycogen storage in diabetic rats. • FVP enhanced bile acid excretion in diabetic rats. • FVP regulated gut microbiota in diabetic rats. • FVP regulated gene expression related to glucose and lipid metabolism in diabetic rats. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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